公开(公告)号：US20070060598A1

公开(公告)日：2007-03-15

申请号：US11411413

申请日：2006-04-26

申请人： Ronald Albers ,  Leticia Ayala ,  Steven Clareen ,  Maria Delgado Mederos ,  Robert Hilgraf ,  Sayee Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne Sloss ,  Elise Sudbeck ,  Jonathan Wright

发明人： Ronald Albers ,  Leticia Ayala ,  Steven Clareen ,  Maria Delgado Mederos ,  Robert Hilgraf ,  Sayee Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne Sloss ,  Elise Sudbeck ,  Jonathan Wright

IPC分类号： A61K31/52 ,  C07D473/14

CPC分类号： A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R 1，R 2和R 3如本文所定义，包含有效量的组合物 的氨基嘌呤化合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关的方法 条件，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的氨基嘌呤化合物。

公开(公告)号：US20060287344A1

公开(公告)日：2006-12-21

申请号：US11332617

申请日：2006-01-12

申请人： Ronald Albers ,  Leticia Ayala ,  Steven Clareen ,  Maria Delgado Mederos ,  Robert Hilgraf ,  Sayee Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne Sloss ,  Elise Sudbeck ,  Jonathan Wright

发明人： Ronald Albers ,  Leticia Ayala ,  Steven Clareen ,  Maria Delgado Mederos ,  Robert Hilgraf ,  Sayee Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne Sloss ,  Elise Sudbeck ,  Jonathan Wright

IPC分类号： A61K31/52 ,  C07D473/14

CPC分类号： C07D473/00 ,  A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R 1，R 2和R 3如本文所定义，组合物包含有效的 氨基嘌呤化合物的量和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛及相关综合征，疾病相关性消耗，石棉 - 相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的氨基嘌呤化合物。

公开(公告)号：US20130029987A1

公开(公告)日：2013-01-31

申请号：US13451574

申请日：2012-04-20

申请人： Brydon L. Bennett ,  Jan Elsner ,  Paul Erdman ,  Robert Hilgraf ,  Laurie Ann LeBrun ,  Meg McCarrick ,  Mehran F. Moghaddam ,  Mark A. Nagy ,  Stephen Norris ,  David A. Paisner ,  Marianne Sloss ,  William J. Romanow ,  Yoshitaka Satoh ,  Jayashree Tikhe ,  Won Hyung Yoon ,  Mercedes Delgado

发明人： Brydon L. Bennett ,  Jan Elsner ,  Paul Erdman ,  Robert Hilgraf ,  Laurie Ann LeBrun ,  Meg McCarrick ,  Mehran F. Moghaddam ,  Mark A. Nagy ,  Stephen Norris ,  David A. Paisner ,  Marianne Sloss ,  William J. Romanow ,  Yoshitaka Satoh ,  Jayashree Tikhe ,  Won Hyung Yoon ,  Mercedes Delgado

IPC分类号： A61K31/505 ,  C07D405/12 ,  C07D401/12 ,  A61K31/506 ,  C07D405/14 ,  C12N5/071 ,  C07D413/12 ,  A61K31/5377 ,  A61P1/16 ,  A61P3/10 ,  A61P3/00 ,  C07D239/48 ,  C07D403/12

CPC分类号： C07D239/48 ,  A61K31/505 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： Provided herein are Diaminopyrimidine Compounds having the following structures: wherein R1, R2, R3, and R4 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidine Compound, and methods for treating or preventing liver fibrotic disorders or a condition treatable or preventable by inhibition of a JNK pathway.

公开(公告)号：US09139534B2

公开(公告)日：2015-09-22

申请号：US13451574

申请日：2012-04-20

申请人： Brydon L. Bennett ,  Jan Elsner ,  Paul Erdman ,  Robert Hilgraf ,  Laurie Ann LeBrun ,  Meg McCarrick ,  Mehran F. Moghaddam ,  Mark A. Nagy ,  Stephen Norris ,  David A. Paisner ,  Marianne Sloss ,  William J. Romanow ,  Yoshitaka Satoh ,  Jayashree Tikhe ,  Won Hyung Yoon ,  Mercedes Delgado

发明人： Brydon L. Bennett ,  Jan Elsner ,  Paul Erdman ,  Robert Hilgraf ,  Laurie Ann LeBrun ,  Meg McCarrick ,  Mehran F. Moghaddam ,  Mark A. Nagy ,  Stephen Norris ,  David A. Paisner ,  Marianne Sloss ,  William J. Romanow ,  Yoshitaka Satoh ,  Jayashree Tikhe ,  Won Hyung Yoon ,  Mercedes Delgado

IPC分类号： C07D239/48 ,  A61K31/505 ,  C07D401/12 ,  C07D409/12 ,  C07D403/12 ,  C07D401/04 ,  C07D405/12

CPC分类号： C07D239/48 ,  A61K31/505 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： Provided herein are Diaminopyrimidine Compounds having the following structures: wherein R1, R2, R3, and R4 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidine Compound, and methods for treating or preventing liver fibrotic disorders or a condition treatable or preventable by inhibition of a JNK pathway.

摘要翻译： 本文提供具有以下结构的二氨基嘧啶化合物：其中R1，R2，R3和R4如本文所定义，包含有效量的二氨基嘧啶化合物的组合物，以及用于治疗或预防肝纤维化疾病的方法或可治疗或可预防的病症 抑制JNK通路。

公开(公告)号：US20090270418A1

公开(公告)日：2009-10-29

申请号：US12350722

申请日：2009-01-08

申请人： Marianne Sloss ,  Jeffrey McKenna ,  Won Hyung Yoon ,  Stephen Norris ,  Dale Robinson ,  Jason Parnes ,  Graziella Shevlin ,  Paul Erdman ,  Robert Hilgraf ,  Ronald Albers ,  Sayee Hegde ,  Andrew Wallace ,  Henry Chan ,  Loui Madakamutil ,  Heather Raymon

发明人： Marianne Sloss ,  Jeffrey McKenna ,  Won Hyung Yoon ,  Stephen Norris ,  Dale Robinson ,  Jason Parnes ,  Graziella Shevlin ,  Paul Erdman ,  Robert Hilgraf ,  Ronald Albers ,  Sayee Hegde ,  Andrew Wallace ,  Henry Chan ,  Loui Madakamutil ,  Heather Raymon

IPC分类号： A61K31/497 ,  C07D403/12 ,  A61P35/00 ,  C12N9/99

CPC分类号： C07D403/12 ,  C07D401/14 ,  C07D403/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/14

摘要： Provided herein are Pyrazole Pyrazine Amine Compounds having the following structure: Wherein Q and R1-R3 are as defined herein, compositions comprising an effective amount of a Pyrazole Pyrazine Amine Compound and methods for treating or preventing inflammatory conditions, immunological conditions, cancer, neurodegenerative diseases, age-related diseases, cardiovascular diseases and metabolic conditions, or conditions treatable or preventable by inhibition of an IKK, or an IKK pathway, comprising administering an effective amount of a Pyrazole Pyrazine Amine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的吡唑吡嗪胺化合物：其中Q和R 1 -R 3如本文所定义，包含有效量的吡唑吡嗪胺化合物的组合物和治疗或预防炎性病症，免疫学条件，癌症，神经变性疾病的方法 ，年龄相关疾病，心血管疾病和代谢病症，或通过抑制IKK或IKK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的吡唑吡嗪胺化合物。