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公开(公告)号：US08543208B2
公开(公告)日：2013-09-24
申请号：US12554959
申请日：2009-09-07
IPC分类号： A61N1/00
CPC分类号： A61B5/076 , A61B5/0006 , A61B5/0031 , A61B5/0478 , A61B5/0482 , A61B5/4094 , A61B5/686 , A61B5/742 , A61B5/7475 , A61N1/36064 , A61N1/36135 , A61N1/37252 , A61N1/37258 , A61N1/37282 , G06F19/00
摘要： An interactive implantable medical device system includes an implantable medical device and a network-enabled external device capable of bi-directional communication and interaction with the implantable medical device. The external device is programmed to interact with other similarly-enabled devices. The system facilitates improved patient care by eliminating unnecessary geographic limitations on implantable medical device interrogation and programming, and by allowing patients, physicians, and other users to access medical records, history, and information and to receive status and care-related alerts and messages anywhere there is access to a communications network.
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公开(公告)号：US07494458B2
公开(公告)日：2009-02-24
申请号：US11974712
申请日：2007-10-15
IPC分类号： A61N2/04
CPC分类号： A61N2/02
摘要： Disclosed is a system and method for treating headaches. The system employs a self-contained, battery operated, readily portable and easy-to-operate head-mounted magnetic depolarizer to generate a transient or time-varying high-intensity magnetic field into and around the user's head or neck. The magnetic depolarizer system can be used to depolarize the neurons of the brain and/or the trigeminal nerve. This type of neuronal depolarization has the capability for terminating migraine or other types of headaches.
摘要翻译： 公开了一种治疗头痛的系统和方法。 该系统采用独立的电池供电，易于携带和易于操作的头戴磁性去极化器，以在用户的头部或颈部内和周围产生瞬时或时变的高强度磁场。 磁去极化系统可用于去极化脑和/或三叉神经的神经元。 这种类型的神经元去极化具有终止偏头痛或其他类型头痛的能力。
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公开(公告)号：US06427086B1
公开(公告)日：2002-07-30
申请号：US09557168
申请日：2000-04-21
申请人： Robert E. Fischell , David R. Fischell , Adrian R. M. Upton , Dennis R. Potts , Benjamin D. Pless
发明人： Robert E. Fischell , David R. Fischell , Adrian R. M. Upton , Dennis R. Potts , Benjamin D. Pless
IPC分类号： A61N136
CPC分类号： A61B5/6814 , A61B5/0476 , A61B5/4094 , A61N1/36017 , A61N1/36025 , A61N1/3605 , A61N1/36064 , A61N1/37235
摘要： Disclosed is a means and method for placing an implantable neurostimulator control module into a place in the cranium where cranial bone has been removed. The method for accomplishing this cranial implantation is by first removing a patient's hair over the site of the implant, then cutting the scalp at that site and pulling it back to expose the cranium. A neurosurgeon would then remove a portion of the cranial bone to accept a control module to be implanted within that hole. The control module would then be placed into that hole. It is also conceived that the control module would be fixed in place by the use of one or more attachment devices such as a multiplicity of bone screws placed through holes in one or more flanges that extend over the cranium beyond the control module. The implantation could also include a fairing placed around the control module to provide a smooth contour under the patient's scalp. Also described is a spacer shim placed under the flange(s) to adjust the position of the control module so that its bottom surface does not put pressure on the dura mater lying directly over the brain tissue at the bottom of the hole. It is also envisioned that a resorbable disk could be placed under the bottom surface of the control module to further protect the brain and/or to elute an anti-biotic or anti-inflammatory substance to reduce the possibility of infection and/or inflammation.
