公开(公告)号：US5925229A

公开(公告)日：1999-07-20

申请号：US642296

申请日：1996-05-03

申请人： Ronald M. Krauss ,  Patricia J. Blanche ,  Joseph Orr

发明人： Ronald M. Krauss ,  Patricia J. Blanche ,  Joseph Orr

IPC分类号： G01N27/447 ,  G01N27/26

CPC分类号： G01N27/44773 ,  G01N27/44747

摘要： A variable rate density gradient electrophoric gel is described which separate LDL subfractions with the precision of ultracentrifugation techniques. Also, an innovative bottom inlet mixing chamber particularly useful for producing these gels is described.

摘要翻译： 描述了可变速率密度梯度电泳凝胶，其以超速离心技术的精度分离LDL亚级分。 此外，描述了特别可用于制造这些凝胶的创新的底部入口混合室。

公开(公告)号：US07699788B2

公开(公告)日：2010-04-20

申请号：US10973815

申请日：2004-10-25

申请人： Kai Kuck ,  Joseph Orr ,  Lara Brewer

发明人： Kai Kuck ,  Joseph Orr ,  Lara Brewer

IPC分类号： A61B5/00

CPC分类号： A61B5/0836 ,  A61B5/091

摘要： Methods for noninvasively measuring, or estimating, functional residual capacity or effective lung volume include obtaining carbon dioxide and flow measurements at or near the mouth of a subject. Such measurements are obtained during baseline breathing and during and shortly after inducement of a change in the subject's effective ventilation. The obtained measurements are evaluated to determine the amount of time required for exhaled carbon dioxide levels to return to normal—effectively an evaluation of carbon dioxide “washout” from the subject's lungs. Conversely, carbon dioxide and flow measurements may be evaluated to determine the amount of time it takes carbon dioxide to “wash in,” or reach peak levels within, the lungs of the subject following the change in the subject's effective ventilation. Apparatus for effective such methods are also disclosed.

摘要翻译： 用于非侵入性测量或估计功能残余容量或有效肺体积的方法包括在受试者的嘴部或附近获得二氧化碳和流量测量。 在基线呼吸期间和受试者的有效通气改变之后及之后不久，获得这些测量。 评估所获得的测量值，以确定呼出二氧化碳水平回复正常有效地评估受试者肺部二氧化碳“冲洗”所需的时间。 相反，可以评估二氧化碳和流量测量，以确定在受试者有效通气改变之后二氧化碳“洗涤”所需的时间，或达到受试者肺部内的峰值水平。 还公开了用于有效的这种方法的装置。

公开(公告)号：US20060111749A1

公开(公告)日：2006-05-25

申请号：US11157218

申请日：2005-06-20

申请人： Dwayne Westenskow ,  Joseph Orr ,  Noah Syroid ,  Daniel Snell ,  James Agutter ,  Frank Drews ,  Srinath Lingutta ,  Santosh Balakrishnan ,  Kai Kuck ,  Lara Brewer

发明人： Dwayne Westenskow ,  Joseph Orr ,  Noah Syroid ,  Daniel Snell ,  James Agutter ,  Frank Drews ,  Srinath Lingutta ,  Santosh Balakrishnan ,  Kai Kuck ,  Lara Brewer

IPC分类号： A61N1/39

CPC分类号： G09B19/00 ,  A61M16/0051 ,  A61M16/024 ,  A61M16/1055 ,  A61M16/106 ,  A61M2205/502 ,  A61M2205/581 ,  A61M2205/583 ,  A61M2230/04 ,  A61M2230/205 ,  A61M2230/42 ,  A61M2230/432 ,  A61N1/39 ,  A61N1/3993 ,  G09B23/288

摘要： A basic life support system (BLSS) includes a processing element and an output element, such as a display screen or an audio output element, for providing an individual with real-time instructions on providing emergency medical care to a patient until paramedics or other healthcare professionals arrive to take over care for the patient. The instructions may be provided as graphics, including animations, as text, audibly, or as a combination of visible and audible elements. The BLSS may be configured for providing emergency medical care to individuals who have suffered from ventricular fibrillation. Accordingly, the BLSS may also include a defibrillation apparatus, an air or oxygen supply, a respiratory interface, one or more sensors, or a combination thereof.

