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    DIAGNOSIS OF FETAL ABNORMALITIES USING POLYMORPHISMS INCLUDING SHORT TANDEM REPEATS
    1.
    发明申请
    DIAGNOSIS OF FETAL ABNORMALITIES USING POLYMORPHISMS INCLUDING SHORT TANDEM REPEATS 审中-公开
    使用多态性诊断不良反应，包括短暂的重复

    公开(公告)号：US20080050739A1

    公开(公告)日：2008-02-28

    申请号：US11763426

    申请日：2007-06-14

    申请人： Roland Stoughton ,  Ravi Kapur ,  Barb Cohen

    发明人： Roland Stoughton ,  Ravi Kapur ,  Barb Cohen

    IPC分类号： C12Q1/68 ,  G06G7/48

    CPC分类号： G01N1/30 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G16B20/00

    摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a determination and report a non-informative case. The present invention involves quantifying regions of genomic DNA from a mixed sample. More particularly the invention involves quantifying DNA polymorphisms from the mixed sample.

    摘要翻译： 本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常（即非整倍体）的系统，装置和方法。 此外，本发明提供了确定何时胎儿细胞不足以确定并报告非信息性病例的方法。 本发明涉及量化来自混合样品的基因组DNA的区域。 更具体地，本发明涉及从混合样品中定量DNA多态性。

    Methods for improving fertility and selectivity for desired offspring sex in artificial insemination
    3.
    发明授权
    Methods for improving fertility and selectivity for desired offspring sex in artificial insemination 有权
    提高人工授精期望后代性能的生育力和选择性的方法

    公开(公告)号：US09383369B2

    公开(公告)日：2016-07-05

    申请号：US12571361

    申请日：2009-09-30

    申请人： Barb Cohen

    发明人： Barb Cohen

    IPC分类号： A01N1/02 ,  G01N33/68

    CPC分类号： G01N33/5091 ,  G01N33/689 ,  G01N33/92 ,  G01N2333/47 ,  G01N2405/04 ,  G01N2800/367

    摘要： A method for providing semen optimized for use in artificial insemination is described. Methods involve monitoring sperm cell metabolism by assays that produce results in real time, while sperm are still being processed into doses for use in insemination. Processing is modified in response to assay results, to optimize sperm performance.

    摘要翻译： 描述了用于提供优化用于人工授精的精液的方法。 方法包括通过能够实时产生结果的测定来监测精子细胞代谢，而精子仍然被加工成用于授精的剂量。 响应于测定结果修饰加工，以优化精子性能。

    Method for sex biasing spermatozoa
    5.
    发明申请
    Method for sex biasing spermatozoa 审中-公开

    公开(公告)号：US20050114915A1

    公开(公告)日：2005-05-26

    申请号：US10723268

    申请日：2003-11-26

    申请人： Barb Cohen ,  Michael Morris

    发明人： Barb Cohen ,  Michael Morris

    IPC分类号： A01K67/027 ,  C12N5/00 ,  C12N5/071 ,  G01N20060101

    CPC分类号： C12N5/0612 ,  A01K2227/101 ,  A01K2227/105 ,  C12N2517/10

    摘要： A method is described for treating a specimen of semen containing sperm cells to increase the relative number of sperm cells of a desired sex type in a treated specimen to increase the potential for conceiving an offspring of the desired sex. A specimen of semen is treated after a predetermined time to increase the relative ability of a at least a portion of the semen to conceive an offspring of the desired sex. The treatment preferably comprises contacting the sperm cells with an agent that preferentially effects sperm cells of a selected sex type. In some preferred embodiments, the semen is separated into two components. A first component has a higher number of sperm of the desired sex type than sperm of a non desired sex type and a second component has a higher number of sperm of the non desired sex type relative to sperm of the desired sex type. In one embodiment, the separating step is performed after a predetermined percent of the sperm cells exhibit a punctate pattern, which is capable of determination by labeling the sperm cells with Koo antibody and determining the percent of cells labeled. In another embodiment, the separating step is performed after waiting for a time determined by locating a maximum in the curve obtained by plotting percent female cells determined by FISH against percent Koo positive cells, determining the time at which the maximum percent female cells occurs, and beginning the following step no earlier than about one hour before the time of the maximum percent female cells. In yet another embodiment, the separating step is performed after waiting for a period of time between about 2 hours and about 24 hours after collection of the ejaculate. Preferably, in the separating step, the sperm is contacted with a cell binding agent, permitting the sperm of the non desired sex type to preferentially bind to the cell binding agent, and the cell binding agent with preferentially bound sperm of the non desired sex type is separated from non bound sperm.