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1.发明授权Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems 有权氟化合物通过光化学或化学方法转化为荧光团，并在生物系统中的应用公开(公告)号：US08153446B2
公开(公告)日：2012-04-10
申请号：US12454273
申请日：2009-05-13
申请人： Robert J. Twieg , William E. Moerner , Samuel J. Lord , Na Liu , Reichel Samuel
发明人： Robert J. Twieg , William E. Moerner , Samuel J. Lord , Na Liu , Reichel Samuel
IPC分类号： G01N33/53
CPC分类号： C07D307/30 , C07D213/42 , C07D249/16 , C07D265/38 , C07D271/12 , C07D309/34 , Y10S436/80
摘要： Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived from a thermal reaction of an alkyne-pi-acceptor fluorogen with an azide are also disclosed. The fluorophores can readily be activated by light and can be used to label a biomolecule and imaged on a single-molecule level in living cells.
摘要翻译： 公开了衍生自可光活化叠氮受体氟原子的荧光团或来自叠氮受体氟原子与烯烃或炔烃的热反应。 还公开了衍生自炔 - 吡啶受体氟原子与叠氮化物的热反应的荧光团。 荧光团可以容易地被光激活，并且可以用于标记生物分子并在活细胞中在单分子水平上成像。
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2.发明授权Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems 失效氟化合物通过光化学或化学方法转化为荧光团，并在生物系统中的应用公开(公告)号：US08772048B2
公开(公告)日：2014-07-08
申请号：US13409818
申请日：2012-03-01
申请人： Robert J. Twieg , William E. Moerner , Samuel J. Lord , Na Liu , Reichel Samuel
发明人： Robert J. Twieg , William E. Moerner , Samuel J. Lord , Na Liu , Reichel Samuel
IPC分类号： G01N33/533 , G01N33/532 , C07K1/10
CPC分类号： C07D307/30 , C07D213/42 , C07D249/16 , C07D265/38 , C07D271/12 , C07D309/34 , Y10S436/80
摘要： Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived from a thermal reaction of an alkyne-pi-acceptor fluorogen with an azide are also disclosed. The fluorophores can readily be activated by light and can be used to label a biomolecule and imaged on a single-molecule level in living cells.
摘要翻译： 公开了衍生自可光活化叠氮受体氟原子的荧光团或来自叠氮受体氟原子与烯烃或炔烃的热反应。 还公开了衍生自炔 - pi受体氟原子与叠氮化物的热反应的荧光团。 荧光团可以容易地被光激活，并且可以用于标记生物分子并在活细胞中在单分子水平上成像。
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3.发明申请Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems 有权氟化合物通过光化学或化学方法转化为荧光团，并在生物系统中的应用公开(公告)号：US20100029952A1
公开(公告)日：2010-02-04
申请号：US12454273
申请日：2009-05-13
申请人： Robert J. Tweg , William E. Moerner , Samuel J. Lord , Na Liu , Reichel Samuel
发明人： Robert J. Tweg , William E. Moerner , Samuel J. Lord , Na Liu , Reichel Samuel
IPC分类号： C07D213/02 , C07D307/02 , C07D249/04 , C07D271/12
CPC分类号： C07D307/30 , C07D213/42 , C07D249/16 , C07D265/38 , C07D271/12 , C07D309/34 , Y10S436/80
摘要： Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived from a thermal reaction of an alkyne-pi-acceptor fluorogen with an azide are also disclosed. The fluorophores can readily be activated by light and can be used to label a biomolecule and imaged on a single-molecule level in living cells.
摘要翻译： 公开了衍生自可光活化叠氮受体氟原子的荧光团或来自叠氮受体氟原子与烯烃或炔烃的热反应。 还公开了衍生自炔 - 吡啶受体氟原子与叠氮化物的热反应的荧光团。 荧光团可以容易地被光激活，并且可以用于标记生物分子并在活细胞中在单分子水平上成像。
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公开(公告)号：US5361148A
公开(公告)日：1994-11-01
申请号：US6450
申请日：1993-01-21
申请人： Gary C. Bjorklund , Donald M. Burland , Marcus C. J. M. Donckers , Robert D. Miller , William E. Moerner , Scott M. Silence , Robert J. Twieg , Cecilia A. Walsh
发明人： Gary C. Bjorklund , Donald M. Burland , Marcus C. J. M. Donckers , Robert D. Miller , William E. Moerner , Scott M. Silence , Robert J. Twieg , Cecilia A. Walsh
CPC分类号： G02F1/3615 , G03H1/02 , G03H2001/026 , G03H2001/0264 , G03H2260/54
摘要： The present invention relates to an improved process for producing photorefractive net gain two beam coupling utilizing polymeric materials.
