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公开(公告)号：US5955719A
公开(公告)日：1999-09-21
申请号：US994684
申请日：1997-12-19
CPC分类号： G06K7/10881 , G06K17/0022 , G06K7/10772
摘要： A data well arrangement for storing data and for interfacing with a writing implement having a writing end with a writing tip and data transfer end with a data transfer tip is described. The data well arrangement has a housing with an inlet opening for receiving an end of the implement. A data reader resides in the housing for facing the data transfer tip to exchange data with the implement when the data transfer end of the implement is received in the opening. A shutter in the housing is engageable with an engagement portion of the implement for moving of shutter between a writing end storage position in which the data reader is inaccessible, and an interface position in which the data reader is accessible to the data transfer tip with the shutter being engaged by the engagement portion of the implement, only when the data transfer end is received in this opening.
摘要翻译： 描述了用于存储数据并且与具有写入端的写入工具进行接口的数据井布置，所述写入工具具有写入尖端和具有数据传送末端的数据传送结束。 数据井布置具有壳体，其具有用于接收工具的端部的入口。 数据读取器驻留在外壳中，用于面向数据传输提示，以在工具的数据传输端在开口中接收时与工具交换数据。 壳体中的快门可与工具的接合部分接合，用于在数据读取器不可访问的写入端存储位置和用于在数据读取器不可访问的数据读取器能够访问数据读取器的位置之间移动快门 仅当在该开口中接收到数据传送端时，挡板被工具的接合部分接合。
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公开(公告)号：US06213398B1
公开(公告)日：2001-04-10
申请号：US09255564
申请日：1999-02-22
IPC分类号： G06K714
CPC分类号： G06K7/10881 , G06K7/10772 , G06K17/0022
摘要： A data well arrangement is for storing data and for interfacing with a writing implement having a writing end with a writing tip and data transfer end with a data transfer tip. The data well arrangement has a housing with an inlet opening for receiving an end of the implement. A data reader is in the housing for facing the data transfer tip to exchange data with the implement when the data transfer end of the implement is received in the opening. A shutter in the housing is engageable with an engagement portion of the implement for moving of shutter between a writing end storage position in which the data reader is inaccessible, and an interface position in which the data reader is accessible to the data transfer tip with the shutter being engaged by the engagement portion of the implement, only when the data transfer end is received in this opening.
摘要翻译： 数据井布置用于存储数据，并用于与具有写入端的写入工具进行接口，该写入工具具有写入尖端和具有数据传输提示的数据传送结束。 数据井布置具有壳体，其具有用于接收工具的端部的入口。 数据读取器在壳体内面向数据传输提示，以在工具的数据传输端在开口中被接收时与工具交换数据。 壳体中的快门可与工具的接合部分接合，用于在数据读取器不可访问的写入端存储位置和用于在数据读取器不可访问的数据读取器能够访问数据读取器的位置之间移动快门 仅当在该开口中接收到数据传送端时，挡板被工具的接合部分接合。
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3.发明授权Method and apparatus for storing reference codes in a writing instrument and for retrieving information identifed by the reference codes 失效用于在书写工具中存储参考代码并用于检索由参考代码识别的信息的方法和装置公开(公告)号：US06446871B1
公开(公告)日：2002-09-10
申请号：US09335119
申请日：1999-06-17
申请人： John E. Buckley , Thomas H. Peterson , Paul E. Linderson , Frank Mercurio , Robert O. Southworth
发明人： John E. Buckley , Thomas H. Peterson , Paul E. Linderson , Frank Mercurio , Robert O. Southworth
IPC分类号： G06K710
CPC分类号： G06F3/03545 , G06F3/002 , G06K7/10772 , G06K7/10881 , G06K17/0022
摘要： An interactive data transfer system and method is provided. In embodiments of the invention, the data transfer system includes a computing device, and a data well for interfacing with an elongate instrument, the elongate instrument having a data transfer end with a data transfer tip. The data well has a housing with an opening for receiving the data transfer tip of the elongate instrument. The data well also has a communications port operatively coupled to the computing device to provide data to the computing device, and the data well has a data communication device contained in the housing for interfacing with the data transfer tip when the data transfer end of the elongate instrument is received in the opening The computing device is programmed to receive data from the data well. The received data includes data indicative of at least one address on a global communications network. The computer device is also programmed, upon receipt of the at least one address, to launch an application to retrieve information related to the at least one address from the global communications network and transmit such information to the computing device.
