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16 条记录 (耗时 0.028 秒)

    Substituted indole antagonists derivatives which are angiotensin II
    2.
    发明授权
    Substituted indole antagonists derivatives which are angiotensin II 失效
    作为血管紧张素II拮抗剂的取代的吲哚衍生物

    公开(公告)号：US5212195A

    公开(公告)日：1993-05-18

    申请号：US882390

    申请日：1992-05-13

    申请人： Robin D. Clark ,  David E. Clarke ,  Lawrence E. Fisher ,  Alam Jahangir

    发明人： Robin D. Clark ,  David E. Clarke ,  Lawrence E. Fisher ,  Alam Jahangir

    IPC分类号： A61K31/40 ,  A61K31/44 ,  C07D403/10 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04

    CPC分类号： C07D403/10 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04

    摘要： Compound of the Formula (I), (II), or (III): ##STR1## wherein: R.sup.1 is lower alkyl or 2"-(1H-tetrazol-5-yl)biphenyl-4'-ylmethyl;R.sup.2 is lower alkyl when R.sup.1 is 2"-(1H-tetrazol-5-yl)biphenyl-4'-ylmethyl; or R.sup.2 is 2"-(1H-tetrazol-5-yl)biphenyl-4'-ylmethyl when R.sup.1 is lower alkyl;R.sup.3 is hydrogen or lower alkyl;X is hydrogen, lower alkyl, halogen, --C(O)CF.sub.3, --CO.sub.2 R.sup.4, or --C(O)NR.sup.5 R.sup.6 ;Y is hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen, or --CO.sub.2 R.sup.4 ;Z is hydrogen, lower alkyl, lower alkoxy, or halogen; with the proviso that Y and Z cannot be attached to the nitrogen atom in Formula (II); whereinR.sup.4 is hydrogen or lower alkyl;R.sup.5 is hydrogen or lower alkyl;R.sup.6 is hydrogen or lower alkyl; orR.sup.5 and R.sup.6 taken together with the nitrogen to which they are attached represent a heterocycle;and pharmaceutically acceptable salts thereof, exhibit useful pharmacological properties, and are particularly useful as angiotensin II antagonists.

    摘要翻译： （I），（II）或（III）的化合物：其中：R1是低级烷基或2“ - （1H-四唑 -5-基）联苯基-4'-基甲基; 当R 1为2“ - （1H-四唑-5-基）联苯-4'-基甲基时，R 2为低级烷基; 或当R 1为低级烷基时，R 2为2“ - （1H-四唑-5-基）联苯-4'-基甲基; R3是氢或低级烷基; X是氢，低级烷基，卤素，-C（O）CF 3，-CO 2 R 4或-C（O）NR 5 R 6; Y是氢，低级烷基，低级烷氧基，羟基，卤素或-CO 2 R 4; Z是氢，低级烷基，低级烷氧基或卤素; 条件是Y和Z不能连接到式（II）中的氮原子上; 其中R4是氢或低级烷基; R5是氢或低级烷基; R6是氢或低级烷基; 或者R 5和R 6与它们所连接的氮一起代表杂环; 其药学上可接受的盐显示出有用的药理学性质，并且特别可用作血管紧张素II拮抗剂。

    Article suitable for wiping hard surfaces
    4.
    发明授权
    Article suitable for wiping hard surfaces 失效
    文章适用于擦硬面

    公开(公告)号：US4448704A

    公开(公告)日：1984-05-15

    申请号：US381612

    申请日：1982-05-24

    申请人： Donald Barby ,  David E. Clarke ,  John Lloyd ,  Zia Haq

    发明人： Donald Barby ,  David E. Clarke ,  John Lloyd ,  Zia Haq

    IPC分类号： C11D17/00 ,  A47L1/15 ,  A47L13/16 ,  A47L13/17 ,  A47L13/28 ,  B08B1/00 ,  C11D17/04

    CPC分类号： A47L13/17 ,  B08B1/00 ,  C11D17/049

    摘要： An article is disclosed which is suitable for wiping hard surfaces such as glass to give a streak-free finish. The article comprises a substrate (preferably paper or non-woven fabric) carrying a homogeneous aqueous composition having a surface tension below 45 mNm.sup.-1 and which on drying does not form discrete droplets or particles larger than 0.25 .mu.m. The liquid composition advantageously includes a (preferably nonionic) surface-active agent and a partially esterified resin such as a partially esterified styrene/maleic anhydride copolymer. The article may be wet (for example, coated or impregnated with the liquid composition) or dry up to the point of use (for example, the liquid may be within pressure-rupturable microcapsules). Preferably the article is produced by a process which includes prewashing the substrate to remove any potentially streak-forming impurities.

