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公开(公告)号：US20090209582A1
公开(公告)日：2009-08-20
申请号：US11920817
申请日：2006-05-24
申请人： Robert Murray McKinnell , Roland Gendron , Lan Jiang , Seok-ki Choi , Daniel D. Long , Paul R. Fatheree , Daniel Marquess , Sean Dalziel , Kirsten M. Phizackerley
发明人： Robert Murray McKinnell , Roland Gendron , Lan Jiang , Seok-ki Choi , Daniel D. Long , Paul R. Fatheree , Daniel Marquess , Sean Dalziel , Kirsten M. Phizackerley
IPC分类号： A61K31/4545 , C07D401/14 , A61P1/00
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , G01N33/5058
摘要： The invention relates to benzimidazole-carboxamide 5-HT4 receptor agonist compounds of formula (I) wherein R1 and X are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds. The invention further relates to crystalline forms of a compound of formula (I).
摘要翻译： 本发明涉及式（I）的苯并咪唑 - 甲酰胺5-HT 4受体激动剂化合物，其中R 1和X如说明书中所定义，或其药学上可接受的盐或溶剂合物或立体异构体。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗与5-HT 4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。 本发明还涉及式（I）化合物的结晶形式。
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2.发明授权公开(公告)号：US08377964B2
公开(公告)日：2013-02-19
申请号：US12796902
申请日：2010-06-09
申请人： Robert Murray McKinnell , Roland Gendron , Lan Jiang , Seok-ki Choi , Daniel D. Long , Paul R. Fatheree , Daniel Marquess
发明人： Robert Murray McKinnell , Roland Gendron , Lan Jiang , Seok-ki Choi , Daniel D. Long , Paul R. Fatheree , Daniel Marquess
IPC分类号： A61K31/4545
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , G01N33/5058
摘要： The invention relates to benzimidazole-carboxamide 5-HT4 receptor agonist compounds of formula (I) wherein R1 and X are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及式（I）的苯并咪唑 - 甲酰胺5-HT 4受体激动剂化合物，其中R 1和X如说明书中所定义，或其药学上可接受的盐或溶剂合物或立体异构体。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗与5-HT 4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20130273568A1
公开(公告)日：2013-10-17
申请号：US13742783
申请日：2013-01-16
申请人： Robert Murray McKinnell , Roland Gendron , Lan Jiang , Seok-Ki Choi , Daniel D. Long , Paul R. Fatheree , Daniel Marquess
发明人： Robert Murray McKinnell , Roland Gendron , Lan Jiang , Seok-Ki Choi , Daniel D. Long , Paul R. Fatheree , Daniel Marquess
IPC分类号： G01N33/50
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , G01N33/5058
摘要： The invention relates to benzimidazole-carboxamide 5-HT4 receptor agonist compounds of formula (I) wherein R1 and X are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
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4.发明授权公开(公告)号：US07759363B2
公开(公告)日：2010-07-20
申请号：US11439671
申请日：2006-05-24
申请人： Robert Murray McKinnell , Roland Gendron , Lan Jiang , Seok-ki Choi , Daniel D. Long , Paul R. Fatheree , Daniel Marquess
发明人： Robert Murray McKinnell , Roland Gendron , Lan Jiang , Seok-ki Choi , Daniel D. Long , Paul R. Fatheree , Daniel Marquess
IPC分类号： A61K31/4545 , C07D403/14
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , G01N33/5058
摘要： The invention relates to benzimidazole-carboxamide 5-HT4 receptor agonist compounds of formula (I) wherein R1 and X are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及式（I）的苯并咪唑 - 甲酰胺5-HT 4受体激动剂化合物，其中R 1和X如说明书中所定义，或其药学上可接受的盐或溶剂合物或立体异构体。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗与5-HT 4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20100249186A1
公开(公告)日：2010-09-30
申请号：US12796902
申请日：2010-06-09
申请人： Robert Murray McKinnell , Roland Gendron , Lan Jiang , Seoki-ki Choi , Daniel D. Long , Paul R. Fatheree , Daniel Marquess