摘要翻译： 公开了一种用于将可植入的神经刺激器控制模块放置在颅骨已被移除的头颅中的位置的手段和方法。 完成这种颅骨植入的方法是首先将患者的头发去除植入物的部位，然后在该部位切割头皮并将其拉回以暴露颅骨。 然后，神经外科医生将去除颅骨的一部分以接受待植入该孔内的控制模块。 然后将控制模块放入该孔中。 还可以想到，控制模块将通过使用一个或多个附接装置固定在适当的位置，例如通过一个或多个凸缘中的孔布置的多个骨螺钉，所述多个骨螺钉在颅骨上延伸超过控制模块。 植入还可以包括放置在控制模块周围的整流罩，以在患者的头皮下面提供平滑的轮廓。 还描述了放置在凸缘下方的间隔垫片，以调节控制模块的位置，使得其底部表面不对直接位于孔底部的脑组织的硬脑膜施加压力。 还可以设想，可再吸收的盘可以放置在控制模块的底表面下方以进一步保护大脑和/或洗脱抗生素或抗炎物质以减少感染和/或炎症的可能性。
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4.发明授权EEG d-c voltage shift as a means for detecting the onset of a neurological event 失效EEG d-c电压偏移作为检测神经系统事件发作的手段
公开(公告)号：US6061593A
公开(公告)日：2000-05-09
申请号：US65739
申请日：1998-04-24
IPC分类号： A61N1/36 , A61D5/0476
CPC分类号： A61B5/0476 , A61B5/4094 , A61B5/6814 , A61N1/3605 , A61N1/36025 , A61N1/36082 , A61N1/37211
摘要： Disclosed herein is a multiple electrode, closed-loop system for the treatment of certain neurological disorders such as epilepsy, migraine headaches and Parkinson's disease. Specifically, the present invention combines a multi-electrode array with sophisticated signal processing techniques to achieve reliable detection of the onset of a neurological event (such as an epileptic seizure or migraine headache) typically originating from a focus of limited spatial extent within the brain. It is highly desirable to detect an epileptic seizure at least 5 seconds before the onset of clinical symptoms. Since there is often a d-c shift in the EEG voltage more than 5 seconds before the seizure, disclosed herein is a means for utilizing the d-c shift of the EEG for early detection of the seizure.
摘要翻译： 本文公开了用于治疗某些神经障碍如癫痫，偏头痛和帕金森病的多电极闭环系统。 具体地，本发明将多电极阵列与复杂的信号处理技术相结合，以实现通常来自脑内有限空间范围内的焦点的神经系统事件（例如癫痫发作或偏头痛头痛）的发作的可靠检测。 在临床症状发作前至少5秒检测癫痫发作是非常需要的。 由于在癫痫发作前超过5秒脑电图经常发生d-c偏移，所以这里公开了利用脑电图的d-c位移来早期检测癫痫发作的手段。
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5.发明授权Low frequency magnetic neurostimulator for the treatment of neurological disorders 有权低频磁神经刺激仪用于治疗神经系统疾病公开(公告)号：US07601116B2
公开(公告)日：2009-10-13
申请号：US11436676
申请日：2006-05-16
IPC分类号： A61N2/04
CPC分类号： A61N2/006 , A61N1/32 , A61N1/36021 , A61N1/36025 , A61N1/36064 , A61N1/36071 , A61N1/36082 , A61N2/008 , A61N2/02
摘要： A system for treating neurological conditions by low-frequency time varying electrical stimulation includes an electrical device for applying such low-frequency energy, in a range below approximately 10 Hz, to the patient's brain tissue. An implantable embodiment applies direct electrical stimulation to electrodes implanted in or on the patient's brain, while a non-invasive embodiment causes a magnetic field to induce electrical currents in the patient's brain.
摘要翻译： 用于通过低频时变电刺激治疗神经病症的系统包括用于将低频能量（在约10Hz以下的范围）施加到患者的脑组织的电气装置。 可植入实施例对植入在患者大脑中或患者大脑上的电极施加直接电刺激，而非侵入性实施例导致磁场诱导患者大脑中的电流。
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公开(公告)号：US6016449A
公开(公告)日：2000-01-18
申请号：US957869
申请日：1997-10-27
IPC分类号： A61N1/36
CPC分类号： A61B5/0476 , A61B5/4094 , A61B5/6814 , A61N1/3605 , A61N1/36025 , A61N1/36082 , A61N1/37211
摘要： Disclosed is a multiple electrode, closed-loop, responsive system for the treatment of certain neurological diseases such as epilepsy, migraine headaches and Parkinson's disease. Brain electrodes would be placed in close proximity to the brain or deep within brain tissue. When a neurological event such as the onset of an epileptic seizure occurs, EEG signals from the electrodes are processed by signal conditioning means in a control module that can be placed beneath the patient's scalp, within the patient's chest, or situated externally on the patient. Neurological event detection means in the control module will then cause a response to be generated for stopping the neurological event. The response could be an electrical signal to brain electrodes or to electrodes located remotely in the patient's body. The response could also be the release of medication or the application of a sensory input such as sound, light or mechanical vibration or electrical stimulation of the skin. The response to the neurological event can originate from devices either internal or external to the patient. The system also has the capability for multi-channel recording of EEG related signals that occur both before and after the detection of a neurological event. Programmability of many different operating parameters of the system by means of external equipment provides adaptability for treating patients who manifest different symptoms and who respond differently to the response generated by the system.
