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    Extended dynamic range reading of chemical arrays
    1.
    发明申请
    Extended dynamic range reading of chemical arrays 审中-公开
    扩大化学阵列的动态范围读数

    公开(公告)号：US20070178480A1

    公开(公告)日：2007-08-02

    申请号：US11344773

    申请日：2006-01-31

    申请人： John F. Corson ,  Bo Curry ,  Charles Troup ,  Xiangyang Zhou

    发明人： John F. Corson ,  Bo Curry ,  Charles Troup ,  Xiangyang Zhou

    IPC分类号： C12Q1/68 ,  G06F19/00

    CPC分类号： G16B25/00

    摘要： Methods of reading chemical arrays are provided. Aspects of the methods include reading an array at a first and second detector gain setting to produce linked data sets of an array, where each reading may be made using a different detector gain setting. Aspects of the methods further include extracting features from the linked data sets, where in certain embodiments a merged data set feature extraction protocol is employed. Aspects of the invention further include programming for operating devices, e.g., chemical array readers, as well as readers comprising such programming.

    摘要翻译： 提供读取化学阵列的方法。 方法的方面包括以第一和第二检测器增益设置读取阵列以产生阵列的相关联的数据集，其中可以使用不同的检测器增益设置来进行每次读取。 方法的方面还包括从链接的数据集中提取特征，其中在某些实施例中采用了合并的数据集特征提取协议。 本发明的方面还包括用于操作设备的编程，例如化学阵列读取器，以及包括这种编程的读取器。

    Method and system for automated focus-distance determination for molecular array scanners
    3.
    发明授权
    Method and system for automated focus-distance determination for molecular array scanners 失效
    分子阵列扫描仪的自动聚焦距离测定方法和系统

    公开(公告)号：US06770892B2

    公开(公告)日：2004-08-03

    申请号：US10086743

    申请日：2002-02-28

    申请人： John F. Corson ,  Stanley P. Woods ,  Russell A. Parker ,  Xiangyang Zhou ,  Bo U. Curry

    发明人： John F. Corson ,  Stanley P. Woods ,  Russell A. Parker ,  Xiangyang Zhou ,  Bo U. Curry

    IPC分类号： G01T2164

    CPC分类号： G01N21/6452 ,  G01N21/6458 ,  G01N2021/6463

    摘要： An automated method and system for determining an optimal focus distance for scanning a molecular array scanner. Blocks of rows of a reference array are automatically scanned at successively greater distances of the stage from a light gathering medium, such as an optical fiber, or z-positions, to produce data providing a functional relationship between z-position and measured signal intensities. The data is then processed by a peak-height-based, or window-based, focus-finding routine that selects an optimal focus-distance for data scans.

    摘要翻译： 一种用于确定用于扫描分子阵列扫描仪的最佳聚焦距离的自动化方法和系统。 参考阵列的行的块自动地从阶段相对较远的距离光收集介质（诸如光纤或z位置）扫描，以产生提供z位置和测量的信号强度之间的功能关系的数据。 然后通过基于峰值高度或基于窗口的聚焦寻找程序处理数据，该程序为数据扫描选择最佳聚焦距离。

    Method and system for automated focus-distance determination for molecular array scanners
    4.
    发明申请
    Method and system for automated focus-distance determination for molecular array scanners 审中-公开
    分子阵列扫描仪的自动聚焦距离测定方法和系统

    公开(公告)号：US20050067583A1

    公开(公告)日：2005-03-31

    申请号：US10910562

    申请日：2004-08-02

    申请人： John Corson ,  Stanley Woods ,  Russell Parker ,  Xiangyang Zhou ,  Bo Curry

    发明人： John Corson ,  Stanley Woods ,  Russell Parker ,  Xiangyang Zhou ,  Bo Curry

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6452 ,  G01N21/6458 ,  G01N2021/6463

    摘要： An automated method and system for determining an optimal focus distance for scanning a molecular array by a molecular array scanner. Blocks of rows of a reference array are automatically scanned at successively greater distances of the stage from a light gathering medium, such as an optical fiber, or z-positions, to produce data providing a functional relationship between z-position and measured signal intensities. The data is then processed by a peak-height-based, or window-based, focus-finding routine that selects an optimal focus-distance for data scans.

