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公开(公告)号:US08927559B2
公开(公告)日:2015-01-06
申请号:US13878654
申请日:2011-10-06
申请人: Robert G. Aslanian , Christopher W. Boyce , Robert D. Mazzola, Jr. , Brian A. McKittrick , Kevin D. McCormick , Anandan Palani , Jun Qin , Haiqun Tang , Dong Xiao , Younong Yu , John P. Caldwell , Elizabeth Helen Kelley , Hongjun Zhang , Phieng Siliphaivanh , Rachel N. MacCoss , Joey L. Methot , Jolicia Polivina Gauuan , Qin Jiang , Andrew J. Leyhane , Purakkattle Johny Biju , Li Dong , Xianhai Huang , Ning Shao , Wei Zhou , Pawan K. Dhondi , Ashwin U. Rao
发明人: Robert G. Aslanian , Christopher W. Boyce , Robert D. Mazzola, Jr. , Brian A. McKittrick , Kevin D. McCormick , Anandan Palani , Jun Qin , Haiqun Tang , Dong Xiao , Younong Yu , John P. Caldwell , Elizabeth Helen Kelley , Hongjun Zhang , Phieng Siliphaivanh , Rachel N. MacCoss , Joey L. Methot , Jolicia Polivina Gauuan , Qin Jiang , Andrew J. Leyhane , Purakkattle Johny Biju , Li Dong , Xianhai Huang , Ning Shao , Wei Zhou , Pawan K. Dhondi , Ashwin U. Rao
IPC分类号: A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号: C07D239/91 , A61K31/517 , A61K31/5395 , A61K31/55 , A61K45/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/10 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D471/04 , C07D498/10
摘要: This application provides for compounds of the formula Formula I or a pharmaceutically acceptable salt thereof, wherein the individual variables are defined herein, as well as processes to prepare these compounds, pharmaceutical compositions comprising the same and their use in treating disease state associated with the CRTH2 receptor.
摘要翻译: 本申请提供式I化合物或其药学上可接受的盐,其中各个变量在本文中定义,以及制备这些化合物的方法,包含其的药物组合物及其用于治疗与CRTH2相关的疾病状态 受体。
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公开(公告)号:US20130210805A1
公开(公告)日:2013-08-15
申请号:US13878654
申请日:2011-10-06
申请人: Robert G. Aslanian , Christopher W. Boyce , Robert D. Mazzola, JR. , Brian A. McKittrick , Kevin D. McCormick , Anandan Palani , Jun Qin , Haiqun Tang , Dong Xiao , Younong Yu , John P. Caldwell , Elizabeth Helen Kelley , Hongjun Zhang , Phieng Siliphaivanh , Rachel N. MacCoss , Joey L. Methot , Jolicia Polivina Gauuan , Qin Jiang , Andrew J. Leyhane , Johny Biju , Li Dong , Xian Huang , Ning Shao , Wei Zhou , Pawan K. Dhondi
发明人: Robert G. Aslanian , Christopher W. Boyce , Robert D. Mazzola, JR. , Brian A. McKittrick , Kevin D. McCormick , Anandan Palani , Jun Qin , Haiqun Tang , Dong Xiao , Younong Yu , John P. Caldwell , Elizabeth Helen Kelley , Hongjun Zhang , Phieng Siliphaivanh , Rachel N. MacCoss , Joey L. Methot , Jolicia Polivina Gauuan , Qin Jiang , Andrew J. Leyhane , Johny Biju , Li Dong , Xian Huang , Ning Shao , Wei Zhou , Pawan K. Dhondi
IPC分类号: C07D239/91 , A61K31/517 , A61K45/06 , C07D403/10 , C07D417/10 , C07D413/10 , C07D405/10 , C07D413/14 , C07D498/10 , C07D403/14 , A61K31/55 , C07D401/14 , A61K31/5395 , C07D471/04 , C07D401/10
CPC分类号: C07D239/91 , A61K31/517 , A61K31/5395 , A61K31/55 , A61K45/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/10 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D471/04 , C07D498/10
摘要: This application provides for compounds of the formula Formula I or a pharmaceutically acceptable salt thereof, wherein the individual variables are defined herein, as well as processes to prepare these compounds, pharmaceutical compositions comprising the same and their use in treating disease state associated with the CRTH2 receptor.
摘要翻译: 本申请提供式I化合物或其药学上可接受的盐,其中各个变量在本文中定义,以及制备这些化合物的方法,包含其的药物组合物及其用于治疗与CRTH2相关的疾病状态 受体。
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3.
