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    Genes and proteins encoded thereby
    4.
    发明授权
    Genes and proteins encoded thereby 有权
    由此编码的基因和蛋白质

    公开(公告)号：US06440732B1

    公开(公告)日：2002-08-27

    申请号：US09661711

    申请日：2000-09-14

    申请人： Paul R. Russell ,  Jorge E. Vialard ,  Michael N. Boddy ,  Paul A. Shanahan ,  Antonia Lopez-Girona ,  Cecile-Marie D. D. Denis

    发明人： Paul R. Russell ,  Jorge E. Vialard ,  Michael N. Boddy ,  Paul A. Shanahan ,  Antonia Lopez-Girona ,  Cecile-Marie D. D. Denis

    IPC分类号： C07H1700

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/4738 ,  C12N9/22

    摘要： The present invention encompasses novel mammalian cell cycle checkpoint genes/DNA repair genes, cDNA or genomic DNA, isolated nucleic acids corresponding thereto, expression vectors comprising said nucleic acids, host cells transformed with said expression vectors, pharmaceutical compositions and the formulation of such compositions comprising said nucleic acids or proteins expressed therefrom, methods for treating a cell using such nucleic acids, proteins or pharmaceutical compositions, and the use of such nucleic acids or proteins in formulating a pharmaceutical preparation.

    摘要翻译： 本发明包括新的哺乳动物细胞周期检查点基因/ DNA修复基因，cDNA或基因组DNA，与其相对应的分离的核酸，包含所述核酸的表达载体，用所述表达载体转化的宿主细胞，药物组合物和这些组合物的制剂，其包含 由此表达的核酸或蛋白质，使用这种核酸，蛋白质或药物组合物治疗细胞的方法，以及这些核酸或蛋白质在配制药物制剂中的用途。

    Methods To Identify Compounds Useful For The Treatment Of Proliferative And Differentiative Disorders
    5.
    发明申请
    Methods To Identify Compounds Useful For The Treatment Of Proliferative And Differentiative Disorders 审中-公开
    识别可用于增殖和分化障碍治​​疗的化合物的方法

    公开(公告)号：US20120164656A1

    公开(公告)日：2012-06-28

    申请号：US13323227

    申请日：2011-12-12

    申请人： Michele Pagano ,  Frank Mercurio ,  Weilin Xie ,  Antonia Lopez-Girona ,  Angelo Peschiaroli

    发明人： Michele Pagano ,  Frank Mercurio ,  Weilin Xie ,  Antonia Lopez-Girona ,  Angelo Peschiaroli

    IPC分类号： C12Q1/68 ,  G01N33/566 ,  G01N33/53

    CPC分类号： G01N33/5023 ,  A61K31/7088 ,  A61K38/02 ,  A61K38/1709 ,  A61K39/3955 ,  G01N33/573 ,  G01N33/574 ,  G01N2333/4703 ,  G01N2333/9015 ,  G01N2500/00 ,  G01N2500/04

    摘要： The present invention relates to the discovery, identification and characterization of nucleotide sequences that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases, and transgenic mice, knock-out mice, host-cell expression systems and proteins encoded by the nucleotides of the novel substrate-targeting subunits. The present invention relates to screening assays that use novel and known substrate-targeting subunits of ubiquitin ligases to identify potential therapeutic agents such as small molecules, compounds or derivatives and analogues of the novel and known ubiquitin ligases which modulate activity of the novel and known ubiquitin ligases for the treatment of proliferative and differentiative disorders, such as cancer, major opportunistic infections, immune disorders, certain cardiovascular diseases, and inflammatory disorders. The invention further encompasses therapeutic protocols and pharmaceutical compositions designed to target ubiquitin ligases and their substrates for the treatment of proliferative and differentiative disorders.

