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公开(公告)号：US09163091B2
公开(公告)日：2015-10-20
申请号：US12406874
申请日：2009-03-18
申请人： Roger A. Sabbadini , William A. Garland , James Stephen Swaney , Rosalia Matteo , Gordon Mills , Jonathan Michael Wojciak
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , James Stephen Swaney , Rosalia Matteo , Gordon Mills , Jonathan Michael Wojciak
CPC分类号： C07K16/44 , A61K2039/505 , C07K16/18 , C07K16/3076 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12Q1/6883 , C12Q1/6886 , G01N33/92
摘要： Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described. Variable domain and complementarity determining region amino acid sequences of several monoclonal antibodies against LPA are disclosed, as is a consensus anti-LPA monoclonal antibody variable domain sequence.
摘要翻译： 描述了用于制备和使用抗LPA剂的组合物和方法，例如单克隆抗体。 公开了针对LPA的几种单克隆抗体的可变结构域和互补决定区氨基酸序列，以及共有抗LPA单克隆抗体可变结构域序列。
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公开(公告)号：US08158124B2
公开(公告)日：2012-04-17
申请号：US12129109
申请日：2008-05-29
IPC分类号： C07K16/00
CPC分类号： G01N33/92 , A61K2039/505 , C07K16/3076 , C07K16/44 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/54386 , G01N33/577 , G01N2405/04
摘要： Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described.
摘要翻译： 描述了用于制备和使用抗LPA剂的组合物和方法，例如单克隆抗体。
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公开(公告)号：US08401799B2
公开(公告)日：2013-03-19
申请号：US12794668
申请日：2010-06-04
IPC分类号： A61K39/395 , C07K16/44 , G06G7/60
CPC分类号： C07K16/18 , G01N33/92 , G01N2405/08 , G06F19/12
摘要： Methods for designing optimized antibodies, including optimized humainized or human antibodies, to target bioactive lipids are provided. These methods may be performed in silico and may be intended to enhance binding affinity of an antibody to its original target lipid, and/or to alter binding specificity. Antibodies produced by these methods are also provided, as are methods for using them.
摘要翻译： 提供了设计优化的抗体（包括优化的人类或人类抗体）以靶向生物活性脂质的方法。 这些方法可以在硅胶中进行，并且可以旨在增强抗体与其原始靶脂质的结合亲和力和/或改变结合特异性。 还提供了通过这些方法产生的抗体，以及使用它们的方法。
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4.发明申请COMBINATIONS OF ANTI-S1P ANTIBODIES AND SHPINGOLIPID PATHWAY INHIBITORS 审中-公开抗S1P抗体与SHPINGOLIPID途径抑制剂的组合公开(公告)号：US20130344087A1
公开(公告)日：2013-12-26
申请号：US13702551
申请日：2011-06-04
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , A61K2039/545 , C07K16/28 , C07K2317/14
摘要： Methods for administering combinations of compositions comprising anti-S1P antibodies or antibody fragments and modulators of sphingolipid metabolic pathway enzymes are described. Such methods allow aberrant or undesirable levels of S1P to be reduced in patients known or suspected to have a disease or disorder correlated with aberrant S1P levels, and thus will be useful in treating such diseases and disorders.
摘要翻译： 描述了包含抗S1P抗体或抗体片段的组合物组合的神经鞘脂代谢途径酶的调节剂的方法。 这样的方法允许在已知或疑似患有与异常S1P水平相关的疾病或病症的患者中减少异常或不良水平的S1P，因此可用于治疗这些疾病和病症。
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5.发明授权公开(公告)号：US09274130B2
公开(公告)日：2016-03-01
申请号：US13182644
申请日：2011-07-14
申请人： Roger A. Sabbadini , Rosalia Matteo
发明人： Roger A. Sabbadini , Rosalia Matteo
IPC分类号： G01N33/92 , C07K16/18 , C07K16/30 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/92
摘要： Methods for preventing or treating pain are provided. Such methods comprise administering to a subject (e.g., a human subject) an antibody or antibody fragment that binds LPA. The antibody may be a humanized monoclonal antibody.
