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1.发明申请Neural Proteins as Biomarkers for Nervous System Injury and Other Neural Disorders 审中-公开神经蛋白作为神经系统损伤和其他神经疾病的生物标志物公开(公告)号：US20090087868A1
公开(公告)日：2009-04-02
申请号：US12137194
申请日：2008-06-11
申请人： Kevin Ka-Wang Wang , Ronald Hayes , Ming Chen Liu , Monika Oli
发明人： Kevin Ka-Wang Wang , Ronald Hayes , Ming Chen Liu , Monika Oli
IPC分类号： G01N33/53
CPC分类号： C12Q1/6883 , G01N33/6896 , G01N2800/28 , G01N2800/52
摘要： The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
摘要翻译： 本发明鉴定诊断神经细胞损伤和/或神经元疾病的生物标志物。 本发明的不同生物标志物的检测也可以诊断神经损伤的严重程度，损伤中涉及的细胞以及损伤的亚细胞定位。
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公开(公告)号：US07456027B2
公开(公告)日：2008-11-25
申请号：US11106932
申请日：2005-04-15
申请人： Kevin Ka-Wang Wang , Ronald Hayes , Ming Chen Liu , Monika Oli
发明人： Kevin Ka-Wang Wang , Ronald Hayes , Ming Chen Liu , Monika Oli
IPC分类号： G01N33/567 , G01N33/48
CPC分类号： G01N33/6896 , C12Q1/37 , Y10T436/118339 , Y10T436/25375
摘要： The present invention identifies biomarkers that are diagnostic of nerve cell injury, organ injury, and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
摘要翻译： 本发明鉴定诊断神经细胞损伤，器官损伤和/或神经元障碍的生物标志物。 本发明的不同生物标志物的检测也可以诊断神经损伤的严重程度，损伤中涉及的细胞以及损伤的亚细胞定位。
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公开(公告)号：US07396654B2
公开(公告)日：2008-07-08
申请号：US11107248
申请日：2005-04-15
申请人： Ronald Hayes , Kevin Ka-Wang Wang , Ming Chen Liu , Monika Oli
发明人： Ronald Hayes , Kevin Ka-Wang Wang , Ming Chen Liu , Monika Oli
IPC分类号： G01N33/53 , G01N33/542 , G01N33/537 , G01N33/566 , G01N33/567 , C12Q1/00
CPC分类号： C12Q1/6883 , G01N33/6896 , G01N2800/28 , G01N2800/52
摘要： The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
摘要翻译： 本发明鉴定诊断神经细胞损伤和/或神经元疾病的生物标志物。 本发明的不同生物标志物的检测也可以诊断神经损伤的严重程度，损伤中涉及的细胞以及损伤的亚细胞定位。
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4.发明申请SYNAPTOTAGMIN AND COLLAPSIN RESPONSE MEDIATOR PROTEIN AS BIOMARKERS FOR TRAUMATIC BRAIN INJURY 审中-公开SYNAPTOTAGMIN和COLLAPSIN反应介质蛋白作为生物标志物治疗脑损伤公开(公告)号：US20120196307A1
公开(公告)日：2012-08-02
申请号：US13337588
申请日：2011-12-27
申请人： ANDREW K. OTTENS , Firas H. Kobaissy , Ka-Wang (Kevin) Wang , Ronald L. Hayes , Zhiqun Zhang , Ming Chen Liu , Monika Oli
发明人： ANDREW K. OTTENS , Firas H. Kobaissy , Ka-Wang (Kevin) Wang , Ronald L. Hayes , Zhiqun Zhang , Ming Chen Liu , Monika Oli
IPC分类号： G01N33/566 , C07K2/00
CPC分类号： G01N33/6896 , G01N2800/28
摘要： Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological samples after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (biological samples). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.
摘要翻译： 在创伤性脑损伤（TBI）神经损伤后，Collapsin反应介质蛋白（CRMPs）在组织中减少，生物样品中增加。 CRMP1，CRMP2，CRMP4和CRMP5的显着降低伴随着由钙蛋白酶的蛋白水解切割引起的不同的58kDa（CRMP-2）或55kDa（CRMP-4）分解产物的出现。 Synaptotagmin分解产物也与TBI相关，可与人脑脊髓液（生物样品）中的完整蛋白一起检测。 在人类生物流体中检测到两种生物标志物，并与创伤性脑损伤恢复相关。
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5.发明申请Synaptotagmin and Collapsin Response Mediator Protein as Biomarkers for Traumatic Brain Injury 有权Synaptotagmin和Collapsin Response Mediator Protein作为创伤性脑损伤的生物标志物公开(公告)号：US20100047817A1
公开(公告)日：2010-02-25
申请号：US12535960
申请日：2009-08-05
申请人： Andrew K. Ottens , Firas H. Kobaissy , Ka-Wang (Kevin) Wang , Ronald L. Hayes , Zhiqun Zhang , Ming Chen Liu , Monika Oli
发明人： Andrew K. Ottens , Firas H. Kobaissy , Ka-Wang (Kevin) Wang , Ronald L. Hayes , Zhiqun Zhang , Ming Chen Liu , Monika Oli
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2800/28
摘要： Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological fluids after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (CSF). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.