    摘要翻译： 本发明涉及编码泛素连接酶的新的底物靶向亚基的核苷酸序列的发现，鉴定和表征。 本发明包括编码泛素连接酶的新的底物靶向亚基的核苷酸，以及转基因小鼠，敲除小鼠，宿主细胞表达系统和由新型底物靶向亚基的核苷酸编码的蛋白质。 本发明涉及使用泛素连接酶的新型和已知的底物靶向亚基的筛选测定法来鉴定潜在的治疗剂，例如调节新型和已知的泛素的活性的新型和已知的泛素连接酶的小分子，化合物或衍生物和类似物 用于治疗增殖性和分化性疾病如癌症，主要机会性感染，免疫疾病，某些心血管疾病和炎症性疾病的连接酶。 本发明还包括旨在靶向泛素连接酶及其底物以治疗增殖性和分化性疾病的治疗方案和药物组合物。

    Methods to identify compounds useful for the treatment of proliferative and differentiative disorders
    6.
    发明授权
    Methods to identify compounds useful for the treatment of proliferative and differentiative disorders 有权
    鉴定可用于治疗增殖性和分化性疾病的化合物的方法

    公开(公告)号：US08119421B2

    公开(公告)日：2012-02-21

    申请号：US12315862

    申请日：2008-12-05

    申请人： Michele Pagano ,  Frank Mercurio ,  Weilin Xie ,  Antonia Lopez-Girona ,  Angelo Peschiaroli

    发明人： Michele Pagano ,  Frank Mercurio ,  Weilin Xie ,  Antonia Lopez-Girona ,  Angelo Peschiaroli

    IPC分类号： G01N33/566 ,  G01N33/53 ,  C12Q1/00 ,  C12Q1/68

    CPC分类号： G01N33/5023 ,  A61K31/7088 ,  A61K38/02 ,  A61K38/1709 ,  A61K39/3955 ,  G01N33/573 ,  G01N33/574 ,  G01N2333/4703 ,  G01N2333/9015 ,  G01N2500/00 ,  G01N2500/04

    摘要： The present invention relates to the discovery, identification and characterization of nucleotide sequences that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases: FBP1, FBP2, FBP3, FBP4, FBP5, FBP6, FBP7, FBP8, FBP9, FBP10, FBP11, FBP12, FBP13, FBP14, FBP15, FBP16, FBP17, FBP18, FBP19, FBP20, FBP21, FBP22, FBP23, FBP24, and FBP25, transgenic mice, knock-out mice, host-cell expression systems and proteins encoded by the nucleotides of the novel substrate-targeting subunits. The present invention relates to screening assays that use novel and known substrate-targeting subunits of ubiquitin ligases to identify potential therapeutic agents such as small molecules, compounds or derivatives and analogues of the novel and known ubiquitin ligases which modulate activity of the novel and known ubiquitin ligases for the treatment of proliferative and differentiative disorders, such as cancer, major opportunistic infections, immune disorders, certain cardiovascular diseases, and inflammatory disorders. The invention further encompasses therapeutic protocols and pharmaceutical compositions designed to target ubiquitin ligases and their substrates for the treatment of proliferative and differentiative disorders.

    摘要翻译： 本发明涉及编码泛素连接酶的新的底物靶向亚基的核苷酸序列的发现，鉴定和表征。 本发明包括编码泛素连接酶的新型底物靶向亚基的核苷酸：FBP1，FBP2，FBP3，FBP4，FBP5，FBP6，FBP7，FBP8，FBP9，FBP10，FBP11，FBP12，FBP13，FBP14，FBP15，FBP16，FBP17，FBP18， FBP19，FBP20，FBP21，FBP22，FBP23，FBP24和FBP25，转基因小鼠，敲除小鼠，宿主细胞表达系统和由新型底物靶向亚基的核苷酸编码的蛋白质。 本发明涉及使用泛素连接酶的新型和已知的底物靶向亚基的筛选测定法来鉴定潜在的治疗剂，例如调节新型和已知的泛素的活性的新型和已知的泛素连接酶的小分子，化合物或衍生物和类似物 用于治疗增殖性和分化性疾病如癌症，主要机会性感染，免疫疾病，某些心血管疾病和炎症性疾病的连接酶。 本发明还包括旨在靶向泛素连接酶及其底物以治疗增殖性和分化性疾病的治疗方案和药物组合物。