    摘要翻译： 一种用于通过分子阵列扫描仪确定用于扫描分子阵列的最佳聚焦距离的自动化方法和系统。 参考阵列的行的块自动地从阶段相对较远的距离光收集介质（诸如光纤或z位置）扫描，以产生提供z位置和测量的信号强度之间的功能关系的数据。 然后通过基于峰值高度或基于窗口的聚焦寻找程序处理数据，该程序为数据扫描选择最佳聚焦距离。

    System and methods for automated processing of multiple chemical arrays
    6.
    发明申请
    System and methods for automated processing of multiple chemical arrays 有权
    用于自动处理多个化学阵列的系统和方法

    公开(公告)号：US20070174007A1

    公开(公告)日：2007-07-26

    申请号：US11233560

    申请日：2005-09-22

    申请人： Jayati Ghosh ,  Charles Troup ,  Xiangyang Zhou

    发明人： Jayati Ghosh ,  Charles Troup ,  Xiangyang Zhou

    IPC分类号： G06F19/00

    CPC分类号： G06F19/20

    摘要： Methods, systems and computer readable media for bifurcating automated feature extraction processing of chemical arrays. A plurality of arrays may be image-processed sequentially, and then, outputs resulting from the image processing of at least two of the plurality of the arrays may be post-processed in an automated batch process to obtain processed outputs. In another aspect, a plurality of arrays may be image-processed in an automated batch process, and then outputs resulting from the image processing may be post-processed according to different post-processing protocols with respect to at least two of the plurality of the arrays. In another aspect, an array may be image-processed, and then an output of the image processing may be post-processed in an automated batch process, where at least two different post-processing protocols are assigned to the output of image processing, so that processed outputs are outputted for each of the processing protocols. In still another aspect, methods, systems and computer readable media perform inter-array analysis. A first array is image-processed with a first image processing protocol to obtain a first output, a second array is image-processed with a second image processing protocol to obtain a second output, and the first and second outputs of the image processing of the first and second arrays are post-processed together in an automated batch process to obtain processed outputs. In another aspect, methods, systems and computer readable media are provided for feature extraction processing multiple arrays contained on a single substrate. The multiple arrays are image-processed in an automated batch process, and then outputs of individual arrays, resulting from-image processing of the multiple arrays, are post-processed according to at least one post-processing protocol.

    摘要翻译： 用于分叉化学阵列自动特征提取处理的方法，系统和计算机可读介质。 可以顺次对多个阵列进行图像处理，然后，可以在自动分批处理中对由多个阵列中的至少两个的图像处理产生的输出进行后处理，以获得经处理的输出。 在另一方面，多个阵列可以在自动批处理过程中被图像处理，然后可以根据不同的后处理协议对图像处理产生的输出进行后处理，关于多个 阵列 在另一方面，阵列可以被图像处理，然后图像处理的输出可以在自动批处理过程中进行后处理，其中至少两个不同的后处理协议被分配给图像处理的输出，因此 为每个处理协议输出处理后的输出。 在另一方面，方法，系统和计算机可读介质执行阵列间分析。 利用第一图像处理协议对第一阵列进行图像处理以获得第一输出，利用第二图像处理协议对第二阵列进行图像处理以获得第二输出，并且所述第一和第二输出的图像处理 第一和第二阵列在自动分批过程中一起进行后处理以获得经处理的输出。 在另一方面，提供方法，系统和计算机可读介质用于特征提取处理包含在单个基板上的多个阵列。 多个阵列在自动批处理过程中进行图像处理，然后根据至少一个后处理协议对多个阵列的图像处理产生的各个阵列的输出进行后处理。

    Automated feature extraction processes and systems
    7.
    发明申请
    Automated feature extraction processes and systems 审中-公开
    自动特征提取过程和系统

    公开(公告)号：US20060056671A1

    公开(公告)日：2006-03-16

    申请号：US10941501

    申请日：2004-09-15

    申请人： Jayati Ghosh ,  Christian Le Cocq. ,  Xiangyang Zhou ,  John Corson ,  Glenda Delenstarr ,  Charles Troup

    发明人： Jayati Ghosh ,  Christian Le Cocq. ,  Xiangyang Zhou ,  John Corson ,  Glenda Delenstarr ,  Charles Troup

    IPC分类号： G06K9/00 ,  G06K9/46 ,  C12M1/34

    CPC分类号： G06T7/00 ,  G06T2207/30072 ,  G16B25/00

    摘要： Methods, systems and computer readable media for automatically feature extracting array images in batch mode. At least two images to be feature extracted are loaded into a batch project, and the system automatically and sequentially feature extracts the images in the batch project. At least one of the images may be feature extracted based upon a different grid template or protocol than at least one other of the images. Methods, systems and computer readable media are provided to automatically feature extract a single array image having an identifier indicating that it is a multipack, multiple array image. A system provided for feature extracting array images in batch mode includes a user interface with a feature enabling a user to select images to be loaded into a batch project; and based upon the loaded images in the batch project, the system may automatically assign a grid template to each image loaded into the batch project. Further, the system may automatically assign a protocol to each image loaded into the batch project.