摘要翻译： 公开了一种用于治疗某些神经系统疾病如癫痫，偏头痛和帕金森病的多重电极闭环应答系统。 脑电极将放置在靠近脑部或脑组织深处。 当出现诸如癫痫发作的神经系统事件时，来自电极的EEG信号由控制模块中的信号调节装置处理，该控制模块可以放置在患者的头皮之下，患者的胸部内，或者位于病人的外部。 然后，控制模块中的神经事件检测装置将产生用于停止神经系统事件的响应。 响应可以是对脑电极或位于病人身体远端的电极的电信号。 该反应也可以是药物的释放或者诸如声音，光或机械振动或电刺激皮肤的感觉输入的应用。 对神经系统事件的反应可以来自患者内部或外部的装置。 该系统还具有在检测神经系统事件之前和之后发生的EEG相关信号的多通道记录的能力。 通过外部设备对系统的许多不同操作参数的可编程性提供了适应性，用于治疗表现不同症状的患者，并且对系统产生的反应有不同的反应。
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7.发明授权公开(公告)号：US08140160B2
公开(公告)日：2012-03-20
申请号：US11436190
申请日：2006-05-16
IPC分类号： A61N1/36
CPC分类号： A61B5/076 , A61B5/0006 , A61B5/0031 , A61B5/0478 , A61B5/0482 , A61B5/4094 , A61B5/686 , A61B5/742 , A61B5/7475 , A61N1/36064 , A61N1/36135 , A61N1/37252 , A61N1/37258 , A61N1/37282 , G06F19/00
摘要： An interactive implantable medical device system includes an implantable medical device and a network-enabled external device capable of bi-directional communication and interaction with the implantable medical device. The external device is programmed to interact with other similarly-enabled devices. The system facilitates improved patient care by eliminating unnecessary geographic limitations on implantable medical device interrogation and programming, and by allowing patients, physicians, and other users to access medical records, history, and information and to receive status and care-related alerts and messages anywhere there is access to a communications network.
摘要翻译： 交互式可植入医疗装置系统包括能够与可植入医疗装置进行双向通信和交互的可植入医疗装置和能够启用网络的外部装置。 外部设备被编程为与其他类似启用的设备进行交互。 该系统通过消除对植入式医疗设备询问和编程的不必要的地理限制，以及允许患者，医生和其他用户访问医疗记录，历史和信息以及随时接收状态和护理相关的警报和消息来促进改善患者护理 可以访问通信网络。
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公开(公告)号：US06402678B1
公开(公告)日：2002-06-11
申请号：US09629210
申请日：2000-07-31
IPC分类号： A61N204
CPC分类号： A61N2/02
摘要： Disclosed is a means and method for the treatment of migraine headaches. Patients who have migraine headaches typically have a band of excited brain neurons that are a precursor of the headache. By placing an intense alternating magnetic field onto a certain region of the brain, an electrical current can be generated in the cerebral cortex that can depolarize these excited brain neurons. This procedure can stop a migraine headache in some patients or at least decrease its severity. The device to perform this function can be called a “magnetic depolarizer”. The magnetic depolarizer can be placed in some headgear such as a bicycle helmet in order to place the magnetic field at the correct location relative to the patient's cerebral cortex. This technique can be particularly valuable for patients who have a perceptible aura that occurs prior to the onset of a migraine headache. A visual aura caused by the progression of an excited band of neurons in a patient's occipital lobe, which aura occurs 20 to 30 minutes prior to the onset of head pain, would be particularly well treated by means of the magnetic depolarizer.
