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1.发明申请METHODS AND COMPOSITIONS FOR TREATING DISORDERS ASSOCIATED WITH HYPERACTIVE IMMUNE SYSTEM 审中-公开用于治疗与高血压免疫系统相关的疾病的方法和组合物公开(公告)号：US20130295111A1
公开(公告)日：2013-11-07
申请号：US13816121
申请日：2011-08-09
IPC分类号： A61K39/395 , A61K31/713
CPC分类号： A61K39/3955 , A61K31/00 , A61K31/713 , A61K2039/505 , C07K16/2866
摘要： The present invention provides methods and compositions for treating disorders associated with hyperactive immune responses. The invention also provides methods for lithibiting activation of CD4+ T cells and/or suppressing proliferation other overactivated T cells (e.g., CD4CD8 T cells). These methods typically involve the administration to the subject a therapeutically effective amount of a compound that lithibits or suppresses IL-7 signaling or IL- 15 signaling.
摘要翻译： 本发明提供了用于治疗与多动症免疫应答相关的疾病的方法和组合物。 本发明还提供了用于刺激CD4 + T细胞的活化和/或抑制其它过度活化的T细胞（例如CD4CD8T细胞）的增殖的方法。 这些方法通常涉及向受治疗者施用治疗有效量的化学物质，其可以利用或抑制IL-7信号传导或IL-15信号传导。
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公开(公告)号：US4342566A
公开(公告)日：1982-08-03
申请号：US123562
申请日：1980-02-22
IPC分类号： G01N33/00 , G01N33/53 , G01N33/536 , G01N33/543 , G01N33/564 , G01N33/54 , G01N33/56
CPC分类号： G01N33/564 , Y10S435/971
摘要： A solid phase assay which specifically detects C-fixing ICs by reacting ICs or aggregated gammaglobulin in normal serum with matrix-bound F(ab')2 anti-C3 and measuring the amount of Ig by radioimmunoassay or enzyme-linking techniques, and means for carrying out the assay are disclosed.
摘要翻译： 通过使正常血清中的IC或聚集的丙种球蛋白与基质结合的F（ab'）2抗C3反应并通过放射免疫测定或酶联免疫技术测量Ig的量来特异性检测C固定IC的固相测定法， 公开了进行该测定。
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公开(公告)号：US4636463A
公开(公告)日：1987-01-13
申请号：US597179
申请日：1984-04-05
IPC分类号： G01N33/53 , A61K39/00 , C07K7/08 , C07K14/005 , C07K14/195 , C07K14/52 , C07K14/54 , C07K14/55 , C07K16/00 , C07K16/24 , C07K17/02 , C07K17/14 , C07K19/00 , C12P21/02 , C12Q1/00 , G01N33/577 , G01N33/68 , G01N33/531 , G01N33/535
CPC分类号： G01N33/6869 , C07K14/55 , C07K16/246 , C07K2317/34 , Y10S435/81 , Y10S435/975 , Y10S436/808 , Y10S436/823 , Y10S930/141
摘要： Chemically synthesized polypeptides containing about 6 to about 40 amino acid residues having amino acid residue sequences that substantially correspond to the amino acid residue sequences of antigenic determinants of interleukin-2, when administered alone or as polymers or as conjugates bound to carriers, induce the production of antibodies of predetermined specificities. The polypeptides and the antibodies produced thereto can be used in diagnostic systems to measure the presence and amount of interleukin-2 and interleukin-2 cell surface receptors or binding sites in an assayed sample.
摘要翻译： 包含约6至约40个氨基酸残基的化学合成的多肽具有氨基酸残基序列，其基本上对应于白细胞介素-2的抗原决定簇的氨基酸残基序列，当单独施用或作为聚合物或结合至载体的缀合物时，诱导产生 的预定特异性抗体。 多肽及其产生的抗体可用于诊断系统，以测量测定样品中白介素-2和白细胞介素-2细胞表面受体或结合位点的存在和数量。
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公开(公告)号：US4960712A
公开(公告)日：1990-10-02
申请号：US213312
申请日：1988-06-30
IPC分类号： G01N33/564
CPC分类号： G01N33/564 , Y10S435/965 , Y10S435/973 , Y10S436/804 , Y10S436/821
摘要： The present invention relates to systems and methods used to assay for particular complement component fragments. The invention can be used to determine the amount of a particular complement component fragment in a sample. The fragment can be fluid phase or bound to an immune complex. Generally, specific binding agents, such as antibodies, directed to the complement component fragments and immune complexes are used in the assay.
摘要翻译： 本发明涉及用于测定特定补体成分片段的系统和方法。 本发明可用于确定样品中特定的补体成分片段的量。 该片段可以是流体相或结合到免疫复合物。 通常，在测定中使用针对补体成分片段和免疫复合物的特异性结合剂，例如抗体。
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