-
1.发明授权Heterocyclic substituted 2-acylamino-5-thiazoles, their preparation and pharmaceutical compositions containing them 失效杂环取代的2-酰基氨基-5-噻唑，其制备方法和含有它们的药物组合物
公开(公告)号：US5314889A
公开(公告)日：1994-05-24
申请号：US889910
申请日：1992-05-29
IPC分类号： A61K31/425 , A61K31/426 , A61K31/427 , A61P1/00 , A61P1/04 , A61P1/18 , A61P25/04 , A61P29/00 , A61P35/00 , A61P43/00 , C07D277/20 , C07D277/38 , C07D277/40 , C07D277/46 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , A61K31/495 , A61K31/415 , A61K31/50 , C07D405/00 , C07D411/00 , C07D413/00 , C07D417/00
CPC分类号： C07D417/06 , C07D277/40 , C07D417/12 , C07D417/14 , C07D513/04
摘要： A 2-Acylaminothiazole of formula: ##STR1## in which R.sub.1 is H, an alkyl or a substituted alkyl; R.sub.IV is a cycloalkyl, an aromatic group such as phenyl or a heterocyclic group which are unsubstituted or substituted; R.sub.V is a substituted alkyl, a substituted carboxy such as an ester or an amide; or R.sub.IV and R.sub.V together represent a phenoxyalkylene group which may be substituted on the phenyl; and Z is a heterocyclic e.g. indolyl group; or a salt of compound (I).
摘要翻译： 下式的2-酰基氨基噻唑：其中R 1是H，烷基或取代的烷基; RIV是未取代或取代的环烷基，芳基如苯基或杂环基; RV是取代的烷基，取代的羧基如酯或酰胺; 或RIV和RV一起表示可在苯基上取代的苯氧基亚烷基; Z是杂环的。 吲哚基 或化合物（I）的盐。
-
公开(公告)号：US5656648A
公开(公告)日：1997-08-12
申请号：US474548
申请日：1995-06-07
申请人： Robert Boigegrain , Roger Brodin , Daniel Frehel , Danielle Gully , Jean-Charles Molimard , Dominique Olliero
发明人： Robert Boigegrain , Roger Brodin , Daniel Frehel , Danielle Gully , Jean-Charles Molimard , Dominique Olliero
IPC分类号： A61K31/404 , A61K31/425 , A61K31/427 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/505 , A61P1/00 , A61P3/08 , A61P25/00 , A61P25/18 , C07D277/40 , C07D417/04 , C07D417/12 , C07D417/14 , A01K31/425
CPC分类号： C07D417/12 , A61K31/425 , A61K31/427 , A61K31/47 , A61K31/4709 , C07D277/40 , C07D417/14
摘要： The invention relates to the use of a compound of formula: ##STR1## in which Y represents a 3-quinolyl group or a 2-indolyl group of formula: ##STR2## in which: X is chosen from 4-chloro-2,6-dimethoxyphenyl, 2,6-dimethoxy-4-methylphenyl, 2,4,5-trimethoxyphenyl, 4-methyl-2,3,6-trimethoxyphenyl, 2,6-dimethoxy-4-ethylphenyl, 2,4,6-trimethoxy-5-chlorophenyl, 2,4,6-trimethoxy-3-pyridyl, 2,4-dimethoxy-6-methyl-3-pyridyl, 6-chloro-2,4-dimethoxy-5-pyrimidinyl, 2,4,6-trimethoxy-5-pyrimidinyl, 5-chloro-2,4-dimethoxyphenyl, 5-chloro-2-methoxy-4-methylphenyl, 2,5-dimethoxy-4-methylphenyl, 4-trifluoromethyl-2,6-dimethoxyphenyl, 2,4-dimethoxy-5-methylphenyl, 5-ethyl-2,4-dimethoxyphenyl and 2,4-dimethoxyphenyl groups;Z represents H, a C.sub.1 -C.sub.4 -alkyl or a benzyl;for combating complaints whose treatment necessitates a stimulation of the cholecystokinin receptors by a total or partial agonist effect.