摘要翻译： 基本生命支持系统（BLSS）包括处理元件和诸如显示屏或音频输出元件的输出元件，用于向个人提供关于向患者提供紧急医疗护理的实时指令，直到护理人员或其他保健 专业人员到医院接受治疗。 指令可以作为图形，包括动画，文本，听觉地或作为可见和可听元素的组合来提供。 BLSS可能被配置为为患有心室颤动的个人提供紧急医疗。 因此，BLSS还可以包括除颤装置，空气或氧气供应，呼吸界面，一个或多个传感器或其组合。

公开(公告)号：US20060004297A1

公开(公告)日：2006-01-05

申请号：US11150378

申请日：2005-06-10

申请人： Joseph Orr ,  Kai Kuck ,  Lara Brewer

发明人： Joseph Orr ,  Kai Kuck ,  Lara Brewer

IPC分类号： A61B5/08

CPC分类号： A61B5/029 ,  A61B5/082 ,  A61B5/083 ,  A61B5/0836 ,  A61B5/087 ,  A61B5/091 ,  G01N33/497

摘要： Methods for noninvasively evaluating indicators of cardio-pulmonary performance of a subject, such as cardiac output, pulmonary capillary blood flow, and blood carbon dioxide content, include obtaining data of an expiratory carbon dioxide signal and comparing data generated by an algorithmic lung model to the data of the expiratory carbon dioxide signal of a subject. The variables that are input into the algorithmic lung model are adjusted until the data generated thereby reflects that of the measured expiratory carbon dioxide signal with a desired degree of accuracy. Once the algorithmic lung model replicates the data of the measured expiratory carbon dioxide signal with the desired degree of accuracy, one or more of the input values may be used to determine one or more of the cardiac output, pulmonary capillary blood flow, or a blood gas content of the subject from which the expiratory carbon dioxide signal was obtained.

摘要翻译： 用于非侵入性评估受试者的心肺功能指标（如心输出量，肺毛细血管血流量和血二氧化碳含量）的方法包括获得呼气二氧化碳信号的数据，并将算法肺模型产生的数据与 受检者呼气二氧化碳信号的数据。 调整输入到算法肺模型中的变量，直到由此产生的数据以所需的准确程度反映测量的呼气二氧化碳信号的数据。 一旦算法肺模型以期望的准确度复制测量的呼气二氧化碳信号的数据，则一个或多个输入值可用于确定心输出量，肺毛细血管血流量或血液中的一个或多个 获得呼气二氧化碳信号的对象的气体含量。

公开(公告)号：US08800561B2

公开(公告)日：2014-08-12

申请号：US13600952

申请日：2012-08-31

申请人： Joseph Orr ,  Dwayne Westenskow ,  Derek Sakata

发明人： Joseph Orr ,  Dwayne Westenskow ,  Derek Sakata

IPC分类号： A62B7/10 ,  A62B19/00 ,  A62B23/02 ,  A61M16/00

CPC分类号： A61M16/009 ,  A61M16/0093 ,  A61M16/0816 ,  A61M16/105 ,  A61M16/1065 ,  A61M16/107

摘要： Systems, methods, and apparatus for removing volatile anesthetics from an anesthesia or ventilation system to minimize the effects of malignant hyperthermia in susceptible patients. According to one aspect of the present invention, a system for removing volatile anesthetics is provided. A first filter component placed in fluid communication with an inspiratory limb of an anesthesia or ventilation system such that volatile anesthetics will pass through the first filter component during operation of the anesthesia or ventilation system. A second filter component is operably coupled to the expiration port of the anesthesia or ventilation system such that gases passing through the expiratory limb of the anesthesia or ventilation system pass through the second filter component. The first filter component and second filter component are adapted to effectively remove volatile anesthetics passing through the respective filters.

摘要翻译： 用于从麻醉或通气系统中去除挥发性麻醉剂的系统，方法和装置，以最小化易感患者的恶性高热的影响。 根据本发明的一个方面，提供了一种用于除去挥发性麻醉剂的系统。 第一过滤器部件与麻醉或通气系统的吸气肢流体连通，使得挥发性麻醉剂在麻醉或通气系统的操作期间将通过第一过滤器部件。 第二过滤器部件可操作地联接到麻醉或通气系统的呼气端口，使得穿过麻醉或通气系统的呼气肢体的气体通过第二过滤器部件。 第一过滤器部件和第二过滤器部件适于有效地去除通过各个过滤器的挥发性麻醉剂。

