公开(公告)号：US20050056776A1

公开(公告)日：2005-03-17

申请号：US10862304

申请日：2004-06-07

申请人： Ross Willoughby ,  Edward Sheehan ,  Craig Whitehouse

发明人： Ross Willoughby ,  Edward Sheehan ,  Craig Whitehouse

IPC分类号： H01J49/00

CPC分类号： H01J49/164 ,  H01J49/06

摘要： Atmospheric pressure, intermediate pressure and vacuum laser desorption ionization methods and ion sources are configured to increase ionization efficiency and the efficiency of transmitting ions to a mass to charge analyzer or ion mobility analyzer. An electric field is applied in the region of a sample target to accumulate ions generated from a local ion source on a solid or liquid phase sample prior to applying a laser desorption pulse. The electric field is changed just prior to or during the desorption laser pulse to promote the desorption of charged species and improve the ionization efficiency of desorbed sample species. After a delay, the electric field may be further changed to optimize focusing and transmission of ions into a mass spectrometer or ion mobility analyzer. Charged species may also be added to the region of the laser desorbed sample plume to promote ion-molecule reactions between the added ions and desorbed neutral sample species, increasing desorbed sample ionization efficiency and/or creating desired product ion species. The cycling of electric field changes is repeated in a timed sequence with one or more desorption laser pulse occurring per electric field change cycle. Embodiments of the invention comprise atmospheric pressure, intermediate pressure and vacuum pressure laser desorption ionization source methods and devices for increasing the analytical flexibility and improving the sensitivity of mass spectrometric analysis.

摘要翻译： 大气压力，中压和真空激光解吸电离方法和离子源被配置为增加电离效率和将离子传输到质量计量分析器或离子迁移率分析仪的效率。 在样品靶的区域内施加电场，以在施加激光解吸脉冲之前，在固相或液相样品上积聚从局部离子源产生的离子。 电场在解吸激光脉冲之前或期间改变，以促进带电物质的解吸附并提高解吸样品的离子化效率。 延迟后，可以进一步改变电场以优化离子聚焦和传输到质谱仪或离子迁移率分析仪中。 带电物质也可以加入到激光解吸样品羽流的区域中，以促进添加的离子和解吸的中性样品物质之间的离子 - 分子反应，增加解吸的样品电离效率和/或产生所需的产物离子种类。 以定时序列重复电场变化的循环，每个电场变化周期发生一个或多个解吸激光脉冲。 本发明的实施例包括大气压力，中压和真空压力激光解吸电离源的方法和装置，用于增加分析灵活性并提高质谱分析的灵敏度。

公开(公告)号：US20050269503A1

公开(公告)日：2005-12-08

申请号：US11173377

申请日：2005-07-02

申请人： Edward Sheehan ,  Ross Willoughby

发明人： Edward Sheehan ,  Ross Willoughby

IPC分类号： B01D20060101 ,  B01D59/44 ,  H01J49/00 ,  H01J49/06 ,  H01J49/10

CPC分类号： H01J49/067 ,  H01J49/0404

摘要： Improvements have been made for selective collecting, focusing, and directing of ions and/or charged particles generated at atmospheric or near atmospheric pressure sources, such as but not limited to, electrospray; atmospheric pressure discharge ionization, chemical ionization, photoionization, and matrix assisted laser desorption ionization; and inductively coupled plasma ionization. A multiple-aperture laminated structure is place at the interface of two pressure regions. Electric fields geometries and strengths across the laminated structure and diameters of the apertures; all of which act to optimize the transfer of the ions from the higher pressure region into the lower pressure region while reducing the gas-load on the lower pressure region. Embodiments of this invention are methods and devices for improving sensitivity of mass spectrometry when coupled to atmospheric, near atmospheric, or higher pressure ionization sources by reducing the gas-load on the vacuum system.

摘要翻译： 已经改进了在大气压或近大气压源（例如但不限于电喷雾）下产生的离子和/或带电粒子的选择性收集，聚焦和引导; 大气压放电电离，化学电离，光电离和基体辅助激光解吸电离; 和电感耦合等离子体电离。 多孔层叠结构位于两个压力区的界面处。 横跨层叠结构和孔直径的电场几何形状和强度; 所有这些都用于优化离子从较高压力区域转移到较低压力区域，同时降低低压区域上的气体负载。 本发明的实施方案是当通过减少真空系统上的气体负载耦合到大气压，接近大气压或更高压力的电离源时，提高质谱的灵敏度的方法和装置。