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1.发明申请公开(公告)号：US20160339030A1
公开(公告)日：2016-11-24
申请号：US15159444
申请日：2016-05-19
申请人： Robert R. Redfield , Alonso Heredia , Charles E. Davis , Ronald B. Gartenhaus , Edward A. Sausville
发明人： Robert R. Redfield , Alonso Heredia , Charles E. Davis , Ronald B. Gartenhaus , Edward A. Sausville
IPC分类号： A61K31/519 , A61K45/06 , A61K31/5377 , A61K31/4745 , A61K31/501
CPC分类号： A61K31/519 , A61K31/4745 , A61K31/501 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： Methods are provided for treating HIV and cancer in a subject in need thereof by administering to the subject therapeutically effective amounts of an mTOR inhibitor. Other methods are provided for treating subjects infected with HIV by administering to the subject therapeutically effective amounts of the mTOR inhibitor INK128, GSK2126458, AZD2014 or Torin-2.
摘要翻译： 提供了通过向受试者施用治疗有效量的mTOR抑制剂来治疗有需要的受试者中的HIV和癌症的方法。 提供了其它方法用于治疗感染HIV的受试者，通过向受试者施用治疗有效量的mTOR抑制剂INK128，GSK2126458，AZD2014或Torin-2。
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公开(公告)号：US20200016160A1
公开(公告)日：2020-01-16
申请号：US16580988
申请日：2019-09-24
IPC分类号： A61K31/519 , A61K31/4745 , A61K31/501 , A61K31/5377 , A61K45/06
摘要： Methods are provided for treating HIV and cancer in a subject in need thereof by administering to the subject therapeutically effective amounts of an mTOR inhibitor. Other methods are provided for treating subjects infected with HIV by administering to the subject therapeutically effective amounts of the mTOR inhibitor INK128, GSK2126458, AZD2014 or Torin-2.
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公开(公告)号：US11364242B2
公开(公告)日：2022-06-21
申请号：US16580988
申请日：2019-09-24
IPC分类号： A61K31/519 , A61K31/44 , A61K31/4745 , A61K31/501 , A61K31/5377 , A61K45/06
摘要： Methods are provided for treating HIV and cancer in a subject in need thereof by administering to the subject therapeutically effective amounts of an mTOR inhibitor. Other methods are provided for treating subjects infected with HIV by administering to the subject therapeutically effective amounts of the mTOR inhibitor INK128, GSK2126458, AZD2014 or Torin-2.
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4.发明授权Compositions for down-regulation of CCR5 expression and methods of use thereof 失效用于下调CCR5表达的组合物及其使用方法公开(公告)号：US07863242B2
公开(公告)日：2011-01-04
申请号：US11281195
申请日：2005-11-16
IPC分类号： A61K38/00 , A61K31/445 , A61K31/33
CPC分类号： A61K31/17 , A61K31/33 , A61K31/35 , A61K31/355 , A61K31/385 , A61K31/404 , A61K31/435 , A61K31/513 , A61K31/522 , A61K31/551 , A61K31/70 , A61K38/12 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the downregulation of surface receptor CCR5 expression through manipulation of the cell cycle in activated lymphocytes by administering a composition that arrests the G1 phase of the cell cycle, thereby reducing receptor sites for entry of HIV into T cells, and thus, the effects of HIV. Further, compositions are disclosed that include at least one G1 phase arresting agent and at least one antiviral agent, wherein the combination of agents synergistically enhances the activity of the antiviral agent.
摘要翻译： 本发明涉及通过施用阻止细胞周期的G1期的组合物，从而减少HIV进入T细胞的受体位点，通过操纵活化的淋巴细胞中的细胞周期来下调表面受体CCR5的表达， 艾滋病毒的影响。 此外，公开了包含至少一种G1停滞剂和至少一种抗病毒剂的组合物，其中所述试剂的组合协同地增强抗病毒剂的活性。
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公开(公告)号：US06479466B1
公开(公告)日：2002-11-12
申请号：US09637652
申请日：2000-08-11
IPC分类号： A61K3152
CPC分类号： A61K31/7076 , A61K31/03 , A61K31/505 , A61K31/52 , A61K31/70 , A61K31/7068 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： Methods and combinations of an agent that promotes DNA synthesis in a virally-targeted cell and a nucleoside analogue having antiviral activity are provided for treating a viral infection in a subject in need thereof. Such compositions are particularly effective where the subject has resistance to a nucleoside analogue, where the subject has resting cellular reservoirs of such a virus, or to induce a post-treatment period of replication incompetence of such a virus.