    Methods to identify compounds useful for the treatment of proliferative and differentiative disorders
    9.
    发明申请
    Methods to identify compounds useful for the treatment of proliferative and differentiative disorders 有权
    鉴定可用于治疗增殖性和分化性疾病的化合物的方法

    公开(公告)号：US20090297528A1

    公开(公告)日：2009-12-03

    申请号：US12315862

    申请日：2008-12-05

    申请人： Michele Pagano ,  Frank Mercurio ,  Weilin Xie ,  Antonia Lopez-Girona ,  Angelo Peschiaroli

    发明人： Michele Pagano ,  Frank Mercurio ,  Weilin Xie ,  Antonia Lopez-Girona ,  Angelo Peschiaroli

    IPC分类号： A61K39/395 ,  C12Q1/00 ,  G01N33/53 ,  C12Q1/68 ,  A61K38/02 ,  A61K31/7088

    CPC分类号： G01N33/5023 ,  A61K31/7088 ,  A61K38/02 ,  A61K38/1709 ,  A61K39/3955 ,  G01N33/573 ,  G01N33/574 ,  G01N2333/4703 ,  G01N2333/9015 ,  G01N2500/00 ,  G01N2500/04

    摘要： The present invention relates to the discovery, identification and characterization of nucleotide sequences that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases: FBP1, FBP2, FBP3, FBP4, FBP5, FBP6, FBP7, FBP8, FBP9, FBP10, FBP11, FBP12, FBP13, FBP14, FBP15, FBP16, FBP17, FBP18, FBP19, FBP20, FBP21, FBP22, FBP23, FBP24, and FBP25, transgenic mice, knock-out mice, host-cell expression systems and proteins encoded by the nucleotides of the novel substrate-targeting subunits. The present invention relates to screening assays that use novel and known substrate-targeting subunits of ubiquitin ligases to identify potential therapeutic agents such as small molecules, compounds or derivatives and analogues of the novel and known ubiquitin ligases which modulate activity of the novel and known ubiquitin ligases for the treatment of proliferative and differentiative disorders, such as cancer, major opportunistic infections, immune disorders, certain cardiovascular diseases, and inflammatory disorders. The invention further encompasses therapeutic protocols and pharmaceutical compositions designed to target ubiquitin ligases and their substrates for the treatment of proliferative and differentiative disorders.

    摘要翻译： 本发明涉及编码泛素连接酶的新的底物靶向亚基的核苷酸序列的发现，鉴定和表征。 本发明包括编码泛素连接酶的新型底物靶向亚基的核苷酸：FBP1，FBP2，FBP3，FBP4，FBP5，FBP6，FBP7，FBP8，FBP9，FBP10，FBP11，FBP12，FBP13，FBP14，FBP15，FBP16，FBP17，FBP18， FBP19，FBP20，FBP21，FBP22，FBP23，FBP24和FBP25，转基因小鼠，敲除小鼠，宿主细胞表达系统和由新型底物靶向亚基的核苷酸编码的蛋白质。 本发明涉及使用泛素连接酶的新型和已知的底物靶向亚基的筛选测定法来鉴定潜在的治疗剂，例如调节新型和已知的泛素的活性的新型和已知的泛素连接酶的小分子，化合物或衍生物和类似物 用于治疗增殖性和分化性疾病如癌症，主要机会性感染，免疫疾病，某些心血管疾病和炎症性疾病的连接酶。 本发明还包括旨在靶向泛素连接酶及其底物以治疗增殖性和分化性疾病的治疗方案和药物组合物。