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公开(公告)号：US20060264395A1
公开(公告)日：2006-11-23
申请号：US10553722
申请日：2004-04-15
申请人： Rosanne Crooke , Mark Graham , Kristina Tarbet , Kenneth Dobie
发明人： Rosanne Crooke , Mark Graham , Kristina Tarbet , Kenneth Dobie
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2320/30 , C12N2330/31 , C12N2310/3521
摘要： Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.
摘要翻译： 提供化合物，组合物和方法用于调节载脂蛋白C-III的表达。 组合物包含靶向编码载脂蛋白C-III的核酸的寡核苷酸。 提供了使用这些化合物调节载脂蛋白C-III表达和用于诊断和治疗与载脂蛋白C-III表达相关的疾病的方法。
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公开(公告)号：US20050009088A1
公开(公告)日：2005-01-13
申请号：US10920612
申请日：2004-08-17
申请人： Rosanne Crooke , Mark Graham , Kristina Tarbet , Kenneth Dobie
发明人： Rosanne Crooke , Mark Graham , Kristina Tarbet , Kenneth Dobie
IPC分类号： A61K38/00 , C12N15/113 , C12Q1/68 , A61K48/00 , C07H21/04
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/13 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节载脂蛋白B的表达。组合物包含靶向编码载脂蛋白B的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节载脂蛋白B表达和治疗疾病的方法 与载脂蛋白B的表达相关。
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3.发明申请公开(公告)号：US20050222073A1
公开(公告)日：2005-10-06
申请号：US11071724
申请日：2005-03-02
申请人： C. Bennett , Brett Monia , Rosanne Crooke , Mark Graham , Susan Freier , Pamela Nero , Edward Wancewicz , Nicholas Dean , Lex Cowsert , Kenneth Dobie
发明人： C. Bennett , Brett Monia , Rosanne Crooke , Mark Graham , Susan Freier , Pamela Nero , Edward Wancewicz , Nicholas Dean , Lex Cowsert , Kenneth Dobie
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of thyroid hormone receptor interactor 6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding thyroid hormone receptor interactor 6. Methods of using these compounds for modulation of thyroid hormone receptor interactor 6 expression and for treatment of diseases associated with expression of thyroid hormone receptor interactor 6 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节甲状腺激素受体相互作用体6的表达。该组合物包含靶向编码甲状腺激素受体相互作用核酸的反义化合物，特别是反义寡核苷酸。6.使用这些化合物调节甲状腺激素的方法 受体相互作用6表达和用于治疗与甲状腺激素受体相互作用者6的表达相关的疾病。
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公开(公告)号：US20060019920A1
公开(公告)日：2006-01-26
申请号：US11179128
申请日：2005-07-11
申请人： C. Bennett , Susan Freier , Brett Monia , Nicholas Dean , Hong Zhang , Robert McKay , Donna Ward , William Gaarde , Jacqueline Wyatt , Andrew Watt , Rosanne Crooke , Mark Graham , Pamela Nero , Kenneth Dobie , Alexander Borchers , Eric Marcusson , Mark Roach
发明人： C. Bennett , Susan Freier , Brett Monia , Nicholas Dean , Hong Zhang , Robert McKay , Donna Ward , William Gaarde , Jacqueline Wyatt , Andrew Watt , Rosanne Crooke , Mark Graham , Pamela Nero , Kenneth Dobie , Alexander Borchers , Eric Marcusson , Mark Roach
CPC分类号： C12N9/1205 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MEKK4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK4. Methods of using these compounds for modulation of MEKK4 expression and for treatment of diseases associated with expression of MEKK4 are provided.
