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    CONTAINER-CLOSURE SYSTEM FOR USE IN LYOPHILIZATION APPLICATIONS
    1.
    发明申请
    CONTAINER-CLOSURE SYSTEM FOR USE IN LYOPHILIZATION APPLICATIONS 审中-公开
    用于LYOPHILIZATION应用的集装箱封闭系统

    公开(公告)号：US20090001042A1

    公开(公告)日：2009-01-01

    申请号：US12144872

    申请日：2008-06-24

    申请人： Robert Sever ,  Balazs Hunek ,  Nigel Grinter ,  Gurjit Baring

    发明人： Robert Sever ,  Balazs Hunek ,  Nigel Grinter ,  Gurjit Baring

    IPC分类号： B65D51/16 ,  B65D41/50

    CPC分类号： B65D51/241 ,  A61J1/1468 ,  B65D41/28 ,  B65D51/002 ,  B65D2251/0015 ,  B65D2251/0075 ,  B65D2539/005

    摘要： A container closure system for use in lyophilization processes employing depressurization to initiate nucleation is provided. The present container closure system includes a container and a closure element disposed proximate to and adapted for sealing the opening of the container. The closure element includes a first sealing surface adapted for sealably contacting an interior surface of the container and a second sealing surface adapted for sealably contacting the top surface of the container when the container closure system is in a closed position. The closure element also includes a plurality of closure legs extending from the second sealing surface that define a plurality of side vents between each of the closure legs when the container closure system is in the open position. The length, thickness, number, and shape of the legs are chosen to produce an effective total side vent area that is at least 50% of the area of the container opening. Alternatively, the length, thickness, number, and shape of the legs are chosen to produce an effective total side vent area that is greater than the cumulative surface area of the outwardly facing surface of the closure legs.

    摘要翻译： 提供了一种用于使用减压引发成核的冻干方法的容器封闭系统。 本发明的容器封闭系统包括容器和靠近并适于密封容器开口的封闭元件。 闭合元件包括适于密封地接触容器的内表面的第一密封表面和适于在容器封闭系统处于关闭位置时密封地接触容器的顶表面的第二密封表面。 闭合元件还包括从第二密封表面延伸的多个封闭柱，当容器封闭系统处于打开位置时，封闭件在每个封闭支柱之间限定多个侧通风口。 选择腿的长度，厚度，数量和形状以产生至少占容器开口面积的50％的有效总侧排气面积。 或者，选择腿的长度，厚度，数量和形状以产生大于闭合腿的面向外的表面的累积表面积的有效总侧排气面积。

    Bioreactor with upward flowing impeller system for use in a mammalian cell culture process
    3.
    发明授权
    Bioreactor with upward flowing impeller system for use in a mammalian cell culture process 有权
    具有向上流动的叶轮系统的生物反应器用于哺乳动物细胞培养过程

    公开(公告)号：US09181521B2

    公开(公告)日：2015-11-10

    申请号：US13559957

    申请日：2012-07-27

    申请人： Alan T. Y. Cheng ,  Ying Zhou ,  Amitabh Gupta ,  Balazs Hunek ,  Nigel Grinter

    发明人： Alan T. Y. Cheng ,  Ying Zhou ,  Amitabh Gupta ,  Balazs Hunek ,  Nigel Grinter

    IPC分类号： C12M1/06 ,  C12M1/00 ,  C12N1/38 ,  C12M1/08 ,  C12M1/34 ,  C12M1/36

    CPC分类号： C12M27/20 ,  C12M27/02 ,  C12M27/24 ,  C12M29/06 ,  C12M41/12 ,  C12M41/26 ,  C12M41/32 ,  C12M41/48 ,  C12N1/38

    摘要： A bioreactor with an upward flowing impeller system for controlling a mammalian cell culture process is provided. The disclosed system enables control of the cell culture process by controlling the level of dissolved carbon dioxide in the cell culture media and prevent increases in the osmolality level is achieved by enhanced stripping of carbon dioxide via surface gas exchange with little or no damage to the mammalian cells. The use of an upward flow impeller combined with vertical baffles converts the swirling motions of the cell culture media into a largely vertical flow and promotes the removal of dissolved carbon dioxide via surface gas exchange with a sweep gas flowing over the top surface of the cell culture media within the bioreactor vessel.

    摘要翻译： 提供了一种具有向上流动的叶轮系统用于控制哺乳动物细胞培养过程的生物反应器。 所公开的系统能够通过控制细胞培养基中溶解的二氧化碳的水平来控制细胞培养过程，并且通过经由表面气体交换增强汽提二氧化碳来实现渗透压浓度的增加，对哺乳动物几乎没有或没有损伤 细胞。 使用与垂直挡板结合的向上流动叶轮将细胞培养基的旋转运动转化为大体垂直的流动，并通过与流过细胞培养物顶表面的吹扫气体的表面气体交换促进去除溶解的二氧化碳 生物反应器容器内的介质。

    BIOREACTOR WITH UPWARD FLOWING IMPELLER SYSTEM FOR USE IN A MAMMALIAN CELL CULTURE PROCESS
    7.
    发明申请
    BIOREACTOR WITH UPWARD FLOWING IMPELLER SYSTEM FOR USE IN A MAMMALIAN CELL CULTURE PROCESS 有权
    具有向上流动的叶轮系统的生物反应器在马马里细胞培养过程中使用

    公开(公告)号：US20130189767A1

    公开(公告)日：2013-07-25

    申请号：US13559957

    申请日：2012-07-27

    申请人： Alan T. Y. Cheng ,  Ying Zhou ,  Amitabh Gupta ,  Balazs Hunek ,  Nigel Grinter