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐：其中Y表示3-喹啉基或下式的2-吲哚基，其中：X选自4-氯 - 2,6-二甲氧基苯基，2,6-二甲氧基-4-甲基苯基，2,4,5-三甲氧基苯基，4-甲基-2,3,6-三甲氧基苯基，2,6-二甲氧基-4-乙基苯基， 6-三甲氧基-5-氯苯基，2,4,6-三甲氧基-3-吡啶基，2,4-二甲氧基-6-甲基-3-吡啶基，6-氯-2,4-二甲氧基-5-嘧啶基， 4,6-三甲氧基-5-嘧啶基，5-氯-2,4-二甲氧基苯基，5-氯-2-甲氧基-4-甲基苯基，2,5-二甲氧基-4-甲基苯基，4-三氟甲基 - 二甲氧基苯基，2,4-二甲氧基-5-甲基苯基，5-乙基-2,4-二甲氧基苯基和2,4-二甲氧基苯基; Z表示H，C1-C4烷基或苄基; 用于对付其治疗需要通过全部或部分激动剂作用刺激胆囊收缩素受体的投诉。
-
3.发明授权Heterocyclic substituted 2-acylamino-5-thiazoles, their preparation and pharmaceutical compositions containing them 失效杂环取代的2-酰基氨基-5-噻唑，其制备方法和含有它们的药物组合物
公开(公告)号：US5380736A
公开(公告)日：1995-01-10
申请号：US205408
申请日：1994-03-03
IPC分类号： A61K31/425 , A61K31/426 , A61K31/427 , A61P1/00 , A61P1/04 , A61P1/18 , A61P25/04 , A61P29/00 , A61P35/00 , A61P43/00 , C07D277/20 , C07D277/38 , C07D277/40 , C07D277/46 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04
CPC分类号： C07D417/06 , C07D277/40 , C07D417/12 , C07D417/14 , C07D513/04
摘要： Heterocyclic substituted 2-acylamino-5-thiazoles, their preparation and pharmaceutical compositions containing them.A 2-Acylaminothiazole of formula: ##STR1## in which R.sub.1 is H, an alkyl or a substituted alkyl; R.sub.IV is a cycloalkyl, an aromatic group such as phenyl or a heterocyclic group which are unsubstituted or substituted; R.sub.V is a substituted alkyl, a substituted carboxy such as an ester or an amide; or R.sub.IV and R.sub.V together represent a phenoxyalkylene group which may be substituted on the phenyl; and Z is a heterocyclic e.g. indolyl group; or a salt of compound (I).
摘要翻译： 杂环取代的2-酰基氨基-5-噻唑，其制备方法和含有它们的药物组合物。 下式的2-酰基氨基噻唑：取代的烷基; RIV是未取代或取代的环烷基，芳基如苯基或杂环基; RV是取代的烷基，取代的羧基如酯或酰胺; 或RIV和RV一起表示可在苯基上取代的苯氧基亚烷基; Z是杂环的。 吲哚基 或化合物（I）的盐。
-
4.发明授权3-amidopyrazole derivatives, process for preparing these and pharmaceutical compositions containing them 失效3-酰氨基吡唑衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5744491A
公开(公告)日：1998-04-28
申请号：US778105
申请日：1997-01-02
IPC分类号： A61K31/415 , A61K31/41 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61P1/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/18 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C07D453/02 , C07D453/06 , C07D495/04
CPC分类号： C07D403/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/06 , Y02P20/55
摘要： The present invention relates to new pyrazole derivatives possessing an amide group substituted with an amino acid or one of its derivatives at position 3 and variously substituted in positions 1, 2, 4 or 5 of the pyrazole ring, to a process for preparing these and to pharmaceutical compositions containing the said pyrazole derivatives as an active ingredient.
