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    Small-scale mill and method thereof
    1.
    发明授权
    Small-scale mill and method thereof 有权
    小型碾磨机及其制造方法

    公开(公告)号：US06431478B1

    公开(公告)日：2002-08-13

    申请号：US09583893

    申请日：2000-05-31

    申请人： Robert Gary Reed ,  David A. Czekai ,  H. William Bosch ,  Niels Peter Ryde ,  Tuula Ryde

    发明人： Robert Gary Reed ,  David A. Czekai ,  H. William Bosch ,  Niels Peter Ryde ,  Tuula Ryde

    IPC分类号： B02C1716

    CPC分类号： B02C17/166 ,  B02C17/20 ,  Y10S977/775 ,  Y10S977/84

    摘要： A small-scale or micro media-mill and a method of milling materials or products, especially pharmaceutical products, use a dispersion containing attrition milling media and the product to be milled. The milling media can be polymeric, formed of polystyrene or cross-linked polystyrene, having a nominal diameter of no greater than 500 microns. Other sizes include 200 microns and 50 microns and a mixture of these sizes. The mill has a relatively small vessel having an opening, an agitator, a coupling, and a motor. The agitator can have a rotor and a shaft extending therefrom. The rotor can be cylindrical or have other configurations, and can have tapered end surfaces. The coupling can close the vessel opening, or attaching the coupling to the motor can close the opening. The coupling has an opening through which the rotor shaft extends into the motor. A sealing mechanism, such as a mechanical or lip seals the shaft while permitting the rotor shaft to rotate. The vessel can contain one or more ports for circulating the dispersion, where milling can be made in batches or recirculated through the milling chamber. The media can be retained in the vessel or recirculated along with the process fluid. The rotor is dimensioned so that its outer periphery is spaced with a small gap from an inner surface of the vessel. The vessel also can have a way of cooling the dispersion.

    摘要翻译： 小型或微型培养基研磨机和研磨材料或产品，特别是药物产品的方法使用含有磨碎研磨介质和待研磨产品的分散体。 研磨介质可以是由聚苯乙烯或交联聚苯乙烯形成的聚合物，其标称直径不大于500微米。 其他尺寸包括200微米和50微米以及这些尺寸的混合物。 研磨机具有相对较小的具有开口的容器，搅拌器，联接器和马达。 搅拌器可以具有转子和从其延伸的轴。 转子可以是圆柱形的或具有其它构造，并且可以具有锥形端面。 联接器可以关闭容器开口，或者将联接器附接到马达可以关闭开口。 联轴器具有开口，转子轴通过该开口延伸到电动机中。 密封机构，例如机械或唇部，密封轴，同时允许转子轴旋转。 容器可以包含用于循环分散体的一个或多个端口，其中可以批量制造或再循环通过研磨室。 介质可以保留在容器中或与过程流体一起再循环。 转子的尺寸被设计成使得其外围与容器的内表面间隔开小间隙。 容器还可以具有冷却分散体的方法。