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公开(公告)号：US09075010B2
公开(公告)日：2015-07-07
申请号：US13274915
申请日：2011-10-17
摘要： The present disclosure relates to an apparatus, and methods of use, for enhancement of molecular emission by nano-antennas. Using the nano-antennas, the life-time is greatly shortened or the strength of broadly peaking spectral emission of fluorescent molecules is greatly enhanced by a generated electric field. The electric field generated is due to opposing charges located at two metallic end portions of the nano-antenna in response to receiving optical energy.
摘要翻译： 本公开涉及一种用于增强纳米天线的分子发射的装置和使用方法。 通过使用纳米天线，生命周期大大缩短，荧光分子的光谱发射强度大大提高。 产生的电场是由于响应于接收光能而位于纳米天线的两个金属端部处的相反电荷。
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公开(公告)号：US20120091365A1
公开(公告)日：2012-04-19
申请号：US13274915
申请日：2011-10-17
IPC分类号： G01N21/64
摘要： The present disclosure relates to an apparatus, and methods of use, for enhancement of molecular emission by nano-antennas. Using the nano-antennas, the life-time is greatly shortened or the strength of broadly peaking spectral emission of fluorescent molecules is greatly enhanced by a generated electric field. The electric field generated is due to opposing charges located at two metallic end portions of the nano-antenna in response to receiving optical energy.
摘要翻译： 本公开涉及一种用于增强纳米天线的分子发射的装置和使用方法。 通过使用纳米天线，生命周期大大缩短，荧光分子的光谱发射强度大大提高。 产生的电场是由于响应于接收光能而位于纳米天线的两个金属端部处的相反电荷。
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公开(公告)号：US08057655B1
公开(公告)日：2011-11-15
申请号：US11207593
申请日：2005-08-19
申请人： Adam E. Cohen , William E. Moerner
发明人： Adam E. Cohen , William E. Moerner
IPC分类号： G01N27/26
CPC分类号： B03C5/026 , Y10T436/11
摘要： Sub-micron objects are manipulated. According to an example embodiment of the present invention, Brownian motion effects are mitigated to facilitate the analysis and/or manipulation of sub-micron objects. In some applications, an electric field is applied to facilitate the manipulation of sub-micron objects in solution, facilitating the analysis of the manipulated objects. In other applications, fluid flow is used to effect the manipulation of sub-micron objects in solution.
摘要翻译： 亚微米物体被操纵。 根据本发明的一个示例性实施例，布朗运动效应得到缓解以促进亚微米物体的分析和/或操纵。 在一些应用中，施加电场以便于在解决方案中操纵亚微米物体，便于对被操纵物体的分析。 在其他应用中，使用流体流动来实现对溶液中亚微米物体的操纵。
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公开(公告)号：US5361148A
公开(公告)日：1994-11-01
申请号：US6450
申请日：1993-01-21
申请人： Gary C. Bjorklund , Donald M. Burland , Marcus C. J. M. Donckers , Robert D. Miller , William E. Moerner , Scott M. Silence , Robert J. Twieg , Cecilia A. Walsh
发明人： Gary C. Bjorklund , Donald M. Burland , Marcus C. J. M. Donckers , Robert D. Miller , William E. Moerner , Scott M. Silence , Robert J. Twieg , Cecilia A. Walsh
CPC分类号： G02F1/3615 , G03H1/02 , G03H2001/026 , G03H2001/0264 , G03H2260/54
摘要： The present invention relates to an improved process for producing photorefractive net gain two beam coupling utilizing polymeric materials.
摘要翻译： 本发明涉及利用聚合材料制造光折变增益双光束耦合的改进方法。
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5.发明授权Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems 有权氟化合物通过光化学或化学方法转化为荧光团，并在生物系统中的应用公开(公告)号：US08153446B2
公开(公告)日：2012-04-10
申请号：US12454273
申请日：2009-05-13
申请人： Robert J. Twieg , William E. Moerner , Samuel J. Lord , Na Liu , Reichel Samuel
发明人： Robert J. Twieg , William E. Moerner , Samuel J. Lord , Na Liu , Reichel Samuel
IPC分类号： G01N33/53
CPC分类号： C07D307/30 , C07D213/42 , C07D249/16 , C07D265/38 , C07D271/12 , C07D309/34 , Y10S436/80
摘要： Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived from a thermal reaction of an alkyne-pi-acceptor fluorogen with an azide are also disclosed. The fluorophores can readily be activated by light and can be used to label a biomolecule and imaged on a single-molecule level in living cells.
摘要翻译： 公开了衍生自可光活化叠氮受体氟原子的荧光团或来自叠氮受体氟原子与烯烃或炔烃的热反应。 还公开了衍生自炔 - 吡啶受体氟原子与叠氮化物的热反应的荧光团。 荧光团可以容易地被光激活，并且可以用于标记生物分子并在活细胞中在单分子水平上成像。
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6.发明申请Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems 有权氟化合物通过光化学或化学方法转化为荧光团，并在生物系统中的应用公开(公告)号：US20100029952A1
公开(公告)日：2010-02-04
申请号：US12454273
申请日：2009-05-13
申请人： Robert J. Tweg , William E. Moerner , Samuel J. Lord , Na Liu , Reichel Samuel
发明人： Robert J. Tweg , William E. Moerner , Samuel J. Lord , Na Liu , Reichel Samuel
IPC分类号： C07D213/02 , C07D307/02 , C07D249/04 , C07D271/12
CPC分类号： C07D307/30 , C07D213/42 , C07D249/16 , C07D265/38 , C07D271/12 , C07D309/34 , Y10S436/80
摘要： Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived from a thermal reaction of an alkyne-pi-acceptor fluorogen with an azide are also disclosed. The fluorophores can readily be activated by light and can be used to label a biomolecule and imaged on a single-molecule level in living cells.