    摘要翻译： 公开了适用于擦拭诸如玻璃的硬表面以产生无条纹表面的制品。 该制品包括承载具有低于45mNm-1的表面张力的均匀水性组合物的基材（优选纸或非织造织物），并且其在干燥时不形成离散的小滴或大于0.25μm的颗粒。 液体组合物有利地包括（优选非离子的）表面活性剂和部分酯化的树脂，例如部分酯化的苯乙烯/马来酸酐共聚物。 制品可以是湿的（例如，用液体组合物涂布或浸渍）或干燥直到使用点（例如，液体可以在压力可破裂的微胶囊内）。 优选地，制品通过包括预洗涤基底以除去任何潜在条纹形成杂质的方法制备。

    General-purpose cleaning composition
    5.
    发明授权
    General-purpose cleaning composition 失效
    通用清洁剂组合物

    公开(公告)号：US4759868A

    公开(公告)日：1988-07-26

    申请号：US39049

    申请日：1987-04-16

    申请人： David E. Clarke

    发明人： David E. Clarke

    IPC分类号： C11D1/72 ,  C11D3/37 ,  C11D10/02 ,  C11D1/68

    CPC分类号： C11D3/3765 ,  C11D1/72

    摘要： A liquid general-purpose cleaner, having improved non-streak and cleaning properties, is obtained if in a liquid-compatible medium which comprises a nonionic surfactant, an at least partially esterified resin and water or a mixture of water and a water-miscible organic solvent, as nonionic a topped nonionic surfactant is used containing less than 2% by weight of non-alkoxylated material and less than 4% by weight of mono-alkoxylated material. By using this nonionic surfactant, less partially esterified resin and less perfume are required to achieve effects similar to those obtained when a non-topped nonionic surfactant is used.

    Solid bleaching block
    6.
    发明授权
    Solid bleaching block 失效
    实心漂白块

    公开(公告)号：US4741853A

    公开(公告)日：1988-05-03

    申请号：US13514

    申请日：1987-02-11

    申请人： Adrian W. Walker ,  David E. Clarke

    发明人： Adrian W. Walker ,  David E. Clarke

    IPC分类号： C11D7/26 ,  A61L9/05 ,  C11D3/20 ,  C11D3/39 ,  C11D7/54 ,  C11D7/60 ,  C11D17/00

    CPC分类号： C11D17/0056 ,  A61L9/05 ,  C11D3/2079 ,  C11D3/3942

    摘要： The present invention provides a solid bleaching block on the basis of an alkali metal monopersulphate for use in an in-cistern dispensing device, also comprising at least 5% by weight of an alkaline earth metal soap. By the use of these soaps, blocks are obtained which release the bleaching agent at an acceptable rate yet maintain their block structure.

    摘要翻译： 本发明提供了一种用于在水箱分配装置中使用的碱金属单过硫酸盐的固体漂白块，还包含至少5重量％的碱土金属皂。 通过使用这些皂，获得了以可接受的速率释放漂白剂并保持它们的嵌段结构的嵌段。

    Bridging bar attachment means for bi-elevational platform lift
    7.
    发明授权
    Bridging bar attachment means for bi-elevational platform lift 失效
    桥梁连接装置用于双平台升降机

    公开(公告)号：US4394888A

    公开(公告)日：1983-07-26

    申请号：US270995

    申请日：1981-06-05

    申请人： David E. Clarke

    发明人： David E. Clarke

    IPC分类号： B65G69/28 ,  B66F7/06 ,  B66F7/28 ,  B66B9/00

    CPC分类号： B66F7/065 ,  B65G69/2811 ,  B66F7/28

    摘要： Extendable bridging bar frame members are pivotally mounted to an angularly adjustable loading platform level of a bi-elevational platform lift apparatus. The bridging bar frame members are selectively extendable to engage an associated dock side loading surface in order to suspend a free end non-attached portion of the loading platform at dock side level while the opposite end portion of the loading platform is adjusted for alignment with a vertically offset dock side. This will allow angular adjustment of the loading platform level while still utilizing the mechanical support of the bridging bar frame members.

    摘要翻译： 可伸缩的桥接杆框架构件枢转地安装到双向平台升降装置的可角度可调的装载平台水平。 桥接杆框架构件选择性地可延伸以接合相关联的底座侧装载表面，以便在托架侧水平面悬挂装载平台的自由端非附接部分，同时调节装载平台的相对端部分以与 垂直偏移码头侧。 这将允许加载平台水平的角度调节，同时仍然利用桥接杆框架构件的机械支撑。

    Collapsible safety guard for platform lift
    8.
    发明授权
    Collapsible safety guard for platform lift 失效
    平台升降机的可折叠安全防护装置

    公开(公告)号：US4091906A

    公开(公告)日：1978-05-30

    申请号：US772493

    申请日：1977-02-28

    申请人： David E. Clarke ,  Lawrence I. Richards

    发明人： David E. Clarke ,  Lawrence I. Richards

    IPC分类号： B66F17/00 ,  F16D9/00

    CPC分类号： B66F17/00

    摘要： A collapsible electric foot-toe guard is employed with a loading platform having electric controlled lift and descent movements, functioning as a safety device in the protection against unwitting protrusion of human limbs into the path of descent of the platform lift, said collapsible foot-toe guard being comprised of an outwardly depended contact plate moveably engaging a base support plate through hinge means to permit said contact plate with contact thereof to fold toward the base support plate, such folding movement effective to break a normally open, held closed electric limit switch circuit to arrest descent of the platform lift.