公开(公告)号：US20120325213A1

公开(公告)日：2012-12-27

申请号：US13600952

申请日：2012-08-31

申请人： Joseph Orr ,  Dwayne Westenskow ,  Derek Sakata

发明人： Joseph Orr ,  Dwayne Westenskow ,  Derek Sakata

IPC分类号： A61M16/01 ,  A61M16/00

CPC分类号： A61M16/009 ,  A61M16/0093 ,  A61M16/0816 ,  A61M16/105 ,  A61M16/1065 ,  A61M16/107

摘要： Systems, methods, and apparatus for removing volatile anesthetics from an anesthesia or ventilation system to minimize the effects of malignant hyperthermia in susceptible patients. According to one aspect of the present invention, a system for removing volatile anesthetics is provided. A first filter component placed in fluid communication with an inspiratory limb of an anesthesia or ventilation system such that volatile anesthetics will pass through the first filter component during operation of the anesthesia or ventilation system. A second filter component is operably coupled to the expiration port of the anesthesia or ventilation system such that gases passing through the expiratory limb of the anesthesia or ventilation system pass through the second filter component. The first filter component and second filter component are adapted to effectively remove volatile anesthetics passing through the respective filters.

摘要翻译： 用于从麻醉或通气系统中去除挥发性麻醉剂的系统，方法和装置，以最小化易感患者的恶性高热的影响。 根据本发明的一个方面，提供了一种用于除去挥发性麻醉剂的系统。 第一过滤器部件与麻醉或通气系统的吸气肢流体连通，使得挥发性麻醉剂在麻醉或通气系统的操作期间将通过第一过滤器部件。 第二过滤器部件可操作地联接到麻醉或通气系统的呼气端口，使得穿过麻醉或通气系统的呼气肢体的气体通过第二过滤器部件。 第一过滤器部件和第二过滤器部件适于有效地去除通过各个过滤器的挥发性麻醉剂。

公开(公告)号：US20100269828A1

公开(公告)日：2010-10-28

申请号：US12431644

申请日：2009-04-28

申请人： Joseph Orr ,  Dwayne Westenskow ,  Derek Sakata

发明人： Joseph Orr ,  Dwayne Westenskow ,  Derek Sakata

IPC分类号： A61M16/00

CPC分类号： A61M16/009 ,  A61M16/0093 ,  A61M16/0816 ,  A61M16/105 ,  A61M16/1065 ,  A61M16/107

摘要： Systems, methods, and apparatus for removing volatile anesthetics from an anesthesia or ventilation system to minimize the effects of malignant hyperthermia in susceptible patients. According to one aspect of the present invention, a system for removing volatile anesthetics is provided. A first filter component placed in fluid communication with an inspiratory limb of an anesthesia or ventilation system such that volatile anesthetics will pass through the first filter component during operation of the anesthesia or ventilation system. A second filter component is operably coupled to the expiration port of the anesthesia or ventilation system such that gases passing through the expiratory limb of the anesthesia or ventilation system pass through the second filter component. The first filter component and second filter component are adapted to effectively remove volatile anesthetics passing through the respective filters.

摘要翻译： 用于从麻醉或通气系统中去除挥发性麻醉剂的系统，方法和装置，以最小化易感患者的恶性高热的影响。 根据本发明的一个方面，提供了一种用于除去挥发性麻醉剂的系统。 第一过滤器部件与麻醉或通气系统的吸气肢流体连通，使得挥发性麻醉剂在麻醉或通气系统的操作期间将通过第一过滤器部件。 第二过滤器部件可操作地联接到麻醉或通气系统的呼气端口，使得穿过麻醉或通气系统的呼气肢体的气体通过第二过滤器部件。 第一过滤器部件和第二过滤器部件适于有效地去除通过各个过滤器的挥发性麻醉剂。

公开(公告)号：US20060129054A1

公开(公告)日：2006-06-15

申请号：US11346913

申请日：2006-02-03

申请人： Joseph Orr ,  Michael Jaffe ,  Scott Kofoed ,  Dwayne Westenskow

发明人： Joseph Orr ,  Michael Jaffe ,  Scott Kofoed ,  Dwayne Westenskow

IPC分类号： A61B5/08 ,  G01N33/497 ,  F41A19/00

CPC分类号： A61B5/029 ,  A61B5/0836 ,  A61M16/0045 ,  A61M16/0833 ,  A61M2016/0036 ,  A61M2230/432 ,  G01N33/004 ,  Y02A50/243

摘要： Methods for non-invasively determining the cardiac output or pulmonary capillary blood flow of a subject include monitoring the subject's respiration during two ventilatory states. Such a method may include determining parameters of at least one of the ventilatory states based on one or more characteristics of the subject. Data obtained from monitoring the subject's respiration, such as an amount of gas present in exhaled gases and respiratiory flow, may be used to estimate respiratory or blood gas parameters, such as an amount of gas exchanged between blood and gases in the subject's lungs or an indicator of a content of the gas in the subject's blood.