发明人： Robert Murray McKinnell , Roland Gendron , Lan Jiang , Seoki-ki Choi , Daniel D. Long , Paul R. Fatheree , Daniel Marquess
IPC分类号： A61K31/4545 , A61P1/00 , A61P1/04
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , G01N33/5058
摘要： The invention relates to benzimidazole-carboxamide 5-HT4 receptor agonist compounds of formula (I) wherein R1 and X are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及式（I）的苯并咪唑 - 甲酰胺5-HT 4受体激动剂化合物，其中R 1和X如说明书中所定义，或其药学上可接受的盐或溶剂合物或立体异构体。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗与5-HT 4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US07875629B2
公开(公告)日：2011-01-25
申请号：US12234906
申请日：2008-09-22
申请人： Adam A. Goldblum , Seok-ki Choi , Paul R. Fatheree , Roland Gendron , Lan Jiang , Daniel D. Long , Daniel Marquess , S. Derek Turner
发明人： Adam A. Goldblum , Seok-ki Choi , Paul R. Fatheree , Roland Gendron , Lan Jiang , Daniel D. Long , Daniel Marquess , S. Derek Turner
IPC分类号： A61K31/46
CPC分类号： C07D451/04 , C07D453/02
摘要： The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供新的喹啉酮 - 甲酰胺5-HT 4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20090036483A1
公开(公告)日：2009-02-05
申请号：US12234906
申请日：2008-09-22
申请人： Adam A. Goldblum , Seok-ki Choi , Paul R. Fatheree , Roland Gendron , Lan Jiang , Daniel D. Long , Daniel Marquess , S. Derek Turner
发明人： Adam A. Goldblum , Seok-ki Choi , Paul R. Fatheree , Roland Gendron , Lan Jiang , Daniel D. Long , Daniel Marquess , S. Derek Turner
IPC分类号： A61K31/46
CPC分类号： C07D451/04 , C07D453/02
摘要： The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供新的喹啉酮 - 甲酰胺5-HT 4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US07446114B2
公开(公告)日：2008-11-04
申请号：US11365320
申请日：2006-03-01
申请人： Adam A. Goldblum , Seok-ki Choi , Paul R. Fatheree , Roland Gendron , Lan Jiang , Daniel D. Long , Daniel Marquess , S. Derek Turner
发明人： Adam A. Goldblum , Seok-ki Choi , Paul R. Fatheree , Roland Gendron , Lan Jiang , Daniel D. Long , Daniel Marquess , S. Derek Turner
IPC分类号： A01N43/42 , A61K31/44 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D421/00 , C07D451/00
CPC分类号： C07D451/04 , C07D453/02
摘要： The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供新颖的喹啉酮 - 甲酰胺5-HT 4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT 4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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9.发明授权公开(公告)号：US07772239B2
公开(公告)日：2010-08-10
申请号：US11986212
申请日：2007-11-20
申请人： Roland Gendron , Seok-ki Choi , Paul R. Fatheree , Adam A. Goldblum , Daniel D. Long , Daniel Marquess , S. Derek Turner
发明人： Roland Gendron , Seok-ki Choi , Paul R. Fatheree , Adam A. Goldblum , Daniel D. Long , Daniel Marquess , S. Derek Turner
IPC分类号： A61K31/46 , A61K31/496 , A61P1/00
CPC分类号： C07D451/04 , A61K31/46 , A61K31/496
摘要： The invention provides novel benzoimidazolone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供新的苯并咪唑酮 - 甲酰胺5-HT4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20080146807A1
公开(公告)日：2008-06-19
申请号：US12012579
申请日：2008-02-04
申请人： Daniel Marquess , Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Adam A. Goldblum , Daniel D. Long , S. Derek Turner , Jyanwei Liu
发明人： Daniel Marquess , Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Adam A. Goldblum , Daniel D. Long , S. Derek Turner , Jyanwei Liu
IPC分类号： C07D451/02
CPC分类号： G01N33/5044 , C07D451/04 , G01N33/5008 , G01N2333/70571
摘要： The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供了新的吲唑 - 甲酰胺5-HT 4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT 4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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