摘要翻译： 披露了治疗偏头痛的手段和方法。 患有偏头痛头痛的患者通常具有一系列兴奋的脑神经元，这是头痛的前兆。 通过将强烈的交变磁场置于大脑的某一区域，可以在大脑皮质中产生电流，这可以使这些兴奋的脑神经元去极化。 该程序可以阻止一些患者的偏头痛，或至少降低其严重程度。 执行此功能的设备可称为“磁去极化器”。 磁性去极化器可以放置在诸如自行车头盔的某些头盔中，以便将磁场放置在相对于患者大脑皮质的正确位置。 这种技术对于在偏头痛发作之前出现可感知的光环的患者可能是特别有价值的。 通过磁性去极化器特别良好地治疗患者枕叶中激发的神经元带的进展引起的视觉光环，其在头痛发作之前20至30分钟发生的光环。
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9.发明授权
公开(公告)号：US6134474A
公开(公告)日：2000-10-17
申请号：US483806
申请日：2000-01-15
IPC分类号： A61N1/36
CPC分类号： A61B5/0476 , A61B5/4094 , A61B5/6814 , A61N1/3605 , A61N1/36025 , A61N1/36082 , A61N1/37211
摘要： Disclosed is a multiple electrode, closed-loop, responsive system for the treatment of certain neurological diseases such as epilepsy, migraine headaches and Parkinson's disease. Brain electrodes would be placed in close proximity to the brain or deep within brain tissue. When a neurological event such as the onset of an epileptic seizure occurs, EEG signals from the electrodes are processed by signal conditioning means in a control module that can be placed beneath the patient's scalp, within the patient's chest, or situated externally on the patient. Neurological event detection means in the control module will then cause a response to be generated for stopping the neurological event. The response could be an electrical signal to brain electrodes or to electrodes located remotely in the patient's body. The response could also be the release of medication or the application of a sensory input such as sound, light or mechanical vibration or electrical stimulation of the skin. The response to the neurological event can originate from devices either internal or external to the patient. The system also has the capability for multi-channel recording of EEG related signals that occur both before and after the detection of a neurological event. Programmability of many different operating parameters of the system by means of external equipment provides adaptability for treating patients who manifest different symptoms and who respond differently to the response generated by the system.
摘要翻译： 公开了一种用于治疗某些神经系统疾病如癫痫，偏头痛和帕金森病的多重电极闭环应答系统。 脑电极将放置在靠近脑部或脑组织深处。 当出现诸如癫痫发作的神经系统事件时，来自电极的EEG信号由控制模块中的信号调节装置处理，该控制模块可以放置在患者的头皮之下，患者的胸部内，或者位于病人的外部。 然后，控制模块中的神经事件检测装置将产生用于停止神经系统事件的响应。 响应可以是对脑电极或位于病人身体远端的电极的电信号。 该反应也可以是药物的释放或者诸如声音，光或机械振动或电刺激皮肤的感觉输入的应用。 对神经系统事件的反应可以来自患者内部或外部的设备。 该系统还具有在检测神经系统事件之前和之后发生的EEG相关信号的多通道记录的能力。 通过外部设备对系统的许多不同操作参数的可编程性提供了适应性，用于治疗表现不同症状的患者，并且对系统产生的反应有不同的反应。
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10.发明授权公开(公告)号：US06591138B1
公开(公告)日：2003-07-08
申请号：US09652964
申请日：2000-08-31
IPC分类号： A61N136
CPC分类号： A61N2/006 , A61N1/32 , A61N1/36021 , A61N1/36025 , A61N1/36064 , A61N1/36071 , A61N1/36082 , A61N2/008 , A61N2/02
摘要： A system for treating neurological conditions by low-frequency time varying electrical stimulation includes an electrical device for applying such low-frequency energy, in a range below approximately 10 Hz, to the patient's brain tissue. An implantable embodiment applies direct electrical stimulation to electrodes implanted in or on the patient's brain, while a non-invasive embodiment causes a magnetic field to induce electrical currents in the patient's brain.
摘要翻译： 用于通过低频时变电刺激治疗神经病症的系统包括用于将低频能量（在约10Hz以下的范围）施加到患者的脑组织的电气装置。 可植入实施例对植入在患者大脑中或患者大脑上的电极施加直接电刺激，而非侵入性实施例导致磁场诱导患者大脑中的电流。
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