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公开(公告)号：US08916529B2
公开(公告)日：2014-12-23
申请号：US11673486
申请日：2007-02-09
申请人： Roderic M. K. Dale , Amy Arrow , Terry Thompson
发明人： Roderic M. K. Dale , Amy Arrow , Terry Thompson
IPC分类号： C12N15/113 , A61K38/00
CPC分类号： C12N15/1137 , A61K8/606 , A61K38/00 , A61K2800/74 , A61Q19/00 , C12N15/113 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/321 , C12N2320/35 , C12Y101/01088 , C12Y103/99005 , C12Y111/01006 , C12Y113/11012 , C12Y114/99001 , C12Y203/01026 , C12Y203/01085 , C12Y301/01003 , C12Y301/03048 , C12Y304/1401 , C12Y304/15001 , C12Y304/24011 , C12Y306/0301 , C12Y604/01002 , C12N2310/3521
摘要： The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.
摘要翻译： 本发明涉及含有适用于给予人和其它哺乳动物的寡核苷酸的方法和组合物。
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公开(公告)号：US08188259B2
公开(公告)日：2012-05-29
申请号：US11673508
申请日：2007-02-09
申请人： Roderic M. K. Dale , Amy Arrow , Terry Thompson
发明人： Roderic M. K. Dale , Amy Arrow , Terry Thompson
IPC分类号： C07H21/04
CPC分类号： C12N15/1137 , A61K8/606 , A61K38/00 , A61K2800/74 , A61Q19/00 , C12N15/113 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/321 , C12N2320/35 , C12Y101/01088 , C12Y103/99005 , C12Y111/01006 , C12Y113/11012 , C12Y114/99001 , C12Y203/01026 , C12Y203/01085 , C12Y301/01003 , C12Y301/03048 , C12Y304/1401 , C12Y304/15001 , C12Y304/24011 , C12Y306/0301 , C12Y604/01002 , C12N2310/3521
摘要： The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.
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公开(公告)号：US08183361B2
公开(公告)日：2012-05-22
申请号：US11673509
申请日：2007-02-09
申请人： Roderic M. K. Dale , Amy Arrow , Terry Thompson
发明人： Roderic M. K. Dale , Amy Arrow , Terry Thompson
IPC分类号： C07H21/04
CPC分类号： C12N15/1137 , A61K8/606 , A61K38/00 , A61K2800/74 , A61Q19/00 , C12N15/113 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/321 , C12N2320/35 , C12Y101/01088 , C12Y103/99005 , C12Y111/01006 , C12Y113/11012 , C12Y114/99001 , C12Y203/01026 , C12Y203/01085 , C12Y301/01003 , C12Y301/03048 , C12Y304/1401 , C12Y304/15001 , C12Y304/24011 , C12Y306/0301 , C12Y604/01002 , C12N2310/3521
摘要： The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.
摘要翻译： 本发明涉及含有适用于给予人和其它哺乳动物的寡核苷酸的方法和组合物。
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公开(公告)号：US06211349B1
公开(公告)日：2001-04-03
申请号：US09222009
申请日：1998-12-30
IPC分类号： C07H2102
摘要： The novel discovery that protonated nucleic acids inhibit bacterial growth is reported and methods for the preparation and therapeutic use of nuclease resistant and acid resistant protonated/acidified nucleic acids for administration to animals including man, to treat or prevent a bacterial infection are described.
摘要翻译： 报道质子化核酸抑制细菌生长的新发现，描述了用于制剂和治疗用途的核酸酶抗性和酸抗性的质子化/酸化核酸给予包括人在内的动物，用于治疗或预防细菌感染的方法。
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公开(公告)号：US07176191B2
公开(公告)日：2007-02-13
申请号：US10937094
申请日：2004-09-08
IPC分类号： A61K31/66
CPC分类号： A61K31/66 , A01N57/12 , A01N57/16 , A61K9/0014 , A61K31/70
摘要： The present invention provides protonated compounds having antimicrobial activity. The invention also provides antimicrobial compositions comprising protonated compounds of the invention. The protonated compounds of the invention provide efficacious antimicrobial activity against resistant strains of bacteria and opportunistic fungi.
摘要翻译： 本发明提供具有抗微生物活性的质子化化合物。 本发明还提供包含本发明的质子化化合物的抗微生物组合物。 本发明的质子化化合物为细菌和机会真菌的抗性菌株提供有效的抗微生物活性。
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公开(公告)号：US20080161257A1
公开(公告)日：2008-07-03
申请号：US11673486
申请日：2007-02-09
申请人： Roderic M.K. Dale , Amy Arrow , Terry Thompson
发明人： Roderic M.K. Dale , Amy Arrow , Terry Thompson
IPC分类号： A61K31/7088 , A61P3/00 , A61P19/00 , A61P25/00 , A61P17/00
CPC分类号： C12N15/1137 , A61K8/606 , A61K38/00 , A61K2800/74 , A61Q19/00 , C12N15/113 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/321 , C12N2320/35 , C12Y101/01088 , C12Y103/99005 , C12Y111/01006 , C12Y113/11012 , C12Y114/99001 , C12Y203/01026 , C12Y203/01085 , C12Y301/01003 , C12Y301/03048 , C12Y304/1401 , C12Y304/15001 , C12Y304/24011 , C12Y306/0301 , C12Y604/01002 , C12N2310/3521
摘要： The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.