摘要翻译： 提供促进病毒靶向细胞中的DNA合成的试剂和具有抗病毒活性的核苷类似物的方法和组合，用于治疗有需要的受试者的病毒感染。 当受试者具有对核苷类似物的抗性时，这种组合物是特别有效的，其中受试者具有这种病毒的休眠细胞储库，或者诱导这种病毒的复制后期无效期。
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6.发明申请Compositions for inducing increased levels of beta-chemokines and methods of use therefor 审中-公开用于诱导β-趋化因子水平升高的组合物及其使用方法公开(公告)号：US20060099170A1
公开(公告)日：2006-05-11
申请号：US10527904
申请日：2003-09-12
IPC分类号： A61K38/19 , A61K38/12 , A61K31/7076 , A61K39/395 , A61K31/551 , A61K31/522 , A61K31/355 , A61K31/19
CPC分类号： A61K31/19 , A61K31/34 , A61K31/355 , A61K31/36 , A61K31/505 , A61K31/522 , A61K31/551 , A61K31/7076
摘要： The present invention relates to compositions and methods for inducing increased levels and availability of β-chemokines by administering to a subject at least one G1 phase arresting compound, wherein the increased levels and availability of β-chemokines block chemokine/viral receptors thereby preventing or treating viral infections.
摘要翻译： 本发明涉及通过向受试者施用至少一种G1期阻滞化合物来诱导增加的β-趋化因子水平和可用性的组合物和方法，其中增加的β-趋化因子的水平和可利用性阻断趋化因子/病毒受体从而预防或治疗 病毒感染。
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7.发明授权Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor 失效鸟苷类似物逆转录酶抑制剂和肌苷单磷酸脱氢酶抑制剂的协同组合及其用途公开(公告)号：US06514979B1
公开(公告)日：2003-02-04
申请号：US09261712
申请日：1999-03-03
申请人： David Margolis , Alonso Heredia , David Oldach , Robert Redfield
发明人： David Margolis , Alonso Heredia , David Oldach , Robert Redfield
IPC分类号： A61K3152
CPC分类号： A61K31/52 , A61K31/365 , A61K2300/00
摘要： Synergistic combinations of guanosine nucleoside analog reverse transcriptase inhibitors such as abacavir with inosine monophosphate dehydrogenase inhibitors such as mycophenolates, pharmaceutical compositions comprising such combinations, and therapeutic methods comprising administering the synergistic combinations to subjects in need thereof, for treating a viral infection, such as an HIV-1 infection.
摘要翻译： 鸟苷核苷类似物逆转录酶抑制剂如阿巴卡韦与肌苷单磷酸酯脱氢酶抑制剂如霉酚酸酯的协同组合，包含这些组合的药物组合物以及治疗方法包括向有需要的受试者施用协同组合，用于治疗病毒感染，例如 HIV-1感染。
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8.发明申请Compositions for down-regulation of CCR5 expression and methods of use thereof 失效用于下调CCR5表达的组合物及其使用方法公开(公告)号：US20060154857A1
公开(公告)日：2006-07-13
申请号：US11281195
申请日：2005-11-16
IPC分类号： A61K38/12 , A61K31/522 , A61K31/513 , A61K31/4745 , A61K31/404 , A61K39/42 , A61K31/551
CPC分类号： A61K31/17 , A61K31/33 , A61K31/35 , A61K31/355 , A61K31/385 , A61K31/404 , A61K31/435 , A61K31/513 , A61K31/522 , A61K31/551 , A61K31/70 , A61K38/12 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the downregulation of surface receptor CCR5 expression through manipulation of the cell cycle in activated lymphocytes by administering a composition that arrests the G1 phase of the cell cycle, thereby reducing receptor sites for entry of HIV into T cells, and thus, the effects of HIV. Further, compositions are disclosed that include at least one G1 phase arresting agent and at least one antiviral agent, wherein the combination of agents synergistically enhances the activity of the antiviral agent.
摘要翻译： 本发明涉及通过施用阻止细胞周期的G1期的组合物，从而减少HIV进入T细胞的受体位点，通过操纵活化的淋巴细胞中的细胞周期来下调表面受体CCR5的表达， 艾滋病毒的影响。 此外，公开了包含至少一种G1停滞剂和至少一种抗病毒剂的组合物，其中所述试剂的组合协同地增强抗病毒剂的活性。
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