公开(公告)号：US06530031B1

公开(公告)日：2003-03-04

申请号：US09436113

申请日：1999-11-08

申请人： David Lee Randall ,  David Ross Willoughby

发明人： David Lee Randall ,  David Ross Willoughby

IPC分类号： G06F114

CPC分类号： G06F9/4401 ,  G06F1/14

摘要： A method and apparatus to provide accurate and automated timing of firmware routines, such as initialization tasks at boot time, is provided. Since each task sends a progress indicator code to a display buffer when it starts to run, by saving processor time stamps at the time these codes change, it is possible to calculate and store the time duration for each routine. In the case of system initialization, these time durations can be an indication of problems if they are much longer than normal or an indication of excessive, inefficient, or ineffective processing that might be speed up in order to reduce the total boot time.

摘要翻译： 提供了一种提供固件例程的准确和自动定时的方法和装置，例如在启动时的初始化任务。 由于每个任务在开始运行时都会将进度指示器代码发送到显示缓冲区，通过在这些代码更改时保存处理器时间戳，可以计算并存储每个例程的持续时间。 在系统初始化的情况下，如果这些持续时间比正常时间长得多，或者指示可能加速以减少总启动时间的过程，低效或无效的处理，这些持续时间可以是问题的指示。

公开(公告)号：US20100096542A1

公开(公告)日：2010-04-22

申请号：US12368712

申请日：2009-02-10

申请人： Craig Whitehouse ,  Thomas White ,  Ross Willoughby ,  Ed Sheehan

发明人： Craig Whitehouse ,  Thomas White ,  Ross Willoughby ,  Ed Sheehan

IPC分类号： H01J49/26 ,  H01T19/04 ,  H01J49/04 ,  H01J49/10

CPC分类号： H01J49/165 ,  H01J49/0431 ,  H01J49/107 ,  H01J49/168 ,  H01J49/26

摘要： A multiple function atmospheric pressure ion source interfaced to a mass spectrometer comprises multiple liquid inlet probes configured such that the sprays from two or more probes intersect in a mixing region. Gas phase sample ions or neutral species generated in the spray of one probe can react with reagent gas ions generated from one or more other probes by such ionization methods as Electrospray, photoionization, corona discharge and glow discharge ionization. Reagent ions may be optimally selected to promote such processes as Atmospheric Pressure Chemical Ionization of neutral sample molecules, or charge reduction or electron transfer dissociation of multiply charged sample ions. Selected neutral reagent species can also be introduced into the mixing region to promote charge reduction of multiply charged sample ions through ion-neutral reactions. Different operating modes can be performed alternately or simultaneously, and can be rapidly turned on and off under manual or software control.

摘要翻译： 与质谱仪接口的多功能大气压离子源包括多个液体入口探针，其配置成使得来自两个或更多个探针的喷雾在混合区域相交。 在一个探针的喷雾中产生的气相样品离子或中性物质可以通过诸如电喷雾，光离子化，电晕放电和辉光放电电离的电离方法与从一个或多个其它探针产生的反应气体离子反应。 可以最佳地选择试剂离子以促进诸如中性样品分子的大气压化学电离或多电荷样品离子的电荷还原或电子转移离解的过程。 还可以将选定的中性试剂物质引入混合区域，以通过离子 - 中性反应促进多电荷样品离子的电荷还原。 可以交替或同时执行不同的操作模式，并且可以在手动或软件控制下快速打开和关闭。

公开(公告)号：US20050056776A1

公开(公告)日：2005-03-17

申请号：US10862304

申请日：2004-06-07

申请人： Ross Willoughby ,  Edward Sheehan ,  Craig Whitehouse

发明人： Ross Willoughby ,  Edward Sheehan ,  Craig Whitehouse

IPC分类号： H01J49/00

CPC分类号： H01J49/164 ,  H01J49/06

摘要： Atmospheric pressure, intermediate pressure and vacuum laser desorption ionization methods and ion sources are configured to increase ionization efficiency and the efficiency of transmitting ions to a mass to charge analyzer or ion mobility analyzer. An electric field is applied in the region of a sample target to accumulate ions generated from a local ion source on a solid or liquid phase sample prior to applying a laser desorption pulse. The electric field is changed just prior to or during the desorption laser pulse to promote the desorption of charged species and improve the ionization efficiency of desorbed sample species. After a delay, the electric field may be further changed to optimize focusing and transmission of ions into a mass spectrometer or ion mobility analyzer. Charged species may also be added to the region of the laser desorbed sample plume to promote ion-molecule reactions between the added ions and desorbed neutral sample species, increasing desorbed sample ionization efficiency and/or creating desired product ion species. The cycling of electric field changes is repeated in a timed sequence with one or more desorption laser pulse occurring per electric field change cycle. Embodiments of the invention comprise atmospheric pressure, intermediate pressure and vacuum pressure laser desorption ionization source methods and devices for increasing the analytical flexibility and improving the sensitivity of mass spectrometric analysis.