摘要翻译： 提供了一种交互式数据传输系统和方法。 在本发明的实施例中，数据传输系统包括计算设备和用于与细长仪器对接的数据井，该细长仪器具有带有数据传送端头的数据传送端。 数据井具有用于接收细长仪器的数据传送尖端的开口的壳体。 数据还具有可操作地耦合到计算设备的通信端口，以向计算设备提供数据，并且数据井具有包含在壳体中的数据通信设备，用于当细长的数据传输端与数据传输端口对接时 仪器被接收在开放中计算设备被编程为从数据井接收数据。 所接收的数据包括指示全球通信网络上的至少一个地址的数据。 在接收到至少一个地址时，计算机设备也被编程，以启动应用以从全球通信网络检索与至少一个地址相关的信息，并将该信息发送到计算设备。
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公开(公告)号：USD632434S1
公开(公告)日：2011-02-08
申请号：US29341645
申请日：2009-08-10
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公开(公告)号：USD621096S1
公开(公告)日：2010-08-03
申请号：US29341643
申请日：2009-08-10
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公开(公告)号：US07759476B2
公开(公告)日：2010-07-20
申请号：US11876570
申请日：2007-10-22
申请人： Frank Mercurio , Hengyi Zhu , Miguel Barbosa , Jian Wu Li , Brion W. Murray
发明人： Frank Mercurio , Hengyi Zhu , Miguel Barbosa , Jian Wu Li , Brion W. Murray
IPC分类号： C07H21/04
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/4702
摘要： Compositions and methods are provided for treating NF-κB-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-κB cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-κB activation.
摘要翻译： 提供组合物和方法用于治疗NF-和κB相关病症。 特别地，本发明提供了一种刺激诱导型IKK信号通路及其组件和变体。 IKK信号或其组分可用于例如鉴定通过NF-κB级联抑制或激活信号转导的抗体和其它调节剂。 IKK信号肽，其组分和/或调节剂也可用于治疗与NF-κB活化相关的疾病。
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7.发明申请Methods to identify compounds useful for the treatment of proliferative and differentiative disorders 有权鉴定可用于治疗增殖性和分化性疾病的化合物的方法公开(公告)号：US20090297528A1
公开(公告)日：2009-12-03
申请号：US12315862
申请日：2008-12-05
IPC分类号： A61K39/395 , C12Q1/00 , G01N33/53 , C12Q1/68 , A61K38/02 , A61K31/7088
CPC分类号： G01N33/5023 , A61K31/7088 , A61K38/02 , A61K38/1709 , A61K39/3955 , G01N33/573 , G01N33/574 , G01N2333/4703 , G01N2333/9015 , G01N2500/00 , G01N2500/04
摘要： The present invention relates to the discovery, identification and characterization of nucleotide sequences that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases: FBP1, FBP2, FBP3, FBP4, FBP5, FBP6, FBP7, FBP8, FBP9, FBP10, FBP11, FBP12, FBP13, FBP14, FBP15, FBP16, FBP17, FBP18, FBP19, FBP20, FBP21, FBP22, FBP23, FBP24, and FBP25, transgenic mice, knock-out mice, host-cell expression systems and proteins encoded by the nucleotides of the novel substrate-targeting subunits. The present invention relates to screening assays that use novel and known substrate-targeting subunits of ubiquitin ligases to identify potential therapeutic agents such as small molecules, compounds or derivatives and analogues of the novel and known ubiquitin ligases which modulate activity of the novel and known ubiquitin ligases for the treatment of proliferative and differentiative disorders, such as cancer, major opportunistic infections, immune disorders, certain cardiovascular diseases, and inflammatory disorders. The invention further encompasses therapeutic protocols and pharmaceutical compositions designed to target ubiquitin ligases and their substrates for the treatment of proliferative and differentiative disorders.
