摘要:
A drive train having a clutch assembly for transmitting torque between an engine and a transmission. The clutch assembly is selectable for transmitting torque between the engine and the transmission and includes at least one friction clutch, the clutch assembly being supported on the transmission housing so that the clutch assembly is radially fixed and displaceable in an axially limited manner.
摘要:
A drive train having a clutch assembly for transmitting torque between an engine and a transmission. The clutch assembly is selectable for transmitting torque between the engine and the transmission and includes at least one friction clutch, the clutch assembly being supported on the transmission housing so that the clutch assembly is radially fixed and displaceable in an axially limited manner.
摘要:
A drive train having a clutch assembly for transmitting torque between an engine and a transmission. The clutch assembly is selectable for transmitting torque between the engine and the transmission and includes at least one friction clutch, the clutch assembly being supported on the transmission housing so that the clutch assembly is radially fixed and displaceable in an axially limited manner.
摘要:
A method is proposed for verification of time data from a time signal modulated on a continuous carrier signal with steps to receive a first time signal with a first reference time, to receive a second time signal with a second reference time, which follows the first reference time in time, for calculation of the target time interval lying between the reference times from the time data contained in the received time signal, to determine a time interval and determine a reference time interval, using counting of periods of the continuous carrier signal within the time interval, for comparison of the target time interval with the reference time interval and to send an error signal, if the deviation determined by the comparison surpasses a stipulated tolerance value.
摘要:
The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.
摘要:
The crystalline Polymorph B of N-(2-aminophenyl)-4-[N-(pyridine-3-yl)methoxy-carbonyaminomethyl]benzamide (MS-275) of formula I is described, as well as the process for the production of said compound, and its use as a medicament for the treatment of selected diseases.
摘要:
The present invention relates to 11β-fluoro-3-acetoxyestra-3,5-dien-17-one as a suitable intermediate in the preparation of 11-fluoro-substituted steroids and to the process for preparation thereof. For this purpose, 11α-hydroxyestra-4-ene-3,17-dione is reacted with 1 to 3 equivalents of n-nonafluorobutanesulfonyl fluoride and 3 to 5 equivalents of diazabicycloundecene (DBU) at −40 to −20° C. in an organic aprotic solvent and, after an aqueous workup, reacted with 5 to 10 equivalents of acetic anhydride and 0.01 to 1 equivalent of a strong acid. The desired product precipitates spontaneously out of the reaction solution and is obtained in a very high purity by filtration. The process is notable for the very high yield, avoidance of a chromatographic purification of the product, a reduced proportion of wastes and significantly increased process throughput. The process according to the invention is therefore especially suitable for preparing 11β-fluoro-3-acetoxyestra-3,5-dien-17-one on a large industrial scale.
摘要:
The present invention relates generally to azatriocyclic containing pharmaceutical agents, and in particular, to azatricyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azatricyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
摘要:
A method for operating an electric control device for at least one power unit of a motor vehicle, an operating temperature range being assigned to the control device, and the control device being automatically switched off if its temperature exceeds the operating temperature range. A switch-on of the automatically switched-off control device may be implemented only if its temperature is within the operating temperature range. Furthermore, a corresponding electric control device.
摘要:
The present invention relates generally to pharmaceutical agents containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP-13 inhibiting compounds with a benzoxazinone moiety, that exhibit an increased potency and selectivity in relation to currently known MMP-13 inhibitors.