Probe design methods and microarrays for comparative genomic hybridization and location analysis
    2.
    发明授权
    Probe design methods and microarrays for comparative genomic hybridization and location analysis 有权
    用于比较基因组杂交和位置分析的探针设计方法和微阵列

    公开(公告)号:US08036835B2

    公开(公告)日:2011-10-11

    申请号:US12797521

    申请日:2010-06-09

    IPC分类号: G06F7/00

    摘要: Methods and systems for identifying and selecting nucleic acid probes for detecting a target with a nucleic acid probe array or comparative genome hybridization microarray, comprising selecting a plurality of potential target sequences, generating a plurality of candidate probes from the target sequences, filtering the plurality of candidate probes by analyzing candidate probes for selected probe properties in silico. Microarrays comprising probes selected by the methods of the invention are particularly useful for comparative genome hybridization and location analysis.

    摘要翻译: 用于鉴定和选择用于用核酸探针阵列或比较基因组杂交微阵列检测靶的核酸探针的方法和系统,包括选择多个潜在靶序列,从靶序列产生多个候选探针,过滤多个 通过分析选择的探针属性的候选探针在硅胶中的候选探针。 包含通过本发明方法选择的探针的微阵列特别可用于比较基因组杂交和位置分析。

    METHOD FOR CHROMOSOME ENUMERATION
    4.
    发明申请
    METHOD FOR CHROMOSOME ENUMERATION 审中-公开
    染色体计算方法

    公开(公告)号:US20100221708A1

    公开(公告)日:2010-09-02

    申请号:US12396308

    申请日:2009-03-02

    IPC分类号: C12Q1/68

    CPC分类号: C12Q1/6841 C12Q2565/102

    摘要: A method of sample analysis is provided. The method comprises: a) contacting a genomic sample comprising a plurality of intact chromosomes, i.e., metaphase or interphase chromosomes, with a first set of labeled oligonucleotide probes under in situ hybridization conditions to produce a contacted sample comprising labeled chromosomes, where i. each of the labeled oligonucleotide probes is complementary to a non-repetitive, unique sequence in a region that flanks the centromere of a single chromosome of the plurality of chromosomes; and ii. hybridization of the labeled oligonucleotide probes to the chromosomes produces a distinct labeling pattern for each hybridized chromosome, thereby allowing each of the labeled chromosomes to be distinguished from one another; b) imaging the hybridized chromosomes to provide an image showing the labeling pattern for each labeled chromosome; and c) enumerating a labeled chromosome based on the labeling pattern of said labeled chromosome. A composition and kits for performing the method are also provided.

    摘要翻译: 提供了样品分析的方法。 该方法包括:a)在原位杂交条件下将包含多个完整染色体(即中期或间期染色体)的基因组样品与第一组标记的寡核苷酸探针接触,以产生包含标记染色体的接触样品,其中i。 每个标记的寡核苷酸探针与在多个染色体的单个染色体的着丝粒侧翼的区域中的非重复的唯一序列互补; 和ii。 标记的寡核苷酸探针与染色体的杂交为每个杂交的染色体产生不同的标记图案,从而允许每个标记的染色体彼此区分; b)对杂交的染色体进行成像以提供显示每个标记的染色体的标记图案的图像; 和c)基于所述标记的染色体的标记图案来列举标记的染色体。 还提供了用于执行该方法的组合物和试剂盒。

    Hybrid model for DNA probe design and validation using nonlinear and linear regression methods
    5.
    发明申请
    Hybrid model for DNA probe design and validation using nonlinear and linear regression methods 审中-公开
    使用非线性和线性回归方法的DNA探针设计和验证的混合模型

    公开(公告)号:US20070037201A1

    公开(公告)日:2007-02-15

    申请号:US11580583

    申请日:2006-10-13

    IPC分类号: C12Q1/68 G06F19/00

    摘要: Methods and systems for selecting oligonucleotide probes for use in microarray applications are provided herein. The described methods use a combination of measured probe performance and predicted probe performance to select probes. Nucleic acid arrays containing probes selected by the described methods are described. Also included are algorithms for performing the subject methods recorded on computer-readable media and computational systems for analysis.

