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    METHODS AND COMPOSITIONS FOR DETECTION AND ANALYSIS OF ANALYTES
    1.
    发明申请
    METHODS AND COMPOSITIONS FOR DETECTION AND ANALYSIS OF ANALYTES 有权

    公开(公告)号：US20210088511A1

    公开(公告)日：2021-03-25

    申请号：US17039245

    申请日：2020-09-30

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Peter CRISALLI ,  Dmitriy GREMYACHINSKIY ,  Dieter HEINDL ,  Hannes KUCHELMEISTER ,  Michael SCHRAEML ,  Andrew TRANS

    IPC: G01N33/543 ,  G01N33/487

    Abstract: Provided are nanopore-based methods, compositions, and systems for assessing analyte-ligand interactions and analyte concentration in a fluid solution. The compositions include an analyte detection complex that is associated with a nanopore to form a nanopore assembly, the analyte detection complex including an analyte ligand. As a first voltage is applied across the nanopore assembly, the analyte ligand is presented to an analyte in the solution. As a second voltage that is opposite in polarity to the first voltage is applied across the nanopore assembly, the analyte binds to the analyte. By comparing the total number of analyte-ligand binding pairs to a control binding count, the concentration of the analyte can be determined. In other examples, further increasing the second voltage can result in dissociation of the analyte-ligand pair, from which a dissociation voltage—and hence a dissociation constant—can be determined.

    ANTI-CSF-IR ANTIBODY
    6.
    发明申请
    ANTI-CSF-IR ANTIBODY 有权

    公开(公告)号：US20220235139A1

    公开(公告)日：2022-07-28

    申请号：US17704706

    申请日：2022-03-25

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： David CASAGOLDA VALLRIBERA ,  Michael GERG ,  Michael SCHRAEML

    IPC: C07K16/28 ,  G01N33/574

    Abstract: The present invention relates to a monoclonal antibody, or fragment thereof, which binds to CSF-1R (Colony stimulating factor 1 receptor), in particular to human CSF-1R. The present invention further relates to the in vitro use of the monoclonal antibody, or fragment thereof, of the present invention for the detection of CSF-1R in a sample. Further encompassed by the present invention is a complex comprising the monoclonal antibody, or fragment thereof, of the present invention and CSF-1R such as the human CSF-1R polypeptide.

    HYBRIDIZING all-LNA OLIGONUCLEOTIDES
    7.
    发明申请
    HYBRIDIZING all-LNA OLIGONUCLEOTIDES 有权

    公开(公告)号：US20220195497A1

    公开(公告)日：2022-06-23

    申请号：US17544110

    申请日：2021-12-07

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Frank BERGMANN ,  Dieter HEINDL ,  Michael SCHRAEML ,  JOHANNES STOECKEL

    IPC: C12Q1/6816

    Abstract: The present report relates to hybridizing single-stranded (ss-) oligonucleotides which entirely consist of locked nucleic acid (LNA) monomers. The present document shows hybridization experiments with pairs of entirely complementary ss-oligonucleotides which fail to form a duplex within a given time interval. The present report provides methods to identify such incompatible oligonucleotide pairs. In another aspect, the present report provides pairs of complementary ss-oligonucleotides which are capable of rapid duplex formation. The present report also provides methods to identify and select compatible oligonucleotide pairs. In yet another aspect the present report provides use of compatible oligonucleotide pairs as binding partners in binding assays, e.g. receptor-based assays.

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