公开(公告)号：US20050203003A1

公开(公告)日：2005-09-15

申请号：US10067857

申请日：2002-02-08

申请人： A. Craig ,  David Griffin ,  Baldomero Olivera ,  Maren Watkins ,  David Hillyard ,  Julita Imperial ,  Lourdes Cruz ,  John Wagstaff ,  Richard Layer ,  Robert Jones ,  R. McCabe

发明人： A. Craig ,  David Griffin ,  Baldomero Olivera ,  Maren Watkins ,  David Hillyard ,  Julita Imperial ,  Lourdes Cruz ,  John Wagstaff ,  Richard Layer ,  Robert Jones ,  R. McCabe

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K7/08 ,  C07K9/00 ,  C07K14/435 ,  C07K14/575 ,  C12N15/12 ,  A61K38/14 ,  A61K38/10

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K9/001 ,  C07K14/575

摘要： The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr10-contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.

摘要翻译： 本发明涉及对于cDNA克隆的contulakin-G（其是天然糖基化肽），去糖基化的唾液蛋白-G（称为Thr 10 -contulakin-G）及其衍生物 编码该成熟肽的前体和前体肽。 本发明进一步涉及该肽作为抗癫痫发作，抗炎，抗休克，抗血栓，降血压，止痛，抗精神病，帕金森病，胃肠道疾病，抑郁状态，认知功能障碍 焦虑症，迟发性运动障碍，药物依赖性，恐慌发作，躁狂症，肠易激综合征，腹泻，溃疡，胃肠道肿瘤，杜氏综合征，亨廷顿氏舞蹈病，血管渗漏，抗动脉硬化，血管和血管舒张障碍，以及神经系统，神经功能和 神经精神药理学障碍。

公开(公告)号：US20060014673A1

公开(公告)日：2006-01-19

申请号：US11174996

申请日：2005-07-06

申请人： Richard Layer ,  Karen Pemberton ,  Robert Jones ,  James Garrett ,  Baldomero Olivera ,  J. McIntosh ,  David Hillyard ,  Michelle Grilley ,  Maren Watkins ,  Ameurfina Santos ,  Glenn Zafaralla ,  A. Craig

发明人： Richard Layer ,  Karen Pemberton ,  Robert Jones ,  James Garrett ,  Baldomero Olivera ,  J. McIntosh ,  David Hillyard ,  Michelle Grilley ,  Maren Watkins ,  Ameurfina Santos ,  Glenn Zafaralla ,  A. Craig

IPC分类号： A61K38/16 ,  C07K14/435

CPC分类号： A61K38/17 ,  C07K14/43504

摘要： The present invention is directed to kappaA (κA) conopeptides and the use of these peptides for blocking the flow of potassium ions through voltage-gated potassium channels. The κA conopeptides include unglycosylated and O-glycosylated peptides.

摘要翻译： 本发明涉及kappaA（kappaA）肽以及这些肽用于阻断通过电压门控钾通道的钾离子流动的用途。 κA肽包括非糖基化和O-糖基化肽。

公开(公告)号：US20060223984A1

公开(公告)日：2006-10-05

申请号：US10647519

申请日：2003-08-26

申请人： Michael Fainzilber ,  Karel Kits ,  Alma Burlingame ,  Baldomero Olivera ,  Craig Walker ,  Maren Watkins ,  Reshma Shetty ,  Lourdes Cruz ,  Julita Imperial ,  Clark Colledge

发明人： Michael Fainzilber ,  Karel Kits ,  Alma Burlingame ,  Baldomero Olivera ,  Craig Walker ,  Maren Watkins ,  Reshma Shetty ,  Lourdes Cruz ,  Julita Imperial ,  Clark Colledge