摘要翻译： 本发明涉及利用聚合材料制造光折变增益双光束耦合的改进方法。
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公开(公告)号：US5607799A
公开(公告)日：1997-03-04
申请号：US230987
申请日：1994-04-21
CPC分类号： G11B7/244 , G03H1/02 , G03H2001/026 , G03H2001/0264 , G03H2260/54
摘要： The present invention relates to a three-component optical photorefractive article having improved diffraction efficiency. The article comprises (i) nonphotoconductive polymer, (ii) benzimidazoline, and (iii) a sensitizer.
摘要翻译： 本发明涉及具有改进的衍射效率的三组分光学光折射制品。 该制品包括（i）非光导电聚合物，（ii）苯并咪唑啉和（iii）敏化剂。
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公开(公告)号：US5460907A
公开(公告)日：1995-10-24
申请号：US311281
申请日：1994-09-22
CPC分类号： G02F1/0018 , G02F1/3615 , G02F1/3616 , G03H1/02 , G03H2001/026 , G03H2001/0264 , G03H2260/35 , G03H2260/54
摘要： The present invention relates to polymeric materials that exhibit an erasable photorefractive effect which can be fabricated into optical devices such as optical wave guides.
摘要翻译： 本发明涉及可以制造成光学器件如光波导的可擦除光折射效应的聚合材料。
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公开(公告)号：US5064264A
公开(公告)日：1991-11-12
申请号：US604560
申请日：1990-10-26
CPC分类号： G02F1/0018 , G02F1/3615 , G02F1/3616 , G03H1/02 , G03H2001/026 , G03H2001/0264 , G03H2260/35 , G03H2260/54
摘要： The present invention relates to polymeric materials that exhibit an erasable photorefractive effect which can be fabricated into optical devices such as optical wave guides.
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公开(公告)号：US08057655B1
公开(公告)日：2011-11-15
申请号：US11207593
申请日：2005-08-19
申请人： Adam E. Cohen , William E. Moerner
发明人： Adam E. Cohen , William E. Moerner
IPC分类号： G01N27/26
CPC分类号： B03C5/026 , Y10T436/11
摘要： Sub-micron objects are manipulated. According to an example embodiment of the present invention, Brownian motion effects are mitigated to facilitate the analysis and/or manipulation of sub-micron objects. In some applications, an electric field is applied to facilitate the manipulation of sub-micron objects in solution, facilitating the analysis of the manipulated objects. In other applications, fluid flow is used to effect the manipulation of sub-micron objects in solution.
摘要翻译： 亚微米物体被操纵。 根据本发明的一个示例性实施例，布朗运动效应得到缓解以促进亚微米物体的分析和/或操纵。 在一些应用中，施加电场以便于在解决方案中操纵亚微米物体，便于对被操纵物体的分析。 在其他应用中，使用流体流动来实现对溶液中亚微米物体的操纵。
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公开(公告)号：US09075010B2
公开(公告)日：2015-07-07
申请号：US13274915
申请日：2011-10-17
摘要： The present disclosure relates to an apparatus, and methods of use, for enhancement of molecular emission by nano-antennas. Using the nano-antennas, the life-time is greatly shortened or the strength of broadly peaking spectral emission of fluorescent molecules is greatly enhanced by a generated electric field. The electric field generated is due to opposing charges located at two metallic end portions of the nano-antenna in response to receiving optical energy.
摘要翻译： 本公开涉及一种用于增强纳米天线的分子发射的装置和使用方法。 通过使用纳米天线，生命周期大大缩短，荧光分子的光谱发射强度大大提高。 产生的电场是由于响应于接收光能而位于纳米天线的两个金属端部处的相反电荷。
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公开(公告)号：US20120091365A1
公开(公告)日：2012-04-19
申请号：US13274915
申请日：2011-10-17
IPC分类号： G01N21/64
摘要： The present disclosure relates to an apparatus, and methods of use, for enhancement of molecular emission by nano-antennas. Using the nano-antennas, the life-time is greatly shortened or the strength of broadly peaking spectral emission of fluorescent molecules is greatly enhanced by a generated electric field. The electric field generated is due to opposing charges located at two metallic end portions of the nano-antenna in response to receiving optical energy.
摘要翻译： 本公开涉及一种用于增强纳米天线的分子发射的装置和使用方法。 通过使用纳米天线，生命周期大大缩短，荧光分子的光谱发射强度大大提高。 产生的电场是由于响应于接收光能而位于纳米天线的两个金属端部处的相反电荷。
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