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    Cardiac disease treatment and device
    3.
    发明授权
    Cardiac disease treatment and device 失效
    心脏病治疗及器械

    公开(公告)号：US07326174B2

    公开(公告)日：2008-02-05

    申请号：US10839724

    申请日：2004-05-04

    申请人： James Cox ,  Michael J. Girard ,  Donald F. Palme, II ,  Donald G. Rohrbaugh ,  Hani N. Sabbah ,  J. Edward Shapland, II ,  Robert G. Walsh

    发明人： James Cox ,  Michael J. Girard ,  Donald F. Palme, II ,  Donald G. Rohrbaugh ,  Hani N. Sabbah ,  J. Edward Shapland, II ,  Robert G. Walsh

    IPC分类号： A61F13/00 ,  A61F2/00

    CPC分类号： A61F2/2481 ,  D04B21/12 ,  D10B2509/08 ,  Y10S977/907

    摘要： A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device including a jacket adapted to be secured to the heart, and a non-adherent material in association with the jacket. The jacket is fabricated from a flexible material defining a volume between an upper and a lower end, the jacket being adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain expansion of the heart beyond the maximum adjusted volume during diastole and permit substantially unimpeded contraction of the heart during systole. As a result of the flexible material, the jacket allows unimpeded diastolic filling of the heart. Also described is a method for treating cardiac disease including surgically accessing the heart, applying the treatment device of the invention, securing the treatment device to the heart, and surgically closing access to the heart while leaving the treatment device on the heart.

    摘要翻译： 一种用于治疗心脏的心脏疾病的装置，其具有由A-V凹槽分隔的上部和下部，所述装置包括适于固定到心脏的护套以及与护套相关联的非粘附材料。 护套由限定上下端之间的体积的柔性材料制成，护套适于在心脏上调节以紧密地符合心脏的外部几何形状，并假设用于护套约束的最大调节体积 舒张期心脏扩张超出最大调节体积，并允许心脏在收缩期间基本无阻碍地收缩心脏。 作为柔性材料的结果，护套可以无阻碍地舒张心脏填充心脏。 还描述了一种治疗心脏疾病的方法，包括手术进入心脏，施用本发明的治疗装置，将治疗装置固定到心脏，以及在将治疗装置留在心脏上时手术闭合进入心脏。

    Cardiac disease treatment and device
    4.
    发明授权
    Cardiac disease treatment and device 有权
    心脏病治疗及器械

    公开(公告)号：US06730016B1

    公开(公告)日：2004-05-04

    申请号：US09591875

    申请日：2000-06-12

    申请人： James Cox ,  Michael J. Girard ,  Donald F. Palme, II ,  Donald G. Rohrbaugh ,  Hani N. Sabbah ,  J. Edward Shapland, II ,  Robert G. Walsh

    发明人： James Cox ,  Michael J. Girard ,  Donald F. Palme, II ,  Donald G. Rohrbaugh ,  Hani N. Sabbah ,  J. Edward Shapland, II ,  Robert G. Walsh

    IPC分类号： A61F200

    CPC分类号： A61F2/2481 ,  D04B21/12 ,  D10B2509/08 ,  Y10S977/907

    摘要： A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device including a jacket adapted to be secured to the heart, and a non-adherent material in association with the jacket. The jacket is fabricated from a flexible material defining a volume between an upper and a lower end, the jacket being adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain expansion of the heart beyond the maximum adjusted volume during diastole and permit substantially unimpeded contraction of the heart during systole. As a result of the flexible material, the jacket allows unimpeded diastolic filling of the heart. Also described is a method for treating cardiac disease including surgically accessing the heart, applying the treatment device of the invention, securing the treatment device to the heart, and surgically closing access to the heart while leaving the treatment device on the heart.

