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    Immunogenicity-reduced anti-cr1 antibody and compositions and methods of treatment based thereon
    2.
    发明申请
    Immunogenicity-reduced anti-cr1 antibody and compositions and methods of treatment based thereon 审中-公开
    免疫原性降低的抗cr1抗体及其组合物和治疗方法

    公开(公告)号：US20070224196A1

    公开(公告)日：2007-09-27

    申请号：US10551525

    申请日：2004-03-29

    申请人： Jeff Himawan ,  Anita Hamilton ,  Francis Carr

    发明人： Jeff Himawan ,  Anita Hamilton ,  Francis Carr

    IPC分类号： A61K48/00 ,  A61K31/70 ,  A61K39/395 ,  C12N5/06 ,  C07K16/28

    CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31

    摘要： The invention provides immunogenicity-reduced antibodies or antibody fragments that bind a human CR1 receptor. The immunogenicity-reduced anti-CR1 antibody of the invention comprises one or more non-human sequences modified to comprise one or more amino acid substitutions so that the immunogenicity-reduced antibody id non-immunogenic or less immunogenic to a human. The invention also provides bispecific molecules comprising such an immunogenicity-reduced anti-CR1 antibody and an antigen-recognition portion that binds a pathogen. The invention further provides methods and compositions for the treatment of diseases or disorders caused by a blood-borne immunogenic pathogen using the bispecific molecule the invention of the invention.

    摘要翻译： 本发明提供结合人CR1受体的免疫原性降低的抗体或抗体片段。 本发明的免疫原性降低的抗CR1抗体包含一个或多个修饰为包含一个或多个氨基酸取代的非人序列，使得免疫原性降低的抗体id对人免疫原性较小或免疫原性较小。 本发明还提供了包含这种免疫原性降低的抗CR1抗体和结合病原体的抗原识别部分的双特异性分子。 本发明还提供了用于治疗由使用本发明的本发明的双特异性分子的由血源性免疫原性病原体引起的疾病或病症的方法和组合物。

    Method for the production of non-immunogenic proteins
    8.
    发明申请
    Method for the production of non-immunogenic proteins 有权
    生产非免疫原性蛋白的方法

    公开(公告)号：US20070014796A1

    公开(公告)日：2007-01-18

    申请号：US11516295

    申请日：2006-09-06

    申请人： Francis Carr ,  Fiona Adair ,  Anita Hamilton ,  Graham Carter

    发明人： Francis Carr ,  Fiona Adair ,  Anita Hamilton ,  Graham Carter

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C07K16/30 ,  C07K14/74

    CPC分类号： G01N33/6878 ,  A61K38/00 ,  C07K14/3153 ,  C07K16/461 ,  C07K2319/00 ,  G06F19/00

    摘要： A target protein is rendered less immunogenic to a given species by (a) determining at least part of the amino acid sequence of the target protein; (b) identifying in the amino acid sequence one or more potential epitopes for T-cells (“T-cell epitopes”) of the given species; and (c) modifying the amino acid sequence to eliminate at least one of the T-cell epitopes identified in step (b) to reduce the immunogenicity of the protein when exposed to the immune system of the given species.

    摘要翻译： 通过（a）确定靶蛋白的至少一部分氨基酸序列，靶蛋白对给定物种的免疫原性降低; （b）在氨基酸序列中鉴定给定物种的T细胞（“T细胞表位”）的一个或多个潜在表位; 和（c）修饰氨基酸序列以消除步骤（b）中鉴定的至少一种T细胞表位，以降低当暴露于给定物种的免疫系统时蛋白质的免疫原性。