公开(公告)号：US20050131458A1

公开(公告)日：2005-06-16

申请号：US10913511

申请日：2004-08-09

申请人： Christopher Batich ,  Matthew Eadens ,  Robert Mericle ,  Matthew Burry ,  Courtney Watkins ,  Swadeshmukul Santra ,  Patrick Leamy

发明人： Christopher Batich ,  Matthew Eadens ,  Robert Mericle ,  Matthew Burry ,  Courtney Watkins ,  Swadeshmukul Santra ,  Patrick Leamy

IPC分类号： A61B20060101 ,  A61B17/08 ,  A61B17/12 ,  A61K9/00 ,  A61K9/50 ,  A61K9/51 ,  A61K49/04 ,  A61L24/00 ,  A61L24/02 ,  A61L31/02 ,  A61L31/18

CPC分类号： A61L24/02 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/12186 ,  A61B2017/00876 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/5015 ,  A61K9/5115 ,  A61K9/5153 ,  A61K49/0404 ,  A61K49/0423 ,  A61K49/0485 ,  A61L24/001 ,  A61L31/022 ,  A61L31/18 ,  A61L2400/06 ,  A61L2430/36 ,  B82Y5/00

摘要： A flowable, biodegradable endovascular embolic composition effective for embolizing a vascular defect consisting essentially of: (a) a biocompatible, biodegradable polymer or polymeric material forming composition; (b) a biocompatible embolic solvent for the polymer or polymer forming composition capable of diffusion into mammalian tissue; (c) biocompatible magnetic particles responsive to a magnetic field; wherein: the polymer or polymeric forming material and solvent are present in the composition in amounts and relative proportions such that (1) the composition is deliverable to a vascular defect site and (2) upon delivery to the site, solidifies into an embolic mass; and the magnetic particles are present in the composition in an amount sufficient to enable the composition being deliverable to the vascular site by a magnetic field. Also disclosed are methods and articles of manufacture embodying the above-described composition.

摘要翻译： 一种可流动的，可生物降解的血管内栓塞组合物，其有效栓塞血管缺损，其基本上由以下组成：（a）生物相容的，可生物降解的聚合物或形成聚合物的组合物; （b）能够扩散入哺乳动物组织的聚合物或聚合物形成组合物的生物相容性栓塞溶剂; （c）响应于磁场的生物相容性磁性颗粒; 其中：聚合物或聚合物形成材料和溶剂以数量和相对比例存在于组合物中，使得（1）组合物可输送到血管缺损部位，和（2）在递送至部位后，固化成栓塞体; 并且磁性颗粒以足以使组合物通过磁场输送到血管部位的量存在于组合物中。 还公开了体现上述组合物的方法和制品。

公开(公告)号：US20050049691A1

公开(公告)日：2005-03-03

申请号：US10652557

申请日：2003-09-02

申请人： Robert Mericle ,  Swadeshmukul Santra ,  Matthew Burry ,  Christopher Batich ,  Courtney Watkins

发明人： Robert Mericle ,  Swadeshmukul Santra ,  Matthew Burry ,  Christopher Batich ,  Courtney Watkins

IPC分类号： A61F2/06 ,  A61L31/06

CPC分类号： A61F2/06 ,  A61L31/06 ,  C08L83/04 ,  C08L75/04

摘要： A coaxial double lumen tube adapted for forming an endovascular graft which comprises an outer tube positioned over an inner tube, both tubes being made of a material acceptable for use in endovascular grafts and having an internal and external diameter and a wall thickness, the outer tube having an internal diameter and the inner tube having an external diameter such that a space is created between the outer tube and inner tube, said space being at least partially filled with an uncured adhesive which, upon curing after endovascular implantation, cures to adhere said inner and outer tubes together to form a self-supportive tube.

摘要翻译： 一种适于形成血管内移植物的同轴双腔管，其包括位于内管上方的外管，两个管由可接受用于血管内移植物并具有内径和外径和壁厚的材料制成，外管 具有内径，并且所述内管具有外径，使得在所述外管和所述内管之间产生空间，所述空间至少部分地填充有未固化的粘合剂，所述未固化的粘合剂在血管内植入后固化，固化以将所述内部 和外管一起形成自支撑管。