-
公开(公告)号：US09834765B2
公开(公告)日：2017-12-05
申请号：US14200325
申请日：2014-03-07
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Bergmann , Bruno Frey , Dieter Heindl
CPC classification number: C12N15/1065 , C12Q1/6806 , C12Q1/6848 , C12Q1/6853 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2525/155 , C12Q2525/179 , C12Q2525/191 , C12Q2535/122 , C12Q2537/16
Abstract: Provided herein is a new class of nucleic acid tagging molecules which are essentially free of homopolymer stretches. The tagging molecules can tag a plurality of individual target molecules for detection with a high degree of accuracy. The tagging molecules can be used to tag at least 105 or 106 individual target molecules. The tagged individual target molecules can be subjected to high throughput sequence analysis.
-
公开(公告)号：US09499573B2
公开(公告)日：2016-11-22
申请号：US14610244
申请日：2015-01-30
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Bergmann , Robert Cysewski , Luisa de Cola , Sebastian Dziadek , Jesus Miguel Fernandez Hernandez , Hans-Peter Josel , Elena Longhi , Christoph Seidel
CPC classification number: C07F15/0033 , C09K11/06 , C09K2211/1007 , C09K2211/1029 , C09K2211/1059 , C09K2211/14 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/1475 , C09K2211/1491 , C09K2211/185 , G01N33/582 , G01N2458/30
Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
-
公开(公告)号：US20150147752A1
公开(公告)日：2015-05-28
申请号：US14610244
申请日：2015-01-30
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Bergmann , Robert Cysewski , Luisa de Cola , Sebastian Dziadek , Jesus Miguel Fernandez Hernandez , Hans-Peter Josel , Elena Longhi , Christoph Seidel
CPC classification number: C07F15/0033 , C09K11/06 , C09K2211/1007 , C09K2211/1029 , C09K2211/1059 , C09K2211/14 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/1475 , C09K2211/1491 , C09K2211/185 , G01N33/582 , G01N2458/30
Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
-
公开(公告)号：US20210155976A1
公开(公告)日：2021-05-27
申请号：US17126439
申请日：2020-12-18
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Bergmann , Dieter Heindl , Michael Schraeml , Johannes Stoeckel
IPC: C12Q1/6816
Abstract: The present report relates to hybridizing single-stranded (ss-) oligonucleotides which entirely consist of locked nucleic acid (LNA) monomers. The present document shows hybridization experiments with pairs of entirely complementary ss-oligonucleotides which fail to form a duplex within a given time interval. The present report provides methods to identify such incompatible oligonucleotide pairs. In another aspect, the present report provides pairs of complementary ss-oligonucleotides which are capable of rapid duplex formation. The present report also provides methods to identify and select compatible oligonucleotide pairs. In yet another aspect the present report provides use of compatible oligonucleotide pairs as binding partners in binding assays, e.g. immunoassays.
-
公开(公告)号：US20150140561A1
公开(公告)日：2015-05-21
申请号：US14542980
申请日：2014-11-17
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Bergmann , Dieter Heindl , Jessica Steger-Domandl
IPC: C12Q1/68
CPC classification number: C12Q1/6869 , C07H19/10 , C07H19/20 , C12Q2525/186
Abstract: The present invention provides deoxynucleoside tri- or tetraphosphate comprising a 3′ nitrate and a detectable label covalently bound to the oxygen atom of an oxymethyl or oxyallyl or oxypropargyl substitution of a nucleobase. Such compounds provide new possibilities for future Sequencing by Synthesis technologies.
Abstract translation: 本发明提供了脱氧核苷三磷酸酯或四磷酸酯，其包含3'硝酸盐和可与氧原子共价结合的可检测标记，其中氧基甲氧基或氧杂环烷基或氧代炔基取代为核碱基。 这些化合物为将来通过Synthesis技术测序提供了新的可能性。
-
Patent Agency Ranking
公开(公告)号：US20150147750A1
公开(公告)日：2015-05-28
申请号：US14609552
申请日：2015-01-30
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Bergmann , Robert Cysewski , Luisa de Cola , Sebastian Dziadek , Jesus Miguel Fernandez Hernandez , Hans-Peter Josel , Christoph Seidel
CPC classification number: C07F15/0033 , C09K11/06 , C09K11/07 , C09K2211/1003 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/1059 , C09K2211/1074 , C09K2211/14 , C09K2211/185 , G01N33/582
Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
-
公开(公告)号：US09410197B2
公开(公告)日：2016-08-09
申请号：US14542980
申请日：2014-11-17
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Bergmann , Dieter Heindl , Jessica Steger-Domandl
CPC classification number: C12Q1/6869 , C07H19/10 , C07H19/20 , C12Q2525/186
Abstract: The present invention provides deoxynucleoside tri- or tetraphosphate comprising a 3′ nitrate and a detectable label covalently bound to the oxygen atom of an oxymethyl or oxyallyl or oxypropargyl substitution of a nucleobase. Such compounds provide new possibilities for future Sequencing by Synthesis technologies.
Abstract translation: 本发明提供了脱氧核苷三磷酸酯或四磷酸酯，其包含3'硝酸盐和可与氧原子共价结合的可检测标记，其中氧基甲氧基或氧杂环烷基或氧代炔基取代为核碱基。 这些化合物为将来通过Synthesis技术测序提供了新的可能性。
-
公开(公告)号：US09399654B2
公开(公告)日：2016-07-26
申请号：US14609552
申请日：2015-01-30
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Bergmann , Robert Cysewski , Luisa de Cola , Sebastian Dziadek , Jesus Miguel Fernandez Hernandez , Hans-Peter Josel , Christoph Seidel
CPC classification number: C07F15/0033 , C09K11/06 , C09K11/07 , C09K2211/1003 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/1059 , C09K2211/1074 , C09K2211/14 , C09K2211/185 , G01N33/582
Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
-
公开(公告)号：US20150147751A1
公开(公告)日：2015-05-28
申请号：US14609649
申请日：2015-01-30
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Bergmann , Robert Cysewski , Luisa de Cola , Sebastian Dziadek , Jesus Miguel Fernandez Hernandez , Hans-Peter Josel , Christoph Seidel
CPC classification number: C07F15/0033 , C09K11/06 , C09K11/07 , C09K2211/1007 , C09K2211/1029 , C09K2211/14 , C09K2211/1408 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/185 , G01N33/582
Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
Abstract translation: 本发明涉及新型的基于铱的Ir（III）发光复合物，包含这些络合物作为标记的缀合物及其应用，例如， 在基于电化学发光的分析物检测中。
-
公开(公告)号：US20150140682A1
公开(公告)日：2015-05-21
申请号：US14610372
申请日：2015-01-30
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Frank Bergmann , Robert Cysewski , Luisa de Cola , Sebastian Dziadek , Jesus Miguel Fernandez Hernandez , Hans-Peter Josel , Christoph Seidel
CPC classification number: C07F15/0033 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/14 , C09K2211/1408 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/185 , G01N33/582
Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
Abstract translation: 本发明涉及新型的基于铱的Ir（III）发光复合物，包含这些络合物作为标记的缀合物及其应用，例如， 在基于电化学发光的分析物检测中。
-
-
-
-
-
-
-
-
-
Search Results
16
records
(took 0.023 seconds)
