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公开(公告)号：US4732974A
公开(公告)日：1988-03-22
申请号：US836535
申请日：1986-03-05
IPC分类号： C07K16/00 , A61K39/395 , A61K51/00 , A61K51/08 , A61K51/10 , C07K1/107 , C07K1/113 , C07K1/13 , C07K14/00 , G01N33/532 , G01N33/534 , G01N33/574 , C07K3/08 , A61K39/00 , A61K39/42 , A61K43/00
CPC分类号： G01N33/534 , A61K51/1048 , A61K51/1093 , C07K1/1077 , G01N33/532 , A61K2121/00 , A61K2123/00
摘要： A conjugate of a protein or polypeptide and a metal ion is prepared by reacting a metal ion transfer complex comprising a chelate of 4,5-dihydroxyl-m-benzenedisulfonic acid or a salt thereof with a protein or polypeptide that is covalently bound to an exogenous chelating group having a greater affinity than 4,5-dihydroxyl-m-benzenedisulfonic acid for the metal ion.
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2.发明授权Coupling agents for joining radionuclide metal ions with biologically useful proteins 失效将放射性核素金属离子与生物有用的蛋白质结合的偶联剂
公开(公告)号：US4861869A
公开(公告)日：1989-08-29
申请号：US868800
申请日：1986-05-29
IPC分类号： C07K16/00 , A61K31/40 , A61K39/395 , A61K51/00 , A61K51/10 , A61P35/00 , C07C327/32 , C07D207/46 , C07D233/60 , C07D233/64 , C07D521/00 , C07K1/113 , C07K5/06 , C07K14/00 , C07K16/30 , C12P21/00 , C12P21/08 , G01N33/534 , G01N33/574
CPC分类号： C07D231/12 , A61K51/10 , A61K51/1093 , C07D207/46 , C07D233/56 , C07D249/08 , A61K2121/00 , A61K2123/00 , Y10S530/866
摘要： This invention relates to bifunctional coupling agents useful in forming conjugates with biologically useful molecules, such as antibodies. These conjugates can be complexed with radionuclide metal ions to provide materials useful for in vivo diagnostic and therapeutic applications.
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3.发明授权Coupling agents for joining radionuclide metal ions with biologically useful proteins 失效将放射性核素金属离子与生物有用的蛋白质结合的偶联剂
公开(公告)号：US5082930A
公开(公告)日：1992-01-21
申请号：US275415
申请日：1988-11-23
IPC分类号： A61K51/10 , C07D207/46 , C07D521/00
CPC分类号： C07D231/12 , A61K51/10 , A61K51/1093 , C07D207/46 , C07D233/56 , C07D249/08 , A61K2121/00 , A61K2123/00 , Y10S424/809 , Y10S435/96 , Y10S435/968 , Y10S530/866
摘要： This invention relates to bifunctional coupling agents useful in forming conjugates with biologically useful molecules, such as antibodies. These conjugates can be complexed with radionuclide metal ions to provide materials useful for in vivo diagnostic and therapeutic applications.
摘要翻译： 本发明涉及可用于与生物有用分子形成缀合物的双功能偶联剂，例如抗体。 这些缀合物可以与放射性核素金属离子络合，以提供可用于体内诊断和治疗应用的材料。
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公开(公告)号：US4837003A
公开(公告)日：1989-06-06
申请号：US650127
申请日：1984-09-13
申请人： Robert A. Nicolotti
发明人： Robert A. Nicolotti
IPC分类号： A61K51/00 , A61K39/395 , A61K51/10 , A61P35/00 , C07D207/44 , C07D207/452
CPC分类号： C07D207/452 , A61K51/1093 , A61K2121/00 , A61K2123/00 , Y10S436/804 , Y10S436/813 , Y10S530/866
摘要： Methods and reagents for attaching radionuclide metal ions to antibody fragments are disclosed. A coupling agent is employed which contains a maleimidyl group linked, through a divalent organic moiety, to a group capable of forming a chelate complex with the radionuclide metal ion. Antibody fragments labeled with radionuclide metal ions by the disclosed procedure are useful for in vivo diagnostic or therapeutic applications.
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公开(公告)号：US4659839A
公开(公告)日：1987-04-21
申请号：US659456
申请日：1984-10-10
IPC分类号： G01N33/534 , A61K47/48 , A61K49/16 , A61K51/00 , A61K51/10 , C07D207/44 , C07D207/452 , G01N33/563 , C07D207/40 , A61K43/00 , A61K49/00
CPC分类号： C07D207/452 , A61K47/48715 , A61K49/16 , A61K51/1093 , A61K2123/00
摘要： Bifunctional coupling agent for joining radionuclide metal ions to biologically useful molecules, including antibody Fab' fragments are disclosed. The coupling agents contain a maleimide moiety and a paramagnetic or radionuclide chelating moiety. The maleimide can be used to selectively bind to free sulfhydryl groups, or amine groups.
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