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公开(公告)号：US09931503B2
公开(公告)日：2018-04-03
申请号：US11792811
申请日：2005-12-09
申请人： Benny Rousso , Yuval Mika , Hani N. Sabbah , Shlomo Ben-Haim
发明人： Benny Rousso , Yuval Mika , Hani N. Sabbah , Shlomo Ben-Haim
摘要： A method of modifying cardiac tissue behavior, comprising applying a therapeutically effective electric field having an effect of modifying protein activation levels of at least one protein, and repeatedly applying the field at time intervals timed to increase the activation levels of the at least one protein beyond an activation level achieved by natural and/or paced excitation of the muscle without the application, to an extent about at least as high as a decay of the activation between applications of the field.
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公开(公告)号：US20130211182A1
公开(公告)日：2013-08-15
申请号：US13742322
申请日：2013-01-15
申请人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
发明人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
IPC分类号： A61F2/24
CPC分类号： A61F2/2478 , A61B17/00491 , A61B17/12022 , A61B17/12045 , A61B17/12122 , A61B17/12136 , A61B17/12181 , A61B17/12186 , A61B17/1219 , A61B2017/00243 , A61B2017/048 , A61B2017/1205 , A61B2017/12127 , A61F2/2481 , A61F2002/249 , A61F2250/0067 , A61L31/005
摘要： Cardiomyopathy may be treated by distributing a space-occupying diastole-assist agent within the myocardium or within the cardiac venous system in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress, stabilize or even reduce chamber size, and/or improve diastolic function. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Patterns of distribution of space-occupying agent within the myocardium for global resizing may also be used or augmented to treat localized conditions such as myocardial infarctions, overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions, and mitral regurgitation due to a noncompliant mitral valve. These techniques may also be used to treat localized conditions that may not yet have progressed to cardiomyopathy.
摘要翻译： 心肌病可以通过以围绕心脏的一个或多个腔室的模式在心肌内或心脏静脉系统内分布空间占据舒张辅助剂来治疗，使得空间改变剂整合入并增稠至少部分 围绕腔室的心脏壁，以便全局地减小壁应力，稳定或甚至减小腔室尺寸，和/或改善舒张功能。 一些模式也引起了对室的有益的全局整形。 这些变化迅速发生并且是可持续的，并且对心脏功能具有快速和可持续的治疗作用。 用于全局调整大小的心肌内的空间占位剂的分布模式也可以被使用或增加以治疗局部的情况，例如心肌梗死，通常形成响应于大的透壁性心肌梗死的心室壁的明显的动脉瘤和二尖瓣反流 到不合规的二尖瓣。 这些技术也可用于治疗可能尚未进展为心肌病的局部病症。
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公开(公告)号：US08352031B2
公开(公告)日：2013-01-08
申请号：US11802685
申请日：2007-05-24
申请人： Benny Rousso , Hani N. Sabbah
发明人： Benny Rousso , Hani N. Sabbah
IPC分类号： A61N1/37
CPC分类号： A61N1/3621 , A61N1/3627
摘要： A method of treating a cardiac arrhythmia, comprising: determining a desired arrhythmia control; selecting an electric field having an expected effect of modifying protein activity of at least one protein as a response of a cardiac tissue to the field, said expected effect correlated with said desired arrhythmia control; and applying said field to said cardiac tissue.
摘要翻译： 一种治疗心律失常的方法，包括：确定所需的心律失常对照; 选择具有将至少一种蛋白质的蛋白质活性改变为心脏组织的应答的预期效果的电场，所述预期效果与所述期望的心律失常控制相关; 以及将所述场应用于所述心脏组织。
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4.发明授权公开(公告)号：US08419711B2
公开(公告)日：2013-04-16
申请号：US12972186
申请日：2010-12-17
申请人： Hani N. Sabbah
发明人： Hani N. Sabbah
IPC分类号： A61M31/00
CPC分类号： A61F2/2478 , A61B17/00491 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12122 , A61B17/12136 , A61B17/12186 , A61B17/1219 , A61B17/12195 , A61B2017/00243 , A61B2017/048 , A61B2017/1205 , A61B2017/12127 , A61F2/2451 , A61F2002/30583 , A61F2210/0085
摘要： Structurally supportive material is implanted or injected into cardiac veins as discrete masses at various sites in the cardiac venous system to reinforce the myocardium for the purpose of preventing, moderating, stopping or reversing negative cardiac remodeling due to various adverse cardiac conditions, both acute and chronic, or for the purpose of treating localize anomalies of the heart, or for both purposes. The sites may be arranged in a pattern about one or more chambers of the heart such that the masses cooperatively reduce stress in the chamber wall and reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function.