摘要翻译： 本发明涉及编码泛素连接酶的新的底物靶向亚基的核苷酸序列的发现，鉴定和表征。 本发明包括编码泛素连接酶的新型底物靶向亚基的核苷酸：FBP1，FBP2，FBP3，FBP4，FBP5，FBP6，FBP7，FBP8，FBP9，FBP10，FBP11，FBP12，FBP13，FBP14，FBP15，FBP16，FBP17，FBP18， FBP19，FBP20，FBP21，FBP22，FBP23，FBP24和FBP25，转基因小鼠，敲除小鼠，宿主细胞表达系统和由新型底物靶向亚基的核苷酸编码的蛋白质。 本发明涉及使用泛素连接酶的新型和已知的底物靶向亚基的筛选测定法来鉴定潜在的治疗剂，例如调节新型和已知的泛素的活性的新型和已知的泛素连接酶的小分子，化合物或衍生物和类似物 用于治疗增殖性和分化性疾病如癌症，主要机会性感染，免疫疾病，某些心血管疾病和炎症性疾病的连接酶。 本发明还包括旨在靶向泛素连接酶及其底物以治疗增殖性和分化性疾病的治疗方案和药物组合物。
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8.发明申请公开(公告)号：US20080210271A1
公开(公告)日：2008-09-04
申请号：US12030027
申请日：2008-02-12
摘要： By providing a shaver receiving and supporting housing which is constructed for enabling cleaning fluid to be delivered directly to the interior of a shaver in a highly efficient manner, a fully integrated shaving cleaning system is realized which is capable of providing automated cleaning of the shaver in an efficient and effective manner. In accordance with the present invention, the cleaning fluid if forced through portals formed in the shaver for enabling the fluid to be forcibly delivered directly into the hair pocket of the shaver, thereby enabling the surfaces of the hair pocket, the cutting foils, and the cutting blades to be completely and thoroughly cleaned, with the fluid draining out of the shaver through the cutting foils. In addition, the present invention is constructed for thoroughly and completely cleaning both rotary shavers and foil shavers.
摘要翻译： 通过提供一种剃须刀接收和支撑壳体，其被构造用于使清洁流体能够以高效的方式直接输送到剃须刀的内部，实现了完全集成的剃刮清洁系统，其能够提供剃须刀的自动清洁 高效有效的方式。 根据本发明，如果强制通过形成在剃须刀中的入口的清洁流体，以使流体能够被强制地输送到剃须刀的毛发袋中，从而使得头发袋，切割箔和 切割刀片被完全和彻底地清洁，液体通过切割箔从剃须刀排出。 此外，本发明构造成用于彻底且全面地清洁旋转剃须刀和箔片剃须刀。
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公开(公告)号：US20070208167A1
公开(公告)日：2007-09-06
申请号：US11698848
申请日：2007-01-25
申请人： Anthony Manning , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
发明人： Anthony Manning , Frank Mercurio , Sharon Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
IPC分类号： C07H21/04
CPC分类号： C12N9/93 , A61K38/00 , C12Y603/02019
摘要： Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated IκBα and/or IκBβ. Such compositions may be used for treating diseases associated with NF-κB activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
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公开(公告)号：US07186503B2
公开(公告)日：2007-03-06
申请号：US10665715
申请日：2003-09-19
申请人： Anthony M. Manning , Frank Mercurio , Sharo Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
发明人： Anthony M. Manning , Frank Mercurio , Sharo Amit , Yinon Ben-Neriah , Matti Davis , Ada Hatzubai , Avraham Yaron , Irit Alkalay , Aaron Ciechanover
CPC分类号： C12N9/93 , A61K38/00 , C12Y603/02019
摘要： Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated IκBα and/or IκBβ. Such compositions may be used for treating diseases associated with NF-κB activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
摘要翻译： 提供了调节核因子κB（NF-κB）活化的组成和方法。 组合物包含一种或多种调节磷酸化IkappaBalpha和/或IkappaBβ的泛素化的试剂。 这样的组合物可用于治疗与NF-κB活化相关的疾病。 调节剂包括人E3泛素连接酶，抗体及其变体，以及相关蛋白质。
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