-
公开(公告)号：US06740530B1
公开(公告)日：2004-05-25
申请号：US09718733
申请日：2000-11-22
IPC分类号： G01N110
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00585 , B01J2219/00596 , B01J2219/00603 , B01J2219/00659 , B01J2219/00693 , B41J2/14008 , B41J2002/14322 , C40B60/14 , Y10T436/25 , Y10T436/2575
摘要： Methods for testing proper operation of drop ejection units in a multi-ejector system are provided to determine whether the drop ejectors have been properly filled and/or the ejectors are emitting fully formed droplets. The methods include testing the ejectors prior to drop ejection. In this method, a priming system is used wherein fluid received by the priming system is ejected onto a test substrate to allow a scanner to determine the existence of the fluids at selected locations. The selected locations are correlated to the drop ejection units to determine which ejection units do not have biofluid or sufficient biofluid. A further method allows for ejection prior to printing, on a test substrate wherein testing for both the fullness of the ejector units as well as proper emission of the ejectors of droplets may be tested. The ejectors after being primed, eject the biofluids which are then scanned and correlated to each individual ejector. A further method provided is a laser scattering method wherein a laser beam is interposed between the drop emission path of the ejectors. Laser detection then determines whether a correlated drop ejector is properly emitting droplets.
摘要翻译： 提供了用于测试多喷射器系统中液滴喷射单元的正确操作的方法，以确定液滴喷射器是否已经被适当地填充和/或喷射器正在发射完全形成的液滴。 这些方法包括在喷射之前测试喷射器。 在该方法中，使用起动系统，其中由起动系统接收的流体被喷射到测试基板上，以允许扫描仪确定在选定位置处的流体的存在。 所选择的位置与液滴喷射单元相关，以确定哪些喷射单元不具有生物流体或足够的生物流体。 另外的方法允许在打印之前在测试基板上进行喷射，其中可以测试喷射器单元的充满度以及液滴喷射器的适当发射。 喷射器被喷涂后，喷射生物流体，然后将其扫描并与每个喷射器相关联。 提供的另一种方法是激光散射方法，其中激光束插入在喷射器的液滴发射路径之间。 然后，激光检测确定相关的液滴喷射器是否正确地发射液滴。
-
公开(公告)号：US06713022B1
公开(公告)日：2004-03-30
申请号：US09724987
申请日：2000-11-22
申请人： Jaan Noolandi , David A. Horine , Babur B. Hadimioglu , Richard H. Bruce , Joy Roy , Scott A. Elrod
发明人： Jaan Noolandi , David A. Horine , Babur B. Hadimioglu , Richard H. Bruce , Joy Roy , Scott A. Elrod
IPC分类号： B41J2175
CPC分类号： B01L3/0268 , B01L2400/0439 , G01N35/1002 , G01N2035/102 , G01N2035/1041
摘要： A biofluid drop ejection unit for ejecting biofluid drops. A biofluid drop ejection mechanism of such a unit includes a transducer, which generates energy used to emit the biofluid drop. Further provided is a reagent cartridge or biofluid containment area which holds the biofluid. The reagent cartridge or biofluid containment area is configured to hold low volumes of biofluid and to avoid contamination of the biofluid. The reagent cartridge or biofluid containment area is in operational connection with the drop ejection mechanism such that upon operation of the drop ejection mechanism, biofluid drops are emitted. The biofluid drop ejection mechanism is a high efficiency device, and may be configured as two separate pieces or as a single disposable unit.
