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公开(公告)号：US08715673B2
公开(公告)日：2014-05-06
申请号：US13719214
申请日：2012-12-18
发明人： Davide Luciano Foletti , Javier Fernando Chaparro Riggers , Jacob Eli Gunn Glanville , Lee Mary Beth Shaughnessy , David Louis Shelton , Pavel Strop , Wenwu Zhai
IPC分类号： A61K39/40
CPC分类号： C07K16/1271 , A61K39/40 , A61K2039/505 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K2300/00
摘要： The present invention provides antagonizing antibodies that bind to S. aureus alpha-toxin. The invention further provides a method of obtaining such antibodies and antibody encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies for the treatment and/or prevention of staphylococcal disease, including, for example, pneumonia, bacteremia, sepsis, eye infection, and abscess.
摘要翻译： 本发明提供了结合金黄色葡萄球菌α-毒素的拮抗性抗体。 本发明还提供了获得这样的抗体和编码抗体的核酸的方法。 本发明还涉及用于这些抗体用于治疗和/或预防葡萄球菌疾病（包括例如肺炎，菌血症，败血症，眼睛感染和脓肿）的治疗方法。
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2.发明授权Method of treating type 1 diabetes with antagonist IL-7 receptor antibodies 有权用拮抗剂IL-7受体抗体治疗1型糖尿病的方法公开(公告)号：US09346885B2
公开(公告)日：2016-05-24
申请号：US14109267
申请日：2013-12-17
发明人： Chia-Yang Lin , Li-Fen Lee , Wenwu Zhai
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.
摘要翻译： 本发明提供了结合白细胞介素-7受体（IL-7R）的拮抗性抗体。 本发明还提供了获得这样的抗体和抗体编码核酸的方法。 本发明还涉及这些抗体及其抗原结合部分用于治疗和/或预防2型糖尿病和免疫学障碍（包括1型糖尿病，多发性硬化症，类风湿性关节炎，移植物抗宿主病）的治疗方法 ，和狼疮。
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公开(公告)号：US20130028916A1
公开(公告)日：2013-01-31
申请号：US13627601
申请日：2012-09-26
发明人： Chia-Yang Lin , Li-Fen Lee , Wenwu Zhai
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.
摘要翻译： 本发明提供了结合白细胞介素-7受体（IL-7R）的拮抗性抗体。 本发明还提供了获得这样的抗体和抗体编码核酸的方法。 本发明还涉及这些抗体及其抗原结合部分用于治疗和/或预防2型糖尿病和免疫学障碍（包括1型糖尿病，多发性硬化症，类风湿性关节炎，移植物抗宿主病）的治疗方法 ，和狼疮。
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公开(公告)号：US10059772B2
公开(公告)日：2018-08-28
申请号：US15136584
申请日：2016-04-22
发明人： Chia-Yang Lin , Li-Fen Lee , Wenwu Zhai
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.
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公开(公告)号：US08637273B2
公开(公告)日：2014-01-28
申请号：US13627601
申请日：2012-09-26
发明人： Chia-Yang Lin , Li-Fen Lee , Wenwu Zhai
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.
摘要翻译： 本发明提供了结合白细胞介素-7受体（IL-7R）的拮抗性抗体。 本发明还提供了获得这样的抗体和抗体编码核酸的方法。 本发明还涉及这些抗体及其抗原结合部分用于治疗和/或预防2型糖尿病和免疫学障碍（包括1型糖尿病，多发性硬化症，类风湿性关节炎，移植物抗宿主病）的治疗方法 ，和狼疮。
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