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公开(公告)号：US08062908B2
公开(公告)日：2011-11-22
申请号：US12350488
申请日：2009-01-08
IPC分类号： G01N33/53
CPC分类号： A61B10/0051 , A61B2010/0006 , G01N30/90 , Y10S435/974 , Y10S436/81
摘要： A method for rapid collection and assay of oral fluids is disclosed. The method comprising the steps of: (a) placing an assay device into an oral cavity, (b) removing said assay device from said oral cavity; and (c) determining the presence or absence of at least one analyte. The assay device used in the method comprises: (i) an assay portion housing an immunochrornatographic lateral flow assay strip, the lateral flow assay strip containing at least one reagent selected from an antigen and an antibody that is used to detect one of the presence or absence of at least one analyte in a fluid; (ii) a neck portion extending from the assay portion, the neck portion forming a channel for delivery of fluid to said assay strip and the channel being defined by a first, narrow part proximal to the assay portion and a second part including an opening for receiving the oral fluid, wherein the second part includes a channel width that is substantially wider than the channel width at the narrow end; (iii) a collection strip in fluid communication with the lateral flow assay strip, the collection strip having a first portion disposed within the channel and a second portion protruding outwardly from the neck portion opening; and (iv) a blocking strip coupled between and in flow communication with the lateral flow assay strip and the collection strip.
摘要翻译： 公开了一种用于快速收集和测定口腔液体的方法。 该方法包括以下步骤：（a）将测定装置放入口腔，（b）从所述口腔中除去所述测定装置; 和（c）确定至少一种分析物的存在或不存在。 该方法中使用的测定装置包括：（i）容纳免疫色谱横向测定条的测定部分，所述侧流测定条含有至少一种选自抗原和抗体的试剂，所述试剂用于检测其中的一种存在或 在流体中不存在至少一种分析物; （ii）从分析部分延伸的颈部，颈部形成用于将流体输送到所述测定条的通道，并且所述通道由靠近测定部分的第一窄部分限定，第二部分包括用于 接收所述口腔流体，其中所述第二部分包括基本上宽于所述狭窄端处的通道宽度的通道宽度; （iii）与所述侧流测定条流体连通的收集条，所述收集条具有设置在所述通道内的第一部分和从所述颈部开口向外突出的第二部分; 和（iv）连接在侧流测定条和收集条之间并与其流动连通的阻挡条。
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公开(公告)号：US20100239458A1
公开(公告)日：2010-09-23
申请号：US12544333
申请日：2009-08-20
CPC分类号： G01N33/558 , B01L3/5023 , B01L2300/0825 , B01L2300/12 , B01L2400/0406 , G01N30/91
摘要： An apparatus and process for transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. A lateral chromatographic strip is placed within a cavity defined in a housing. The lateral chromatography strip extends within the cavity and is disposed along the housing to an inspection site. At least one inspection site to the lateral chromate phic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. This porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids. The porous wick material readily releases oral fluid to the lateral chromatographic strip. Prevention of reverse flow to the oral cavity from the lateral chromatographic strip naturally occurs due to the circuitous flow path of the porous wick material. By observing the lateral chromatographic strip while the entire test device is in the mouth immediate test results are obtained.
摘要翻译： 公开了一种用于将水性流体从口腔输送到用于测试的侧向色谱条的装置和方法。 侧向色谱条被放置在限定在壳体中的空腔内。 侧向色谱条在腔内延伸并且沿着壳体设置到检查位置。 提供至少一个侧向铬酸盐条带的检查部位，以便检查侧向色谱条上的选定部位以进行测试。 多孔芯材料在一端从外壳突出到外壳的收集位置，并在另一端与侧向色谱条连通。 该多孔芯材料具有颗粒结构，该颗粒吸附口腔液体水以将流体从嘴部输送到侧向色谱条而无需实质的吸收。 多孔芯材料的颗粒被结合在一起以限定用于要输送的口腔液体的流动的连续间隙体积，并被处理为与吸附的口腔液体亲水。 多孔芯材料容易地将口腔液体释放到侧向色谱条上。 由于多孔芯材料的迂回流动路径，防止从侧向色谱条带逆向流入口腔。 通过在整个测试装置处于口中立即测试结果，观察侧向色谱条。
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公开(公告)号：US07192555B2
公开(公告)日：2007-03-20
申请号：US09973956
申请日：2001-10-11
IPC分类号： G01N33/558
CPC分类号： A61B10/0051 , A61B2010/0006 , G01N30/90 , Y10S435/974 , Y10S436/81 , Y10T436/25
摘要： A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. The porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids. The porous wick material readily releases oral fluid to the lateral chromatographic strip. Prevention of reverse flow to the oral cavity from the lateral chromatographic strip naturally occurs due to the circuitous flow path of the porous wick material. A bite plate is coupled to the housing and insertable between the teeth of the patient to position the porous wick in the oral cavity for collecting the oral fluid. The bite plate is typically held in place by the occlusal force of the teeth, preferably the molars and/or the bicuspids, to position the porous wick in the buccal space. By observing the lateral chromatographic strip while the test device is in the mouth immediate test results are obtained.