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公开(公告)号：US20050153924A1
公开(公告)日：2005-07-14
申请号：US11013543
申请日：2004-12-15
申请人： C. Bennett , Brett Monia , Susan Murray , Madeline Butler , Nicholas Dean , Rosanne Crooke , Mark Graham , Hong Zhang , Susan Freier , Brenda Baker , Eric Marcusson , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Andrew Watt
发明人： C. Bennett , Brett Monia , Susan Murray , Madeline Butler , Nicholas Dean , Rosanne Crooke , Mark Graham , Hong Zhang , Susan Freier , Brenda Baker , Eric Marcusson , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Andrew Watt
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Interferon gamma receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interferon gamma receptor 2. Methods of using these compounds for modulation of Interferon gamma receptor 2 expression and for treatment of diseases associated with expression of Interferon gamma receptor 2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节干扰素γ受体2的表达。组合物包含靶向编码干扰素γ受体2的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节干扰素γ受体2的方法 提供了与干扰素γ受体2表达相关的疾病的表达和治疗。
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公开(公告)号：US20050227938A1
公开(公告)日：2005-10-13
申请号：US11015193
申请日：2004-12-17
申请人： C. Bennett , Brenda Baker , Nicholas Dean , Brett Monia , Susan Freier , James Karras , Hong Zhang , Susan Murray , Madeline Butler , Erich Koller , Thomas Condon , William Gaarde , Andrew Watt , Mark Graham , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Mark Roach
发明人： C. Bennett , Brenda Baker , Nicholas Dean , Brett Monia , Susan Freier , James Karras , Hong Zhang , Susan Murray , Madeline Butler , Erich Koller , Thomas Condon , William Gaarde , Andrew Watt , Mark Graham , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Mark Roach
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/335 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3521 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of TFAP2C. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TFAP2C. Methods of using these compounds for modulation of TFAP2C expression and for treatment of diseases associated with expression of TFAP2C are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节TFAP2C的表达。 组合物包含靶向编码TFAP2C的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节TFAP2C表达和治疗与TFAP2C表达相关的疾病的方法。
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公开(公告)号：US20100130589A1
公开(公告)日：2010-05-27
申请号：US12550479
申请日：2009-08-31
申请人： Susan M. Freier , Kenneth Dobie , Eric G. Marcusson , Eric E. Swayze , Balkrishen Bhat , Jeremy Richard Graff , Bruce William Konicek
发明人： Susan M. Freier , Kenneth Dobie , Eric G. Marcusson , Eric E. Swayze , Balkrishen Bhat , Jeremy Richard Graff , Bruce William Konicek
IPC分类号： A61K31/7088 , C07H21/00 , A61P35/00
CPC分类号： C07H21/00 , A61K38/00 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/53 , C12N2310/3525 , C12N2310/3521 , C12N2310/3533
摘要： Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
摘要翻译： 提供低分子化合物，组合物和方法用于调节eIF4E的表达。 反义化合物可以是单链或双链的，并且靶向编码eIF4E的核酸。 提供了使用这些化合物调节eIF4E表达和用于诊断和治疗与eIF4E表达相关的疾病和病症的方法。
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公开(公告)号：US20100113573A1
公开(公告)日：2010-05-06
申请号：US12578468
申请日：2009-10-13
申请人： Eric G. Marcusson , Scott W. Henry , Youngsoo Kim , Kenneth Dobie
发明人： Eric G. Marcusson , Scott W. Henry , Youngsoo Kim , Kenneth Dobie
IPC分类号： A61K31/7088 , C07H21/00 , A61P35/00 , A61P27/02 , C12N5/071
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of HIF1-beta. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1-beta. Methods of using these compounds for modulation of HIF1-beta expression and for diagnosis and treatment of diseases and conditions associated with expression of HIF1-beta are provided.
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公开(公告)号：US20080009456A1
公开(公告)日：2008-01-10
申请号：US11618167
申请日：2006-12-29
申请人： Kenneth Dobie , Erich Koller
发明人： Kenneth Dobie , Erich Koller
CPC分类号： C12N15/113 , A01K2267/0331 , A61K31/711 , A61K31/713 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12N2310/3521
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding kinesin-like 1. Methods of using these compounds for modulation of kinesin-like 1 expression and for treatment of diseases associated with expression of kinesin-like 1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节驱动蛋白样1的表达。组合物包含靶向编码驱动蛋白样物质的核酸的反义化合物，特别是反义寡核苷酸1.使用这些化合物调节驱动蛋白样1 提供表达和用于治疗与驱动蛋白样1的表达相关的疾病。
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公开(公告)号：US20070066549A1
公开(公告)日：2007-03-22
申请号：US10571339
申请日：2004-09-17
申请人： Susan Freier , Kenneth Dobie , Eric Marcusson , Eric Swayze , Balkrishen Bhat , Jeremy Graff , Bruce Konicek
发明人： Susan Freier , Kenneth Dobie , Eric Marcusson , Eric Swayze , Balkrishen Bhat , Jeremy Graff , Bruce Konicek
IPC分类号： A61K48/00 , A61K38/16 , C07H21/02 , A61K31/704 , A61K31/522 , A61K31/403 , A61K31/4745 , A61K31/7072
CPC分类号： C07H21/00 , A61K38/00 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/53 , C12N2310/3525 , C12N2310/3521 , C12N2310/3533
摘要： Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
摘要翻译： 提供低分子化合物，组合物和方法用于调节eIF4E的表达。 反义化合物可以是单链或双链的，并且靶向编码eIF4E的核酸。 提供了使用这些化合物调节eIF4E表达和用于诊断和治疗与eIF4E表达相关的疾病和病症的方法。
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