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    Shape memory alloy articles with improved fatigue performance and methods therefor
    3.
    发明授权
    Shape memory alloy articles with improved fatigue performance and methods therefor 有权
    具有改善疲劳性能的形状记忆合金制品及其方法

    公开(公告)号：US07811393B2

    公开(公告)日：2010-10-12

    申请号：US11557274

    申请日：2006-11-07

    申请人： Bret A. Dooley ,  Christopher C. Lasley ,  Michael R. Mitchell ,  Robert R. Steele ,  Eric M. Tittelbaugh

    发明人： Bret A. Dooley ,  Christopher C. Lasley ,  Michael R. Mitchell ,  Robert R. Steele ,  Eric M. Tittelbaugh

    IPC分类号： A61F2/06 ,  C22C19/03

    CPC分类号： A61F2/82 ,  A61B2017/00867 ,  A61C2201/007 ,  A61L31/022 ,  A61L31/121 ,  A61L31/14 ,  A61L2400/16 ,  C22F1/006

    摘要： Articles made of shape memory alloys having improved fatigue performance and to methods of treating articles formed from shape memory alloy materials by pre-straining the articles (or desired portions of the articles) in a controlled manner so that the resultant articles exhibit improved fatigue performance. The shape memory articles are preferably medical devices, more preferably implantable medical devices. They are most preferably devices of nitinol shape memory alloy, most particularly that is superelastic at normal body temperature. The pre-straining method of the present invention as performed on such articles includes the controlled introduction of non-recoverable tensile strains greater than about 0.20% at the surface of a desired portion of a shape memory alloy article. Controlled pre-straining operations are performed on the shape-set nitinol metal to achieve non-recoverable tensile strain greater than about 0.20% at or near the surface of selected regions in the nitinol metal article. The pre-straining operations result in a significant increase in fatigue life of the selectively treated regions and an overall improvement in the fatigue performance of the device.

    摘要翻译： 由具有改善的疲劳性能的形状记忆合金制成的制品以及通过以受控的方式预制品（或制品的所需部分）来处理由形状记忆合金材料形成的制品的方法，使得所得制品表现出改进的疲劳性能。 形状记忆物品优选是医疗装置，更优选可植入医疗装置。 它们最优选为镍钛诺形状记忆合金的装置，最特别的是在正常体温下是超弹性的。 对这种制品进行的本发明的预应变方法包括在形状记忆合金制品的期望部分的表面处控制引入大于约0.20％的不可恢复的拉伸应变。 在形状组成的镍钛诺金属上进行受控的预应变操作，以在镍钛诺金属制品的选定区域的表面处或附近实现大于约0.20％的不可恢复拉伸应变。 预应变操作导致选择性处理区域的疲劳寿命显着增加，并且整体提高了设备​​的疲劳性能。

    Shape memory alloy articles with improved fatigue performance and methods therefor
    4.
    发明授权
    Shape memory alloy articles with improved fatigue performance and methods therefor 有权
    具有改善疲劳性能的形状记忆合金制品及其方法

    公开(公告)号：US07789979B2

    公开(公告)日：2010-09-07

    申请号：US10428872

    申请日：2003-05-02

    申请人： Bret A. Dooley ,  Christopher C. Lasley ,  Michael R. Mitchell ,  Robert R. Steele ,  Eric M. Tittelbaugh

    发明人： Bret A. Dooley ,  Christopher C. Lasley ,  Michael R. Mitchell ,  Robert R. Steele ,  Eric M. Tittelbaugh

    IPC分类号： C23F1/10

    CPC分类号： A61F2/82 ,  A61B2017/00867 ,  A61C2201/007 ,  A61L31/022 ,  A61L31/121 ,  A61L31/14 ,  A61L2400/16 ,  C22F1/006

    摘要： Articles made of shape memory alloys having improved fatigue performance and to methods of treating articles formed from shape memory alloy materials by pre-straining the articles (or desired portions of the articles) in a controlled manner so that the resultant articles exhibit improved fatigue performance. The shape memory articles are preferably medical devices, more preferably implantable medical devices. They are most preferably devices of nitinol shape memory alloy, most particularly that is superelastic at normal body temperature. The pre-straining method of the present invention as performed on such articles includes the controlled introduction of non-recoverable tensile strains greater than about 0.20% at the surface of a desired portion of a shape memory alloy article. Controlled pre-straining operations are performed on the shape-set nitinol metal to achieve nonrecoverable tensile strain greater than about 0.20% at or near the surface of selected regions in the nitinol metal article. The pre-straining operations result in a significant increase in fatigue life of the selectively treated regions and an overall improvement in the fatigue performance of the device.