摘要翻译： 非侵入性地确定受试者的心输出量或肺毛细血管血流量的方法包括在两个通气状态期间监测受试者的呼吸。 这种方法可以包括基于受试者的一个或多个特征确定至少一个通气状态的参数。 通过监测受试者的呼吸获得的数据，例如呼出气体和呼吸气流中存在的气体的量可用于估计呼吸或血液气体参数，例如受试者的肺中血液和气体之间交换的气体量 对象血液中气体含量的指标。

公开(公告)号：US20060000256A1

公开(公告)日：2006-01-05

申请号：US11157182

申请日：2005-06-20

申请人： Joseph Orr ,  Scott Kofoed

发明人： Joseph Orr ,  Scott Kofoed

IPC分类号： G01N7/00

CPC分类号： G01N1/2247 ,  G01N33/0006 ,  G01N35/00712 ,  G01N2001/2244

摘要： A test system for assessing the performance of an analyzer for a gas or an anesthetic agent includes a source of a calibration gas mixture, a valve for controlling flow of gas from the source, a low-pressure tube, a sample tube in communication with the low-pressure tube, and a connector for assembling the analyzer to the test system. The test system may also include a valve for diverting ambient air into the sample tube instead of the calibration gas mixture. Additionally, the test system may include one or more of a barometer, a flow meter, an analyzer for gas or anesthetic agents, a flow restriction system, and a relatively high pressure source. Methods for testing analyzers are also disclosed.

摘要翻译： 用于评估气体或麻醉剂分析仪的性能的测试系统包括校准气体混合物的源，用于控制来自源的气体流的阀，低压管，与 低压管和用于将分析器组装到测试系统的连接器。 测试系统还可以包括用于将环境空气转移到样品管中而不是校准气体混合物的阀。 此外，测试系统可以包括气压计，流量计，气体或麻醉剂分析器，流量限制系统和相对高压力源中的一个或多个。 还公开了测试分析仪的方法。

公开(公告)号：US08485187B2

公开(公告)日：2013-07-16

申请号：US12431644

申请日：2009-04-28

申请人： Joseph Orr ,  Dwayne Westenskow ,  Derek Sakata

发明人： Joseph Orr ,  Dwayne Westenskow ,  Derek Sakata

IPC分类号： A62B7/10 ,  A62B19/00 ,  A62B23/02

CPC分类号： A61M16/009 ,  A61M16/0093 ,  A61M16/0816 ,  A61M16/105 ,  A61M16/1065 ,  A61M16/107

摘要： Systems, methods, and apparatus for removing volatile anesthetics from an anesthesia or ventilation system to minimize the effects of malignant hyperthermia in susceptible patients. According to one aspect of the present invention, a system for removing volatile anesthetics is provided. A first filter component placed in fluid communication with an inspiratory limb of an anesthesia or ventilation system such that volatile anesthetics will pass through the first filter component during operation of the anesthesia or ventilation system. A second filter component is operably coupled to the expiration port of the anesthesia or ventilation system such that gases passing through the expiratory limb of the anesthesia or ventilation system pass through the second filter component. The first filter component and second filter component are adapted to effectively remove volatile anesthetics passing through the respective filters.

摘要翻译： 用于从麻醉或通气系统中去除挥发性麻醉剂的系统，方法和装置，以最小化易感患者的恶性高热的影响。 根据本发明的一个方面，提供了一种用于除去挥发性麻醉剂的系统。 第一过滤器部件与麻醉或通气系统的吸气肢流体连通，使得挥发性麻醉剂在麻醉或通气系统的操作期间将通过第一过滤器部件。 第二过滤器部件可操作地联接到麻醉或通气系统的呼气端口，使得穿过麻醉或通气系统的呼气肢体的气体通过第二过滤器部件。 第一过滤器部件和第二过滤器部件适于有效地去除通过各个过滤器的挥发性麻醉剂。