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    Internal gelation method for forming multilayer microspheres and product thereof
    1.
    发明授权
    Internal gelation method for forming multilayer microspheres and product thereof 失效
    用于形成多层微球体的内部凝胶化方法及其制备方法

    公开(公告)号：US5744337A

    公开(公告)日：1998-04-28

    申请号：US587798

    申请日：1995-12-26

    申请人： Ronald R. Price ,  Mariam Monshipouri

    发明人： Ronald R. Price ,  Mariam Monshipouri

    IPC分类号： A23L1/00 ,  A23L1/0532 ,  A23L1/054 ,  A23L1/22 ,  A61K9/16 ,  B01J13/18 ,  C12N11/04 ,  C12N11/10

    CPC分类号： C12N11/04 ,  A23L27/72 ,  A23L29/256 ,  A23L29/272 ,  A23P10/30 ,  A61K9/1652 ,  B01J13/18 ,  Y10S435/821

    摘要： Microspheres, of controllable shape and size, encapsulating active ingredients, are made by the internally controlled gelation of an emulsion including a water-soluble polysaccharide, a salt of a di- or trivalent metal cation, a polymerization inhibitor, water, a water-immiscible solvent (as a non-aqueous phase), and the active ingredient. The components of the aqueous phase, containing the water-soluble polysaccharide, polymerization inhibitor, di- or trivalent metal salt, active substance, and water, are blended together. This aqueous phase is then gradually mixed with the oil phase and agitated to form an emulsion. After sufficient time for solidification, the emulsion is broken and the resulting microspheres are collected. The active ingredient may be various substances, including live microorganisms.

    摘要翻译： 通过内部控制的包含水溶性多糖，二价或三价金属阳离子的盐，阻聚剂，水，与水不混溶的多糖的乳液的内部控制的凝胶化，可以形成包封活性成分的微球体 溶剂（作为非水相）和活性成分。 含有水溶性多糖，阻聚剂，二价或三价金属盐，活性物质和水的水相成分混合在一起。 然后将该水相与油相逐渐混合并搅拌形成乳液。 在足够的固化时间之后，乳液被破坏并收集所得微球体。 活性成分可以是各种物质，包括活微生物。

    Method of forming hydrogel particles having a controlled size using liposomes
    3.
    发明授权
    Method of forming hydrogel particles having a controlled size using liposomes 失效
    使用脂质体形成具有受控尺寸的水凝胶颗粒的方法

    公开(公告)号：US5626870A

    公开(公告)日：1997-05-06

    申请号：US556849

    申请日：1995-11-02

    申请人： Mariam Monshipouri ,  Alan S. Rudolph

    发明人： Mariam Monshipouri ,  Alan S. Rudolph

    IPC分类号： A61K9/127 ,  A61K47/48 ,  B01J2/00 ,  B01J2/06 ,  B01J13/02 ,  B01J13/04

    CPC分类号： A61K47/48784 ,  A61K47/48876 ,  A61K47/48923 ,  A61K9/127 ,  B01J13/02 ,  B01J13/04 ,  B01J2/003 ,  B01J2/06 ,  Y10T428/2984

    摘要： A method of fabricating hydrogel particles within liposomes, which entails: a) encapsulating an effective amount of each of one or more hydrogel substances and one or more release agents in liposomes in a liquid medium, b) removing any unencapsulated hydrogel substances and release agents from the liquid medium, c) adding initiator to the liquid medium and into the liposomes, thereby initiating reaction of the one or more hydrogel substances, whereby hydrogel particles are formed in the liposomes, and d) removing any extra-liposomal initiator from the medium.

    摘要翻译： 一种在脂质体内制备水凝胶颗粒的方法，其包括：a）将有效量的一种或多种水凝胶物质和一种或多种脱模剂中的每一种在脂质体中包封在液体介质中，b）将任何未包封的水凝胶物质和脱模剂从 液体介质，c）将引发剂加入到液体介质中并进入脂质体中，从而引发一种或多种水凝胶物质的反应，由此在脂质体中形成水凝胶颗粒，和d）从介质中除去任何脂外体引发剂。