    摘要翻译： 一种用于治疗心脏的心脏疾病的装置，其具有由A-V凹槽分隔的上部和下部，所述装置包括适于固定到心脏的护套以及与护套相关联的非粘附材料。 护套由限定上下端之间的体积的柔性材料制成，护套适于在心脏上调节以紧密地符合心脏的外部几何形状，并且假设用于护套约束的最大调节体积 舒张期心脏扩张超出最大调节体积，并允许心脏在收缩期间基本无阻碍地收缩心脏。 作为柔性材料的结果，护套可以无阻碍地舒张心脏填充心脏。 还描述了一种治疗心脏疾病的方法，包括手术进入心脏，施用本发明的治疗装置，将治疗装置固定到心脏，以及在将治疗装置留在心脏上时手术闭合进入心脏。

    Cardiac Patterning for Improving Diastolic Function
    6.
    发明申请
    Cardiac Patterning for Improving Diastolic Function 审中-公开
    心脏图案改善舒张功能

    公开(公告)号：US20130211182A1

    公开(公告)日：2013-08-15

    申请号：US13742322

    申请日：2013-01-15

    申请人： Hani N. Sabbah ,  Randall J. Lee ,  Andrew G. Hinson

    发明人： Hani N. Sabbah ,  Randall J. Lee ,  Andrew G. Hinson

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2478 ,  A61B17/00491 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12181 ,  A61B17/12186 ,  A61B17/1219 ,  A61B2017/00243 ,  A61B2017/048 ,  A61B2017/1205 ,  A61B2017/12127 ,  A61F2/2481 ,  A61F2002/249 ,  A61F2250/0067 ,  A61L31/005

    摘要： Cardiomyopathy may be treated by distributing a space-occupying diastole-assist agent within the myocardium or within the cardiac venous system in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress, stabilize or even reduce chamber size, and/or improve diastolic function. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Patterns of distribution of space-occupying agent within the myocardium for global resizing may also be used or augmented to treat localized conditions such as myocardial infarctions, overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions, and mitral regurgitation due to a noncompliant mitral valve. These techniques may also be used to treat localized conditions that may not yet have progressed to cardiomyopathy.

    摘要翻译： 心肌病可以通过以围绕心脏的一个或多个腔室的模式在心肌内或心脏静脉系统内分布空间占据舒张辅助剂来治疗，使得空间改变剂整合入并增稠至少部分 围绕腔室的心脏壁，以便全局地减小壁应力，稳定或甚至减小腔室尺寸，和/或改善舒张功能。 一些模式也引起了对室的有益的全局整形。 这些变化迅速发生并且是可持续的，并且对心脏功能具有快速和可持续的治疗作用。 用于全局调整大小的心肌内的空间占位剂的分布模式也可以被使用或增加以治疗局部的情况，例如心肌梗死，通常形成响应于大的透壁性心肌梗死的心室壁的明显的动脉瘤和二尖瓣反流 到不合规的二尖瓣。 这些技术也可用于治疗可能尚未进展为心肌病的局部病症。

    Protein activity modification
    7.
    发明授权
    Protein activity modification 有权
    蛋白活性修饰

    公开(公告)号：US08352031B2

    公开(公告)日：2013-01-08

    申请号：US11802685

    申请日：2007-05-24

    申请人： Benny Rousso ,  Hani N. Sabbah

    发明人： Benny Rousso ,  Hani N. Sabbah

    IPC分类号： A61N1/37

    CPC分类号： A61N1/3621 ,  A61N1/3627

    摘要： A method of treating a cardiac arrhythmia, comprising: determining a desired arrhythmia control; selecting an electric field having an expected effect of modifying protein activity of at least one protein as a response of a cardiac tissue to the field, said expected effect correlated with said desired arrhythmia control; and applying said field to said cardiac tissue.

    摘要翻译： 一种治疗心律失常的方法，包括：确定所需的心律失常对照; 选择具有将至少一种蛋白质的蛋白质活性改变为心脏组织的应答的预期效果的电场，所述预期效果与所述期望的心律失常控制相关; 以及将所述场应用于所述心脏组织。

    Cardiac repair, resizing and reshaping using the venous system of the heart
    8.
    发明授权
    Cardiac repair, resizing and reshaping using the venous system of the heart 有权
    心脏修复，使用心脏静脉系统调整大小和整形