摘要翻译： 用于喷射生物流体滴的生物流体滴落喷射单元。 这种单元的生物流体液滴喷射机构包括换能器，其产生用于发射生物流体滴的能量。 另外还提供了一个保持生物流体的试剂盒或生物流体容纳区域。 试剂盒或生物流体容纳区域被配置为保持低体积的生物流体并避免污染生物流体。 试剂盒或生物流体容纳区域与液滴喷射机构操作连接，使得在液滴喷射机构的操作时，发射生物流体液滴。 生物流体液滴喷射机构是高效率的装置，并且可以被配置为两个分开的部件或者作为单个一次性部件。
-
公开(公告)号：US06861034B1
公开(公告)日：2005-03-01
申请号：US09721388
申请日：2000-11-22
申请人： Scott A. Elrod , Joy Roy , Babur B. Hadimioglu , Richard H. Bruce , Jaan Noolandi , David A. Horine
发明人： Scott A. Elrod , Joy Roy , Babur B. Hadimioglu , Richard H. Bruce , Jaan Noolandi , David A. Horine
CPC分类号： B05B17/0607 , B01L3/0268
摘要： Provided is a priming mechanism for priming a biofluid drop ejection device having a drop ejection opening leading to an ejection reservoir. The priming mechanism includes a vacuum unit which generates a vacuum force, connected to a vacuum nozzle. The vacuum nozzle is located over the drop ejection opening. A disposable sleeve or tubing is attached to the vacuum nozzle and is placed in operational contact with the drop ejection opening. A fluid height detection sensor is positioned to sense a fluid height within at least one of the disposable tubing and the vacuum nozzle. Upon sensing a predetermined fluid height, by the fluid height detection sensor, the priming operation is completed, and the primer mechanism is removed from the operational contact with the drop ejection opening.
摘要翻译： 提供了一种用于起动生物流体液滴喷射装置的起动机构，其具有通向喷射储存器的液滴喷射开口。 起动机构包括产生与真空喷嘴连接的真空力的真空单元。 真空喷嘴位于液滴喷射口的上方。 一次性套筒或管道连接到真空喷嘴并且与液滴喷射口处于操作接触。 液体高度检测传感器被定位成感测至少一个一次性管道和真空喷嘴中的流体高度。 通过流体高度检测传感器感测到预定的流体高度时，完成起动操作，并且将底漆机构从与液滴喷射口的操作接触部分移开。
-
公开(公告)号：US06623700B1
公开(公告)日：2003-09-23
申请号：US09721386
申请日：2000-11-22
IPC分类号： B01L302
CPC分类号： B41J2/17566 , B41J2/1714 , Y10T436/2575
摘要： A level control mechanism is provided for a biofluid drop ejection device which ejects biofluid drops in small volumes. The biofluid drop device includes a drop ejection mechanism having a transducer which generates energy used to emit the biofluid drops. A reagent cartridge or biofluid holding area holds a biofluid, isolated from the drop ejection mechanism to avoid contamination between the biofluid drop ejection mechanism and the reagent cartridge. The reagent cartridge is connected to the drop ejection mechanism such that upon operation of the mechanism, the biofluid is emitted in controlled biofluid drops. A level sensor is positioned to sense a height of the biofluid within the cartridge. Upon sensing the height of the biofluid below a certain level, an adjustment is made to the height by providing at least one of additional biofluid to the cartridge, and raising the level of the entire reagent cartridge.
摘要翻译： 为生物流体液滴喷射装置提供液面控制机构，其以小体积喷射生物流体液滴。 生物流体液滴装置包括液滴喷射机构，其具有产生用于发射生物流体滴的能量的换能器。 试剂盒或生物流体保持区域保持与液滴喷射机构隔离的生物流体，以避免生物流体液滴喷射机构和试剂盒之间的污染。 试剂盒连接到液滴喷射机构，使得在机构操作时，生物流体在受控的生物流体滴下发射。 水平传感器被定位成感测盒内的生物流体的高度。 当感测到生物流体的高度低于一定水平时，通过向盒提供至少一种额外的生物流体，并提高整个试剂盒的水平来调节高度。
-
公开(公告)号：US06514704B2
公开(公告)日：2003-02-04
申请号：US09773804
申请日：2001-02-01
申请人： Richard H. Bruce , Scott A. Elrod , Babur B. Hadimioglu , David A. Horine , Jaan Noolandi , Joy Roy , Robert A. Sprague
发明人： Richard H. Bruce , Scott A. Elrod , Babur B. Hadimioglu , David A. Horine , Jaan Noolandi , Joy Roy , Robert A. Sprague
IPC分类号： C12Q168
CPC分类号： G01N35/10 , G01N35/00712 , G01N35/1009 , G01N2035/1037 , G06F19/00
摘要： A method and mechanism for ensuring quality control in printed biological assays is provided. A multi-ejector system having a plurality of individual drop ejectors is loaded with a variety of biofluids. Biofluids include at least a carrier fluid, a biological material to be used in the testing, and markers, such as fluorescent dyes. Data regarding the biofluid loaded in each of the drop ejectors is stored along with an expected signature output of the biofluid. Particularly, the signature output represents signals from individual ones of the fluorescent markers included within the biofluid. Once a biological assay consisting of the biofluid drops has been printed, a scanner capable of detecting the markers scans the biological assay and obtains signature output signals for each of the drops of the biological assay. A comparing operation is undertaken to compare the obtained signature output through the scanning operation, with the expected signature output signals for the biofluid loaded in the corresponding drop ejector. The biological material itself may also be tagged with a marker to ensure its inclusion in the biofluid. By the comparing operation, it is possible to verify the biofluids were loaded in the proper drop ejector, including the proper biological material, and that the drop ejectors are functioning properly.
