公开(公告)号：US20220235139A1

公开(公告)日：2022-07-28

申请号：US17704706

申请日：2022-03-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： David CASAGOLDA VALLRIBERA ,  Michael GERG ,  Michael SCHRAEML

IPC: C07K16/28 ,  G01N33/574

Abstract: The present invention relates to a monoclonal antibody, or fragment thereof, which binds to CSF-1R (Colony stimulating factor 1 receptor), in particular to human CSF-1R. The present invention further relates to the in vitro use of the monoclonal antibody, or fragment thereof, of the present invention for the detection of CSF-1R in a sample. Further encompassed by the present invention is a complex comprising the monoclonal antibody, or fragment thereof, of the present invention and CSF-1R such as the human CSF-1R polypeptide.

公开(公告)号：US20240377388A1

公开(公告)日：2024-11-14

申请号：US18669957

申请日：2024-05-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael GERG ,  Dieter HEINDL ,  Lars HILLRINGHAUS ,  Klaus HIRZEL ,  Caroline Dorothea HOJER ,  Florian HUBER ,  Hans-Peter JOSEL ,  Thomas MEIER ,  Michael SCHRAEML ,  Edgar VOSS

IPC: G01N33/543 ,  C07K16/44

Abstract: The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as disclosed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.

公开(公告)号：US20220106408A1

公开(公告)日：2022-04-07

申请号：US17551732

申请日：2021-12-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael GERG ,  Lars HILLRINGHAUS ,  Klaus HIRZEL ,  Caroline Dorothea HOJER ,  Hans-Peter JOSEL ,  Christoph SEIDEL ,  Michael SCHRAEML ,  Leopold VON PROFF

IPC: C07K16/44 ,  G01N33/543 ,  C07K16/40 ,  C07K16/00 ,  G01N33/82

Abstract: The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as disclosed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.

公开(公告)号：US20220107310A1

公开(公告)日：2022-04-07

申请号：US17551723

申请日：2021-12-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael GERG ,  Dieter HEINDL ,  Lars HILLRINGHAUS ,  Klaus HIRZEL ,  Caroline Dorothea HOJER ,  Florian HUBER ,  Hans-Peter JOSEL ,  Thomas MEIER ,  Michael SCHRAEML ,  Edgar VOSS

IPC: G01N33/543 ,  C07K16/44

Abstract: The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as disclosed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.

公开(公告)号：US20220107309A1

公开(公告)日：2022-04-07

申请号：US17551716

申请日：2021-12-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael GERG ,  Klaus HIRZEL ,  Caroline HOJER ,  Erasmus HUBER ,  Hans-Peter JOSEL ,  Thomas MEIER ,  Michael SCHRAEML ,  Leopold VON PROFF

IPC: G01N33/543 ,  C07K16/44

Abstract: The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as disclosed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.