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公开(公告)号：US07348004B2
公开(公告)日：2008-03-25
申请号：US11029003
申请日：2005-01-05
申请人： Robert T. Peters , Adam R. Mezo , Daniel S. Rivera , Alan J. Bitonti , Susan C. Low , James Stattel
发明人： Robert T. Peters , Adam R. Mezo , Daniel S. Rivera , Alan J. Bitonti , Susan C. Low , James Stattel
CPC分类号： C07K14/505 , A61K38/00 , C07K5/0806 , C07K5/1013 , C07K7/06 , C07K7/08 , C07K14/475 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/745 , C07K2319/00 , C07K2319/30 , C07K2319/43 , C07K2319/73 , C12N9/6437 , C12N9/644 , C12N9/647 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
摘要翻译： 本发明涉及嵌合单体 - 二聚体杂合蛋白，其中所述蛋白质包含第一和第二多肽链，所述第一多肽链包含至少一部分免疫球蛋白恒定区和生物活性分子，所述第二多肽链包含 至少一部分没有第一链的生物活性分子的免疫球蛋白恒定区。 本发明还涉及制备本发明的嵌合单体 - 二聚体杂交蛋白质的方法和方法。
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公开(公告)号：US20110182919A1
公开(公告)日：2011-07-28
申请号：US12952551
申请日：2010-11-23
申请人： Robert T. PETERS , Adam R. Mezo , Daniel S. Rivera , Alan J. Bitonti , James Stattel , Susan C. Low
发明人： Robert T. PETERS , Adam R. Mezo , Daniel S. Rivera , Alan J. Bitonti , James Stattel , Susan C. Low
IPC分类号： A61K39/395 , C07K19/00 , C12N9/96 , A61P7/04
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
摘要翻译： 本发明涉及嵌合单体 - 二聚体杂合蛋白，其中所述蛋白质包含第一和第二多肽链，所述第一多肽链包含至少一部分免疫球蛋白恒定区和生物活性分子，所述第二多肽链包含 至少一部分没有第一链的生物活性分子的免疫球蛋白恒定区。 本发明还涉及制备本发明的嵌合单体 - 二聚体杂交蛋白质的方法和方法。
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公开(公告)号：US08329182B2
公开(公告)日：2012-12-11
申请号：US12952551
申请日：2010-11-23
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
摘要翻译： 本发明涉及嵌合单体 - 二聚体杂交蛋白，其中蛋白质包含第一和第二多肽链，第一多肽链包含至少一部分免疫球蛋白恒定区和生物活性分子，第二多肽链包含 至少一部分没有第一链的生物活性分子的免疫球蛋白恒定区。 本发明还涉及制备本发明的嵌合单体 - 二聚体杂交蛋白质的使用方法和方法。
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公开(公告)号：US07862820B2
公开(公告)日：2011-01-04
申请号：US11588431
申请日：2006-10-27
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein that comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first polypeptide chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
摘要翻译： 本发明涉及包含第一和第二多肽链的嵌合单体 - 二聚体杂合蛋白，所述第一多肽链包含至少一部分免疫球蛋白恒定区和生物活性分子，第二多肽链包含至少一个 部分免疫球蛋白恒定区，而没有第一多肽链的生物活性分子。 本发明还涉及制备本发明的嵌合单体 - 二聚体杂交蛋白质的方法和方法。
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公开(公告)号：US07404956B2
公开(公告)日：2008-07-29
申请号：US10841250
申请日：2004-05-06
CPC分类号： C07K14/755 , A61K38/00 , A61K47/60 , A61K47/642 , A61K47/68 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/59 , C07K14/61 , C07K14/70503 , C07K14/745 , C07K16/00 , C07K2317/52 , C07K2319/00 , C07K2319/30 , C12N9/6437 , C12N9/644 , C12N9/647 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
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公开(公告)号：US20110182896A1
公开(公告)日：2011-07-28
申请号：US12949564
申请日：2010-11-18
IPC分类号： A61K39/395 , C07K19/00 , C12N9/96 , C12P21/00 , C07H21/04 , C12N15/85 , C12N5/10 , C12N1/00 , A61P7/04
CPC分类号： C12N9/6437 , A61K38/36 , A61K38/4846 , A61K45/06 , A61K47/6815 , A61K47/6835 , A61K2039/60 , C07K14/745 , C07K16/18 , C07K2319/30 , C12N9/644 , C12N9/6454 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric protein comprising at least one clotting factor and at least a portion of an immunoglobulin constant region. The invention relates to a method of treating a hemostatic disorder comprising administering a therapeutically effective amount of a chimeric protein wherein the chimeric protein comprises at least one clotting factor and at least a portion of an immunoglobulin constant region.
摘要翻译： 本发明涉及包含至少一种凝血因子和至少一部分免疫球蛋白恒定区的嵌合蛋白。 本发明涉及一种治疗止血障碍的方法，包括施用治疗有效量的嵌合蛋白，其中所述嵌合蛋白包含至少一种凝血因子和至少一部分免疫球蛋白恒定区。
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公开(公告)号：US08449884B2
公开(公告)日：2013-05-28
申请号：US12949564
申请日：2010-11-18
IPC分类号： A61K39/395
CPC分类号： C12N9/6437 , A61K38/36 , A61K38/4846 , A61K45/06 , A61K47/6815 , A61K47/6835 , A61K2039/60 , C07K14/745 , C07K16/18 , C07K2319/30 , C12N9/644 , C12N9/6454 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to a chimeric protein comprising at least one clotting factor and at least a portion of an immunoglobulin constant region. The invention relates to a method of treating a hemostatic disorder comprising administering a therapeutically effective amount of a chimeric protein wherein the chimeric protein comprises at least one clotting factor and at least a portion of an immunoglobulin constant region.
摘要翻译： 本发明涉及包含至少一种凝血因子和至少一部分免疫球蛋白恒定区的嵌合蛋白。 本发明涉及一种治疗止血障碍的方法，包括施用治疗有效量的嵌合蛋白，其中所述嵌合蛋白包含至少一种凝血因子和至少一部分免疫球蛋白恒定区。
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公开(公告)号：US08815246B2
公开(公告)日：2014-08-26
申请号：US13617498
申请日：2012-09-14
申请人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron K. Sato , Malini Viswanathan
发明人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron K. Sato , Malini Viswanathan
CPC分类号： C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535
摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
摘要翻译： 本公开尤其提供结合FcRn的蛋白质，例如以高亲和力和选择性抑制FcRn的免疫球蛋白。 FcRn结合蛋白可用于治疗多种疾病，包括自身免疫性疾病。
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公开(公告)号：US20130078262A1
公开(公告)日：2013-03-28
申请号：US13617498
申请日：2012-09-14
申请人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato , Malini Viswanathan
发明人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato , Malini Viswanathan
CPC分类号： C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535
摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
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公开(公告)号：US20130045218A1
公开(公告)日：2013-02-21
申请号：US13584221
申请日：2012-08-13
申请人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato , Malini Viswanathan
发明人： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James Stattel , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron Sato , Malini Viswanathan
IPC分类号： C07K16/28 , A61P19/02 , A61P21/04 , G01N33/566 , A61P25/00 , A61P1/04 , A61P37/00 , A61P1/00 , A61K39/395 , A61P3/10
摘要： This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
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