公开(公告)号：US20060293740A1

公开(公告)日：2006-12-28

申请号：US11168048

申请日：2005-06-28

申请人： Ronald Heil ,  Geoffrey Willis

发明人： Ronald Heil ,  Geoffrey Willis

IPC分类号： A61N1/00

CPC分类号： A61N1/0587

摘要： A cardiac pacing lead for electrically communicating with a human heart is attached to the heart using an adhesive. The lead includes a flexible, elongated lead body having a proximal end and a distal end, a pad having an interface surface coupled to the lead body at the distal end. An electrode is coupled to the pad. The lead further includes an adhesive for bonding the pad to the heart such that the electrode is electrically coupled to the heart. The adhesive is delivered to the interface surface after the lead has been inserted into a subject. In one embodiment, the lead system includes an anchor having an interface surface adapted for adhesive coupling to the heart. In this embodiment, the anchor is coupled to a tether and the lead includes a lumen adapted to accept the tether and to allow advancement of the lead over the tether.

摘要翻译： 使用粘合剂将与人心脏电连通的心脏起搏引线附接到心脏。 引线包括具有近端和远端的柔性细长的引线主体，具有在远端处与引线主体耦合的接口表面的焊盘。 电极耦合到焊盘。 引线还包括用于将焊盘接合到心脏的粘合剂，使得电极电耦合到心脏。 在铅被插入到受试者之后，粘合剂被传送到界面表面。 在一个实施例中，引导系统包括具有适于粘附到心脏的界面的锚固件。 在该实施例中，锚固件连接到系绳，并且引线包括适于接纳系绳并允许引线前进到系绳的内腔。

公开(公告)号：US20050149128A1

公开(公告)日：2005-07-07

申请号：US10746134

申请日：2003-12-24

申请人： Ronald Heil ,  Avram Scheiner ,  Imad Libbus

发明人： Ronald Heil ,  Avram Scheiner ,  Imad Libbus

IPC分类号： A61N1/36 ,  A61N1/362 ,  A61N1/365

CPC分类号： A61N1/36117 ,  A61N1/3627 ,  A61N1/36564

摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.

摘要翻译： 本主题的各个方面提供可植入医疗装置。 在各种实施例中，该装置包括脉冲发生器，引线，传感器和控制器。 脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。 引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。 引线包括位于心脏中或靠近心脏的电极以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。 传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。 控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。 本文提供了其他方面。

公开(公告)号：US20050137674A1

公开(公告)日：2005-06-23

申请号：US10972298

申请日：2004-10-22

申请人： M. Coe ,  Ronald Heil ,  Peter Kelley ,  Jason Shiroff ,  Randy Westlund ,  Donald Palme

发明人： M. Coe ,  Ronald Heil ,  Peter Kelley ,  Jason Shiroff ,  Randy Westlund ,  Donald Palme

IPC分类号： A61N1/05

CPC分类号： A61N1/0587 ,  A61N2001/0578

摘要： The present invention is a myocardial lead attachment system for securing a lead within the myocardium. The attachment system includes an anchor configured to engage the heart, a tether coupled to the anchor and a lead body. The lead body has a proximal end, a distal end, a lumen for accepting the tether and a lock housing in the lumen. A lock structure is on the tether and mates with the lock housing and restrains motion of the lead with respect to the tether in either of a proximal or a distal direction.

摘要翻译： 本发明是用于将铅固定在心肌内的心肌引导附着系统。 附接系统包括构造成接合心脏的锚，连接到锚固体的系绳和引导体。 引线体具有近端，远端，用于接纳系绳的内腔和在内腔中的锁定壳体。 锁定结构位于系绳上并且与锁定壳体配合并且在近端或远端方向中抑制引线相对于系绳的运动。

公开(公告)号：US20050119718A1

公开(公告)日：2005-06-02

申请号：US10971577

申请日：2004-10-22

申请人： M. Sean Coe ,  Ronald Heil ,  Peter Kelley ,  Jason Shiroff ,  Randy Westlund ,  Donald Palme

发明人： M. Sean Coe ,  Ronald Heil ,  Peter Kelley ,  Jason Shiroff ,  Randy Westlund ,  Donald Palme

IPC分类号： A61B5/0492 ,  A61B17/04 ,  A61B17/06 ,  A61N1/05

CPC分类号： A61B17/0469 ,  A61B5/0492 ,  A61B17/06109 ,  A61B2017/0417 ,  A61B2017/06042 ,  A61B2017/0608 ,  A61N1/0568 ,  A61N1/0587 ,  A61N2001/0578 ,  A61N2001/058

摘要： A myocardial lead attachment system for securing a distal end of a lead within a myocardium of a patient's heart. The system includes a lead body, an anchor mechanism formed of a bioabsorbable or biodegradable polymer for engaging a surface of the patient's heart and a surface feature formed on a portion of the lead body for promoting formation of scar tissue around said portion of the lead body.

