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1.发明授权公开(公告)号：US07642077B2
公开(公告)日：2010-01-05
申请号：US11007437
申请日：2004-12-07
摘要： This invention relates to a method of immobilizing biocatalysts including protein and cells by co-precipitation with silicate or organosilicate matrices through the action of an organic template molecule. The organic template molecule is in general a polyamine such as polyethylenimine (PEI), or polypeptide compound bearing at least two or three basic residues selected from the group consisting of lysine, arginine, histidine, proline, hydroxyproline, N-methylhistidine, ornithine, taurine, δ-hydroxylysine, and δ-hydroxy-ω-N,N,N trimethyllysine. The invention is also directed to a silica biocomposite comprising co-precipitates of active biocatalysts, silica or organosilicates, and an N-containing organic template molecule. Such silica biocomposites are useful in biocatalysis, and other applications requiring an immobilized biocatalyst. Preferred biocatalysts for this invention are enzymes and whole cells.
摘要翻译： 本发明涉及通过有机模板分子的作用，通过与硅酸盐或有机硅酸盐基质共沉淀来固定包括蛋白质和细胞的生物催化剂的方法。 有机模板分子通常是多胺，例如聚乙烯亚胺（PEI）或具有选自赖氨酸，精氨酸，组氨酸，脯氨酸，羟脯氨酸，N-甲基组氨酸，鸟氨酸，牛磺酸中的至少两个或三个碱性残基的多肽化合物 ，δ-羟基赖氨酸和δ-羟基-ω-N，N，N三甲基赖氨酸。 本发明还涉及包含活性生物催化剂，二氧化硅或有机硅酸盐和含N有机模板分子的共沉淀物的二氧化硅生物复合物。 这种二氧化硅生物复合材料可用于生物催化和其它需要固定化生物催化剂的应用。 本发明优选的生物催化剂是酶和全细胞。
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公开(公告)号：US08574880B2
公开(公告)日：2013-11-05
申请号：US12395242
申请日：2009-02-27
摘要： This invention relates to a method of immobilizing biocatalysts including protein and cells by co-precipitation with silicate or organosilicate matrices through the action of an organic template molecule. The organic template molecule is in general a polyamine such as polyethylenimine (PEI), or polypeptide compound bearing at least two or three basic residues selected from the group consisting of lysine, arginine, histidine, proline, hydroxyproline, N-methylhistidine, ornithine, taurine, δ-hydroxylysine, and δ-hydroxy-ω-N,N,N trimethyllysine. The invention is also directed to a silica biocomposite comprising co-precipitates of active biocatalysts, silica or organosilicates, and an N-containing organic template molecule. Such silica biocomposites are useful in biocatalysis, and other applications requiring an immobilized biocatalyst. Preferred biocatalysts for this invention are enzymes and whole cells.
摘要翻译： 本发明涉及通过有机模板分子的作用，通过与硅酸盐或有机硅酸盐基质共沉淀来固定包括蛋白质和细胞的生物催化剂的方法。 有机模板分子通常是多胺，例如聚乙烯亚胺（PEI）或具有选自赖氨酸，精氨酸，组氨酸，脯氨酸，羟脯氨酸，N-甲基组氨酸，鸟氨酸，牛磺酸中的至少两个或三个碱性残基的多肽化合物 ，δ-羟基赖氨酸和δ-羟基-ω-N，N，N三甲基赖氨酸。 本发明还涉及包含活性生物催化剂，二氧化硅或有机硅酸盐和含N有机模板分子的共沉淀物的二氧化硅生物复合物。 这种二氧化硅生物复合材料可用于生物催化和其它需要固定化生物催化剂的应用。 本发明优选的生物催化剂是酶和全细胞。
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3.发明申请IMMOBILIZATION OF BIOCATALYSTS BY TEMPLATE-DIRECTED SILICATE PRECIPITATION 有权通过模板指导的硅酸盐沉淀法生物活性物质的稳定化公开(公告)号：US20090170180A1
公开(公告)日：2009-07-02
申请号：US12395242
申请日：2009-02-27
IPC分类号： C12N11/08
摘要： This invention relates to a method of immobilizing biocatalysts including protein and cells by co-precipitation with silicate or organosilicate matrices through the action of an organic template molecule. The organic template molecule is in general a polyamine such as polyethylenimine (PEI), or polypeptide compound bearing at least two or three basic residues selected from the group consisting of lysine, arginine, histidine, proline, hydroxyproline, N-methylhistidine, ornithine, taurine, δ-hydroxylysine, and δ-hydroxy-ω-N,N,N trimethyllysine. The invention is also directed to a silica biocomposite comprising co-precipitates of active biocatalysts, silica or organosilicates, and an N-containing organic template molecule. Such silica biocomposites are useful in biocatalysis, and other applications requiring an immobilized biocatalyst. Preferred biocatalysts for this invention are enzymes and whole cells.