公开(公告)号:US20130303517A1
公开(公告)日:2013-11-14
申请号:US13996361
申请日:2011-12-19
申请人: Christopher W. Boyce , Sylvia Joanna Degrado , Xiao Chen , Jun Qin , Robert D. Mazzola, JR. , Younong Yu , Kevin D. McCormick , Anandan Palani , Dong Xiao , Robert George Aslanian , Jie Wu , Ashwin Umesh Rao , Phieng Siliphaivanh , Joey L. Methot , Hongjun Zhang , Elizabeth Helen Kelley , William Colby Brown , Qin Jiang , Jolicia Polivina Gauuan , Andrew J. Leyhane , Purakkattle Johny Biju , Pawan K. Dhondi , Li Dong , Salem Fevrier , Xianhai Huang , Henry M. Vaccaro
发明人: Christopher W. Boyce , Sylvia Joanna Degrado , Xiao Chen , Jun Qin , Robert D. Mazzola, JR. , Younong Yu , Kevin D. McCormick , Anandan Palani , Dong Xiao , Robert George Aslanian , Jie Wu , Ashwin Umesh Rao , Phieng Siliphaivanh , Joey L. Methot , Hongjun Zhang , Elizabeth Helen Kelley , William Colby Brown , Qin Jiang , Jolicia Polivina Gauuan , Andrew J. Leyhane , Purakkattle Johny Biju , Pawan K. Dhondi , Li Dong , Salem Fevrier , Xianhai Huang , Henry M. Vaccaro
IPC分类号: C07D241/42 , C07D401/12 , C07D403/06 , C07D471/04 , A61K31/4985 , C07D471/10 , C07D405/12 , C07D401/14 , A61K31/506 , A61K31/55 , C07D417/12 , C07D498/04 , C07D491/107 , A61K45/06 , A61K31/498
CPC分类号: C07D241/42 , A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/55 , A61K45/06 , C07D241/38 , C07D241/44 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/048 , C07D491/107 , C07D498/04 , C07D498/10
摘要: The invention provides certain quinoxalines and aza-quinoxalines of the Formula (I), and their pharmaceutically acceptable salts, wherein J1, J2, R1, R2, R3, R22, Ra, Rb, Rc, Rd, X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.
摘要翻译: 本发明提供了式(I)的某些喹喔啉和氮杂 - 喹喔啉及其药学上可接受的盐,其中J1,J2,R1,R2,R3,R22,Ra,Rb,Rc,Rd,X,Y,b,n ,和q如本文所定义。 本发明还提供包含这些化合物的药物组合物,以及使用该化合物治疗与不受控制或不适当刺激CRTH2功能相关的疾病或病症的方法。
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4.
公开(公告)号:US09469615B2
公开(公告)日:2016-10-18
申请号:US13996361
申请日:2011-12-19
申请人: Christopher W. Boyce , Sylvia Joanna Degrado , Xiao Chen , Jun Qin , Robert D. Mazzola, Jr. , Younong Yu , Kevin D. McCormick , Anandan Palani , Dong Xiao , Robert George Aslanian , Jie Wu , Ashwin Umesh Rao , Phieng Siliphaivanh , Joey L. Methot , Hongjun Zhang , Elizabeth Helen Kelley , William Colby Brown , Qin Jiang , Jolicia Polivina Gauuan , Andrew J. Leyhane , Purakkattle Johny Biju , Pawan K. Dhondi , Li Dong , Salem Fevrier , Xianhai Huang , Henry M. Vaccaro
发明人: Christopher W. Boyce , Sylvia Joanna Degrado , Xiao Chen , Jun Qin , Robert D. Mazzola, Jr. , Younong Yu , Kevin D. McCormick , Anandan Palani , Dong Xiao , Robert George Aslanian , Jie Wu , Ashwin Umesh Rao , Phieng Siliphaivanh , Joey L. Methot , Hongjun Zhang , Elizabeth Helen Kelley , William Colby Brown , Qin Jiang , Jolicia Polivina Gauuan , Andrew J. Leyhane , Purakkattle Johny Biju , Pawan K. Dhondi , Li Dong , Salem Fevrier , Xianhai Huang , Henry M. Vaccaro
IPC分类号: C07D241/38 , C07D241/42 , A61K31/498 , A61K31/506 , A61K31/4985 , A61K31/55 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D403/06 , C07D471/04 , C07D471/10 , C07D491/107 , C07D498/04 , C07D403/12 , C07D401/06 , C07D403/14 , C07D409/14 , C07D413/06 , C07D241/44 , C07D417/14 , C07D491/048 , C07D498/10
CPC分类号: C07D241/42 , A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/55 , A61K45/06 , C07D241/38 , C07D241/44 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/048 , C07D491/107 , C07D498/04 , C07D498/10
摘要: The invention provides certain quinoxalines and aza-quinoxalines of the Formula (I), and their pharmaceutically acceptable salts, wherein J1, J2, R1, R2, R3, R22, Ra, Rb, Rc, Rd, X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.
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