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公开(公告)号：US5232696A
公开(公告)日：1993-08-03
申请号：US101262
申请日：1987-09-25
CPC分类号： A61K38/465 , A61M1/3687 , A61M1/1678 , A61M2202/046
摘要： A method and apparatus for reducing the levels of low density lipoproteins (LDL) in blood is disclosed. The LDL is contacted with an enzyme which modifies it in a manner such that the LDL is rapidly removed endogenously by the patients' own metabolic processes. The enzyme may be introduced into the patient by injection, transdermal transport, nasal insufflation and ingestion. Additionally, the enzyme may be contained in a reactor for both in vivo and extracorporeal use.
摘要翻译： 公开了一种降低血液中低密度脂蛋白（LDL）水平的方法和装置。 使LDL与以其使得LDL被患者自身的代谢过程内源性快速去除的方式接触的酶接触。 可以通过注射，透皮转运，鼻吹入和摄取将酶引入患者。 此外，酶可以包含在用于体内和体外使用的反应器中。
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公开(公告)号：US5178864A
公开(公告)日：1993-01-12
申请号：US567261
申请日：1990-08-14
CPC分类号： A61K38/465
摘要： A therapeutically effective amount of soluble phospholipase A.sub.2 is administered into a subject for lowering the low density lipoproteins ("LDL") in the blood. Phospholipase A.sub.2 modifies the plasma LDL by hydrolyzing the phospholipids present in LDL. As a result, the modified LDL is rapidly removed from the bloodstream by the catabolic processes.
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3.发明授权Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis 失效低密度脂蛋白结合蛋白及其在诊断和治疗动脉粥样硬化中的应用公开(公告)号：US07807384B2
公开(公告)日：2010-10-05
申请号：US12137832
申请日：2008-06-12
申请人： Ann M. Lees , Robert S. Lees , Simon W. Law , Anibal A. Arjona
发明人： Ann M. Lees , Robert S. Lees , Simon W. Law , Anibal A. Arjona
CPC分类号： A61K49/0004 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C07K14/705 , G01N33/6893 , G01N33/92 , G01N2800/044 , G01N2800/323
摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.
摘要翻译： 描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离多核苷酸。 还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。 还提供药物组合物和疫苗组合物。
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公开(公告)号：US5972890A
公开(公告)日：1999-10-26
申请号：US398046
申请日：1995-02-28
申请人： Robert S. Lees , Ann M. Lees , Allan Fischman , Ing-Lung Shih , Mark A. Findeis
发明人： Robert S. Lees , Ann M. Lees , Allan Fischman , Ing-Lung Shih , Mark A. Findeis
IPC分类号： A61K38/00 , A61K49/14 , A61K51/08 , A61K51/12 , C07K14/775 , C07K14/78 , A61K38/02 , A61K49/00 , C07K5/00
CPC分类号： A61K49/14 , A61K49/085 , A61K51/08 , C07K14/775 , C07K14/78 , A61K2123/00 , A61K38/00
摘要： Vascular disease including asymptomatic atherosclerosis can be diagnosed by administering a synthetic peptide or peptide analog having an affinity for, and propensity to accumulate at, a site of vascular injury to a patient, and then detecting the location of the peptide or peptide analog within the patient's vascular system. The synthetic peptide or peptide analog may include an amino acid sequence sufficiently duplicative of the amino acid sequence of a region of either the apolipoprotein B, apolipoprotein A-I, or elastin proteins such that the peptide or peptide analog accumulates at a site of vascular injury.
摘要翻译： 包括无症状动脉粥样硬化的血管疾病可以通过施用对患者的血管损伤部位具有亲和性和倾向积累的合成肽或肽类似物来诊断，然后检测患者体内肽或肽类似物的位置 血管系统。 合成肽或肽类似物可以包括足够重复载脂蛋白B，载脂蛋白A-1或弹性蛋白蛋白的区域的氨基酸序列的氨基酸序列，使得肽或肽类似物在血管损伤部位积累。
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5.发明授权Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis 失效低密度脂蛋白结合蛋白及其在诊断和治疗动脉粥样硬化中的应用公开(公告)号：US06632923B1
公开(公告)日：2003-10-14
申请号：US09616289
申请日：2000-07-14
申请人： Ann M. Lees , Robert S. Lees , Simon W. Law , Anibal A. Arjona
发明人： Ann M. Lees , Robert S. Lees , Simon W. Law , Anibal A. Arjona
IPC分类号： C07K1400
CPC分类号： A61K49/0004 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C07K14/705 , G01N33/6893 , G01N33/92 , G01N2800/044 , G01N2800/323
摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.