摘要翻译： 将结构支持材料植入或注入心静脉中作为心脏静脉系统各个部位的离散质量，以加强心肌，以预防，调节，停止或逆转由于各种不良心脏病，包括急性和慢性心脏重构 ，或用于治疗心脏的局部异常或两者的目的。 这些部位可以以围绕心脏的一个或多个腔室的图案布置，使得该质量协调地减小腔室壁中的应力并减小腔室尺寸。 一些模式也引起了对室的有益的全局整形。 这些变化迅速发生并且是可持续的，并且对心脏功能具有快速和可持续的治疗作用。
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5.发明授权Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue 有权用于传递电信号以修改心脏组织中的基因表达的装置和方法公开(公告)号：US07840262B2
公开(公告)日：2010-11-23
申请号：US10549216
申请日：2004-03-10
申请人： Yuval Mika , Hani N. Sabbah , Walid Haddad , Benny Rousso
发明人： Yuval Mika , Hani N. Sabbah , Walid Haddad , Benny Rousso
IPC分类号： A61N1/00
CPC分类号： A61N1/0587 , A61N1/326 , A61N1/362 , A61N1/3627 , A61N1/36557
摘要： Method and apparatus (120) for modifying gene expression in cardiac muscle cells (110), by the application of electric fields.
摘要翻译： 用于通过施加电场来修饰心肌细胞（110）中的基因表达的方法和装置（120）。
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6.发明申请公开(公告)号：US20090259212A1
公开(公告)日：2009-10-15
申请号：US12421541
申请日：2009-04-09
申请人： Hani N. Sabbah
发明人： Hani N. Sabbah
CPC分类号： A61M5/46 , A61B2017/3488 , A61M5/158 , A61M25/0068 , A61M25/0084 , A61M2025/0004 , A61M2025/0086 , A61M2025/0089 , A61M2025/0095
摘要： An injector apparatus and associated methods for safely and repeatedly delivering an injectate at a predefined depth into the myocardium of the heart may be catheter-based or implemented in a handheld unit for use in open chest procedures. The injector includes a body, a stabilizer secured to a distal end of the body for stabilizing the distal end of the body relative to the myocardium, and a needle that may be controllably advanced from the distal end of the body into the myocardium. The stabilizer employs any suitable technique for stabilizing the distal end of the catheter body relative to the myocardium while the heart is beating. An enlarged region disposed along the needle functions as a stop to prevent the needle from being advanced into the myocardium beyond a desired penetration depth. To make an injection, the physician brings the distal end of the body in proximity to the endocardium or the epicardium using any suitable technique, actuates the stabilizer to stabilize the distal end relative to the myocardium; and advances the needle into the myocardium. Advancement of the needle into the myocardium is impeded by the enlarged region, thereby placing the needle tip at the desired penetration depth and avoiding puncturing of the heart. The injection is then made, and the needle and catheter are removed.
摘要翻译： 用于将预定深度的注射器安全地和重复地输送到心脏的心肌中的注射器装置和相关联的方法可以是基于导管的或在用于胸腔开放手术的手持单元中实施的。 注射器包括主体，固定到主体的远端的稳定器，用于相对于心肌稳定身体的远端，以及可以从身体的远端可控地前进到心肌的针。 稳定器采用任何合适的技术来在心脏跳动时相对于心肌稳定导管主体的远端。 沿着针布置的放大区域用作止挡件，以防止针进入心肌超过期望的穿透深度。 为了进行注射，医师使用任何合适的技术使身体的远端接近心内膜或心外膜，致动稳定器以相对于心肌稳定远端; 并将针进入心肌。 将针进入心肌的区域被放大的区域阻碍，从而将针尖放置在期望的穿透深度并避免刺穿心脏。 然后进行注射，并去除针和导管。
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公开(公告)号：US07326174B2
公开(公告)日：2008-02-05
申请号：US10839724
申请日：2004-05-04
申请人： James Cox , Michael J. Girard , Donald F. Palme, II , Donald G. Rohrbaugh , Hani N. Sabbah , J. Edward Shapland, II , Robert G. Walsh
发明人： James Cox , Michael J. Girard , Donald F. Palme, II , Donald G. Rohrbaugh , Hani N. Sabbah , J. Edward Shapland, II , Robert G. Walsh
CPC分类号： A61F2/2481 , D04B21/12 , D10B2509/08 , Y10S977/907
摘要： A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device including a jacket adapted to be secured to the heart, and a non-adherent material in association with the jacket. The jacket is fabricated from a flexible material defining a volume between an upper and a lower end, the jacket being adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain expansion of the heart beyond the maximum adjusted volume during diastole and permit substantially unimpeded contraction of the heart during systole. As a result of the flexible material, the jacket allows unimpeded diastolic filling of the heart. Also described is a method for treating cardiac disease including surgically accessing the heart, applying the treatment device of the invention, securing the treatment device to the heart, and surgically closing access to the heart while leaving the treatment device on the heart.
