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1.发明授权Genetically modified cyanobacteria for the production of ethanol, the constructs and method thereof 有权用于生产乙醇的转基因蓝细菌，其构建及其方法公开(公告)号：US06699696B2
公开(公告)日：2004-03-02
申请号：US09861819
申请日：2001-05-21
IPC分类号： C12P706
摘要： The invention provides a genetically modified Cyanobacteria having a construct comprising DNA fragments encoding pyruvate decarboxylase (pdc) and alcohol dehydrogenase (adh) enzymes obtained from the Zymomonas mobilis plasmid pLOI295. The Cyanobacteria are capable of producing ethanol in recoverable quantities of at least 1.7 &mgr;mol ethanol per mg of chlorophyll per hour.
摘要翻译： 本发明提供了具有构建体的经遗传修饰的蓝细菌，该构建体包含从运动发酵单胞菌素质粒pLOI295获得的编码丙酮酸脱羧酶（pdc）和醇脱氢酶（adh）的DNA片段。 蓝细菌能够以每小时每mg叶绿素的可回收量至少为1.7微摩尔乙醇生产乙醇。
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2.发明授权Genetically modified cyanobacteria for the production of ethanol, the constructs and method thereof 失效用于生产乙醇的转基因蓝细菌，其构建及其方法公开(公告)号：US06306639B1
公开(公告)日：2001-10-23
申请号：US09026845
申请日：1998-02-20
IPC分类号： C12N120
摘要： The invention relates to the genetic modification of Cyanobacteria for the production of ethanol, and more particularly, to the genetic modification of Cyanobacteria by incorporating the genetic information encoding for pyruvate decarboxylase (pdc) and alcohol dehydrogenase (adh).
摘要翻译： 本发明涉及用于生产乙醇的蓝细菌的遗传修饰，更具体地说，涉及编码丙酮酸脱羧酶（pdc）和醇脱氢酶（adh）的遗传信息对蓝细菌的遗传修饰。
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公开(公告)号：US09476032B2
公开(公告)日：2016-10-25
申请号：US12594173
申请日：2008-03-31
申请人： Eckard Wimmer , Steve Skiena , Steffen Mueller , Bruce Futcher , Dimitris Papamichail , John Robert Coleman , Jeronimo Cello
发明人： Eckard Wimmer , Steve Skiena , Steffen Mueller , Bruce Futcher , Dimitris Papamichail , John Robert Coleman , Jeronimo Cello
CPC分类号： C12N7/00 , A61K39/13 , A61K39/145 , A61K2039/5254 , C07K14/005 , C12N2720/12361 , C12N2740/15061 , C12N2760/16061 , C12N2760/16121 , C12N2760/16134 , C12N2760/16162 , C12N2770/20061 , C12N2770/24161 , C12N2770/32061 , C12N2770/32621 , C12N2770/32634 , C12N2770/32661 , C12N2770/32662 , C12N2770/32671 , C12N2770/32721 , C12N2770/32761 , C12N2770/32762 , Y02A50/386 , Y02A50/388 , Y02A50/466
摘要： This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.
摘要翻译： 本发明提供了一种减毒病毒，其包含经修饰的病毒基因组，其含有在基因组中多个位置工程改造的核苷酸取代，其中所述取代引入同义脱酮密码子进入基因组。 本发明的减毒病毒可用于疫苗组合物中以在受试者中诱导保护性免疫应答。 本发明还提供了合成即时减毒病毒的方法。 此外，本发明进一步提供了一种防止受试者患有病毒相关疾病的方法，包括向受试者施用预防有效剂量的包含即时减毒病毒的疫苗组合物。
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公开(公告)号：US20120269849A1
公开(公告)日：2012-10-25
申请号：US13501045
申请日：2010-10-11
申请人： Eckard Wimmer , Steve Skiena , Steffen Mueller , Bruce Futcher , Dimitris Papamichail , John Robert Coleman , Jeronimo Cello
发明人： Eckard Wimmer , Steve Skiena , Steffen Mueller , Bruce Futcher , Dimitris Papamichail , John Robert Coleman , Jeronimo Cello
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , A61K2039/5254 , A61K2039/543 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162
摘要： The present provides attenuated influenza viruses comprising a modified viral genome containing a plurality of nucleotide substitutions. The nucleotide substitutions result in the rearrangement of preexisting codons of one or more protein encoding sequences and changes in codon pair bias. Substitutions of non-synonymous and synonymous codons may also be included. The attenuated influenza viruses enable production of improved vaccines and are used to elicit protective immune responses.
摘要翻译： 本发明提供减毒流感病毒，其包含含有多个核苷酸取代的经修饰的病毒基因组。 核苷酸取代导致一个或多个蛋白质编码序列的预先存在的密码子的重排以及密码子对偏差的变化。 也可以包括非同义和同义密码子的取代。 减毒的流感病毒能够生产改进的疫苗，并用于引发保护性免疫应答。
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公开(公告)号：US20100209454A1
公开(公告)日：2010-08-19
申请号：US12594173
申请日：2008-03-31
申请人： Eckard Wimmer , Steve Skiena , Steffen Mueller , Bruce Futcher , Dimitris Papamichail , John Robert Coleman , Jeronimo Cello
发明人： Eckard Wimmer , Steve Skiena , Steffen Mueller , Bruce Futcher , Dimitris Papamichail , John Robert Coleman , Jeronimo Cello
CPC分类号： C12N7/00 , A61K39/13 , A61K39/145 , A61K2039/5254 , C07K14/005 , C12N2720/12361 , C12N2740/15061 , C12N2760/16061 , C12N2760/16121 , C12N2760/16134 , C12N2760/16162 , C12N2770/20061 , C12N2770/24161 , C12N2770/32061 , C12N2770/32621 , C12N2770/32634 , C12N2770/32661 , C12N2770/32662 , C12N2770/32671 , C12N2770/32721 , C12N2770/32761 , C12N2770/32762 , Y02A50/386 , Y02A50/388 , Y02A50/466
摘要： This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.
摘要翻译： 本发明提供了一种减毒病毒，其包含经修饰的病毒基因组，其含有在基因组中多个位置工程改造的核苷酸取代，其中所述取代引入同义脱酮密码子进入基因组。 本发明的减毒病毒可用于疫苗组合物中以在受试者中诱导保护性免疫应答。 本发明还提供了合成即时减毒病毒的方法。 此外，本发明进一步提供了一种防止受试者患有病毒相关疾病的方法，包括向受试者施用预防有效剂量的包含即时减毒病毒的疫苗组合物。
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