IPC分类号： C07K7/08 ,  C07K14/435

CPC分类号： C07K14/43504 ,  A61K38/00

摘要： This invention relates to relatively short peptides about 25-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogs to the naturally available peptides, and which include three cyclizing disulfide linkages and one or more γcarboxyglutamate residues. More specifically, the present invention is directed to γ-conopeptides having the general formula I: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Cys-Xaa6-Cys-Xaa7 (SEQ ID NO:1), as described herein; or having the general formula II: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Xaa6-Cys-Xaa7-Cys-Xaa8 (SEQ ID NO:2), as defined herein; or having the general formula III: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa6-Cys-Xaa7 (SEQ ID NO:3), as described herein; or having the general formula IV: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa6-Cys-Xaa7 (SEQ ID NO:4), as described herein; or having the general formula V: Xaa1-Xaa2-Cys-Xaa3-Xaa4-Phe-Xaa5-Cys-Thr-Xaa6-Ser-Xaa7-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Gln-Thr-Tyr-Cys-Xaa8-Leu-Xaa9 (SEQ ID NO:5), as described herein. The invention further relates to specific γ-conopeptides, specific pro-γ-conopeptides and nucleic acids encoding the pro-γ-conopeptides. The invention also includes pharmaceutically acceptable salts of the conopeptides. These conopeptides are useful as agonists of neuronal pacemaker calcium channels.

公开(公告)号：US20060247173A1

公开(公告)日：2006-11-02

申请号：US11482148

申请日：2006-07-07

申请人： Baldomero Olivera ,  Richard Layer ,  Maren Watkins ,  David Hillyard ,  J. McIntosh ,  Robert Schoenfeld ,  Jacob Nielsen ,  Robert Jones

发明人： Baldomero Olivera ,  Richard Layer ,  Maren Watkins ,  David Hillyard ,  J. McIntosh ,  Robert Schoenfeld ,  Jacob Nielsen ,  Robert Jones

IPC分类号： A61K38/17 ,  C07K14/435

CPC分类号： C07K14/435 ,  A61K38/00 ,  C07K14/43504

摘要： The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The α-conotoxins, as described herein, are useful for as neuromuscular blocking agents, such as muscle relaxants.

公开(公告)号：US20050214903A1

公开(公告)日：2005-09-29

申请号：US10839227

申请日：2004-05-06

申请人： Baldomero Olivera ,  G. Cartier ,  Maren Watkins ,  David Hillyard ,  J. McIntosh ,  Richard Layer ,  Robert Jones

发明人： Baldomero Olivera ,  G. Cartier ,  Maren Watkins ,  David Hillyard ,  J. McIntosh ,  Richard Layer ,  Robert Jones

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61P3/10 ,  A61P9/00 ,  A61P9/06 ,  A61P11/06 ,  A61P25/00 ,  A61P25/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/20 ,  A61P25/28 ,  A61P25/36 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  A61P39/00 ,  A61P43/00 ,  C07K14/435 ,  C12N15/09 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07H21/04

CPC分类号： C07K14/43504 ,  A61K38/00

摘要： The invention relates to relatively short peptides (termed O-Superfamily conotoxins herein), about 20-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

摘要翻译： 本发明涉及相对较短的肽（本文中称为O超家族芋螺毒素），长度约20-40个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且其优选包括 两个二硫键。

公开(公告)号：US20050214213A1

公开(公告)日：2005-09-29

申请号：US11097315

申请日：2005-04-04

申请人： Baldomero Olivera ,  J. McIntosh ,  Maren Watkins ,  James Garrett ,  Lourdes Cruz ,  Michelle Grilley ,  Robert Schoenfeld ,  Craig Walker ,  Reshma Shetty ,  Robert Jones

发明人： Baldomero Olivera ,  J. McIntosh ,  Maren Watkins ,  James Garrett ,  Lourdes Cruz ,  Michelle Grilley ,  Robert Schoenfeld ,  Craig Walker ,  Reshma Shetty ,  Robert Jones

IPC分类号： A61K38/00 ,  C07K14/435 ,  C12N5/02 ,  A61K51/00 ,  A61K38/16

CPC分类号： C07K14/43504 ,  A61K38/00

摘要： The present invention is directed to conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, voltage-gated ligand channels and/or receptors. The invention is further directed to nucleic acid sequences encoding the conotoxin peptides and encoding propeptides, as well as the propeptides.