摘要翻译： 大气压力，中压和真空激光解吸电离方法和离子源被配置为增加电离效率和将离子传输到质量计量分析器或离子迁移率分析仪的效率。 在样品靶的区域内施加电场，以在施加激光解吸脉冲之前，在固相或液相样品上积聚从局部离子源产生的离子。 电场在解吸激光脉冲之前或期间改变，以促进带电物质的解吸附并提高解吸样品的离子化效率。 延迟后，可以进一步改变电场以优化离子聚焦和传输到质谱仪或离子迁移率分析仪中。 带电物质也可以加入到激光解吸样品羽流的区域中，以促进添加的离子和解吸的中性样品物质之间的离子 - 分子反应，增加解吸的样品电离效率和/或产生所需的产物离子种类。 以定时序列重复电场变化的循环，每个电场变化周期发生一个或多个解吸激光脉冲。 本发明的实施例包括大气压力，中压和真空压力激光解吸电离源的方法和装置，用于增加分析灵活性并提高质谱分析的灵敏度。

公开(公告)号：US07650530B2

公开(公告)日：2010-01-19

申请号：US10262055

申请日：2002-09-30

申请人： Bradley Ryan Harrington ,  David Lee Randall ,  Scott Douglas Walton ,  David Ross Willoughby

发明人： Bradley Ryan Harrington ,  David Lee Randall ,  Scott Douglas Walton ,  David Ross Willoughby

IPC分类号： G06F11/00

CPC分类号： G06F11/1417

摘要： EEH methods are used during the boot process to actively disable a defective PCI adapter, thereby allowing the system boot to continue without disruption. This allows faulty adapters to be present in the machine without interrupting the boot process. The slots appear to be empty and the devices/adapters residing therein can be actively “hot swapped” out without altering the rest of the machine state.

摘要翻译： 在引导过程中使用EEH方法主动禁用有缺陷的PCI适配器，从而允许系统启动继续而不中断。 这允许错误的适配器存在于机器中，而不会中断启动过程。 插槽看起来是空的，其中驻留在其中的设备/适配器可以在不改变机器状态的其余部分的情况下主动“热插拔”。

公开(公告)号：US20060255261A1

公开(公告)日：2006-11-16

申请号：US11396968

申请日：2006-04-03

申请人： Craig Whitehouse ,  Thomas White ,  Ross Willoughby ,  Ed Sheehan

发明人： Craig Whitehouse ,  Thomas White ,  Ross Willoughby ,  Ed Sheehan

IPC分类号： H01J49/00 ,  B01D59/44

CPC分类号： H01J49/165 ,  H01J49/0431 ,  H01J49/107 ,  H01J49/168 ,  H01J49/26

摘要： A multiple function atmospheric pressure ion source interfaced to a mass spectrometer comprises multiple liquid inlet probes configured such that the sprays from two or more probes intersect in a mixing region. Gas phase sample ions or neutral species generated in the spray of one probe can react with reagent gas ions generated from one or more other probes by such ionization methods as Electrospray, photoionization, corona discharge and glow discharge ionization. Reagent ions may be optimally selected to promote such processes as Atmospheric Pressure Chemical Ionization of neutral sample molecules, or charge reduction or electron transfer dissociation of multiply charged sample ions. Selected neutral reagent species can also be introduced into the mixing region to promote charge reduction of multiply charged sample ions through ion-neutral reactions. Different operating modes can be performed alternately or simultaneously, and can be rapidly turned on and off under manual or software control.

摘要翻译： 与质谱仪接口的多功能大气压离子源包括多个液体入口探针，其配置成使得来自两个或更多个探针的喷雾在混合区域相交。 在一个探针的喷雾中产生的气相样品离子或中性物质可以通过诸如电喷雾，光离子化，电晕放电和辉光放电电离的电离方法与从一个或多个其它探针产生的反应气体离子反应。 可以最佳地选择试剂离子以促进诸如中性样品分子的大气压化学电离或多电荷样品离子的电荷还原或电子转移离解的过程。 还可以将选定的中性试剂物质引入混合区域，以通过离子 - 中性反应促进多电荷样品离子的电荷还原。 可以交替或同时执行不同的操作模式，并且可以在手动或软件控制下快速打开和关闭。

公开(公告)号：US20050269503A1

公开(公告)日：2005-12-08

申请号：US11173377

申请日：2005-07-02

申请人： Edward Sheehan ,  Ross Willoughby

发明人： Edward Sheehan ,  Ross Willoughby

IPC分类号： B01D20060101 ,  B01D59/44 ,  H01J49/00 ,  H01J49/06 ,  H01J49/10

CPC分类号： H01J49/067 ,  H01J49/0404

摘要： Improvements have been made for selective collecting, focusing, and directing of ions and/or charged particles generated at atmospheric or near atmospheric pressure sources, such as but not limited to, electrospray; atmospheric pressure discharge ionization, chemical ionization, photoionization, and matrix assisted laser desorption ionization; and inductively coupled plasma ionization. A multiple-aperture laminated structure is place at the interface of two pressure regions. Electric fields geometries and strengths across the laminated structure and diameters of the apertures; all of which act to optimize the transfer of the ions from the higher pressure region into the lower pressure region while reducing the gas-load on the lower pressure region. Embodiments of this invention are methods and devices for improving sensitivity of mass spectrometry when coupled to atmospheric, near atmospheric, or higher pressure ionization sources by reducing the gas-load on the vacuum system.

