公开(公告)号：US11740254B2

公开(公告)日：2023-08-29

申请号：US16646622

申请日：2018-11-29

Applicant: Hitachi High-Tech Corporation ,  Roche Diagnostics Operations, Inc.

Inventor： Yuichiro Ota ,  Takaaki Hagiwara ,  Yoshihiro Yamashita ,  Koshin Hamasaki ,  Michaela Windfuhr ,  Heike Guggemos ,  Johannes Stoeckel ,  Guenter Ziegler ,  Michael Kuehnl

IPC: G01N35/10

CPC classification number: G01N35/1011 ,  G01N35/1016 ,  G01N2035/1025

Abstract: The object of the invention is to provide an automatic analysis apparatus capable of setting a dispensing mechanism for measuring dispensing accuracy and a dispensing volume, and capable of performing dispensing accuracy measurement without absorbance measurement. Regarding a dispensing accuracy, a dispensing mechanism to be measured is designated. Parameters including a dispensing volume and the like are input. A dispensing operation of the input dispensing volume is automatically performed for each designated dispensing mechanism. A reaction vessel contains, for example, a reagent of the input dispensing volume which has been dispensed by the designated dispensing mechanism. By measuring a weight of the reagent in the reaction vessel, or the like, it is possible to measure the dispensing accuracy of the designated dispensing mechanism.

公开(公告)号：US20210155976A1

公开(公告)日：2021-05-27

申请号：US17126439

申请日：2020-12-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Frank Bergmann ,  Dieter Heindl ,  Michael Schraeml ,  Johannes Stoeckel

IPC: C12Q1/6816

Abstract: The present report relates to hybridizing single-stranded (ss-) oligonucleotides which entirely consist of locked nucleic acid (LNA) monomers. The present document shows hybridization experiments with pairs of entirely complementary ss-oligonucleotides which fail to form a duplex within a given time interval. The present report provides methods to identify such incompatible oligonucleotide pairs. In another aspect, the present report provides pairs of complementary ss-oligonucleotides which are capable of rapid duplex formation. The present report also provides methods to identify and select compatible oligonucleotide pairs. In yet another aspect the present report provides use of compatible oligonucleotide pairs as binding partners in binding assays, e.g. immunoassays.

公开(公告)号：US09341575B2

公开(公告)日：2016-05-17

申请号：US13844778

申请日：2013-03-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Andreas Finke ,  Bernhard Hauptmann ,  Johannes Stoeckel ,  Michaela Windfuhr

IPC: B01L3/00 ,  G01N21/66 ,  G01N21/76

CPC classification number: G01N21/76 ,  B01L3/502715 ,  B01L3/502761 ,  G01N21/66

Abstract: The application provides methods for the detection of an analyte in a sample by electrochemiluminescence using certain reagent compositions. Reagent compositions, reagent kits for measuring electrochemiluminescence (ECL) and electrochemiluminescence detection methods using the reagent compositions are disclosed. In particular, the application relates to the use of novel combinations of compounds, which can be used in said measurements to provide improved ECL assay performance.

Abstract translation: 该应用提供了使用某些试剂组合物通过电化学发光检测样品中的分析物的方法。 公开了试剂组合物，用于测量电化学发光的试剂盒（ECL）和使用该试剂组合物的电化学发光检测方法。 特别地，本申请涉及化合物的新组合的使用，其可用于所述测量以提供改进的ECL测定性能。