    摘要翻译: 本文提供了用于选择用于微阵列应用的寡核苷酸探针的方法和系统。 所描述的方法使用测量的探针性能和预测的探针性能的组合来选择探针。 描述了含有由所述方法选择的探针的核酸阵列。 还包括用于执行记录在计算机可读介质上的主题方法和用于分析的计算系统的算法。

    Activity monitoring
    6.
    发明申请
    Activity monitoring 有权
    活动监控

    公开(公告)号:US20060155218A1

    公开(公告)日:2006-07-13

    申请号:US10537881

    申请日:2003-11-21

    IPC分类号: A61B5/103

    CPC分类号: A61B5/1118 A61B2562/0219

    摘要: An activity monitor is provided that corrects for the effects of motion external to the entity being monitored. For example, the activity monitor can overcome the effects of vehicular travel.

    摘要翻译: 提供一个活动监视器,用于校正被监视实体外部运动的影响。 例如,活动监视器可以克服车辆行驶的影响。

    Method and system for communicating wirelessly between devices
    7.
    发明申请
    Method and system for communicating wirelessly between devices 审中-公开
    设备间无线通信的方法和系统

    公开(公告)号:US20050176463A1

    公开(公告)日:2005-08-11

    申请号:US10520868

    申请日:2003-06-25

    摘要: The invention relates to a method and a system (200) for communicating wirelessly between devices. Wireless communication can be a very appropriate way of interconnecting nearby devices, such as devices located within a home. However, equipping all devices with a wireless transceiver may not be desirable. Furthermore, an ordinary user should be able to connect devices in a straightforward and convenient way. The invention addresses these issues by means of a wireless communication key (250, 260, 270). This is a key-like object equipped with a transceiver. A key can be attached to a device (220, 230, 240) for which a wireless connection is required. A key may have to be powered by the device to which it gets attached and can then establish a wireless connection (280, 282) with another device. The other device is determined by the key used. A key may be associated with a fixed endpoint device (210), permanently equipped with a transceiver (212). Alternatively, a key may be associated with a second key that is to be attached to the other device.

    摘要翻译: 本发明涉及用于在设备之间进行无线通信的方法和系统(200)。 无线通信可以是互连附近设备(例如位于家庭内的设备)的非常适当的方式。 然而,将所有设备配备无线收发器可能不是所期望的。 此外,普通用户应该能够以简单方便的方式连接设备。 本发明通过无线通信密钥(250,260,270)来解决这些问题。 这是一个装有收发器的键状物体。 可以将密钥附加到需要无线连接的设备(220,230,240)。 密钥可能必须由其所附接的设备供电,然后可以与另一设备建立无线连接(280,282)。 其他设备由使用的密钥决定。 密钥可以与永久配备有收发器(212)的固定端点设备(210)相关联。 或者,密钥可以与要附接到另一个设备的第二密钥相关联。

    Polymeric membrane air separator for a turbocharger and brake system in
a vehicle
    8.
    发明授权
    Polymeric membrane air separator for a turbocharger and brake system in a vehicle 失效
    用于车辆中的涡轮增压器和制动系统的聚合物膜分离器

    公开(公告)号:US4883023A

    公开(公告)日:1989-11-28

    申请号:US284266

    申请日:1988-12-14

    IPC分类号: F02B3/06 F02M25/12 F02M33/00

    摘要: In a vehicle having a turbocharger (12) for supplying pressurized air to a combustion chamber in an engine (10) and a storage reservoir (34) for supplying pressurized air as a power source for a brake system (35), a polymeric fiber membrane (46) for separating pressurized air from a compressor (18) into moist oxygen enriched air and dry nitrogen enriched air. The moist oxygen enriched air is added to inlet air of the turbocharger (12) to enhance combustion of fuel in the combustion chamber while the dry nitrogen enriched air is communicated to the storage reservoir (34) to operate the brake system (35) and reduce the possibility of oxidization of components therein.

    摘要翻译: 在具有用于向发动机(10)中的燃烧室供给加压空气的涡轮增压器(12)和用于供给加压空气作为制动系统(35)的动力源的储存器(34)的车辆中,聚合物纤维膜 (46),用于将压缩机(18)中的加压空气分离成潮湿的富氧空气和干燥的富氮空气。 将富氧的富氧空气添加到涡轮增压器(12)的入口空气中,以增强燃烧室中燃料的燃烧,同时将富氮的空气与储存容器(34)连通以操作制动系统(35)并减少 其中组分氧化的可能性。