摘要翻译： 用于将铅的远端固定在患者心脏的心肌内的心肌引线附着系统。 该系统包括引线体，由生物可吸收或可生物降解的聚合物形成的锚固机构，用于接合患者心脏的表面，以及形成在引线体的一部分上的表面特征，用于促进在引线体的所述部分周围形成瘢痕组织 。

公开(公告)号：US20080033236A1

公开(公告)日：2008-02-07

申请号：US11870324

申请日：2007-10-10

申请人： Ronald Heil

发明人： Ronald Heil

IPC分类号： A61F2/02 ,  A61N1/05

CPC分类号： A61B17/00234 ,  A61B17/0401 ,  A61B2017/00243 ,  A61B2017/00867 ,  A61B2017/0441 ,  A61B2017/0496 ,  A61F2/2487

摘要： A splint assembly includes an elongate body. An active fixation fastener is coupled substantially adjacent to a distal end of the elongate body. The splint assembly includes at least one flange coupled to the elongate body proximal the active fixation fastener. In one option, a stop of the at least one flange projects outside of an outer perimeter of the elongate body. In another option, the active fixation fastener is spaced from the at least one flange where the active fixation fastener and the at least one flange pull at least one heart chamber toward a substantially unexpanded shape when in an implanted condition within the heart an artery or a vein. In yet another option, the elongate body includes a predetermined curvature along at least a portion of the elongate body between the active fixation fastener and the at least one flange.

摘要翻译： 夹板组件包括细长体。 主动固定紧固件基本上与细长主体的远端相邻地联接。 夹板组件包括至少一个法兰，该凸缘联接到靠近主动固定紧固件的细长主体。 在一个选项中，所述至少一个凸缘的止挡突出在所述细长体的外周的外侧。 在另一种选择中，主动固定紧固件与至少一个凸缘间隔开，其中主动固定紧固件和至少一个凸缘将至少一个心脏腔室拉向基本上未膨胀的形状，当处于心脏内的植入状态时，动脉或 静脉。 在另一个选择中，细长主体沿着细长主体的至少一部分在主动固定紧固件和至少一个凸缘之间包括预定的曲率。

公开(公告)号：US20070123923A1

公开(公告)日：2007-05-31

申请号：US11290355

申请日：2005-11-30

申请人： Curtis Lindstrom ,  Ronald Heil ,  Jason Shiroff ,  Paul Haefner ,  Adam Cates ,  Darrell Wagner

发明人： Curtis Lindstrom ,  Ronald Heil ,  Jason Shiroff ,  Paul Haefner ,  Adam Cates ,  Darrell Wagner

IPC分类号： A61N1/375 ,  A61F2/04

CPC分类号： A61F2/0095 ,  A61N1/375

摘要： Housings for implantable medical devices are configured so as to engage with surrounding tissues inside of a body and resist both rotation in place and movement through the body. Device housings include shapes, surface features, and/or standard surfaces and may include attached implements that engage the surrounding tissue. Shapes include elongated members, flared ends, and so forth. Surface features include pores, grooves, through-holes, and so forth. Attached implements include needles, barbs, tension springs, and so forth. Also provided are methods for engaging an implantable medical device with surrounding tissues.