摘要翻译： 本发明涉及具有酰胺基的新的吡唑衍生物，其被取代为吡唑环的氨基酸或其位置3的衍生物，或其取代的吡唑环的第1,2,4或5位，其制备方法和 含有所述吡唑衍生物作为活性成分的药物组合物。
-
公开(公告)号：US5616592A
公开(公告)日：1997-04-01
申请号：US394756
申请日：1995-02-27
IPC分类号： A61K31/415 , A61K31/41 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61P1/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/18 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C07D453/02 , C07D453/06 , C07D495/04 , A61K31/47
CPC分类号： C07D403/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/06 , Y02P20/55
摘要： The present invention relates to new pyrazole derivatives possessing an amide group substituted with an amino acid or one of its derivatives at position 3 and variously substituted in positions 1, 2, 4 or 5 of the pyrazole ring, to a process for preparing these and to pharmaceutical compositions containing the said pyrazole derivatives as an active ingredient.
-
6.发明授权Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors, their preparation and pharmaceutical compositions containing them 失效对神经降压素受体有活性的取代的1-苯基-3-吡唑酰胺，其制剂和含有它们的药物组合物
公开(公告)号：US5723483A
公开(公告)日：1998-03-03
申请号：US630761
申请日：1996-04-10
申请人： Bernard Labeeuw , Danielle Gully , Francis Jeanjean , Jean-Charles Molimard , Robert Boigegrain
发明人： Bernard Labeeuw , Danielle Gully , Francis Jeanjean , Jean-Charles Molimard , Robert Boigegrain
IPC分类号： A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/435 , A61K31/439 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5377 , A61P1/00 , A61P25/00 , A61P35/00 , A61P43/00 , C07C61/20 , C07C62/34 , C07C243/22 , C07C255/66 , C07C309/45 , C07C309/47 , C07C311/21 , C07D231/12 , C07D231/14 , C07D231/38 , C07D233/62 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D413/04 , C07D413/12 , C07D453/02 , A01N43/56
CPC分类号： C07D401/10 , C07C243/22 , C07C255/66 , C07C309/45 , C07C309/47 , C07C311/21 , C07D231/14 , C07D401/12 , C07D403/10 , C07D403/12 , C07D413/04 , C07D453/02 , C07C2101/02 , C07C2101/08 , C07C2102/10
摘要： The invention relates to new substituted 1-phenyl-3-pyrazolecarboxamides having a great affinity for human neurotensin receptors, to a process for preparing them and to pharmaceutical compositions containing them as active principles. More particularly, this invention relates to the discovery that the affinity for neurotensin receptors, especially human neurotensin receptors, is increased by substituting the phenyl group of 1-phenyl-3-pyrazolecarboxamide compounds with particular groups.
摘要翻译： 本发明涉及对人神经降压素受体具有很大亲和力的新的取代的1-苯基-3-吡唑酰胺，其制备方法和含有它们作为活性成分的药物组合物。 更具体地，本发明涉及通过用特定基团取代1-苯基-3-吡唑甲酰胺化合物的苯基来增加对神经降压素受体，特别是人神经降压素受体的亲和性的发现。
-
公开(公告)号：US5635526A
公开(公告)日：1997-06-03
申请号：US393829
申请日：1995-02-24
IPC分类号： A61K31/415 , A61K31/41 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61P1/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/18 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C07D453/02 , C07D453/06 , C07D495/04 , C07D231/18 , C07D231/20
CPC分类号： C07D403/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/06 , Y02P20/55
摘要： The present invention relates to new pyrazole derivatives possessing an amide group substituted with an amino acid or one of its derivatives at position 3 and variously substituted in positions 1, 2, 4 or 5 of the pyrazole ring, to a process for preparing these and to pharmaceutical compositions containing the said pyrazole derivatives as an active ingredient.