摘要翻译： 本发明涉及通过有机模板分子的作用，通过与硅酸盐或有机硅酸盐基质共沉淀来固定包括蛋白质和细胞的生物催化剂的方法。 有机模板分子通常是多胺，例如聚乙烯亚胺（PEI）或具有选自赖氨酸，精氨酸，组氨酸，脯氨酸，羟脯氨酸，N-甲基组氨酸，鸟氨酸，牛磺酸中的至少两个或三个碱性残基的多肽化合物 ，δ-羟基赖氨酸和δ-羟基-ω-N，N，N三甲基赖氨酸。 本发明还涉及包含活性生物催化剂，二氧化硅或有机硅酸盐和含N有机模板分子的共沉淀物的二氧化硅生物复合物。 这种二氧化硅生物复合材料可用于生物催化和其它需要固定化生物催化剂的应用。 本发明优选的生物催化剂是酶和全细胞。
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4.发明申请COMPOSITION COMPRISING VARIOUS PROTEORHODOPSINS AND/OR BACTERIORHODOPSINS AND USE THEREOF 失效包含各种保护素和/或细菌体的组合物及其用途公开(公告)号：US20120010333A1
公开(公告)日：2012-01-12
申请号：US13181387
申请日：2011-07-12
申请人： Richard R. Bott , Rasmus B. Jensen , Bradley R. Kelemen , Donald E. Ward, II , Gregory M. Whited
发明人： Richard R. Bott , Rasmus B. Jensen , Bradley R. Kelemen , Donald E. Ward, II , Gregory M. Whited
IPC分类号： C09D11/04
CPC分类号： G11C7/00 , C07K14/215 , C09D11/037 , C09D11/50 , G11B7/242 , Y10S430/146 , Y10T428/249921 , Y10T428/31623 , Y10T428/31685 , Y10T428/31725 , Y10T428/31783
摘要： The present invention provides a solid material comprising an immobilized mixture of two or more proteorhodopsins, two or more bacteriorhodopsins, or one or more bacteriorhodopsin and one or more proteorhodopsins. The proteorhodopsins are selected from the group consisting of all-trans-retinal-containing proteorhodopsins and retinal analog-containing proteorhodopsins; all of which have absorption spectra that do not overlap. The bacteriorhodopsins are selected from the group consisting of all-trans-retinal-containing bacteriorhodopsins and retinal analog-containing bacteriorhodopsins; all of which have absorption spectra that do not overlap. The present invention also provides an optical information carrier, such as an optical data storage material and a fraud-proof optical data carrier, comprising the above-described solid material and a substrate selected from the group consisting of glass, paper, metal, fabric material, and plastic material, wherein said solid material is deposited on said substrate. The present invention further provides security ink comprising one or more hydrophilic polymers and a mixture of various photochromic materials.