    摘要翻译： 由具有改善的疲劳性能的形状记忆合金制成的制品以及通过以受控的方式预制品（或制品的所需部分）来处理由形状记忆合金材料形成的制品的方法，使得所得制品表现出改进的疲劳性能。 形状记忆物品优选是医疗装置，更优选可植入医疗装置。 它们最优选为镍钛诺形状记忆合金的装置，最特别的是在正常体温下是超弹性的。 对这种制品进行的本发明的预应变方法包括在形状记忆合金制品的期望部分的表面处控制引入大于约0.20％的不可恢复的拉伸应变。 在形状固定的镍钛诺金属上进行受控的预应变操作，以在镍钛诺金属制品的选定区域的表面处或附近实现大于约0.20％的不可恢复的拉伸应变。 预应变操作导致选择性处理区域的疲劳寿命显着增加，并且整体提高了设备​​的疲劳性能。

    PROGENITOR ENDOTHELIAL CELL CAPTURING WITH A DRUG ELUTING IMPLANTABLE MEDICAL DEVICE
    8.
    发明申请
    PROGENITOR ENDOTHELIAL CELL CAPTURING WITH A DRUG ELUTING IMPLANTABLE MEDICAL DEVICE 有权
    致命的内皮细胞捕获与药物注射植入式医疗装置

    公开(公告)号：US20130295156A1

    公开(公告)日：2013-11-07

    申请号：US13868938

    申请日：2013-04-23

    申请人： OrbusNeich Medical, Inc.

    发明人： Robert John Cottone, Jr. ,  Stephen M. Rowland ,  Sherry Parker

    IPC分类号： A61L31/16 ,  A61L31/10 ,  A61L31/12 ,  A61L31/08

    CPC分类号： A61L31/16 ,  A61F2/91 ,  A61L27/30 ,  A61L27/54 ,  A61L29/10 ,  A61L29/16 ,  A61L31/08 ,  A61L31/082 ,  A61L31/10 ,  A61L31/12 ,  A61L31/121 ,  A61L2300/256 ,  C12N5/0692 ,  C12N2510/00

    摘要： A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.

    摘要翻译： 提供用于植入体内血管或腔内结构的医疗装置，其刺激正血管重塑。 诸如支架和合成移植物之类的医疗装置涂覆有由控释基质和一种或多种用于将药物直接递送到周围组织的药物物质组成的药物组合物。 医疗装置上的涂层还包含配体，例如肽，抗体或小分子，用于在装置的血液接触表面中捕获祖细胞内皮细胞，用于在损伤部位恢复内皮。 特别地，药物涂层的支架用于例如用于预防或抑制再狭窄的球囊血管成形术程序。

    SHAPE MEMORY ALLOY ARTICLES WITH IMPROVED FATIGUE PERFORMANCE AND METHODS THEREFORE
    9.
    发明申请
    SHAPE MEMORY ALLOY ARTICLES WITH IMPROVED FATIGUE PERFORMANCE AND METHODS THEREFORE 有权
    具有改进的疲劳性能的形状记忆合金文章及其方法

    公开(公告)号：US20120323298A1

    公开(公告)日：2012-12-20

    申请号：US13545750

    申请日：2012-07-10

    申请人： Bret A. Dooley ,  Christopher C. Lasley ,  Michael R. Mitchell ,  Robert R. Steele ,  Eric M. Tittelbaugh

    发明人： Bret A. Dooley ,  Christopher C. Lasley ,  Michael R. Mitchell ,  Robert R. Steele ,  Eric M. Tittelbaugh

    IPC分类号： A61F2/82 ,  A61F2/01

    CPC分类号： A61F2/82 ,  A61B2017/00867 ,  A61C2201/007 ,  A61L31/022 ,  A61L31/121 ,  A61L31/14 ,  A61L2400/16 ,  C22F1/006

    摘要： Articles made of shape memory alloys having improved fatigue performance and to methods of treating articles formed from shape memory alloy materials by pre-straining the articles (or desired portions of the articles) in a controlled manner so that the resultant articles exhibit improved fatigue performance. The shape memory articles are preferably medical devices, more preferably implantable medical devices. They are most preferably devices of nitinol shape memory alloy, most particularly that is superelastic at normal body temperature. The pre-straining method of the present invention as performed on such articles includes the controlled introduction of non-recoverable tensile strains greater than about 0.20% at the surface of a desired portion of a shape memory alloy article. Controlled pre-straining operations are performed on the shape-set nitinol metal to achieve non-recoverable tensile strain greater than about 0.20% at or near the surface of selected regions in the nitinol metal article.

    摘要翻译： 由具有改善的疲劳性能的形状记忆合金制成的制品以及通过以受控的方式预制品（或制品的所需部分）来处理由形状记忆合金材料形成的制品的方法，使得所得制品表现出改进的疲劳性能。 形状记忆物品优选是医疗装置，更优选可植入医疗装置。 它们最优选为镍钛诺形状记忆合金的装置，最特别的是在正常体温下是超弹性的。 对这种制品进行的本发明的预应变方法包括在形状记忆合金制品的期望部分的表面处控制引入大于约0.20％的不可恢复的拉伸应变。 在形状组成的镍钛诺金属上进行受控的预应变操作，以在镍钛诺金属制品的选定区域的表面处或附近实现大于约0.20％的不可恢复拉伸应变。