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公开(公告)号：US20080167257A1
公开(公告)日：2008-07-10
申请号：US11673509
申请日：2007-02-09
申请人： Roderic M.K. Dale , Amy Arrow , Terry Thompson
发明人： Roderic M.K. Dale , Amy Arrow , Terry Thompson
CPC分类号： C12N15/1137 , A61K8/606 , A61K38/00 , A61K2800/74 , A61Q19/00 , C12N15/113 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/321 , C12N2320/35 , C12Y101/01088 , C12Y103/99005 , C12Y111/01006 , C12Y113/11012 , C12Y114/99001 , C12Y203/01026 , C12Y203/01085 , C12Y301/01003 , C12Y301/03048 , C12Y304/1401 , C12Y304/15001 , C12Y304/24011 , C12Y306/0301 , C12Y604/01002 , C12N2310/3521
摘要： The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.
摘要翻译： 本发明涉及含有适用于给予人和其它哺乳动物的寡核苷酸的方法和组合物。
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公开(公告)号：US20080234214A1
公开(公告)日：2008-09-25
申请号：US11673508
申请日：2007-02-09
申请人： Roderic M.K. Dale , Amy Arrow , Terry Thompson
发明人： Roderic M.K. Dale , Amy Arrow , Terry Thompson
IPC分类号： A61K31/7052 , A61P25/16 , A61P25/28
CPC分类号： C12N15/1137 , A61K8/606 , A61K38/00 , A61K2800/74 , A61Q19/00 , C12N15/113 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/321 , C12N2320/35 , C12Y101/01088 , C12Y103/99005 , C12Y111/01006 , C12Y113/11012 , C12Y114/99001 , C12Y203/01026 , C12Y203/01085 , C12Y301/01003 , C12Y301/03048 , C12Y304/1401 , C12Y304/15001 , C12Y304/24011 , C12Y306/0301 , C12Y604/01002 , C12N2310/3521
摘要： The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.
摘要翻译： 本发明涉及含有适用于给予人和其它哺乳动物的寡核苷酸的方法和组合物。
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公开(公告)号：US20050107344A1
公开(公告)日：2005-05-19
申请号：US10937094
申请日：2004-09-08
申请人： Roderic Dale , Steven Gatton , Amy Arrow , Terry Thompson
发明人： Roderic Dale , Steven Gatton , Amy Arrow , Terry Thompson
IPC分类号： C07H19/10 , A01N57/12 , A01N57/16 , A61K9/70 , A61K31/66 , A61K31/6615 , A61K31/675 , A61K31/683 , A61K31/70 , A61K31/7024 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K48/00 , A61L2/16 , A61P17/00 , A61P17/02 , A61P31/04 , A61P31/10
CPC分类号： A61K31/66 , A01N57/12 , A01N57/16 , A61K9/0014 , A61K31/70
摘要： The present invention provides protonated compounds having antimicrobial activity. The invention also provides antimicrobial compositions comprising protonated compounds of the invention. The protonated compounds of the invention provide efficacious antimicrobial activity against resistant strains of bacteria and opportunistic fungi.
摘要翻译： 本发明提供具有抗微生物活性的质子化化合物。 本发明还提供包含本发明的质子化化合物的抗微生物组合物。 本发明的质子化化合物为细菌和机会真菌的抗性菌株提供有效的抗微生物活性。
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公开(公告)号：US5860423A
公开(公告)日：1999-01-19
申请号：US761493
申请日：1996-12-06
申请人： Terry Thompson
发明人： Terry Thompson
CPC分类号： A61F5/0113
摘要： The upper part of a brace is concave to receive a human calf and extends forwardly at either side of the calf. Elastic straps extend from the upper right and left sides of the brace downwardly to the top outside of a modified conventional shoe to support the shoe from plantarflexion as well as inversion and eversion. The lower end of the brace is removably and pivotally connected to the heel curve of the shoe.
摘要翻译： 支架的上部是凹的，以接收人的小腿，并且在小腿的两侧向前延伸。 弹性带从支架的右上侧和左侧向下延伸到改进的常规鞋的外部的顶部，以支撑来自跖屈的鞋以及反转和外翻。 支架的下端可拆卸地枢转地连接到鞋的跟部曲线。
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