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    STABILIZED NUCLEIC ACID DARK QUENCHER-FLUOROPHORE PROBES
    3.
    发明申请
    STABILIZED NUCLEIC ACID DARK QUENCHER-FLUOROPHORE PROBES 有权
    稳定的核酸深色探针 - 荧光探针

    公开(公告)号：US20110282041A1

    公开(公告)日：2011-11-17

    申请号：US13193517

    申请日：2011-07-28

    申请人： Ronald M. Cook ,  Matt Lyttle

    发明人： Ronald M. Cook ,  Matt Lyttle

    IPC分类号： C07H19/10 ,  C07H21/00 ,  C07H19/06

    CPC分类号： C12Q1/6876 ,  C07D219/04 ,  C07H19/06 ,  C07H19/073 ,  C09B31/02

    摘要： The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex or higher order aggregation (e.g., hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g., intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g., alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.

    摘要翻译： 本发明提供了用于合成核酸修饰低聚物的新类固体支持物，以及具有在新载体上方便合成的形式的核酸探针。 示例性的固体支持物包括通过连接体与固体支持物结合的至少一种猝灭剂。 各种示例性实施方案包括稳定其本发明的低聚物是组分的核酸的双链体，三链体或更高级聚集（例如杂交）的部分。 固体支持物的其它组分包括稳定核酸聚集的部分，例如嵌入剂，小槽结合部分，用稳定部分修饰的碱基（例如炔基部分和氟烷基部分）和构象稳定部分，例如描述的那些 在共同拥有的美国专利申请公开No.2007 / 0059752中。

    Stabilized nucleic acid dark quencher-fluorophore probes
    4.
    发明授权
    Stabilized nucleic acid dark quencher-fluorophore probes 有权
    稳定的核酸暗猝灭剂 - 荧光团探针

    公开(公告)号：US08674094B2

    公开(公告)日：2014-03-18

    申请号：US13193517

    申请日：2011-07-28

    申请人： Ronald M. Cook ,  Matt Lyttle

    发明人： Ronald M. Cook ,  Matt Lyttle

    IPC分类号： C07F9/6512 ,  C07F9/655

    CPC分类号： C12Q1/6876 ,  C07D219/04 ,  C07H19/06 ,  C07H19/073 ,  C09B31/02

    摘要： The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex or higher order aggregation (e.g., hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g., intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g., alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.

    摘要翻译： 本发明提供了用于合成核酸修饰低聚物的新类固体支持物，以及具有在新载体上方便合成的形式的核酸探针。 示例性的固体支持物包括通过连接体与固体支持物结合的至少一种猝灭剂。 各种示例性实施方案包括稳定其本发明的低聚物是组分的核酸的双链体，三链体或更高级聚集（例如杂交）的部分。 固体支持物的其它组分包括稳定核酸聚集的部分，例如嵌入剂，小槽结合部分，用稳定部分修饰的碱基（例如炔基部分和氟烷基部分）和构象稳定部分，例如描述的那些 在共同拥有的美国专利申请公开No.2007 / 0059752中。

    Stabilized nucleic acid dark quencher-fluorophore probes
    5.
    发明授权
    Stabilized nucleic acid dark quencher-fluorophore probes 有权
    稳定的核酸暗猝灭剂 - 荧光团探针

    公开(公告)号：US08466266B2

    公开(公告)日：2013-06-18

    申请号：US12416901

    申请日：2009-04-01

    申请人： Ronald M. Cook ,  Matt Lyttle

    发明人： Ronald M. Cook ,  Matt Lyttle

    IPC分类号： C07C245/02

    CPC分类号： C12Q1/6876 ,  C07D219/04 ,  C07H19/06 ,  C07H19/073 ,  C09B31/02

    摘要： The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex or higher order aggregation (e.g., hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g., intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g., alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.

    摘要翻译： 本发明提供了用于合成核酸修饰低聚物的新类固体支持物，以及具有在新载体上方便合成的形式的核酸探针。 示例性的固体支持物包括通过连接体与固体支持物结合的至少一种猝灭剂。 各种示例性实施方案包括稳定其本发明的低聚物是组分的核酸的双链体，三链体或更高级聚集（例如杂交）的部分。 固体支持物的其它组分包括稳定核酸聚集的部分，例如嵌入剂，小槽结合部分，用稳定部分修饰的碱基（例如炔基部分和氟烷基部分）和构象稳定部分，例如描述的那些 在共同拥有的美国专利申请公开No.2007 / 0059752中。

    STABILIZED NUCLEIC ACID DARK QUENCHER-FLUOROPHORE PROBES
    6.
    发明申请
    STABILIZED NUCLEIC ACID DARK QUENCHER-FLUOROPHORE PROBES 有权
    稳定的核酸深色探针 - 荧光探针

    公开(公告)号：US20090259030A1

    公开(公告)日：2009-10-15

    申请号：US12416901

    申请日：2009-04-01

    申请人： Ronald M. Cook ,  Matt Lyttle

    发明人： Ronald M. Cook ,  Matt Lyttle

    IPC分类号： C07C245/02 ,  C07H21/00 ,  C07D241/46

    CPC分类号： C12Q1/6876 ,  C07D219/04 ,  C07H19/06 ,  C07H19/073 ,  C09B31/02

    摘要： The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex or higher order aggregation (e.g., hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g., intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g., alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.

    摘要翻译： 本发明提供了用于合成核酸修饰低聚物的新类固体支持物，以及具有在新载体上方便合成的形式的核酸探针。 示例性的固体支持物包括通过连接体与固体支持物结合的至少一种猝灭剂。 各种示例性实施方案包括稳定其本发明的低聚物是组分的核酸的双链体，三链体或更高级聚集（例如杂交）的部分。 固体支持物的其它组分包括稳定核酸聚集的部分，例如嵌入剂，小槽结合部分，用稳定部分修饰的碱基（例如炔基部分和氟烷基部分）和构象稳定部分，例如描述的那些 在共同拥有的美国专利申请公开No.2007 / 0059752中。