摘要翻译： 公开了衍生自可光活化叠氮受体氟原子的荧光团或来自叠氮受体氟原子与烯烃或炔烃的热反应。 还公开了衍生自炔 - 吡啶受体氟原子与叠氮化物的热反应的荧光团。 荧光团可以容易地被光激活，并且可以用于标记生物分子并在活细胞中在单分子水平上成像。
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7.发明授权Room-temperature source of single photons based on a single molecule in a condensed matter host 失效基于聚合物主体中单个分子的单光子的室温源公开(公告)号：US07068698B2
公开(公告)日：2006-06-27
申请号：US10794404
申请日：2004-03-04
申请人： William E. Moerner , Brahim Lounis
发明人： William E. Moerner , Brahim Lounis
CPC分类号： H01S3/091 , H01S3/094034
摘要： A controllable single-photon source having a single illuminated molecule in a condensed phase host is provided. The single molecule is illuminated with a pulse of radiation having a wavelength such that the molecule is excited to a vibrational state higher in energy than an associated excited electronic state. The molecule rapidly, incoherently and irreversibly decays, with a lifetime Tvib, from the vibrational state to the excited electronic state by transferring the corresponding vibrational energy to the host. The excited electronic state has a lifetime T, and with high probability the single molecule makes a radiative transition from this state to emit a single photon. The pump pulse duration Tp satisfies the condition Tvib
摘要翻译： 提供了在凝聚相主体中具有单个照射分子的可控单光子源。 单分子用具有波长的辐射脉冲照射，使得分子被激发到能量高于相关联的激发电子状态的振动状态。 分子通过将相应的振动能量转移到主体，迅速地，不连续地且不可逆地衰减，具有终生的Tvib，从振动状态到激发的电子状态。 激发的电子状态具有寿命T，并且单分子从该状态发射单个光子的辐射跃迁的概率很高。 泵浦脉冲持续时间Tp满足条件Tvib
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8.发明授权Photochromic fluorescent proteins and optical memory storage devices based on fluorescent proteins 失效基于荧光蛋白的光致变色荧光蛋白和光学记忆存储装置
公开(公告)号：US6046925A
公开(公告)日：2000-04-04
申请号：US839685
申请日：1997-04-14
IPC分类号： C07K14/435 , G11B7/0045 , G11B7/005 , G11B7/0055 , G11B7/244 , G11B7/26 , G11C11/56 , G11C13/02 , G11C13/04
CPC分类号： G11C13/0019 , B82Y10/00 , C07K14/43595 , G11B7/00455 , G11B7/0052 , G11B7/244 , G11B7/26 , G11C11/5664 , G11C13/0014 , G11C13/04 , G11B2007/24624 , G11B7/00552
摘要： Photochromic fluorescent protein moiety having two or more stable states having excitation or emission spectra that are shifted from one wavelength region to another wavelength region in the two states are described. The photochromic material switches between states by irradiation with light of appropriate wavelengths. The two states are preferably stable at room temperature and in the dark. The switching between states can be reversible.
摘要翻译： 描述具有两个或更多个稳定状态的光致变色荧光蛋白部分，其具有在两种状态下从一个波长区域移动到另一个波长区域的激发或发射光谱。 光致变色材料通过用适当波长的光照射而在状态之间切换。 两个状态优选在室温下和黑暗中稳定。 状态之间的切换可以是可逆的。
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公开(公告)号：US5607799A
公开(公告)日：1997-03-04
申请号：US230987
申请日：1994-04-21
CPC分类号： G11B7/244 , G03H1/02 , G03H2001/026 , G03H2001/0264 , G03H2260/54
摘要： The present invention relates to a three-component optical photorefractive article having improved diffraction efficiency. The article comprises (i) nonphotoconductive polymer, (ii) benzimidazoline, and (iii) a sensitizer.
摘要翻译： 本发明涉及具有改进的衍射效率的三组分光学光折射制品。 该制品包括（i）非光导电聚合物，（ii）苯并咪唑啉和（iii）敏化剂。
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公开(公告)号：US5460907A
公开(公告)日：1995-10-24
申请号：US311281
申请日：1994-09-22
CPC分类号： G02F1/0018 , G02F1/3615 , G02F1/3616 , G03H1/02 , G03H2001/026 , G03H2001/0264 , G03H2260/35 , G03H2260/54
摘要： The present invention relates to polymeric materials that exhibit an erasable photorefractive effect which can be fabricated into optical devices such as optical wave guides.
摘要翻译： 本发明涉及可以制造成光学器件如光波导的可擦除光折射效应的聚合材料。
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