摘要翻译： 在创伤性脑损伤（TBI）神经损伤后，Collapsin反应介质蛋白（CRMPs）在组织中减少并且生物流体中增加。 CRMP1，CRMP2，CRMP4和CRMP5的显着降低伴随着由钙蛋白酶的蛋白水解切割引起的不同的58kDa（CRMP-2）或55kDa（CRMP-4）分解产物的出现。 Synaptotagmin分解产物也与TBI相关，并可与人脑脊髓液（CSF）中的完整蛋白一起检测。 在人类生物流体中检测到两种生物标志物，并与创伤性脑损伤恢复相关。
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6.发明授权Synaptotagmin and collapsin response mediator protein as biomarkers for traumatic brain injury 有权Synaptotagmin和collapsin应答介质蛋白作为创伤性脑损伤的生物标志物公开(公告)号：US08557526B2
公开(公告)日：2013-10-15
申请号：US12535960
申请日：2009-08-05
申请人： Andrew K. Ottens , Firas H. Kobaissy , Ka-Wang (Kevin) Wang , Ronald L. Hayes , Zhiqun Zhang , Ming Chen Liu , Monika Oli
发明人： Andrew K. Ottens , Firas H. Kobaissy , Ka-Wang (Kevin) Wang , Ronald L. Hayes , Zhiqun Zhang , Ming Chen Liu , Monika Oli
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/6896 , G01N2800/28
摘要： Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological fluids after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (CSF). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.
摘要翻译： 在创伤性脑损伤（TBI）神经损伤后，Collapsin反应介质蛋白（CRMPs）在组织中减少并且生物流体中增加。 CRMP1，CRMP2，CRMP4和CRMP5的显着降低伴随着由钙蛋白酶的蛋白水解切割引起的不同的58kDa（CRMP-2）或55kDa（CRMP-4）分解产物的出现。 Synaptotagmin分解产物也与TBI相关，并可与人脑脊髓液（CSF）中的完整蛋白一起检测。 在人类生物流体中检测到两种生物标志物，并与创伤性脑损伤恢复相关。
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7.发明申请Proteolytic Markers as Diagnostic Biomarkers for Cancer, Organ Injury and Muscle Rehabilitation/Exercise Overtraining 有权蛋白水解标记作为癌症，器官损伤和肌肉康复/运动超调的诊断性生物标志物公开(公告)号：US20090317805A1
公开(公告)日：2009-12-24
申请号：US12137156
申请日：2008-06-11
IPC分类号： C12Q1/68 , G01N33/68 , G01N33/536 , G01N33/567
CPC分类号： G01N33/6896 , C12Q1/37 , Y10T436/118339 , Y10T436/25375
摘要： The present invention identifies biomarkers that are diagnostic of nerve cell injury, organ injury, and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
摘要翻译： 本发明鉴定诊断神经细胞损伤，器官损伤和/或神经元障碍的生物标志物。 本发明的不同生物标志物的检测也可以诊断神经损伤的严重程度，损伤中涉及的细胞以及损伤的亚细胞定位。
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8.发明授权Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining 有权蛋白水解标记物作为癌症，器官损伤和肌肉康复/运动过度训练的诊断性生物标志物公开(公告)号：US08298835B2
公开(公告)日：2012-10-30
申请号：US12137156
申请日：2008-06-11
CPC分类号： G01N33/6896 , C12Q1/37 , Y10T436/118339 , Y10T436/25375
摘要： The present invention identifies biomarkers that are diagnostic of nerve cell injury, organ injury, and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
摘要翻译： 本发明鉴定诊断神经细胞损伤，器官损伤和/或神经元障碍的生物标志物。 本发明的不同生物标志物的检测也可以诊断神经损伤的严重程度，损伤中涉及的细胞以及损伤的亚细胞定位。
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