摘要翻译： 一种用于治疗心脏的心脏疾病的装置，其具有由A-V凹槽分隔的上部和下部，所述装置包括适于固定到心脏的护套以及与护套相关联的非粘附材料。 护套由限定上下端之间的体积的柔性材料制成，护套适于在心脏上调节以紧密地符合心脏的外部几何形状，并假设用于护套约束的最大调节体积 舒张期心脏扩张超出最大调节体积，并允许心脏在收缩期间基本无阻碍地收缩心脏。 作为柔性材料的结果，护套可以无阻碍地舒张心脏填充心脏。 还描述了一种治疗心脏疾病的方法，包括手术进入心脏，施用本发明的治疗装置，将治疗装置固定到心脏，以及在将治疗装置留在心脏上时手术闭合进入心脏。
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公开(公告)号：US06730016B1
公开(公告)日：2004-05-04
申请号：US09591875
申请日：2000-06-12
申请人： James Cox , Michael J. Girard , Donald F. Palme, II , Donald G. Rohrbaugh , Hani N. Sabbah , J. Edward Shapland, II , Robert G. Walsh
发明人： James Cox , Michael J. Girard , Donald F. Palme, II , Donald G. Rohrbaugh , Hani N. Sabbah , J. Edward Shapland, II , Robert G. Walsh
IPC分类号： A61F200
CPC分类号： A61F2/2481 , D04B21/12 , D10B2509/08 , Y10S977/907
摘要： A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device including a jacket adapted to be secured to the heart, and a non-adherent material in association with the jacket. The jacket is fabricated from a flexible material defining a volume between an upper and a lower end, the jacket being adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain expansion of the heart beyond the maximum adjusted volume during diastole and permit substantially unimpeded contraction of the heart during systole. As a result of the flexible material, the jacket allows unimpeded diastolic filling of the heart. Also described is a method for treating cardiac disease including surgically accessing the heart, applying the treatment device of the invention, securing the treatment device to the heart, and surgically closing access to the heart while leaving the treatment device on the heart.
摘要翻译： 一种用于治疗心脏的心脏疾病的装置，其具有由A-V凹槽分隔的上部和下部，所述装置包括适于固定到心脏的护套以及与护套相关联的非粘附材料。 护套由限定上下端之间的体积的柔性材料制成，护套适于在心脏上调节以紧密地符合心脏的外部几何形状，并且假设用于护套约束的最大调节体积 舒张期心脏扩张超出最大调节体积，并允许心脏在收缩期间基本无阻碍地收缩心脏。 作为柔性材料的结果，护套可以无阻碍地舒张心脏填充心脏。 还描述了一种治疗心脏疾病的方法，包括手术进入心脏，施用本发明的治疗装置，将治疗装置固定到心脏，以及在将治疗装置留在心脏上时手术闭合进入心脏。
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公开(公告)号：US09782258B2
公开(公告)日：2017-10-10
申请号：US11900005
申请日：2007-09-07
申请人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
发明人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
CPC分类号： A61F2/2451 , A61F2/2481 , A61F2002/249 , A61F2250/0067 , A61K9/0024 , A61L27/20 , A61L27/3873 , A61L27/52 , A61L2400/06 , A61M5/14 , A61M5/178 , A61M37/00 , A61M37/0069
摘要： Cardiomyopathy may be treated by distributing space-occupying agent within the myocardium in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress and stabilize or even reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Over time the relief of wall stress reduces oxygen consumption and promotes healing. Moreover, various long-term therapeutic effects may be realized depending on the properties of the space-occupying agent, including combinations with other therapeutic materials. Specific cardiac conditions treatable by these systems and methods include, for example, dilated cardiomyopathy (with or without overt aneurismal formations), congestive heart failure, and ventricular arrhythmias. Patterns of distribution of space-occupying agent within the myocardium for global resizing may also be used or augmented to treat localized conditions such as myocardial infarctions, overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions, and mitral regurgitation due to a noncompliant mitral valve. These techniques may also be used to treat localized conditions that may not yet have progressed to cardiomyopathy.
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公开(公告)号：US07658951B2
公开(公告)日：2010-02-09
申请号：US10700032
申请日：2003-11-03
CPC分类号： C12N5/0663 , A61K2035/124 , C12N2500/02
摘要： A method of treating heart failure and improving cardiac function by administering stem cell products to a heart in need of treatment, whereby the stem cell products improve cardiac muscle function thereby treating heart failure and improving cardiac function. A method of enriching or regenerating damaged myocardium by administering stem cell products to damaged myocardium. Stem cell products for use in treating heart failure are also provided. A composition for enriching and regenerating damaged myocardium, the composition having stem cell products in a pharmaceutically acceptable carrier.
摘要翻译： 通过将干细胞产物施用于需要治疗的心脏来治疗心力衰竭和改善心脏功能的方法，由此干细胞产物改善心肌功能，从而治疗心力衰竭并改善心脏功能。 通过向损伤的心肌施用干细胞产物来富集或再生损伤的心肌的方法。 还提供了用于治疗心力衰竭的干细胞产品。 用于富集和再生受损心肌的组合物，该组合物在药学上可接受的载体中具有干细胞产物。
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