    发明人： Alan T. Y. Cheng ,  Ying Zhou ,  Amitabh Gupta ,  Balazs Hunek ,  Nigel Grinter

    IPC分类号： C12M1/00

    CPC分类号： C12M27/20 ,  C12M27/02 ,  C12M27/24 ,  C12M29/06 ,  C12M41/12 ,  C12M41/26 ,  C12M41/32 ,  C12M41/48 ,  C12N1/38

    摘要： A bioreactor with an upward flowing impeller system for controlling a mammalian cell culture process is provided. The disclosed system enables control of the cell culture process by controlling the level of dissolved carbon dioxide in the cell culture media and prevent increases in the osmolality level is achieved by enhanced stripping of carbon dioxide via surface gas exchange with little or no damage to the mammalian cells. The use of an upward flow impeller combined with vertical baffles converts the swirling motions of the cell culture media into a largely vertical flow and promotes the removal of dissolved carbon dioxide via surface gas exchange with a sweep gas flowing over the top surface of the cell culture media within the bioreactor vessel.

    摘要翻译： 提供了一种具有向上流动的叶轮系统用于控制哺乳动物细胞培养过程的生物反应器。 所公开的系统能够通过控制细胞培养基中溶解的二氧化碳的水平来控制细胞培养过程，并且通过经由表面气体交换增强汽提二氧化碳来实现渗透压浓度的增加，对哺乳动物几乎没有或没有损伤 细胞。 使用与垂直挡板结合的向上流动叶轮将细胞培养基的旋转运动转化为大体垂直的流动，并通过与流过细胞培养物顶表面的吹扫气体的表面气体交换促进去除溶解的二氧化碳 生物反应器容器内的介质。

    SYSTEM AND METHOD FOR CONTROLLING A MAMMALIAN CELL CULTURE PROCESS
    8.
    发明申请
    SYSTEM AND METHOD FOR CONTROLLING A MAMMALIAN CELL CULTURE PROCESS 有权
    用于控制MAMMALIAN细胞培养方法的系统和方法

    公开(公告)号：US20100035343A1

    公开(公告)日：2010-02-11

    申请号：US12536559

    申请日：2009-08-06

    申请人： Alan T.Y. Cheng ,  Ying Zhou ,  Balazs Hunek ,  Amitabh Gupta ,  Nigel Grinter

    发明人： Alan T.Y. Cheng ,  Ying Zhou ,  Balazs Hunek ,  Amitabh Gupta ,  Nigel Grinter

    IPC分类号： C12N5/02 ,  C12M1/02 ,  C12M1/34 ,  C12M1/36 ,  C12M1/00

    CPC分类号： C12N1/38 ,  C12M27/02 ,  C12M29/22

    摘要： A system and method for controlling a mammalian cell culture process are provided. Such control of the cell culture process involves control of the level of dissolved carbon dioxide in the cell culture media and the resulting ability to prevent increases in the osmolality level is achieved by enhanced stripping of carbon dioxide with little or no damage to the mammalian cells. The disclosed methods and systems of dissolved carbon dioxide stripping include enhanced surface gas exchange mechanisms within the bioreactor vessel through the use of an upward flow impeller combined with vertical baffles to convert swirling motions of the liquid into a largely vertical flow.

    摘要翻译： 提供了一种用于控制哺乳动物细胞培养方法的系统和方法。 细胞培养过程的这种控制涉及控制细胞培养基中溶解的二氧化碳的水平，并且通过增强对二氧化碳的去除而对哺乳动物细胞几乎没有或没有损伤来实现所产生的渗透压浓度增加的能力。 所公开的溶解二氧化碳汽提方法和系统包括通过使用与垂直挡板结合的向上流动叶轮将生物反应器容器内的表面气体交换机制改进为将液体的旋转运动转化成大体垂直的流动。

    System and method for controlling a mammalian cell culture process
    10.
    发明授权
    System and method for controlling a mammalian cell culture process 有权
    用于控制哺乳动物细胞培养过程的系统和方法

    公开(公告)号：US08241904B2

    公开(公告)日：2012-08-14

    申请号：US12536559

    申请日：2009-08-06

    申请人： Alan T. Y. Cheng ,  Ying Zhou ,  Balazs Hunek ,  Amitabh Gupta ,  Nigel Grinter

    发明人： Alan T. Y. Cheng ,  Ying Zhou ,  Balazs Hunek ,  Amitabh Gupta ,  Nigel Grinter

    IPC分类号： C12N5/02

    CPC分类号： C12N1/38 ,  C12M27/02 ,  C12M29/22

    摘要： A system and method for controlling a mammalian cell culture process are provided. Such control of the cell culture process involves control of the level of dissolved carbon dioxide in the cell culture media and the resulting ability to prevent increases in the osmolality level is achieved by enhanced stripping of carbon dioxide with little or no damage to the mammalian cells. The disclosed methods and systems of dissolved carbon dioxide stripping include enhanced surface gas exchange mechanisms within the bioreactor vessel through the use of an upward flow impeller combined with vertical baffles to convert swirling motions of the liquid into a largely vertical flow.

    摘要翻译： 提供了一种用于控制哺乳动物细胞培养方法的系统和方法。 细胞培养过程的这种控制涉及控制细胞培养基中溶解的二氧化碳的水平，并且通过增强对二氧化碳的去除而对哺乳动物细胞几乎没有或没有损伤来实现所产生的渗透压浓度增加的能力。 所公开的溶解二氧化碳汽提方法和系统包括通过使用与垂直挡板结合的向上流动叶轮将生物反应器容器内的表面气体交换机制改进为将液体的旋转运动转化成大体垂直的流动。