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公开(公告)号：US07541194B2
公开(公告)日：2009-06-02
申请号：US11653916
申请日：2007-01-17
IPC分类号： G01N33/53
CPC分类号： A61B10/0051 , A61B2010/0006 , G01N30/90 , Y10S435/974 , Y10S436/81 , Y10T436/25
摘要： A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. The porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids. The porous wick material readily releases oral fluid to the lateral chromatographic strip. Prevention of reverse flow to the oral cavity from the lateral chromatographic strip naturally occurs due to the circuitous flow path of the porous wick material. A bite plate is coupled to the housing and insertable between the teeth of the patient to position the porous wick in the oral cavity for collecting the oral fluid. The bite plate is typically held in place by the occlusal force of the teeth, preferably the molars and/or the bicuspids, to position the porous wick in the buccal space. By observing the lateral chromatographic strip while the test device is in the mouth immediate test results are obtained.
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公开(公告)号：US06210677B1
公开(公告)日：2001-04-03
申请号：US09112065
申请日：1998-07-07
申请人： Robert C. Bohannon
发明人： Robert C. Bohannon
IPC分类号： A61K39385
CPC分类号： A61K39/0013 , A61K47/61 , A61K47/646 , A61K2039/6037 , A61K2039/6081 , Y02A50/466
摘要： A method to reduce the physiologic effects of drugs in vivo by inducing specific anti-drug antibodies using drugs conjugated to carrier molecules so as to reduce a drug's toxicity and its physiologic effects upon the recipient. This method includes the treatment and prophylactic prevention of drug abuse, specifically for cocaine and nicotine, and to help reduce the toxic effects of drugs, such as anti-neoplastics.
摘要翻译： 通过使用与载体分子缀合的药物诱导特异性抗药物抗体以降低药物的毒性和对接受者的生理作用来降低药物在体内的生理作用的方法。 该方法包括治疗和预防药物滥用，特别是可卡因和尼古丁，并有助于降低药物如抗肿瘤剂的毒性作用。
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公开(公告)号：US5763158A
公开(公告)日：1998-06-09
申请号：US796772
申请日：1997-02-06
申请人： Robert C. Bohannon
发明人： Robert C. Bohannon
IPC分类号： G01N33/533 , G01N33/535 , G01N33/543 , C12Q1/001 , C12Q1/02 , C12Q1/54 , G01N33/53
CPC分类号： G01N33/535 , G01N33/533 , G01N33/54366 , Y10S435/968
摘要： A method for simultaneously testing a sample for the presence of multiple rget antigens or antibodies in the sample, which comprises presenting the sample to a plurality of different binding sites, wherein at least two of the sites are binding sites for different known target antigens or antibodies, each known binding site is composed of at least one molecule of a ligand-enzyme complex attached to a support, and the ligand-enzyme complex is a ligand attached to an enzyme in proximity to the enzyme's active site such that the enzymatic activity of the ligand-enzyme complex is changed when the target antibody or antigen is present in the sample. The ligand-enzyme complex embraces nonenzymatic reporter molecules such as electrochemiluminescent compounds. The method also includes assaying each binding site for a change in enzymatic or other reporter activity compared to a control value. A device for performing simultaneous detection of multiple target antigens or antibodies is also disclosed.