    摘要翻译： 使用可折叠的电动脚踏式防护装置，其具有电控起升和下降运动的装载平台，用作安全装置，以防止人类肢体进入平台升降机的下降路径的不知不觉的突出，所述可折叠的脚趾 防护件由向外依靠的接触板组成，其通过铰链装置可移动地接合基座支撑板，以允许所述接触板与其接触以朝向基座支撑板折叠，这种折叠运动有效地打开常开的保持的闭合电限位开关电路 逮捕平台升降机的后裔。

    N-aryloxyalkyl tryptamine .alpha..sub.1 -adrenergic receptor antagonists
    9.
    发明授权
    N-aryloxyalkyl tryptamine .alpha..sub.1 -adrenergic receptor antagonists 失效
    N-芳氧基烷基色胺α1-肾上腺素能受体拮抗剂

    公开(公告)号：US5436264A

    公开(公告)日：1995-07-25

    申请号：US109294

    申请日：1993-08-19

    申请人： Jurg R. Pfister ,  David E. Clarke

    发明人： Jurg R. Pfister ,  David E. Clarke

    IPC分类号： C07D209/16 ,  A61K31/40 ,  C07D209/14 ,  C07D405/12

    CPC分类号： C07D209/16

    摘要： The present invention relates to novel N-aryloxyalkyl tryptamine .alpha..sub.1 -adrenergic receptor antagonists of the formula I: ##STR1## in which n is 2, 3 or 4; q is 1, 2 or 3; t is 0, 1, 2 or 3; z is 0, 1, 2 or 3; each R.sup.1 and R.sup.2 are independently hydroxy, halogen, cyano, (C.sub.1-8)alkyl, (C.sub.1-8)alkyloxy or trifluoromethyl; and R.sup.2 is hydrogen, (C.sub.1-4)alkyl, fluoro(C.sub.1-4)alkyl, difluoro(C.sub.1-4)alkyl, trifluoro(C.sub.1-4)alkyl, (C.sub.1-4)alkyloxy(C.sub.1-4)alkyl, oxo(C.sub.1-4)alkyl, (C.sub.1-8)cycloalkyl, (C.sub.1-8)cycloalkylmethyl or allyl or phenyl(C.sub.1-4)alkyl or heterocyclo(C.sub.1-8)alkyl (optionally substituted with one to two substituents independently selected from (C.sub.1-4)alkyl, (C.sub.1-4)alkyloxy, trifluoromethyl and halogen); R.sup.3 and R.sup.4 are independently hydrogen, (C.sub.1-4)alkyl, (C.sub.1-8)cycloalkyl, (C.sub.1-8)cycloalkylmethyl or allyl; and R.sup.5 is hydrogen, (C.sub.1-4)alkyl, (C.sub.1-8)cycloalkyl, (C.sub.1-8)cycloalkylmethyl, allyl, (C.sub.1-4)alkylsulfonyl and aminocarbonyl; with the proviso that when n is 2, t is 0, q is 1, z is 0, 1 or 2, R.sup.5 is hydrogen and R.sup.6 is hydroxy or (C.sub.1-8)alkyloxy then at least one of R.sup.3 and R.sup.4 is not hydrogen; and the pharmaceutically acceptable salts, individual isomers, and mixtures of isomers thereof; their uses as therapeutic agents and the methods of their making.

    摘要翻译： 本发明涉及式I的新型N-芳氧基烷基色胺α1-肾上腺素能受体拮抗剂：其中n为2,3或4; q为1,2或3; t为0,1,2或3; z为0,1,2或3; 每个R 1和R 2独立地是羟基，卤素，氰基，（C 1-8）烷基，（C 1-8）烷氧基或三氟甲基; （C 1-4）烷基，二氟（C 1-4）烷基，三氟（C 1-4）烷基，（C 1-4）烷氧基（C 1-4）烷基，氧代 （C 1-4）烷基，（C 1-8）环烷基，（C 1-8）环烷基甲基或烯丙基或苯基（C 1-4）烷基或杂环（C 1-8）烷基（任选被一至两个独立地选自 C 1-4）烷基，（C 1-4）烷氧基，三氟甲基和卤素）; R3和R4独立地是氢，（C1-4）烷基，（C1-8）环烷基，（C1-8）环烷基甲基或烯丙基; 并且R 5是氢，（C 1-4）烷基，（C 1-8）环烷基，（C 1-8）环烷基甲基，烯丙基，（C 1-4）烷基磺酰基和氨基羰基; 条件是当n为2时，t为0，q为1，z为0,1或2，R5为氢，R6为羟基或（C1-8）烷氧基，则R3和R4中的至少一个不为氢 ; 及其药学上可接受的盐，各异构体及其异构体的混合物; 它们作为治疗剂的用途及其制备方法。