-
8.发明授权Substituted 1-naphthyl-3-pyrazolecarboxamides which are active on neurotensin, their preparation and pharmaceutical compositions containing them 失效在神经丝氨酸上具有活性的取代的1-萘基-3-吡唑酰胺，其制备方法和含有它们的药物组合物
公开(公告)号：US5502059A
公开(公告)日：1996-03-26
申请号：US320270
申请日：1994-10-11
申请人： Bernard Labeeuw , Danielle Gully , Francis Jeanjean , Jean-Charles Molimard , Robert Boigegrain
发明人： Bernard Labeeuw , Danielle Gully , Francis Jeanjean , Jean-Charles Molimard , Robert Boigegrain
IPC分类号： A61K31/415 , A61K31/435 , A61P1/00 , A61P1/04 , A61P1/06 , A61P1/14 , A61P25/00 , A61P25/18 , A61P43/00 , C07C243/22 , C07C255/66 , C07D231/14 , C07D401/04 , C07D401/14 , C07D231/10 , A61K31/44 , A61K31/535 , C07D403/00 , C07D413/00 , C07D471/16
CPC分类号： C07D401/04 , C07C243/22 , C07C255/66 , C07D231/14
摘要： The invention relates to substituted 1-naphthyl-3-pyrazolecarboxamides of formula I: ##STR1## Application: These compounds are useful for the treatment of neuropsychiatric disorders, especially those associated with a dysfunction of the dopaminergic systems.
摘要翻译： 本发明涉及式I的取代的1-萘基-3-吡唑酰胺：应用：这些化合物可用于治疗神经精神障碍，特别是与多巴胺能系统的功能障碍相关的疾病。
-
9.发明授权Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors, their preparation and pharamaceutical compositions containing them 失效对神经降压素受体有活性的取代的1-苯基-3-吡唑酰胺，其制剂和含有它们的药用组合物公开(公告)号：US06172239B2
公开(公告)日：2001-01-09
申请号：US09374697
申请日：1999-08-16
申请人： Bernard Labeeuw , Danielle Gully , Francis JeanJean , Jean-Charles Molimard , Robert Boigegrain
发明人： Bernard Labeeuw , Danielle Gully , Francis JeanJean , Jean-Charles Molimard , Robert Boigegrain
IPC分类号： C07D23114
CPC分类号： C07D401/10 , C07C243/22 , C07C255/66 , C07C309/45 , C07C309/47 , C07C311/21 , C07C2601/02 , C07C2601/08 , C07C2602/10 , C07D231/14 , C07D401/12 , C07D403/10 , C07D403/12 , C07D413/04 , C07D453/02
摘要： The invention relates to compounds of the formula The compounds have agreat affinity for the neurotensin receptors.
摘要翻译： 本发明涉及下式的化合物：该化合物对神经降压素受体具有强烈的亲和力。
-
公开(公告)号：US5965579A
公开(公告)日：1999-10-12
申请号：US976309
申请日：1997-11-21
申请人： Bernard Labeeuw , Danielle Gully , Francis Jeanjean , Jean-Charles Molimard , Robert Boigegrain
发明人： Bernard Labeeuw , Danielle Gully , Francis Jeanjean , Jean-Charles Molimard , Robert Boigegrain
IPC分类号： A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/435 , A61K31/439 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5377 , A61P1/00 , A61P25/00 , A61P35/00 , A61P43/00 , C07C61/20 , C07C62/34 , C07C243/22 , C07C255/66 , C07C309/45 , C07C309/47 , C07C311/21 , C07D231/12 , C07D231/14 , C07D231/38 , C07D233/62 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D413/04 , C07D413/12 , C07D453/02
CPC分类号： C07D401/10 , C07C243/22 , C07C255/66 , C07C309/45 , C07C309/47 , C07C311/21 , C07D231/14 , C07D401/12 , C07D403/10 , C07D403/12 , C07D413/04 , C07D453/02 , C07C2101/02 , C07C2101/08 , C07C2102/10
摘要： The invention relates to compounds of the formula: ##STR1## Compounds of the above formula have a great affinity for the neurotensin receptors.
-
-
-
-
-
-
-
-
-
搜索结果
19 条记录 (耗时 0.032 秒)