摘要翻译： 一种用于同时测试样品中样品中存在多种靶抗原或抗体的方法，其包括将样品呈递到多个不同的结合位点，其中至少两个位点是不同已知靶抗原或抗体的结合位点 ，每个已知的结合位点由连接于载体的配体 - 酶复合物的至少一个分子组成，配体 - 酶复合物是与酶活性位点附近的酶连接的配体，使得酶活性 当靶抗体或抗原存在于样品中时，配体 - 酶复合物发生变化。 配体 - 酶复合物包含非酶报道分子如电化学发光化合物。 该方法还包括测定每个结合位点，以便与对照值相比酶或其他报告物活性的变化。 还公开了用于同时检测多种靶抗原或抗体的装置。
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公开(公告)号：US20110300531A1
公开(公告)日：2011-12-08
申请号：US13179333
申请日：2011-07-08
申请人： Robert C. Bohannon
发明人： Robert C. Bohannon
CPC分类号： G01N33/558
摘要： Disclosed are methods and apparatus useful for determining the presence or absence of one or more analytes in a liquid sample, such as a biological or environmental sample. In some embodiments, the method can use an indirect competitive immunochromatographic test strip.
摘要翻译： 公开了可用于确定液体样品如生物或环境样品中一种或多种分析物的存在或不存在的方法和装置。 在一些实施方案中，该方法可以使用间接竞争性免疫色谱测试条。
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公开(公告)号：US4421829A
公开(公告)日：1983-12-20
申请号：US404141
申请日：1982-08-02
申请人： Robert C. Bohannon
发明人： Robert C. Bohannon
IPC分类号： H01M8/22
CPC分类号： H01M8/222
摘要： A powerful hydrogen azide-oxygen fuel cell can be obtained by passing an aqueous solution of Hydrogen Azide (not to exceed 30% by weight) and Sodium Sulphate over a platinized electrode which forms the anode (-) of the fuel cell. Oxidation takes place at the cathode (+) by the introduction of Oxygen over a platinized electrode.The azide (N.sub.3) radical looses electrons and forms gaseous nitrogen while the oxygen atom picks up the electrons, in the presence of platinum, and forms water with the surplus hydrogen atoms (H.sup.+) present. The measured cell voltage is 5 volts.
摘要翻译： 通过使叠氮化氢水溶液（不超过30重量％）和硫酸钠水溶液在形成燃料电池的阳极（ - ）的铂电极上，可获得强大的叠氮化氢燃料电池。 通过在镀铂电极上引入氧气在阴极（+）进行氧化。 叠氮化物（N 3）自由基失去电子并形成气态氮，而在铂的存在下氧原子吸收电子，并形成具有剩余氢原子（H +）的水。 测得的电池电压为5伏。
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公开(公告)号：US20100015172A1
公开(公告)日：2010-01-21
申请号：US12486535
申请日：2009-06-17
申请人： Robert C. Bohannon
发明人： Robert C. Bohannon
IPC分类号： A61K39/00
CPC分类号： A61K39/0013 , A61K47/61 , A61K47/646 , A61K2039/6037 , A61K2039/6081 , Y02A50/466
摘要： A method to reduce the physiologic effects of drugs in vivo by inducing specific anti-drug antibodies using drugs conjugated to carrier molecules so as to reduce a drug's toxicity and its physiologic effects upon the recipient. This method includes the treatment and prophylactic prevention of drug abuse, specifically for cocaine and nicotine, and to help reduce the toxic effects of drugs, such as anti-neoplastics.
摘要翻译： 通过使用与载体分子缀合的药物诱导特异性抗药物抗体以降低药物的毒性和对接受者的生理作用来降低药物在体内的生理作用的方法。 该方法包括治疗和预防药物滥用，特别是可卡因和尼古丁，并有助于降低药物如抗肿瘤剂的毒性作用。
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公开(公告)号：US20090191648A1
公开(公告)日：2009-07-30
申请号：US12378368
申请日：2009-02-12
申请人： Robert C. Bohannon
发明人： Robert C. Bohannon
IPC分类号： G01N33/543
CPC分类号： G01N33/558
摘要： Disclosed are methods and apparatus useful for determining the presence or absence of one or more analytes in a liquid sample, such as a biological or environmental sample. In some embodiments, the method can use an indirect competitive immunochromatographic test strip.
摘要翻译： 公开了可用于确定液体样品如生物或环境样品中一种或多种分析物的存在或不存在的方法和装置。 在一些实施方案中，该方法可以使用间接竞争性免疫色谱测试条。
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