    摘要翻译： 方法，系统和计算机可读介质，用于以批处理模式自动特征提取阵列图像。 要将特征提取的至少两个图像加载到批处理项目中，并且系统自动并顺序地特征提取批处理项目中的图像。 可以基于与至少另一个图像不同的网格模板或协议来提取图像中的至少一个。 提供方法，系统和计算机可读介质以自动特征提取具有指示其是多包多重阵列图像的标识符的单个阵列图像。 提供用于以批处理模式提取阵列图像的特征的系统包括具有使得用户能够选择要加载到批处理项目中的图像的特征的用户界面; 并且基于批处理项目中加载的图像，系统可以自动将网格模板分配给加载到批处理项目中的每个图像。 此外，系统可以自动将协议分配给加载到批处理项目中的每个图像。

    System and method of automated processing of multiple microarray images
    8.
    发明申请
    System and method of automated processing of multiple microarray images 审中-公开
    多个微阵列图像自动处理的系统和方法

    公开(公告)号：US20050281462A1

    公开(公告)日：2005-12-22

    申请号：US10869343

    申请日：2004-06-16

    申请人： Jayati Ghosh ,  Charles Troup ,  Xiangyang Zhou

    发明人： Jayati Ghosh ,  Charles Troup ,  Xiangyang Zhou

    IPC分类号： C12Q1/68 ,  G06T5/00 ,  G06T7/00

    CPC分类号： G06T7/12 ,  G06T7/73 ,  G06T2207/10064 ,  G06T2207/20132 ,  G06T2207/30072 ,  G06T2219/2024

    摘要： Methods, systems and computer readable media for automatically separating multiple microarray images provided as a single combined image of the multiple microarray images. Methods, systems and computer readable media are provided for providing at least one image containing multiple microarray images thereon, automatically locating the features in the microarray images, automatically determining the boundaries of each microarray image based on the locations of the features, and automatically cropping the image containing multiple microarray images to form a group of single images, each containing only one microarray image cropped from the image containing multiple microarray images. Methods, systems and computer readable media are provided for evaluating separation locations of multiple microarray images in a single combined image of the multiple microarray images, and separating the multiple microarray images along the separation locations, wherein the images are represented in a two-dimensional array.

    摘要翻译： 用于自动分离作为多个微阵列图像的单个组合图像提供的多个微阵列图像的方法，系统和计算机可读介质。 提供了方法，系统和计算机可读介质，用于提供至少一个包含多个微阵列图像的图像，将特征自动定位在微阵列图像中，基于特征的位置自动确定每个微阵列图像的边界，并自动裁剪 图像包含多个微阵列图像以形成一组单个图像，每个图像仅包含从包含多个微阵列图像的图像剪切出的一个微阵列图像。 提供了方法，系统和计算机可读介质，用于评估多个微阵列图像的单个组合图像中的多个微阵列图像的分离位置，以及沿着分离位置分离多个微阵列图像，其中图像以二维阵列 。

    Hydrothermal deposition of thin and adherent metal oxide coatings for high temperature corrosion protection
    9.
    发明申请
    Hydrothermal deposition of thin and adherent metal oxide coatings for high temperature corrosion protection 审中-公开
    薄膜和粘附金属氧化物涂层的水热沉积用于高温腐蚀保护

    公开(公告)号：US20060153983A1

    公开(公告)日：2006-07-13

    申请号：US11347396

    申请日：2006-02-02

    申请人： Xiangyang Zhou ,  Zhuang Zhou ,  Serguei Lvov ,  Digby Macdonald

    发明人： Xiangyang Zhou ,  Zhuang Zhou ,  Serguei Lvov ,  Digby Macdonald

    IPC分类号： B05D3/02

    CPC分类号： C23C18/06 ,  C23C18/02 ,  C23C18/1216 ,  C23C18/1241

    摘要： A metal oxide layer can be deposited onto surface of a structure in-situ, by exposing the surface to a precursor solution at an elevated temperature. The precursor solution contains: an organometallic, an oxidant, a surfactant, a chelating agent and water. The precursor solution is injected into the structure and maintained at a specific temperature, pH level, and pressure for a predetermined period of time. The resulting metal oxide layer is permanently attached to the structure's surface with a molecular interface bond and does not require post deposition heat treatment or additional injections of materials. As a result, the electrochemical corrosion potential of the metal surface decreases to less than −230 mVSHE and corrosion in the BWR is mitigated.

    摘要翻译： 金属氧化物层可以通过在升高的温度下将表面暴露于前体溶液而原位沉积在结构的表面上。 前体溶液含有：有机金属，氧化剂，表面活性剂，螯合剂和水。 将前体溶液注入结构中并保持在特定温度，pH水平和压力下一段预定的时间。 所得到的金属氧化物层通过分子界面键永久地附着在结构的表面上，并且不需要后沉积热处理或附加的材料注入。 结果，金属表面的电化学腐蚀电位降低到小于-230mV，并减轻了BWR中的腐蚀。