-
公开(公告)号：US06503454B1
公开(公告)日：2003-01-07
申请号：US09721389
申请日：2000-11-22
IPC分类号： B01L302
CPC分类号： B01L3/0268 , G01N2035/1039 , Y10T436/2575
摘要： A multiple-ejector system for printing arrays of biofluids include a tooling plate having a plurality of sets of tooling pins extending outward from the surface of the tooling plate. A printed circuit board is provided having pairs of power connection pins and ground return pins extending from a surface of the circuit board. A plurality of biofluid drop ejection units are provided and include alignment grooves and at least a transducer. Each of the plurality of biofluid drop ejection units are connected to a corresponding one of a set of tooling pins by connection of the tooling pins and alignment grooves. The power connection pins of the pairs are in operational connection with respective transducers and the ground return connection pins of the pairs are in operational connection with a body portion of the drop ejection units. The different drop ejection units will contain different biofluids which are to be emitted onto a substrate. Verification of drop ejection units containing biofluids, may be obtained in one embodiment through the use of an optical scanner. Detection of drops at defined locations provides a verification that validates a properly formed spot is present on a substrate, and is in the correct position.
摘要翻译： 用于打印生物流体阵列的多喷射器系统包括具有从工具板的表面向外延伸的多组工具销的工具板。 提供一个印刷电路板，其具有从电路板的表面延伸的成对的电源连接引脚和接地返回引脚。 提供多个生物流体液滴喷射单元，并且包括对准凹槽和至少一个换能器。 多个生物流体滴落喷射单元中的每一个通过工具销和对准槽的连接连接到一组加工销中的对应的一个。 成对的电源连接引脚与相应的换能器操作连接，并且对的接地返回连接引脚与液滴喷射单元的主体部分操作连接。 不同的液滴喷射单元将包含将被发射到基底上的不同生物流体。 通过使用光学扫描仪可以在一个实施例中获得包含生物流体的液滴喷射单元的验证。 在限定位置处检测液滴提供验证，验证正确形成的斑点存在于基底上，并处于正确的位置。
-
公开(公告)号：US08293213B2
公开(公告)日：2012-10-23
申请号：US12403124
申请日：2009-03-12
IPC分类号： A61B5/055 , A61K39/395 , A61K38/48 , A61M37/00
摘要： A method and system for affecting a thrombus after ischemic stroke. The method may include injecting a plurality of magnetic particles into a bloodstream and moving or distorting a thrombus formed or lodged in the bloodstream using a magnetic force to manipulate the magnetic particles. The method may include conjugating ferromagnetic particles, paramagnetic particles, or superparamagnetic particles to a thrombus-specific attachment agent such as an anti-fibrin antibody, and injecting the conjugated particles into the bloodstream. Thereafter, the thrombus may be agitated, broken apart, or dissolved using a magnetic field to exert a magnetic force on the conjugated particles. The method may also include injecting a thrombolytic agent into the bloodstream to interact with and further dissolve the thrombus.
