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公开(公告)号:US06992081B2
公开(公告)日:2006-01-31
申请号:US09960634
申请日:2001-09-21
申请人: Roy Hom , Shumeye Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Fang
发明人: Roy Hom , Shumeye Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Fang
IPC分类号: A01N43/46 , A01N43/58 , A61K31/55 , A61K31/54 , A61K31/535
CPC分类号: C07D295/185 , A61K38/00 , C07B2200/07 , C07C237/22 , C07C271/14 , C07C271/18 , C07C271/22 , C07C2601/14 , C07C2603/74 , C07D261/20 , C07D295/13 , C07D307/14 , C07D307/33 , C07D307/52 , C07D403/02 , C07D413/02 , C07D417/02 , C07K5/0207 , C07K7/02
摘要: The present invention is directed toward substituted hydroxyethylene compounds of formulas (XII) (XIII), and (XIV) useful in treating Alzheimer's disease and other similar diseases.
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公开(公告)号:US20050182138A1
公开(公告)日:2005-08-18
申请号:US11075232
申请日:2005-03-08
申请人: Varghese John , Jay Tung , Roy Hom , Ashley Guinn , Lawrence Fang , Andrea Gailunas , Shumeye Mamo
发明人: Varghese John , Jay Tung , Roy Hom , Ashley Guinn , Lawrence Fang , Andrea Gailunas , Shumeye Mamo
IPC分类号: C07K5/02 , C07K5/103 , A61K31/165 , C07C237/40
CPC分类号: C07K5/101 , C07K5/0205
摘要: Dipeptide derived inhibitors of the β-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of Aβ peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce Aβ peptide formation and in pharmaceutical compositions.
摘要翻译: 提供了二肽衍生的β-分泌酶的抑制剂,其可用于治疗阿尔茨海默病和以哺乳动物中Abeta肽沉积为特征的其它疾病。 本发明的化合物提供了通过施用这些抑制剂以减少Aβ肽形成和药物组合物治疗的有用方法。
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公开(公告)号:US20060287306A1
公开(公告)日:2006-12-21
申请号:US11345660
申请日:2006-01-31
申请人: Roy Hom , Shumeye Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Fang
发明人: Roy Hom , Shumeye Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Fang
IPC分类号: A61K31/541 , A61K31/5377 , A61K31/497 , A61K31/496 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号: C07D295/185 , A61K38/00 , C07B2200/07 , C07C237/22 , C07C271/14 , C07C271/18 , C07C271/22 , C07C2601/14 , C07C2603/74 , C07D261/20 , C07D295/13 , C07D307/14 , C07D307/33 , C07D307/52 , C07D403/02 , C07D413/02 , C07D417/02 , C07K5/0207 , C07K7/02
摘要: The present invention is directed toward substituted hydroxyethylene compounds of formulas (XII) (XIII), and (XIV) useful in treating Alzheimer's disease and other similar diseases.
摘要翻译: 本发明涉及用于治疗阿尔茨海默病和其他类似疾病的式(XII)(XIII)和(XIV)的取代的羟基亚乙基化合物。
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公开(公告)号:US20060276642A1
公开(公告)日:2006-12-07
申请号:US11405705
申请日:2006-04-17
申请人: Roy Hom , Shumeye Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Fang
发明人: Roy Hom , Shumeye Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Fang
IPC分类号: C07D471/02 , C07D279/12 , C07D211/26 , C07D237/28
CPC分类号: C07C237/22 , A61K38/00 , C07B2200/07 , C07C271/14 , C07C271/18 , C07C271/22 , C07C2601/14 , C07C2603/74 , C07D261/20 , C07D295/13 , C07D295/185 , C07D307/14 , C07D307/33 , C07D307/52 , C07K5/0207 , C07K7/02
摘要: The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
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公开(公告)号:US07276484B2
公开(公告)日:2007-10-02
申请号:US11075232
申请日:2005-03-08
申请人: Varghese John , Jay Tung , Roy Hom , Ashley Guinn , Lawrence Fang , Andrea Gailunas , Shumeye S. Mamo
发明人: Varghese John , Jay Tung , Roy Hom , Ashley Guinn , Lawrence Fang , Andrea Gailunas , Shumeye S. Mamo
IPC分类号: C07K5/06
CPC分类号: C07K5/101 , C07K5/0205
摘要: Dipeptide derived inhibitors of the β-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of Aβ peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce Aβ peptide formation and in pharmaceutical compositions.