    公开(公告)号：US08419711B2

    公开(公告)日：2013-04-16

    申请号：US12972186

    申请日：2010-12-17

    申请人： Hani N. Sabbah

    发明人： Hani N. Sabbah

    IPC分类号： A61M31/00

    CPC分类号： A61F2/2478 ,  A61B17/00491 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12186 ,  A61B17/1219 ,  A61B17/12195 ,  A61B2017/00243 ,  A61B2017/048 ,  A61B2017/1205 ,  A61B2017/12127 ,  A61F2/2451 ,  A61F2002/30583 ,  A61F2210/0085

    摘要： Structurally supportive material is implanted or injected into cardiac veins as discrete masses at various sites in the cardiac venous system to reinforce the myocardium for the purpose of preventing, moderating, stopping or reversing negative cardiac remodeling due to various adverse cardiac conditions, both acute and chronic, or for the purpose of treating localize anomalies of the heart, or for both purposes. The sites may be arranged in a pattern about one or more chambers of the heart such that the masses cooperatively reduce stress in the chamber wall and reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function.

    摘要翻译： 将结构支持材料植入或注入心静脉中作为心脏静脉系统各个部位的离散质量，以加强心肌，以预防，调节，停止或逆转由于各种不良心脏病，包括急性和慢性心脏重构 ，或用于治疗心脏的局部异常或两者的目的。 这些部位可以以围绕心脏的一个或多个腔室的图案布置，使得该质量协调地减小腔室壁中的应力并减小腔室尺寸。 一些模式也引起了对室的有益的全局整形。 这些变化迅速发生并且是可持续的，并且对心脏功能具有快速和可持续的治疗作用。

    APPARATUS AND METHOD FOR CONTROLLED DEPTH OF INJECTION INTO MYOCARDIAL TISSUE
    10.
    发明申请
    APPARATUS AND METHOD FOR CONTROLLED DEPTH OF INJECTION INTO MYOCARDIAL TISSUE 有权
    控制深度注射到心肌组织的装置和方法

    公开(公告)号：US20090259212A1

    公开(公告)日：2009-10-15

    申请号：US12421541

    申请日：2009-04-09

    申请人： Hani N. Sabbah

    发明人： Hani N. Sabbah

    IPC分类号： A61M5/46 ,  A61M5/32

    CPC分类号： A61M5/46 ,  A61B2017/3488 ,  A61M5/158 ,  A61M25/0068 ,  A61M25/0084 ,  A61M2025/0004 ,  A61M2025/0086 ,  A61M2025/0089 ,  A61M2025/0095

    摘要： An injector apparatus and associated methods for safely and repeatedly delivering an injectate at a predefined depth into the myocardium of the heart may be catheter-based or implemented in a handheld unit for use in open chest procedures. The injector includes a body, a stabilizer secured to a distal end of the body for stabilizing the distal end of the body relative to the myocardium, and a needle that may be controllably advanced from the distal end of the body into the myocardium. The stabilizer employs any suitable technique for stabilizing the distal end of the catheter body relative to the myocardium while the heart is beating. An enlarged region disposed along the needle functions as a stop to prevent the needle from being advanced into the myocardium beyond a desired penetration depth. To make an injection, the physician brings the distal end of the body in proximity to the endocardium or the epicardium using any suitable technique, actuates the stabilizer to stabilize the distal end relative to the myocardium; and advances the needle into the myocardium. Advancement of the needle into the myocardium is impeded by the enlarged region, thereby placing the needle tip at the desired penetration depth and avoiding puncturing of the heart. The injection is then made, and the needle and catheter are removed.

    摘要翻译： 用于将预定深度的注射器安全地和重复地输送到心脏的心肌中的注射器装置和相关联的方法可以是基于导管的或在用于胸腔开放手术的手持单元中实施的。 注射器包括主体，固定到主体的远端的稳定器，用于相对于心肌稳定身体的远端，以及可以从身体的远端可控地前进到心肌的针。 稳定器采用任何合适的技术来在心脏跳动时相对于心肌稳定导管主体的远端。 沿着针布置的放大区域用作止挡件，以防止针进入心肌超过期望的穿透深度。 为了进行注射，医师使用任何合适的技术使身体的远端接近心内膜或心外膜，致动稳定器以相对于心肌稳定远端; 并将针进入心肌。 将针进入心肌的区域被放大的区域阻碍，从而将针尖放置在期望的穿透深度并避免刺穿心脏。 然后进行注射，并去除针和导管。