公开(公告)号：US08715673B2

公开(公告)日：2014-05-06

申请号：US13719214

申请日：2012-12-18

Applicant: Rinat Neuroscience Corp.

Inventor： Davide Luciano Foletti ,  Javier Fernando Chaparro Riggers ,  Jacob Eli Gunn Glanville ,  Lee Mary Beth Shaughnessy ,  David Louis Shelton ,  Pavel Strop ,  Wenwu Zhai

IPC: A61K39/40

CPC classification number: C07K16/1271 ,  A61K39/40 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  A61K2300/00

Abstract: The present invention provides antagonizing antibodies that bind to S. aureus alpha-toxin. The invention further provides a method of obtaining such antibodies and antibody encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies for the treatment and/or prevention of staphylococcal disease, including, for example, pneumonia, bacteremia, sepsis, eye infection, and abscess.

Abstract translation: 本发明提供了结合金黄色葡萄球菌α-毒素的拮抗性抗体。 本发明还提供了获得这样的抗体和编码抗体的核酸的方法。 本发明还涉及用于这些抗体用于治疗和/或预防葡萄球菌疾病（包括例如肺炎，菌血症，败血症，眼睛感染和脓肿）的治疗方法。

公开(公告)号：US11602525B2

公开(公告)日：2023-03-14

申请号：US15306481

申请日：2015-04-21

Applicant: RINAT NEUROSCIENCE CORP. ,  PFIZER INC.

Inventor： Pavel Strop ,  Katherine Anne Delaria ,  Magdalena Dorywalska ,  Davide Luciano Foletti ,  Russell George Dushin ,  David Louis Shelton ,  Arvind Rajpal

IPC: A61K31/427 ,  A61K47/68 ,  A61K47/65 ,  C07K16/30 ,  G01N33/574 ,  A61K39/00

Abstract: The present invention provides transglutaminase-mediated antibody-drug conjugates with high anti-body-drug ratio (DAR) comprising 1) glutamine-containing tags, endogenous glutamines, and/or endogenous glutamines made reactive by antibody engineering or an engineered transglutaminase (e.g., with altered substrate specifity); and 2) amine donor agents comprising amine donor units, linkers, and agent moieties, wherein the DAR is at least about 5. The invention also provides methods of making and methods of using such higher drug loaded antibody-drug conjugates.