摘要翻译: 提供了二肽衍生的β-分泌酶的抑制剂,其可用于治疗阿尔茨海默病和以哺乳动物中Abeta肽沉积为特征的其它疾病。 本发明的化合物提供了通过施用这些抑制剂以减少Aβ肽形成和药物组合物治疗的有用方法。
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公开(公告)号:US06864240B1
公开(公告)日:2005-03-08
申请号:US09594978
申请日:2000-06-15
申请人: Varghese John , Jay Tung , Roy Hom , Ashley Guinn , Lawrence Fang , Andrea Gailunas , Shumeye S. Mamo
发明人: Varghese John , Jay Tung , Roy Hom , Ashley Guinn , Lawrence Fang , Andrea Gailunas , Shumeye S. Mamo
CPC分类号: C07K5/101 , C07K5/0205
摘要: Dipeptide derived inhibitors of the β-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of Aβ peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce Aβ peptide formation and in pharmaceutical compositions.
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公开(公告)号:US06737420B2
公开(公告)日:2004-05-18
申请号:US09815960
申请日:2001-03-23
申请人: Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
发明人: Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
IPC分类号: A01N5502
CPC分类号: C07C237/22 , A61K38/00 , C07B2200/07 , C07C271/14 , C07C271/18 , C07C271/22 , C07C2601/14 , C07C2603/74 , C07D261/20 , C07D295/13 , C07D295/185 , C07D307/14 , C07D307/33 , C07D307/52 , C07K5/0207 , C07K7/02
摘要: The present invention is directed toward substituted hydroxyethylene compounds of formula (XII): useful in treating Alzheimer's disease and other similar diseases.
摘要翻译: 本发明涉及式(XII)的取代羟基亚乙基化合物:可用于治疗阿尔茨海默氏病和其它类似疾病。
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公开(公告)号:US07119085B2
公开(公告)日:2006-10-10
申请号:US09816876
申请日:2001-03-23
申请人: Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
发明人: Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
IPC分类号: A61K31/55 , A61K31/535 , A61K31/35 , A61K31/34
CPC分类号: C07C237/22 , A61K38/00 , C07B2200/07 , C07C271/14 , C07C271/18 , C07C271/22 , C07C2601/14 , C07C2603/74 , C07D261/20 , C07D295/13 , C07D295/185 , C07D307/14 , C07D307/33 , C07D307/52 , C07K5/0207 , C07K7/02
摘要: The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
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公开(公告)号:US07030239B2
公开(公告)日:2006-04-18
申请号:US10847819
申请日:2004-05-18
申请人: Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
发明人: Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
IPC分类号: C07D237/00 , C07D237/02 , C07D237/26 , C07D237/28 , C07D487/00
CPC分类号: C07C237/22 , A61K38/00 , C07B2200/07 , C07C271/14 , C07C271/18 , C07C271/22 , C07C2601/14 , C07C2603/74 , C07D261/20 , C07D295/13 , C07D295/185 , C07D307/14 , C07D307/33 , C07D307/52 , C07K5/0207 , C07K7/02
摘要: The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
摘要翻译: 本发明涉及可用于治疗阿尔茨海默氏病和其他类似疾病的式(XII)的取代的羟基亚乙基化合物。
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公开(公告)号:US20080058336A1
公开(公告)日:2008-03-06
申请号:US11548136
申请日:2006-10-10
申请人: Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
发明人: Roy Hom , Shumeye S. Mamo , Jay Tung , Andrea Gailunas , Varghese John , Lawrence Y. Fang
IPC分类号: A61K31/5375 , A61K31/164 , A61K31/192 , A61K31/195 , A61K31/215 , A61P43/00 , C12N9/99 , A61K31/221 , A61K31/341 , A61K31/421 , A61K31/445
CPC分类号: C07C237/22 , A61K38/00 , C07B2200/07 , C07C271/14 , C07C271/18 , C07C271/22 , C07C2601/14 , C07C2603/74 , C07D261/20 , C07D295/13 , C07D295/185 , C07D307/14 , C07D307/33 , C07D307/52 , C07K5/0207 , C07K7/02
摘要: The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
摘要翻译: 本发明涉及可用于治疗阿尔茨海默氏病和其他类似疾病的式(XII)的取代的羟基亚乙基化合物。
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