摘要翻译： 已经改进了在大气压或近大气压源（例如但不限于电喷雾）下产生的离子和/或带电粒子的选择性收集，聚焦和引导; 大气压放电电离，化学电离，光电离和基体辅助激光解吸电离; 和电感耦合等离子体电离。 多孔层叠结构位于两个压力区的界面处。 横跨层叠结构和孔直径的电场几何形状和强度; 所有这些都用于优化离子从较高压力区域转移到较低压力区域，同时降低低压区域上的气体负载。 本发明的实施方案是当通过减少真空系统上的气体负载耦合到大气压，接近大气压或更高压力的电离源时，提高质谱的灵敏度的方法和装置。

公开(公告)号：US20110309243A1

公开(公告)日：2011-12-22

申请号：US13218800

申请日：2011-08-26

申请人： Craig Whitehouse ,  Thomas White ,  Ross Willoughby ,  Ed Sheehan

发明人： Craig Whitehouse ,  Thomas White ,  Ross Willoughby ,  Ed Sheehan

IPC分类号： H01J49/10 ,  H01J49/26

CPC分类号： H01J49/165 ,  H01J49/0431 ,  H01J49/107 ,  H01J49/168 ,  H01J49/26

摘要： An apparatus for generating ions includes an Electrospray ionization source configured to provide a spray of charged droplets from a sample solution during operation of the apparatus; an atmospheric pressure chemical ionization (APCI) source including a corona discharge needle configured to produce a corona discharge that further ionizes the spray during operation of the apparatus; and a gas delivery system configured to deliver a gas flow to the corona discharge needle during operation of the apparatus, wherein the gas flow comprises a reagent ion gas which facilitates ionization of the spray by the corona discharge.

摘要翻译： 一种用于产生离子的装置包括：电喷雾离子化源，其构造成在装置运行期间提供来自样品溶液的带电液滴的喷雾; 包括电晕放电针的大气压化学电离源（APCI），其被配置为产生电晕放电，所述电晕放电在所述装置的操作期间进一步电离所述喷雾; 以及气体输送系统，其构造成在所述装置的操作期间将气流输送到所述电晕放电针，其中所述气流包括试剂离子气体，所述试剂离子气体有助于所述电晕放电引起所述喷雾的离子化。

公开(公告)号：US08080783B2

公开(公告)日：2011-12-20

申请号：US12368712

申请日：2009-02-10

申请人： Craig Whitehouse ,  Thomas White ,  Ross Willoughby ,  Ed Sheehan

发明人： Craig Whitehouse ,  Thomas White ,  Ross Willoughby ,  Ed Sheehan

IPC分类号： H01J49/00

CPC分类号： H01J49/165 ,  H01J49/0431 ,  H01J49/107 ,  H01J49/168 ,  H01J49/26

摘要： A multiple function atmospheric pressure ion source interfaced to a mass spectrometer comprises multiple liquid inlet probes configured such that the sprays from two or more probes intersect in a mixing region. Gas phase sample ions or neutral species generated in the spray of one probe can react with reagent gas ions generated from one or more other probes by such ionization methods as Electrospray, photoionization, corona discharge and glow discharge ionization. Reagent ions may be optimally selected to promote such processes as Atmospheric Pressure Chemical Ionization of neutral sample molecules, or charge reduction or electron transfer dissociation of multiply charged sample ions. Selected neutral reagent species can also be introduced into the mixing region to promote charge reduction of multiply charged sample ions through ion-neutral reactions. Different operating modes can be performed alternately or simultaneously, and can be rapidly turned on and off under manual or software control.

摘要翻译： 与质谱仪接口的多功能大气压离子源包括多个液体入口探针，其配置成使得来自两个或更多个探针的喷雾在混合区域相交。 在一个探针的喷雾中产生的气相样品离子或中性物质可以通过诸如电喷雾，光离子化，电晕放电和辉光放电电离的电离方法与从一个或多个其它探针产生的反应气体离子反应。 可以最佳地选择试剂离子以促进诸如中性样品分子的大气压化学电离或多电荷样品离子的电荷还原或电子转移离解的过程。 还可以将选定的中性试剂物质引入混合区域，以通过离子 - 中性反应促进多电荷样品离子的电荷还原。 可以交替或同时执行不同的操作模式，并且可以在手动或软件控制下快速打开和关闭。