摘要翻译： 本发明提供了一种固体材料，其包含两种或多种蛋白质视紫红质，两种或更多种细菌视紫红质，或一种或多种细菌视紫红质和一种或多种蛋白质视紫质的固定化混合物。 蛋白质视紫红质选自全反式视黄醛的蛋白质视黄素和含视网膜类似物的蛋白质视紫红质; 所有这些都具有不重叠的吸收光谱。 细菌视紫红质选自全反式视网膜含细菌视紫红质和视网膜类似物的细菌视紫红质; 所有这些都具有不重叠的吸收光谱。 本发明还提供一种光学信息载体，例如光学数据存储材料和防欺诈光学数据载体，其包括上述固体材料和选自玻璃，纸，金属，织物材料的基材 和塑料材料，其中所述固体材料沉积在所述基底上。 本发明还提供了包含一种或多种亲水聚合物和各种光致变色材料的混合物的安全油墨。
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5.发明授权Composition comprising various proteorhodopsins and/or bacteriorhodopsins and use thereof 有权包含各种蛋白质视紫红质和/或细菌视紫红质的组合物及其用途公开(公告)号：US07982000B2
公开(公告)日：2011-07-19
申请号：US11569862
申请日：2005-06-09
申请人： Richard R. Bott , Rasmus B. Jensen , Bradley R. Kelemen , Donald E. Ward, II , Gregory M. Whited
发明人： Richard R. Bott , Rasmus B. Jensen , Bradley R. Kelemen , Donald E. Ward, II , Gregory M. Whited
IPC分类号： C07K17/00 , G11B11/00 , G11B7/085 , G11B7/00 , G11B5/84 , G11B7/24 , B32B3/02 , G03F7/00 , G02F1/09
CPC分类号： G11C7/00 , C07K14/215 , C09D11/037 , C09D11/50 , G11B7/242 , Y10S430/146 , Y10T428/249921 , Y10T428/31623 , Y10T428/31685 , Y10T428/31725 , Y10T428/31783
摘要： The present invention provides a solid material comprising an immobilized mixture of two or more proteorhodopsins, two or more bacteriorhodopsins, or one or more bacteriorhodopsin and one or more proteorhodopsins. The proteorhodopsins are selected from the group consisting of all-trans-retinal-containing proteorhodopsins and retinal analog-containing proteorhodopsins; all of which have absorption spectra that do not overlap. The bacteriorhodopsins are selected from the group consisting of all-trans-retinal-containing bacteriorhodopsins and retinal analog-containing bacteriorhodopsins; all of which have absorption spectra that do not overlap. The present invention also provides an optical information carrier, such as an optical data storage material and a fraud-proof optical data carrier, comprising the above-described solid material and a substrate selected from the group consisting of glass, paper, metal, fabric material, and plastic material, wherein said solid material is deposited on said substrate. The present invention further provides security ink comprising one or more hydrophilic polymers and a mixture of various photochromic materials.
摘要翻译： 本发明提供了一种固体材料，其包含两种或多种蛋白质视紫红质，两种或更多种细菌视紫红质，或一种或多种细菌视紫红质和一种或多种蛋白质视紫质的固定化混合物。 蛋白质视紫红质选自全反式视黄醛的蛋白质视黄素和含视网膜类似物的蛋白质视紫红质; 所有这些都具有不重叠的吸收光谱。 细菌视紫红质选自全反式视网膜含细菌视紫红质和视网膜类似物的细菌视紫红质; 所有这些都具有不重叠的吸收光谱。 本发明还提供一种光学信息载体，例如光学数据存储材料和防欺诈光学数据载体，其包括上述固体材料和选自玻璃，纸，金属，织物材料的基材 和塑料材料，其中所述固体材料沉积在所述基底上。 本发明还提供了包含一种或多种亲水聚合物和各种光致变色材料的混合物的安全油墨。
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6.发明申请Composition Comprising Various Proteorhodopsins and/or Bacteriorhodopsins and Use Thereof 有权包含各种蛋白质视紫红质和/或细菌视紫红质及其用途的组合物公开(公告)号：US20080292828A1
公开(公告)日：2008-11-27
申请号：US11569862
申请日：2005-06-09
申请人： Richard R. Bott , Rasmus B. Jensen , Bradley R. Kelemen , Donald E. Ward, II , Gregory M. Whited
发明人： Richard R. Bott , Rasmus B. Jensen , Bradley R. Kelemen , Donald E. Ward, II , Gregory M. Whited
IPC分类号： C08L89/00 , C07K14/195 , B32B27/00
CPC分类号： G11C7/00 , C07K14/215 , C09D11/037 , C09D11/50 , G11B7/242 , Y10S430/146 , Y10T428/249921 , Y10T428/31623 , Y10T428/31685 , Y10T428/31725 , Y10T428/31783
摘要： The present invention provides a solid material comprising an immobilized mixture of two or more proteorhodopsins, two or more bacteriorhodopsins, or one or more bacteriorhodopsin and one or more proteorhodopsins. The proteorhodopsins are selected from the group consisting of all-trans-retinal-containing proteorhodopsins and retinal analog-containing proteorhodopsins; all of which have absorption spectra that do not overlap. The bacteriorhodopsins are selected from the group consisting of all-trans-retinal-containing bacteriorhodopsins and retinal analog-containing bacteriorhodopsins; all of which have absorption spectra that do not overlap. The present invention also provides an optical information carrier, such as an optical data storage material and a fraud-proof optical data carrier, comprising the above-described solid material and a substrate selected from the group consisting of glass, paper, metal, fabric material, and plastic material, wherein said solid material is deposited on said substrate. The present invention further provides security ink comprising one or more hydrophilic polymers and a mixture of various photochromic materials.
