利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

21 条记录 (耗时 0.025 秒)

    Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
    4.
    发明申请
    Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device 审中-公开
    用药物洗脱植入式医疗装置捕获祖细胞内皮细胞

    公开(公告)号：US20070141107A1

    公开(公告)日：2007-06-21

    申请号：US11560356

    申请日：2006-11-15

    申请人： Michael Kutryk ,  Robert Cottone ,  Stephen Rowland ,  Margaret Yoklavich

    发明人： Michael Kutryk ,  Robert Cottone ,  Stephen Rowland ,  Margaret Yoklavich

    IPC分类号： A61F2/06

    CPC分类号： A61L31/10 ,  A61F2/91 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/256 ,  A61L2300/438 ,  A61L2300/64 ,  A61L2400/12

    摘要： A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is provided with a coating with a pharmaceutical composition containing a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises one or more barrier layers, and a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.

    摘要翻译： 提供用于植入体内血管或腔内结构的医疗装置，其刺激正血管重塑。 医疗装置（例如支架和合成移植物）具有包含含有控释基质和用于将药物直接递送至周围组织的一种或多种药物物质的药物组合物的涂层。 医疗装置上的涂层还包含一个或多个阻挡层，以及用于在损伤部位的用于恢复内皮的装置的血液接触表面中捕获祖细胞内皮细胞的配体，例如肽，抗体或小分子 。 特别地，药物涂层的支架用于例如用于预防或抑制再狭窄的球囊血管成形术程序。

    Medical device with coating that promotes endothelial cell adherence and differentiation
    5.
    发明申请
    Medical device with coating that promotes endothelial cell adherence and differentiation 审中-公开
    具有促进内皮细胞粘附和分化的涂层的医疗装置

    公开(公告)号：US20060135476A1

    公开(公告)日：2006-06-22

    申请号：US11297105

    申请日：2005-12-08

    申请人： Michael Kutryk ,  Robert Cottone ,  Stephen Rowland ,  Michael Kuliszewski

    发明人： Michael Kutryk ,  Robert Cottone ,  Stephen Rowland ,  Michael Kuliszewski

    IPC分类号： A61K31/721 ,  A61F2/06 ,  A61F2/82

    CPC分类号： A61L31/10 ,  A61K31/721 ,  A61L27/34 ,  A61L31/16 ,  C08L5/02

    摘要： Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting the progenitor endothelial cell to accelerate adherence, growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vascular disease such as restenosis, artherosclerosis or other types of vessel obstructions are disclosed.

    摘要翻译： 提供组合物和方法用于生产诸如支架，支架移植物，合成血管移植物，心脏瓣膜的医疗装置，其包被生物相容性基质，其包含抗体，抗体片段或小分子，其识别，结合和/ 或与祖细胞表面抗原相互作用以将细胞固定在装置的表面。 器件上的涂层还可以含有用于促进祖细胞内皮细胞的化合物或生长因子，以加速结合细胞在装置表面上的成熟和功能性内皮细胞的粘附，生长和分化，以防止内膜增生。 公开了制备用于治疗诸如再狭窄，动脉粥样硬化或其它类型的血管障碍的血管疾病的哺乳动物的医疗装置，组合物和方法的方法。

    MEDICAL DEVICE WITH COATING FOR CAPTURING GENETICALLY-ALTERED CELLS AND METHODS FOR USING SAME
    8.
    发明申请
    MEDICAL DEVICE WITH COATING FOR CAPTURING GENETICALLY-ALTERED CELLS AND METHODS FOR USING SAME 审中-公开
    具有用于捕获遗传改变的细胞的涂层的医疗装置及其使用方法

    公开(公告)号：US20070191932A1

    公开(公告)日：2007-08-16

    申请号：US11622985

    申请日：2007-01-12

    申请人： Michael Kutryk ,  Robert Cottone ,  Stephen Rowland ,  Michael Kuliszewski

    发明人： Michael Kutryk ,  Robert Cottone ,  Stephen Rowland ,  Michael Kuliszewski

    IPC分类号： A61F2/82 ,  A61F2/06

    CPC分类号： A61F2/82 ,  A61F2250/0067 ,  A61L31/084 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/252 ,  A61L2300/608

    摘要： Therapeutic and drug delivery systems are provided in the form of medical devices with coatings for capturing and immobilizing target cells such as circulating progenitor or genetically-altered mammalian cells in vivo. The genetically-altered cells are transfected with genetic material for expressing a marker gene and at least one therapeutic gene in a constitutively or controlled manner. The marker gene is a cell membrane antigen not found in circulating cells in the blood stream and therapeutic gene encodes a peptide for the treatment of disease, such as, vascular disease and cancer. The coating on the medical device may be a biocompatible matrix comprising at least one type of ligand, such as antibodies, antibody fragments, other peptides and small molecules, which recognize and bind the target cells. The therapeutic and/or drug delivery systems may be provided with a signal source such as activator molecules for stimulating the modified cells to express and secrete the desired marker and therapeutic gene products.