摘要翻译： 缺血性卒中后影响血栓的方法和系统。 该方法可以包括将多个磁性颗粒注入血液流中，并使用磁力来移动或扭曲在血流中形成或储存的血栓来操纵磁性颗粒。 该方法可以包括将铁磁性颗粒，顺磁性颗粒或超顺磁性颗粒结合到血栓特异性附着剂如抗纤维蛋白抗体，并将缀合的颗粒注入血流中。 此后，可以使用磁场搅动，断开或溶解血栓，以对共轭颗粒施加磁力。 该方法还可以包括将血栓溶解剂注射到血流中以与血栓相互作用并进一步溶解血栓。
-
公开(公告)号：US20110245581A1
公开(公告)日：2011-10-06
申请号：US13163977
申请日：2011-06-20
IPC分类号： A61N2/10
摘要： A method and system for affecting a thrombus after ischemic stroke. The method may include injecting a plurality of magnetic particles into a bloodstream and moving or distorting a thrombus formed or lodged in the bloodstream using a magnetic force to manipulate the magnetic particles. The method may include conjugating ferromagnetic particles, paramagnetic particles, or superparamagnetic particles to a thrombus-specific attachment agent such as an anti-fibrin antibody, and injecting the conjugated particles into the bloodstream. Thereafter, the thrombus may be agitated, broken apart, or dissolved using a magnetic field to exert a magnetic force on the conjugated particles. The method may also include injecting a thrombolytic agent into the bloodstream to interact with and further dissolve the thrombus.
摘要翻译： 缺血性卒中后影响血栓的方法和系统。 该方法可以包括将多个磁性颗粒注入血液流中，并使用磁力来移动或扭曲在血流中形成或储存的血栓来操纵磁性颗粒。 该方法可以包括将铁磁性颗粒，顺磁性颗粒或超顺磁性颗粒结合到血栓特异性附着剂如抗纤维蛋白抗体，并将缀合的颗粒注入血流中。 此后，可以使用磁场搅动，断开或溶解血栓，以对共轭颗粒施加磁力。 该方法还可以包括将血栓溶解剂注射到血流中以与血栓相互作用并进一步溶解血栓。
-
公开(公告)号：US07126134B2
公开(公告)日：2006-10-24
申请号：US10921556
申请日：2004-08-19
申请人： Meng H. Lean , Francisco E. Torres , Huangpin Ben Hsieh , Armin R. Völkel , Bryan Preas , Scott A. Elrod , John S. Fitch , Richard H. Bruce
发明人： Meng H. Lean , Francisco E. Torres , Huangpin Ben Hsieh , Armin R. Völkel , Bryan Preas , Scott A. Elrod , John S. Fitch , Richard H. Bruce
IPC分类号： G21K5/10
CPC分类号： B03C1/253
摘要： A sample manipulator that utilizes electrostatic traveling waves to selectively displace one or more samples deposited on its face is disclosed. The sample manipulator enables an operator to perform a wide variety of processes upon the deposited samples. Also disclosed are strategies for separating two or more samples, focusing a sample, and passing a reagent through a sample, all conducted on the face of the sample manipulator.
-
公开(公告)号：US07727768B2
公开(公告)日：2010-06-01
申请号：US11149632
申请日：2005-06-10
IPC分类号： G01N33/00
CPC分类号： B82Y15/00 , G01N25/4846 , G01N25/4866 , Y10S977/957 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： A method for detecting chemical reactions uses a nanocalorimeter having a substrate including thermal isolation capability residing on the substrate, thermal equilibration regions residing within the thermal isolation capability, and thermal measurement capability residing within each of the thermal equilibration regions. The thermal measurement device is connected to detection electronics. The method includes depositing drops of potentially reactive chemical solutions within the thermal equilibration region. These potentially reactive solution drops are merged through the use of drop merging electrodes residing within the thermal isolation region. The thermal change occurring within the merged solution drops is then measured with the detection electronics.
摘要翻译： 用于检测化学反应的方法使用具有包含驻留在基底上的热隔离能力的基底，驻留在热隔离能力内的热平衡区域和驻留在每个热平衡区域内的热测量能力的纳米光度计。 热测量设备连接到检测电子设备。 该方法包括在热平衡区域内沉积潜在的反应性化学溶液的液滴。 这些潜在的反应性溶液滴通过使用位于热隔离区域内的滴合并电极而合并。 然后用检测电子元件测量在合并溶液中发生的热变化。
-
-
-
-
-
-
-
-
-
搜索结果
66 条记录 (耗时 0.026 秒)