摘要翻译： 本发明涉及芋螺毒素肽，其衍生物或药学上可接受的盐。 本发明进一步涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控离子通道，电压门控配体通道和/或受体相关的病症中的用途。 本发明还涉及编码芋螺毒素肽和编码前肽以及前肽的核酸序列。

公开(公告)号：US20050032705A1

公开(公告)日：2005-02-10

申请号：US10895372

申请日：2004-07-21

申请人： Maren Watkins ,  Baldomero Olivera ,  David Hillyard ,  J. McIntosh ,  Robert Jones

发明人： Maren Watkins ,  Baldomero Olivera ,  David Hillyard ,  J. McIntosh ,  Robert Jones

IPC分类号： A61K38/00 ,  C07K14/435 ,  A61K38/10 ,  C07K7/08

CPC分类号： C07K14/43504 ,  A61K38/00 ,  C07K7/08 ,  C07K9/00 ,  Y10S530/855 ,  Y10S530/857

摘要： The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

摘要翻译： 本发明涉及相对短的肽（本文中称为α-芋螺毒素），长度约10-30个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且其优选包括两个 二硫键。

公开(公告)号：US06344551B1

公开(公告)日：2002-02-05

申请号：US09605990

申请日：2000-06-29

申请人： A. Grey Craig ,  David Griffin ,  Baldomero M. Olivera ,  Maren Watkins ,  David R. Hillyard ,  Julita Imperial ,  Lourdes J. Cruz ,  John D. Wagstaff ,  Richard T. Layer ,  Robert M. Jones ,  R. Tyler McCabe

发明人： A. Grey Craig ,  David Griffin ,  Baldomero M. Olivera ,  Maren Watkins ,  David R. Hillyard ,  Julita Imperial ,  Lourdes J. Cruz ,  John D. Wagstaff ,  Richard T. Layer ,  Robert M. Jones ,  R. Tyler McCabe

IPC分类号： C12N1512

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K9/001 ,  C07K14/575

摘要： The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr10-contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.

摘要翻译： 本发明涉及到编码该成熟肽的前体的cDNA克隆的contulakin-G（其是天然糖基化肽），去糖基化的连翘蛋白-G（称为Thr10-contulakin-G）及其衍生物，以及 到前体肽。 本发明进一步涉及该肽作为抗癫痫发作，抗炎，抗休克，抗血栓，降血压，止痛，抗精神病，帕金森病，胃肠道疾病，抑郁状态，认知功能障碍 焦虑症，迟发性运动障碍，药物依赖性，恐慌发作，躁狂症，肠易激综合征，腹泻，溃疡，胃肠道肿瘤，杜氏综合征，亨廷顿氏舞蹈病，血管渗漏，抗动脉硬化，血管和血管舒张障碍以及神经系统，神经功能和 神经精神药理学障碍。

公开(公告)号：US20060172948A1

公开(公告)日：2006-08-03

申请号：US11385997

申请日：2006-03-22

申请人： Baldomero Olivera ,  J. McIntosh ,  James Garrett ,  Craig Walker ,  Maren Watkins ,  Robert Jones

发明人： Baldomero Olivera ,  J. McIntosh ,  James Garrett ,  Craig Walker ,  Maren Watkins ,  Robert Jones

IPC分类号： A61K38/10 ,  C07K7/08 ,  C07K14/435

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/02 ,  C07K14/43504

摘要： The invention relates to γ-carboxyglutamate containing conopeptides, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.

公开(公告)号：US20050159586A1

公开(公告)日：2005-07-21

申请号：US11018369

申请日：2004-12-22

申请人： Baldomero Olivera ,  J. McIntosh ,  James Garrett ,  Craig Walker ,  Maren Watkins ,  Robert Jones

发明人： Baldomero Olivera ,  J. McIntosh ,  James Garrett ,  Craig Walker ,  Maren Watkins ,  Robert Jones

IPC分类号： A61K38/00 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  C07K14/435

CPC分类号： C07K14/43504 ,  A61K38/00

摘要： The invention relates to linear γ-carboxyglutamate rich conotoxins, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvillsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.

摘要翻译： 本发明涉及富含线性的γ-羧基谷氨酸富含芋螺毒素，其衍生物或其药学上可接受的盐及其用途，包括治疗神经系统疾病和精神病学疾病如抗惊厥药，作为神经保护剂或用于治疗疼痛。 本发明还涉及编码肽和编码前肽以及前肽的核酸序列。