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    Devices for improved wound management
    4.
    发明授权
    Devices for improved wound management 有权
    改善伤口管理的装置

    公开(公告)号：US06627215B1

    公开(公告)日：2003-09-30

    申请号：US09281858

    申请日：1999-03-31

    申请人： Roderic M. K. Dale ,  Steven L. Gatton ,  Amy Arrow

    发明人： Roderic M. K. Dale ,  Steven L. Gatton ,  Amy Arrow

    IPC分类号： A61F1300

    CPC分类号： A01N57/16 ,  A61B17/06166 ,  A61B2017/00893 ,  A61K8/606 ,  A61K31/70 ,  A61L15/46 ,  A61L17/005 ,  A61L17/04 ,  A61L17/105 ,  A61L24/0015 ,  A61L24/106 ,  A61L27/54 ,  A61L27/60 ,  A61L2300/258 ,  A61L2300/404 ,  A61Q19/00

    摘要： The present invention provides devices and compositions for the management of infection of topical lesions, each of the devices and compositions containing protonated/acidified nucleic acids either on its surface, or integrated into the device. These modified nucleic acids are effective as bactericidal and/or bacteriostatic agents without regard to the class of bacteria, so are especially useful when diagnosis is difficult or when multiple infectious organisms are present. The antibiotic activity of nucleic acids of the invention is not dependent on either the specific sequence of the nucleic acid or the length of the nucleic acid molecule. The nucleic acids used in the invention are protonated/acidified to give a pH when dissolved in water of less than pH 7 to about 1, more preferably less than pH 4.5 to about 1, and even more preferably less than pH 2 to about 1.

    摘要翻译： 本发明提供了用于管理局部损伤感染的装置和组合物，每个装置和组合物在其表面上含有质子化/酸化的核酸或整合到装置中。 这些修饰的核酸在不考虑细菌类的情况下作为杀菌剂和/或抑菌剂是有效的，因此当诊断困难时或当存在多种感染性生物时特别有用。 本发明的核酸的抗生素活性不依赖于核酸的特定序列或核酸分子的长度。 本发明中使用的核酸被质子化/酸化，当溶解在低于pH7至约1，更优选小于pH 4.5至约1，甚至更优选小于pH 2至约1的水中时产生pH。

    Pulmonary delivery of protonated/acidified nucleic acids
    5.
    发明授权
    Pulmonary delivery of protonated/acidified nucleic acids 有权
    质子化/酸化核酸的肺转运

    公开(公告)号：US06211162B1

    公开(公告)日：2001-04-03

    申请号：US09282824

    申请日：1999-03-31

    申请人： Roderic M. K. Dale ,  Steven L. Gatton ,  Amy Arrow

    发明人： Roderic M. K. Dale ,  Steven L. Gatton ,  Amy Arrow

    IPC分类号： A61K5100

    CPC分类号： A61K31/7125 ,  A01N57/16 ,  A61K8/606 ,  A61K31/70 ,  A61Q19/00 ,  C07H21/02

    摘要： The present invention provides a method of treating bacterial respiratory infections by pulmonary administration of protonated/acidified nucleic acids. These modified nucleic acids are effective as bactericidal and/or bacteriostatic agents without regard to the class of bacteria, so are especially useful when diagnosis is difficult or when multiple infectious organisms are present. The antibiotic activity of nucleic acids of the invention is not dependent on either the specific sequence of the nucleic acid or the length of the nucleic acid molecule.

    摘要翻译： 本发明提供了一种通过肺施用质子化/酸化的核酸来治疗细菌性呼吸道感染的方法。 这些修饰的核酸在不考虑细菌类的情况下作为杀菌剂和/或抑菌剂是有效的，因此当诊断困难时或当存在多种感染性生物时特别有用。 本发明的核酸的抗生素活性不依赖于核酸的特定序列或核酸分子的长度。