摘要翻译： 本发明提供了一种固体材料，其包含两种或多种蛋白质视紫红质，两种或更多种细菌视紫红质，或一种或多种细菌视紫红质和一种或多种蛋白质视紫质的固定化混合物。 蛋白质视紫红质选自全反式视黄醛的蛋白质视黄素和含视网膜类似物的蛋白质视紫红质; 所有这些都具有不重叠的吸收光谱。 细菌视紫红质选自全反式视网膜含细菌视紫红质和视网膜类似物的细菌视紫红质; 所有这些都具有不重叠的吸收光谱。 本发明还提供一种光学信息载体，例如光学数据存储材料和防欺诈光学数据载体，其包括上述固体材料和选自玻璃，纸，金属，织物材料的基材 和塑料材料，其中所述固体材料沉积在所述基底上。 本发明还提供了包含一种或多种亲水聚合物和各种光致变色材料的混合物的安全油墨。
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7.发明授权Composition comprising various proteorhodopsins and/or bacteriorhodopsins and use thereof 失效包含各种蛋白质视紫红质和/或细菌视紫红质的组合物及其用途公开(公告)号：US08372953B2
公开(公告)日：2013-02-12
申请号：US13181387
申请日：2011-07-12
申请人： Richard R. Bott , Rasmus B. Jensen , Bradley R. Kelemen , Donald E. Ward, II , Gregory M. Whited
发明人： Richard R. Bott , Rasmus B. Jensen , Bradley R. Kelemen , Donald E. Ward, II , Gregory M. Whited
CPC分类号： G11C7/00 , C07K14/215 , C09D11/037 , C09D11/50 , G11B7/242 , Y10S430/146 , Y10T428/249921 , Y10T428/31623 , Y10T428/31685 , Y10T428/31725 , Y10T428/31783
摘要： The present invention provides a solid material comprising an immobilized mixture of two or more proteorhodopsins, two or more bacteriorhodopsins, or one or more bacteriorhodopsin and one or more proteorhodopsins. The proteorhodopsins are selected from the group consisting of all-trans-retinal-containing proteorhodopsins and retinal analog-containing proteorhodopsins; all of which have absorption spectra that do not overlap. The bacteriorhodopsins are selected from the group consisting of all-trans-retinal-containing bacteriorhodopsins and retinal analog-containing bacteriorhodopsins; all of which have absorption spectra that do not overlap. The present invention also provides an optical information carrier, such as an optical data storage material and a fraud-proof optical data carrier, comprising the above-described solid material and a substrate selected from the group consisting of glass, paper, metal, fabric material, and plastic material, wherein said solid material is deposited on said substrate. The present invention further provides security ink comprising one or more hydrophilic polymers and a mixture of various photochromic materials.
摘要翻译： 本发明提供了一种固体材料，其包含两种或多种蛋白质视紫红质，两种或更多种细菌视紫红质，或一种或多种细菌视紫红质和一种或多种蛋白质视紫质的固定化混合物。 蛋白质视紫红质选自全反式视黄醛的蛋白质视黄素和含视网膜类似物的蛋白质视紫红质; 所有这些都具有不重叠的吸收光谱。 细菌视紫红质选自全反式视网膜含细菌视紫红质和视网膜类似物的细菌视紫红质; 所有这些都具有不重叠的吸收光谱。 本发明还提供一种光学信息载体，例如光学数据存储材料和防欺诈光学数据载体，其包括上述固体材料和选自玻璃，纸，金属，织物材料的基材 和塑料材料，其中所述固体材料沉积在所述基底上。 本发明还提供了包含一种或多种亲水聚合物和各种光致变色材料的混合物的安全油墨。
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8.发明授权Photochromic material comprising a proteorhodopsin apoprotein and a retinal analog 失效包含蛋白质视紫红质脱辅基蛋白和视网膜类似物的光致变色材料公开(公告)号：US07638073B2
公开(公告)日：2009-12-29
申请号：US11569864
申请日：2005-06-09
IPC分类号： C07C231/00 , C12Q1/68
CPC分类号： C07C403/14 , A61K31/07 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/275 , A61K38/1709 , C07C47/225 , C07C47/24 , C07C47/548 , C07C2601/16 , C07C2602/30 , G02B5/23 , A61K2300/00
摘要： The present invention relates to a photochromic material comprising a proteorhodopsin apoprotein and a retinal analog. In one embodiment, the retinal analog is an azulenic retinoid compound. In another embodiment, the retinal analog is a compound that is structurally similarly to all-trans-retinal. The proteorhodopsin apoprotein and the retinal analog form a photochromic material having different spectral properties from those of a corresponding photochromic material formed by the same proteorhodopsin apoprotein and all-trans-retinal. In one embodiment of the application, the retinal analog-containing proteorhodopsin has an absorbance spectrum that does not overlap significantly with that of all-trans-retinal-containing proteorhodopsin. In another embodiment of the application, the retinal analog-containing proteorhodopsin yields a red-shifted visual chromophore compared with the all-trans-retinal-containing proteorhodopsin chromophore. The photochromic material of the present invention is useful as an optical data storage carrier, a fraud-proof optical data carrier, security ink, and in other optical applications.