摘要翻译： 描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离多核苷酸。 还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。 还提供了药物组合物和疫苗组合物
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6.发明授权Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis 失效低密度脂蛋白结合蛋白及其在诊断和治疗动脉粥样硬化中的应用公开(公告)号：US06355451B1
公开(公告)日：2002-03-12
申请号：US08979608
申请日：1997-11-26
申请人： Ann M. Lees , Robert S. Lees , Simon W. Law , Anibal A. Arjona
发明人： Ann M. Lees , Robert S. Lees , Simon W. Law , Anibal A. Arjona
IPC分类号： C12P2106
CPC分类号： A61K49/0004 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/705 , G01N33/6893 , G01N33/92 , G01N2800/044 , G01N2800/323
摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.
摘要翻译： 描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离多核苷酸。 还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。 还提供药物组合物和疫苗组合物。
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公开(公告)号：US4937067A
公开(公告)日：1990-06-26
申请号：US227449
申请日：1988-08-02
申请人： Robert S. Lees
发明人： Robert S. Lees
IPC分类号： A61K51/12
CPC分类号： A61K51/1224 , A61K2123/00
摘要： The metabolic activity of the adrenal gland can be monitored by intravenously injecting an infusate composed of low density lipoproteins labelled with a radioisotope that is suitable for extracorporeal imaging and subsequently measuring the intensity of radioisotope accumulation in organs of the body. By monitoring the accumulation at the sites of the adrenal glands, the metabolic activity can be localized and the level of activity can be assessed.
摘要翻译： 可以通过静脉内注射由适合于体外成像的放射性同位素标记的低密度脂蛋白的灌注液，随后测量体内器官中的放射性同位素积累的强度来监测肾上腺的代谢活性。 通过监测肾上腺部位的积累，代谢活动可以局部化，可以评估活动水平。
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公开(公告)号：US4647445A
公开(公告)日：1987-03-03
申请号：US594244
申请日：1984-03-28
申请人： Robert S. Lees
发明人： Robert S. Lees
CPC分类号： A61K51/1224 , A61K2123/00
摘要： Lipoproteins radiolabelled with an isotope of technetium substantially retain their native structure and biological function. The lipoproteins can be radiolabelled by simultaneous reduction of pertechnetate and lipoprotein with sodium dithionite at pH 8-9. The resulting radiolabelled lipoproteins can be used as probes for extracorporeal imaging to analyze lipoprotein metabolism.
摘要翻译： 用锝同位素放射性标记的脂蛋白基本上保留了其天然结构和生物学功能。 脂蛋白可以通过在pH8-9下与连二亚硫酸钠同时还原高锝酸盐和脂蛋白进行放射性标记。 所得放射性标记的脂蛋白可用作体外成像的探针，以分析脂蛋白代谢。
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9.发明授权公开(公告)号：US06605588B1
公开(公告)日：2003-08-12
申请号：US09517849
申请日：2000-03-02
申请人： Ann M. Lees , Robert S. Lees , Simon W. Law , Anibal A. Arjona
发明人： Ann M. Lees , Robert S. Lees , Simon W. Law , Anibal A. Arjona
IPC分类号： A01N3718
CPC分类号： A61K49/0004 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/705 , G01N33/6893 , G01N33/92 , G01N2800/044 , G01N2800/323 , Y10S514/814
摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.
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公开(公告)号：US5989519A
公开(公告)日：1999-11-23
申请号：US290853
申请日：1994-10-11
CPC分类号： A61K51/08 , A61K51/088 , A61K2121/00 , A61K2123/00
摘要： This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to technetium-99m (Tc-99m) labeled leukocyte-binding peptides, methods and kits for making such peptides, and methods for using such peptides to image sites of infection and inflammation in a mammalian body.
摘要翻译： PCT No.PCT / US93 / 02320 Sec。 371日期：1994年10月11日 102（e）日期1994年10月11日PCT 1993年3月12日PCT公布。 出版物WO93 / 17719 日期1993年9月16日本发明涉及放射性标记肽及其生产方法。 具体地，本发明涉及锝-99m（Tc-99m）标记的白细胞结合肽，用于制备这些肽的方法和试剂盒，以及使用这些肽来成像哺乳动物体内的感染和炎症部位的方法。
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