摘要翻译： 提供了预防或治疗疼痛的方法。 这样的方法包括向受试者（例如人受试者）施用结合LPA的抗体或抗体片段。 抗体可以是人源化单克隆抗体。
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6.发明授权Humanized antibody compositions and methods for binding lysophosphatidic acid 失效人源化抗体组合物和结合溶血磷脂酸的方法公开(公告)号：US08604172B2
公开(公告)日：2013-12-10
申请号：US12761584
申请日：2010-04-16
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C12P21/08
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/44 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Compositions and methods for making and using humanized anti-LPA monoclonal antibodies, and fragments and derivatives thereof, are described.
摘要翻译： 描述了制备和使用人源化抗LPA单克隆抗体的组合物和方法及其片段和衍生物。
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7.发明授权Use of anti-sphingosine-1-phosphate antibodies in combination with chemotherapeutic agents 有权抗鞘氨醇-1-磷酸抗体与化学治疗剂的组合使用公开(公告)号：US08361465B2
公开(公告)日：2013-01-29
申请号：US12690033
申请日：2010-01-19
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00 , C12P21/08
CPC分类号： C07K16/44 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K2317/24 , A61K2300/00
摘要： The present invention relates to use of anti-S1P antibodies in combination with chemotherapeutic agents for treatment and/or prevention of cancer, tumor growth, metastasis and/or growth of metastatic tumors.
摘要翻译： 本发明涉及抗S1P抗体与化学治疗剂组合用于治疗和/或预防转移性肿瘤的癌症，肿瘤生长，转移和/或生长的用途。
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8.发明授权公开(公告)号：US08222373B2
公开(公告)日：2012-07-17
申请号：US12258346
申请日：2008-10-24
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P.
摘要翻译： 本发明涉及与S1P特异性反应的抗S1P试剂，特别是人源化单克隆抗体（及其抗原结合片段），含有此类抗体（或片段）的组合物，以及使用这种抗体（或片段），例如 治疗与S1P异常水平相关的疾病和病症。
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9.发明授权Methods of using humanized antibodies and compositions for binding sphingosine-1-phosphate 有权使用人源化抗体和用于结合鞘氨醇-1-磷酸的组合物的方法公开(公告)号：US08025877B2
公开(公告)日：2011-09-27
申请号：US12258355
申请日：2008-10-24
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Williams
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P.
摘要翻译： 本发明涉及与S1P特异性反应的抗S1P试剂，特别是人源化单克隆抗体（及其抗原结合片段），含有此类抗体（或片段）的组合物，以及使用这种抗体（或片段），例如 治疗与S1P异常水平相关的疾病和病症。
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公开(公告)号：US20100226916A1
公开(公告)日：2010-09-09
申请号：US12446723
申请日：2007-10-26
IPC分类号： A61K39/395 , A61K38/08 , A61K38/10 , A61P27/02
CPC分类号： A61K38/08 , A61K38/10 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/56 , C07K2317/92
摘要： The present invention relates to compositions and methods for prevention and treatment of diseases and conditions, particularly ocular diseases and conditions, characterized by aberrant fibrogenesis or scarring, inflammation, and/or aberrant neovascularization or angiogenesis. The compositions and methods of the invention utilize immune-derived moieties that are specifically reactive against the bioactive lipid, sphingosine-1-phosphate, and its variants, which moieties are capable of decreasing the effective concentration of bioactive lipid being targeted. In one embodiment, the immune-derived moiety is a humanized monoclonal antibody that is reactive against sphingosine-1-phosphate.
摘要翻译： 本发明涉及用于预防和治疗疾病和病症，特别是眼部疾病和病症的组合物和方法，其特征在于异常纤维发生或瘢痕形成，炎症和/或异常的新生血管形成或血管生成。 本发明的组合物和方法利用与生物活性脂质，鞘氨醇-1-磷酸及其变体特异性反应的免疫衍生部分，该部分能够降低靶向的生物活性脂质的有效浓度。 在一个实施方案中，免疫衍生部分是对丝氨酸-1-磷酸反应的人源化单克隆抗体。
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