摘要翻译： 本发明涉及包含蛋白质视紫红质脱辅蛋白和视网膜类似物的光致变色材料。 在一个实施方案中，视黄醛类似物是靛蓝色素类化合物。 在另一个实施方案中，视黄醛类似物是在结构上类似于全反式视黄醛的化合物。 蛋白质视紫红质脱辅基蛋白和视网膜类似物形成与由相同的蛋白质视紫红质脱蛋白和全反式视网膜形成的相应的光致变色材料具有不同光谱性质的光致变色材料。 在本申请的一个实施方案中，含视网膜类似物的蛋白质视紫红质具有与全反式视黄醛的蛋白质视紫红质相似的吸收光谱。 在本申请的另一个实施方案中，与含全反式视网膜的蛋白质视紫红质发色团相比，含视网膜类似物的蛋白质视紫红质产生红移视觉发色团。 本发明的光致变色材料可用作光学数据存储载体，防欺诈光学数据载体，安全墨水以及其它光学应用。
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9.发明申请Photochromic Material Comprising a Proteorhodopsin Apoprotein and a Retinal Analog 失效包含蛋白质视紫红质蛋白和视网膜模拟物的光致变色材料公开(公告)号：US20080290328A1
公开(公告)日：2008-11-27
申请号：US11569864
申请日：2005-06-09
IPC分类号： G02B5/23
CPC分类号： C07C403/14 , A61K31/07 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/275 , A61K38/1709 , C07C47/225 , C07C47/24 , C07C47/548 , C07C2601/16 , C07C2602/30 , G02B5/23 , A61K2300/00
摘要： The present invention relates to a photochromic material comprising a proteorhodopsin apoprotein and a retinal analog. In one embodiment, the retinal analog is an azulenic retinoid compound. In another embodiment, the retinal analog is a compound that is structurally similarly to all-trans-retinal. The proteorhodopsin apoprotein and the retinal analog form a photochromic material having different spectral properties from those of a corresponding photochromic material formed by the same proteorhodopsin apoprotein and all-trans-retinal. In one embodiment of the application, the retinal analog-containing proteorhodopsin has an absorbance spectrum that does not overlap significantly with that of all-trans-retinal-containing proteorhodopsin. In another embodiment of the application, the retinal analog-containing proteorhodopsin yields a red-shifted visual chromophore compared with the all-trans-retinal-containing proteorhodopsin chromophore. The photochromic material of the present invention is useful as an optical data storage carrier, a fraud-proof optical data carrier, security ink, and in other optical applications.
摘要翻译： 本发明涉及包含蛋白质视紫红质脱辅蛋白和视网膜类似物的光致变色材料。 在一个实施方案中，视黄醛类似物是靛类视黄醇化合物。 在另一个实施方案中，视黄醛类似物是在结构上类似于全反式视黄醛的化合物。 蛋白质视紫红质脱辅基蛋白和视网膜类似物形成与由相同的蛋白质视紫红质脱蛋白和全反式视网膜形成的相应的光致变色材料具有不同光谱性质的光致变色材料。 在本申请的一个实施方案中，含视网膜类似物的蛋白质视紫红质具有与全反式视黄醛的蛋白质视紫红质相似的吸收光谱。 在本申请的另一个实施方案中，与含全反式视网膜的蛋白质视紫红质发色团相比，含视网膜类似物的蛋白质视紫红质产生红移视觉发色团。 本发明的光致变色材料可用作光学数据存储载体，防欺诈光学数据载体，安全墨水以及其它光学应用。
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