    摘要翻译： 治疗和药物递送系统以医疗装置的形式提供，其具有用于在体内捕获和固定靶细胞如循环祖细胞或遗传改变的哺乳动物细胞的包衣。 遗传改变的细胞用组成型或受控方式表达标志基因和至少一种治疗基因的遗传物质转染。 标记基因是血流中循环细胞中未发现的细胞膜抗原，治疗基因编码用于治疗疾病如血管疾病和癌症的肽。 医疗装置上的涂层可以是生物相容性基质，其包含识别和结合靶细胞的至少一种类型的配体，例如抗体，抗体片段，其他肽和小分子。 治疗和/或药物递送系统可以具有信号源，例如用于刺激修饰的细胞以表达和分泌所需标记物和治疗基因产物的活化剂分子。

    Drug eluting implantable medical device
    9.
    发明申请
    Drug eluting implantable medical device 审中-公开
    药物洗脱植入式医疗器械

    公开(公告)号：US20070134290A1

    公开(公告)日：2007-06-14

    申请号：US11494801

    申请日：2006-07-26

    申请人： Stephen Rowland ,  Ike Juman ,  Robert Cottone ,  David Camp

    发明人： Stephen Rowland ,  Ike Juman ,  Robert Cottone ,  David Camp

    IPC分类号： A61F2/06

    CPC分类号： A61F2/82 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/604 ,  C08L67/04

    摘要： A drug eluting medical device is provided for implanting into vessels or luminal structures within the body of a patient. The coated medical device, such as a stent, vascular, or synthetic graft comprises a coating consisting of a controlled-release matrix of a bioabsorbable, biocompatible, bioerodible, biodegradable, nontoxic material, such as a Poly(DL-Lactide-co-Glycolide) polymer, and at least one pharmaceutical substance, or bioactive agent incorporated within the matrix or layered within layers of matrix. In particular, the drug eluting medical device when implanted into a patient, delivers the drugs or bioactive agents within the matrix to adjacent tissues in a controlled and desired rate depending on the drug and site of implantation.

    摘要翻译： 提供药物洗脱医疗装置用于植入患者体内的血管或腔内结构。 涂覆的医疗装置，例如支架，血管或合成移植物包括由生物可吸收的，生物相容的，可生物降解的，可生物降解的，无毒的材料例如Poly（DL-丙交酯 - 共 - 乙交酯）的控制释放基质 ）聚合物，以及至少一种药物物质或引入基质内的生物活性剂或层叠在基质层内。 特别地，当药物洗脱医疗装置植入患者体内时，根据药物和植入部位以受控和期望的速率将基质内的药物或生物活性剂递送到相邻组织。

    Medical device with coating that promotes endothelial cell adherence and differentiation
    10.
    发明申请
    Medical device with coating that promotes endothelial cell adherence and differentiation 审中-公开
    具有促进内皮细胞粘附和分化的涂层的医疗装置

    公开(公告)号：US20070042017A1

    公开(公告)日：2007-02-22

    申请号：US11482329

    申请日：2006-07-07

    申请人： Michael Kutryk ,  Robert Cottone ,  Stephen Rowland ,  Michael Kuliszewski

    发明人： Michael Kutryk ,  Robert Cottone ,  Stephen Rowland ,  Michael Kuliszewski

    IPC分类号： A61F2/06

    CPC分类号： A61L31/16 ,  A61L27/08 ,  A61L27/303 ,  A61L27/44 ,  A61L27/54 ,  A61L29/103 ,  A61L29/126 ,  A61L29/16 ,  A61L31/084 ,  A61L31/088 ,  A61L31/10 ,  A61L31/125 ,  A61L2300/258 ,  A61L2300/45 ,  B82Y30/00

    摘要： Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting the progenitor endothelial cell to accelerate adherence, growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vascular disease such as restenosis, artherosclerosis or other types of vessel obstructions are disclosed.

    摘要翻译： 提供组合物和方法用于生产诸如支架，支架移植物，合成血管移植物，心脏瓣膜的医疗装置，其包被生物相容性基质，其包含抗体，抗体片段或小分子，其识别，结合和/ 或与祖细胞表面抗原相互作用以将细胞固定在装置的表面。 器件上的涂层还可以含有用于促进祖细胞内皮细胞的化合物或生长因子，以加速结合细胞在装置表面上的成熟和功能性内皮细胞的粘附，生长和分化，以防止内膜增生。 公开了制备用于治疗诸如再狭窄，动脉粥样硬化或其它类型的血管障碍的血管疾病的哺乳动物的医疗装置，组合物和方法的方法。