摘要翻译： 用于可植入医疗装置的壳体构造成与身体内的周围组织接合并抵抗适当位置的旋转和穿过身体的运动。 设备外壳包括形状，表面特征和/或标准表面，并且可以包括接合周围组织的附接工具。 形状包括细长构件，扩口端等。 表面特征包括孔，槽，通孔等。 附件包括针，倒钩，拉伸弹簧等。 还提供了用于使可植入医疗装置与周围组织接合的方法。

公开(公告)号：US20070036770A1

公开(公告)日：2007-02-15

申请号：US11272432

申请日：2005-11-10

申请人： Darrell Wagner ,  Haris Sih ,  Jihong Ou ,  Jeffrey Ross ,  Steven Girouard ,  Ronald Heil

发明人： Darrell Wagner ,  Haris Sih ,  Jihong Ou ,  Jeffrey Ross ,  Steven Girouard ,  Ronald Heil

IPC分类号： A61K48/00 ,  G06F19/00 ,  C12N15/86

CPC分类号： A61K48/0008 ,  A61K48/0083 ,  A61N1/05

摘要： A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.

摘要翻译： 提供了一种系统和装置，其包括通过发射一种或多种刺激来控制存在于或释放的装置中的一种或多种表达盒的表达的基因调控系统。 表达盒包括可调节的转录控制元件，其响应于与感兴趣的开放阅读框架相关联的发射刺激。 该系统可选地包括用于感测指示需要的参数的传感器，用于接收外部命令的遥测模块或用于调节开放阅读框的基因表达的可编程设备。

公开(公告)号：US20060235499A1

公开(公告)日：2006-10-19

申请号：US11105791

申请日：2005-04-14

申请人： Ronald Heil ,  Michael Nelson

发明人： Ronald Heil ,  Michael Nelson

IPC分类号： A61N1/05

CPC分类号： A61N1/0575 ,  A61N1/0568

摘要： In one embodiment, the present invention provides a cardiac lead including a fixation member extending from a distal end of the lead. The fixation member includes a coated portion and an uncoated portion. The coating that forms the coated portion includes a biocompatible polymer material and a therapeutic agent. The coating may provide for the delivery of the therapeutic agent directly at the sight of fixation for an extended period of time.

摘要翻译： 在一个实施例中，本发明提供一种心脏引线，其​​包括从引线的远端延伸的固定构件。 固定构件包括涂覆部分和未涂覆部分。 形成涂布部分的涂层包括生物相容的聚合物材料和治疗剂。 涂层可以提供治疗剂直接在固定的时间内延长的时间段。

公开(公告)号：US20050131509A1

公开(公告)日：2005-06-16

申请号：US10738647

申请日：2003-12-16

申请人： Liliana Atanassoska ,  Ronald Heil ,  David Flynn

发明人： Liliana Atanassoska ,  Ronald Heil ,  David Flynn

IPC分类号： A61N1/05

CPC分类号： A61N1/0565 ,  A61N1/0568

摘要： A method includes sandblasting an electrode surface, applying a conductive oxide precursor solution to the electrode surface, and heating the electrode for at least 5 minutes at a temperature between 350 degrees C. and 550 degrees C. to convert the precursor solution into an oxide coating. One method includes applying a composite material including a conductive component and a non-conductive component to an electrode and curing the composite material to form a coating on the electrode. One method includes providing a metallic oxide coating on an electrode surface and applying a galvanostatic treatment to the electrode to increase the effective surface area of the metallic oxide coating.

摘要翻译： 一种方法包括喷镀电极表面，将导电氧化物前体溶液施加到电极表面，并在350摄氏度至550摄氏度之间的温度下将电极加热至少5分钟，以将前体溶液转化为氧化物涂层 。 一种方法包括将包含导电组分和非导电组分的复合材料施加到电极上并固化复合材料以在电极上形成涂层。 一种方法包括在电极表面上提供金属氧化物涂层并对电极施加恒电流处理以增加金属氧化物涂层的有效表面积。

公开(公告)号：US20070191921A1

公开(公告)日：2007-08-16

申请号：US11738251

申请日：2007-04-20

申请人： Qingsheng Zhu ,  Ronald Heil ,  Mudit Jain

发明人： Qingsheng Zhu ,  Ronald Heil ,  Mudit Jain

IPC分类号： A61N1/05

CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61N1/0568

摘要： An apparatus includes an implantable device, such as a chronically implantable device that has a device body. One or more chemical sensors are coupled with the device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.

摘要翻译： 一种装置包括可植入装置，例如具有装置主体的长期可植入装置。 一个或多个化学传感器与装置本体结合。 药物洗脱物质被布置在包括一个或多个化学传感器中的至少一个，直接相邻或接近的位置，其中药物洗脱物质防止在一个或多个化学传感器上的纤维化生长。